Gene Page: CD74

Summary
GeneID  972
Symbol  CD74
Synonyms  DHLAG|HLADG|Ia-GAMMA
Description  CD74 molecule, major histocompatibility complex, class II invariant chain
See related  HGNC:1697|MIM:142790|Ensembl:ENSG00000019582|HPRD:00825|
Locus tag  -
Gene type  protein-coding
Map location  5q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FPGS0.820.77
SLC25A10.820.79
ADCK40.820.79
GNB20.810.79
VPS280.810.77
CPSF3L0.810.76
C7orf270.810.81
ZNF4080.810.78
MIIP0.810.78
CXXC10.800.77
Top 10 negatively co-expressed genes
AF347015.27-0.57-0.63
C5orf53-0.55-0.58
AF347015.33-0.55-0.62
AF347015.31-0.53-0.59
MT-CYB-0.51-0.59
RAPGEF4-0.50-0.56
RGS5-0.50-0.53
SLCO1A2-0.50-0.63
AF347015.8-0.50-0.60
PLA2G4A-0.49-0.55
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0019955cytokine bindingIPI12782713 
GO:0042289MHC class II protein bindingIEA-
GO:0042289MHC class II protein bindingNAS10981873 
GO:0042802identical protein bindingTAS12782713 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001516prostaglandin biosynthetic processIDA12782713 
GO:0006461protein complex assemblyISS-
GO:0016064immunoglobulin mediated immune responseISS-
GO:0007165signal transductionIDA12782713 
GO:0019882antigen processing and presentationIEA-
GO:0019883antigen processing and presentation of endogenous antigenNAS10981873 
GO:0008283cell proliferationIDA12782713 
GO:0006955immune responseIEA-
GO:0006886intracellular protein transportIEA-
GO:0006886intracellular protein transportISS-
GO:0043066negative regulation of apoptosisIDA12782713 
GO:0043030regulation of macrophage activationNAS12782713 
GO:0045058T cell selectionNAS10981873 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularTAS12782713 
GO:0016020membraneIEA-
GO:0016021integral to membraneTAS6324166 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD1DCD1A | MGC34622 | R3CD1d molecule-HPRD11754812 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD8343954 
CD74DHLAG | HLADG | Ia-GAMMACD74 molecule, major histocompatibility complex, class II invariant chain-HPRD,BioGRID2391366 |7519244 
HLA-DMAD6S222E | DMA | HLADM | RING6major histocompatibility complex, class II, DM alpha-HPRD,BioGRID8574855 
HLA-DMBD6S221E | RING7major histocompatibility complex, class II, DM beta-HPRD,BioGRID8574855 
MIFGIF | GLIF | MMIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor)MIF interacts with CD74BIND12782713 
-HPRD,BioGRID12782713 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 9161All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_D_UP 3823All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_DN 4529All SZGR genes in this pathway
CAVARD_LIVER_CANCER_MALIGNANT_VS_BENIGN 3219All SZGR genes in this pathway
MATTIOLI_MGUS_VS_PCL 11662All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_4 169All SZGR genes in this pathway
TSUNODA_CISPLATIN_RESISTANCE_DN 5138All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
LIU_NASOPHARYNGEAL_CARCINOMA 7038All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_DN 7749All SZGR genes in this pathway
MORI_LARGE_PRE_BII_LYMPHOCYTE_DN 5839All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_UP 5335All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_UP 9062All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_DN 2114All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_UP 6440All SZGR genes in this pathway
WIELAND_UP_BY_HBV_INFECTION 10166All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_UP 5634All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_UP 6235All SZGR genes in this pathway
YU_MYC_TARGETS_DN 5538All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
GREENBAUM_E2A_TARGETS_DN 2111All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP 10176All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
HAN_JNK_SINGALING_DN 3927All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
KIM_LRRC3B_TARGETS 3024All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
BEIER_GLIOMA_STEM_CELL_DN 6642All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN 10265All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
NUTT_GBM_VS_AO_GLIOMA_UP 4634All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP 7049All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
VALK_AML_CLUSTER_6 3322All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_UP 6242All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_UP 10165All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
KIM_GLIS2_TARGETS_UP 8461All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_UP 266142All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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