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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: MED13

Summary

GeneID

9969

Symbol

MED13

Synonyms

Description

mediator complex subunit 13

Locus tag

Gene type

protein-coding

Map location

17q22-q23

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Expression

P value: 1.38

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

DMXL1

0.93

0.95

NF1

0.93

0.95

GARNL1

0.92

ATG2B

0.92

0.93

CXorf39

0.92

DMXL2

0.91

0.92

AC010896.1

0.91

0.95

APPL1

0.91

0.92

SEL1L

0.91

0.94

C9orf5

0.91

0.92

Top 10 negatively co-expressed genes

FXYD1

-0.59

-0.58

AF347015.21

-0.58

-0.56

C1orf61

-0.57

-0.70

C1orf54

-0.57

-0.62

HIGD1B

-0.57

-0.59

MT-CO2

-0.55

-0.56

CSAG1

-0.55

VAMP5

-0.55

-0.53

AC098691.2

-0.55

-0.59

EIF4EBP3

-0.54

-0.57

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004872

receptor activity

IDA

12218053

GO:0016455

RNA polymerase II transcription mediator activity

IDA

10198638

GO:0030374

ligand-dependent nuclear receptor transcription coactivator activity

NAS

10235266

GO:0042809

vitamin D receptor binding

NAS

10235266

GO:0046966

thyroid hormone receptor binding

IDA

10198638

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006367

transcription initiation from RNA polymerase II promoter

IDA

12218053

GO:0006350

transcription

IEA

GO:0030521

androgen receptor signaling pathway

IDA

12218053

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IDA

12037571

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000119

mediator complex

IDA

10198638

GO:0005634

nucleus

IDA

10235267

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Affinity Capture-MS	BioGRID	15208681
CDK8	K35 \| MGC126074 \| MGC126075	cyclin-dependent kinase 8	Affinity Capture-MS	BioGRID	10198638
MED10	L6 \| MGC5309 \| NUT2 \| TRG20	mediator complex subunit 10	Affinity Capture-MS	BioGRID	15175163
MED19	DT2P1G7 \| LCMR1	mediator complex subunit 19	Affinity Capture-MS	BioGRID	15175163
MED26	CRSP7 \| CRSP70	mediator complex subunit 26	Affinity Capture-MS	BioGRID	15175163
MED28	1500003D12Rik \| DKFZp434N185 \| EG1 \| magicin	mediator complex subunit 28	Affinity Capture-MS	BioGRID	15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	Affinity Capture-MS	BioGRID	15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	-	HPRD	14576168
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	Affinity Capture-MS	BioGRID	15175163
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	-	HPRD	14638676
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	Affinity Capture-MS	BioGRID	10198638

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP	177	113	All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP	443	294	All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_D_UP	38	23	All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_UP	181	108	All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL	326	213	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	483	336	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON	335	181	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN	228	146	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP	178	111	All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_DN	264	168	All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP	504	321	All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_5	18	11	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	3084	3090	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-128	760	766	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
				hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-129-5p	3818	3824	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	3818	3824	1A	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-134	263	270	1A,m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-135	2742	2748	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
				hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
				hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
				hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
				hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
				hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
				hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
				hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-136	329	335	1A	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-137	538	544	m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-140	2893	2899	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-142-5p	3623	3629	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-144	3083	3090	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-145	3525	3531	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-145	3525	3531	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-146	1450	1456	1A	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	1450	1456	1A	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-15/16/195/424/497	1595	1601	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-153	2737	2743	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d	3622	3628	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-18	2796	2802	1A	hsa-miR-18a	UAAGGUGCAUCUAGUGCAGAUA
miR-18	2796	2802	1A	hsa-miR-18b	UAAGGUGCAUCUAGUGCAGUUA
miR-183	3740	3746	1A	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-19	1531	1538	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1531	1538	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-194	1017	1023	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-196	1664	1670	1A	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	1664	1670	1A	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-200bc/429	2659	2665	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-205	3628	3634	m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-208	565	572	1A,m8	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-217	582	588	1A	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-24	288	294	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-26	1641	1647	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
				hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	2761	2768	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	2761	2768	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-299-5p	2892	2898	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-323	3034	3040	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-324-3p	3657	3663	1A	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-34b	521	527	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p	603	609	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-369-3p	603	609	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	222	229	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-375	3717	3723	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-379	1662	1668	m8	hsa-miR-379^brain	UGGUAGACUAUGGAACGUA
miR-381	390	396	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	894	900	m8	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
				hsa-miR-410	AAUAUAACACAGAUGGCCUGU
				hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-433-3p	3850	3856	1A	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-448	2737	2743	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p	2776	2783	1A,m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-493-5p	742	748	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
				hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
				hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-499	566	572	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-543	1015	1021	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.