| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 22943 |
Name | DKK1 |
Synonym | DKK-1|SK;dickkopf WNT signaling pathway inhibitor 1;DKK1;dickkopf WNT signaling pathway inhibitor 1 |
Definition | dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1 |
Position | 10q11.2 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 5979 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Presenilin action in Notch and Wnt signaling;PID Curated;200052 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages;PID BioCarta;100152 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | wnt signaling pathway;PID BioCarta;100002 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | wnt lrp6 signalling;PID BioCarta;100003 |
Pathway | multi-step regulation of transcription by pitx2;PID BioCarta;100074 |
Pathway | Wnt signaling network;PID Curated;200055 |
Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Pathway | segmentation clock;PID BioCarta;100146 |
Disease | Electrocardiographic traits;NHGRI |
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External Links |
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Links to Entrez Gene | 22943 |
Links to all GeneRIF Items | 22943 |
Links to iHOP | 22943 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>22943 : length: 801 atgatggctctgggcgcagcgggagctacccgggtctttgtcgcgatggtagcggcggct ctcggcggccaccctctgctgggagtgagcgccaccttgaactcggttctcaattccaac gctatcaagaacctgcccccaccgctgggcggcgctgcggggcacccaggctctgcagtc agcgccgcgccgggaatcctgtacccgggcgggaataagtaccagaccattgacaactac cagccgtacccgtgcgcagaggacgaggagtgcggcactgatgagtactgcgctagtccc acccgcggaggggacgcaggcgtgcaaatctgtctcgcctgcaggaagcgccgaaaacgc tgcatgcgtcacgctatgtgctgccccgggaattactgcaaaaatggaatatgtgtgtct tctgatcaaaatcatttccgaggagaaattgaggaaaccatcactgaaagctttggtaat gatcatagcaccttggatgggtattccagaagaaccaccttgtcttcaaaaatgtatcac accaaaggacaagaaggttctgtttgtctccggtcatcagactgtgcctcaggattgtgt tgtgctagacacttctggtccaagatctgtaaacctgtcctgaaagaaggtcaagtgtgt accaagcataggagaaaaggctctcatggactagaaatattccagcgttgttactgtgga gaaggtctgtcttgccggatacagaaagatcaccatcaagccagtaattcttctaggctt cacacttgtcagagacactaa |
Protein Sequence |
>22943 : length: 266 MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAV SAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKR CMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYH TKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCG EGLSCRIQKDHHQASNSSRLHTCQRH |