Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

22943

Name

DKK1

Synonymous

dickkopf WNT signaling pathway inhibitor 1;DKK1;dickkopf WNT signaling pathway inhibitor 1

Definition

dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1

Position

10q11.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.10.

The copy number variations for various cancers

Top

There is no record for DKK1

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.182G>T; p.S61I; 10:52314616-52314616

 livercarcinomaSubstitution - Missense

c.167C>A; p.P56Q; 10:52314601-52314601

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.183C>T; p.S61S; 10:52314617-52314617

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.390G>A; p.G130G; 10:52315069-52315069

 skinmalignant_melanomaSubstitution - coding silent

c.140C>A; p.P47Q; 10:52314574-52314574

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.187G>T; p.A63S; 10:52314621-52314621

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.358C>T; p.R120C; 10:52315037-52315037

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.113A>C; p.N38T; 10:52314547-52314547

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.579A>G; p.S193S; 10:52316585-52316585

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.99G>A; p.L33L; 10:52314533-52314533

 breastcarcinomaSubstitution - coding silent

c.551A>G; p.Q184R; 10:52316557-52316557

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.352C>T; p.R118*; 10:52315031-52315031

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.352C>T; p.R118*; 10:52315031-52315031

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.245C>A; p.P82Q; 10:52314924-52314924

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.633A>G; p.K211K; 10:52316639-52316639

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.433C>T; p.H145Y; 10:52316321-52316321

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.176C>A; p.A59E; 10:52314610-52314610

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.64G>A; p.G22S; 10:52314498-52314498

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.332G>T; p.C111F; 10:52315011-52315011

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.539A>C; p.H180P; 10:52316427-52316427

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257F; 10:52316776-52316776

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.661A>G; p.T221A; 10:52316667-52316667

 skinmalignant_melanomaSubstitution - Missense

c.463A>G; p.T155A; 10:52316351-52316351

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.120C>A; p.N40K; 10:52314554-52314554

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.566G>C; p.C189S; 10:52316572-52316572

 large_intestine; rectumNSSubstitution - Missense

c.320G>A; p.G107D; 10:52314999-52314999

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.91G>A; p.A31T; 10:52314525-52314525

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.748G>A; p.D250N; 10:52316754-52316754

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.748G>A; p.D250N; 10:52316754-52316754

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.674G>A; p.R225K; 10:52316680-52316680

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.501G>A; p.G167G; 10:52316389-52316389

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.386C>T; p.P129L; 10:52315065-52315065

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.694G>T; p.E232*; 10:52316700-52316700

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.621C>T; p.S207S; 10:52316627-52316627

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.694G>T; p.E232*; 10:52316700-52316700

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.93C>A; p.A31A; 10:52314527-52314527

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.300C>A; p.P100P; 10:52314979-52314979

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.211G>A; p.G71R; 10:52314645-52314645

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.121G>A; p.A41T; 10:52314555-52314555

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.121G>A; p.A41T; 10:52314555-52314555

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.711T>A; p.C237*; 10:52316717-52316717

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.373G>A; p.A125T; 10:52315052-52315052

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.152G>A; p.G51D; 10:52314586-52314586

 skinmalignant_melanomaSubstitution - Missense

c.15C>T; p.G5G; 10:52314449-52314449

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.158C>T; p.A53V; 10:52314592-52314592

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.672G>C; p.R224S; 10:52316678-52316678

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.205C>T; p.P69S; 10:52314639-52314639

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.572G>T; p.R191L; 10:52316578-52316578

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.292G>A; p.A98T; 10:52314971-52314971

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.620C>A; p.S207Y; 10:52316626-52316626

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.230T>C; p.I77T; 10:52314664-52314664

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.85G>T; p.V29L; 10:52314519-52314519

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.527C>A; p.S176*; 10:52316415-52316415

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.707G>A; p.R236H; 10:52316713-52316713

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.391A>C; p.N131H; 10:52315070-52315070

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.668A>G; p.H223R; 10:52316674-52316674

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.668A>G; p.H223R; 10:52316674-52316674

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.552A>C; p.Q184H; 10:52316558-52316558

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.759A>T; p.Q253H; 10:52316765-52316765

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.139C>A; p.P47T; 10:52314573-52314573

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.29C>A; p.T10N; 10:52314463-52314463

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.138C>T; p.P46P; 10:52314572-52314572

 skinmalignant_melanomaSubstitution - coding silent

c.367C>T; p.R123C; 10:52315046-52315046

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.109C>T; p.L37F; 10:52314543-52314543

 skinmalignant_melanomaSubstitution - Missense

c.189G>A; p.A63A; 10:52314623-52314623

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.316G>A; p.A106T; 10:52314995-52314995

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.372C>T; p.H124H; 10:52315051-52315051

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.368G>A; p.R123H; 10:52315047-52315047

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.442_443GG>AA; p.G148K; 10:52316330-52316331

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.680G>A; p.G227D; 10:52316686-52316686

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.244-7C>T; p.?; 10:52314916-52314916

 breastcarcinomaUnknown

c.673A>G; p.R225G; 10:52316679-52316679

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.619T>C; p.S207P; 10:52316625-52316625

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.221A>G; p.Y74C; 10:52314655-52314655

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

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