Entrez Gene

Basic Information
Gene ID	22943
Name	DKK1
Synonymous	DKK-1\|SK;dickkopf WNT signaling pathway inhibitor 1;DKK1;dickkopf WNT signaling pathway inhibitor 1
Definition	dickkopf 1 homolog\|dickkopf related protein-1\|dickkopf-1 like\|dickkopf-like protein 1\|dickkopf-related protein 1\|hDkk-1
Position	10q11.2
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
Dkk-1(h) + LRP6(h) <==> Dkk-1(h):LRP6(h) (binding)
Dkk-1(h) + CORO1(h) <==> Dkk-1(h):CORO1(h) (binding)
I-MF(h) + Dkk-1(h) <==> I-MF(h):Dkk-1(h) (binding)
DKK1(h) --> Dkk-1(h) (expression).
Dkk-1(h) --> KLEIP(h) (transactivation)
Dkk-1(h) --> KRT9(h) (transactivation)
Dkk-1(h) --> GJB6(h) (transactivation)
Dkk-1(h) --/ F2RL1(h) (transrepression)
Dkk-1(h) --/ P4HA2(h) (transrepression)
Dkk-1(h) --/ TULP3(h) (transrepression)
Dkk-1(h) --/ MITF(h) (transrepression)
Dkk-1(h) --> Keratin-9(h) (increase of abundance)
Dkk-1(h) --> kleip(h) (increase of abundance)
Dkk-1(h) --/ GSK3beta(h) (decrease of abundance)
Dkk-1(h) --/ PAR2(h) (decrease of abundance)
Dkk-1(h) --> PRKCB1(h) (transactivation)
Dkk-1(h) --> KRTAP5-9(h) (transactivation)
Dkk-1(h) --> GPR51(h) (transactivation)
Dkk-1(h) --> LRP6(h) (transactivation)
Dkk-1(h) --> GADD45A(h) (transactivation)
Dkk-1(h) --/ beta-catenin(h) (decrease of abundance)
Dkk-1(h) --> LDLR(h) (transactivation)
Dkk-1(h) --> GSK3beta(h){pS9} (increase of phosphorylation)
Dkk-1(h) --> PKCalpha(h) (increase of abundance)
Dkk-1(h) --/ melanin (decrease of abundance)
DKK1(h) --> Dkk-1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
256	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0