| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 23411 |
Name | SIRT1 |
Synonym | SIR2|SIR2L1|hSIR2;sirtuin 1;SIRT1;sirtuin 1 |
Definition | NAD-dependent deacetylase sirtuin-1|NAD-dependent protein deacetylase sirtuin-1|SIR2-like protein 1|SIR2alpha|regulatory protein SIR2 homolog 1|sir2-like 1|sirtuin type 1 |
Position | 10q21.3 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 14961 |
TUSON P-value | 1 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
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Pathways and Diseases |
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Pathway | Regulation of retinoblastoma protein;PID Curated;200191 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Signaling events mediated by HDAC Class III;PID Curated;200020 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | regulation of transcriptional activity by pml;PID BioCarta;100067 |
Pathway | HIF-2-alpha transcription factor network;PID Curated;200030 |
Pathway | FoxO family signaling;PID Curated;200091 |
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External Links |
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Links to Entrez Gene | 23411 |
Links to all GeneRIF Items | 23411 |
Links to iHOP | 23411 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>23411 : length: 1359 atgtttgatattgaatatttcagaaaagatccaagaccattcttcaagtttgcaaaggaa atatatcctggacaattccagccatctctctgtcacaaattcatagccttgtcagataag gaaggaaaactacttcgcaactatacccagaacatagacacgctggaacaggttgcggga atccaaaggataattcagtgtcatggttcctttgcaacagcatcttgcctgatttgtaaa tacaaagttgactgtgaagctgtacgaggagatatttttaatcaggtagttcctcgatgt cctaggtgcccagctgatgaaccgcttgctatcatgaaaccagagattgtgttttttggt gaaaatttaccagaacagtttcatagagccatgaagtatgacaaagatgaagttgacctc ctcattgttattgggtcttccctcaaagtaagaccagtagcactaattccaagttccata ccccatgaagtgcctcagatattaattaatagagaacctttgcctcatctgcattttgat gtagagcttcttggagactgtgatgtcataattaatgaattgtgtcataggttaggtggt gaatatgccaaactttgctgtaaccctgtaaagctttcagaaattactgaaaaacctcca cgaacacaaaaagaattggcttatttgtcagagttgccacccacacctcttcatgtttca gaagactcaagttcaccagaaagaacttcaccaccagattcttcagtgattgtcacactt ttagaccaagcagctaagagtaatgatgatttagatgtgtctgaatcaaaaggttgtatg gaagaaaaaccacaggaagtacaaacttctaggaatgttgaaagtattgctgaacagatg gaaaatccggatttgaagaatgttggttctagtactggggagaaaaatgaaagaacttca gtggctggaacagtgagaaaatgctggcctaatagagtggcaaaggagcagattagtagg cggcttgatggtaatcagtatctgtttttgccaccaaatcgttacattttccatggcgct gaggtatattcagactctgaagatgacgtcttatcctctagttcttgtggcagtaacagt gatagtgggacatgccagagtccaagtttagaagaacccatggaggatgaaagtgaaatt gaagaattctacaatggcttagaagatgagcctgatgttccagagagagctggaggagct ggatttgggactgatggagatgatcaagaggcaattaatgaagctatatctgtgaaacag gaagtaacagacatgaactatccatcaaacaaatcatag |
Protein Sequence |
>23411 : length: 452 MFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAG IQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFG ENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFD VELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVS EDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQM ENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGA EVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGA GFGTDGDDQEAINEAISVKQEVTDMNYPSNKS |