| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 23411 |
Name | SIRT1 |
Synonymous | SIR2|SIR2L1|hSIR2;sirtuin 1;SIRT1;sirtuin 1 |
Definition | NAD-dependent deacetylase sirtuin-1|NAD-dependent protein deacetylase sirtuin-1|SIR2-like protein 1|SIR2alpha|regulatory protein SIR2 homolog 1|sir2-like 1|sirtuin type 1 |
Position | 10q21.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
p53(h) + SIRT1(h) <==> p53(h):SIRT1(h) (binding) | SIRT1(h) + ING1b(h) <==> SIRT1(h):ING1b(h) (binding) | FOXO3a(h) + SIRT1(h) <==> FOXO3a(h):SIRT1(h) (binding) | p300(h) + SIRT1(h) <==> p300(h):SIRT1(h) (binding) | SIRT1(h) + FOXO3a(h) <==> SIRT1(h):FOXO3a(h) (binding) | SIRT1(h) + p/CAF(h) <==> SIRT1(h):p/CAF(h) (binding) | SIRT1(h) + p/CAF(h) + MyoD(h) <==> SIRT1(h):p/CAF(h):MyoD(h) (binding) | SIRT1(h) + FOXO1A(m.s.) <==> SIRT1(h):FOXO1A(m.s.) (binding) | SIRT1(h) + FOXO1A(h) <==> SIRT1(h):FOXO1A(h) (binding) | SIRT1(h) + AR(h) <==> SIRT1(h):AR(h) (binding) | RelA-p65(h) + SIRT1(h) <==> RelA-p65(h):SIRT1(h) (binding) | SIRT1(h) + RelA-p65(m.s.) <==> SIRT1(h):RelA-p65(m.s.) (binding) | SIRT1(h) + hist1h1b(m.s.) <==> SIRT1(h):hist1h1b(m.s.) (binding) | RBBP1(m.s.) + SIRT1(h) <==> RBBP1(m.s.):SIRT1(h) (binding) | SIRT1(h) --> SIRT1(h) (expression). | p53(h){ace} --SIRT1(h)--> p53(h) + acetyl (deacetylation) | FOXO3a(h){ace} --SIRT1(h)--> FOXO3a(h) + acetyl (deacetylation) | p300(h){ace} --SIRT1(h)--> p300(h) + acetyl (deacetylation) | foxo4(h){ace} --SIRT1(h)--> foxo4(h) + acetyl (deacetylation) | RelA-p65(m.s.){ace} --SIRT1(h)--> RelA-p65(m.s.) + acetyl (deacetylation) | p300(h) + SIRT1(h) <==> p300(h):SIRT1(h) (binding) | FOXO1A(m.s.) + SIRT1(h) <==> FOXO1A(m.s.):SIRT1(h) (binding) | SIRT1(h) + Slim-3(h) <==> SIRT1(h):Slim-3(h) (binding) | SIRT1(h) + HES-1(h) <==> SIRT1(h):HES-1(h) (binding) | Hey2(h) + SIRT1(h) <==> Hey2(h):SIRT1(h) (binding) | SIRT1(h) + AR-isoform1(h) <==> SIRT1(h):AR-isoform1(h) (binding) | SIRT1(h) + c-Fos(h) <==> SIRT1(h):c-Fos(h) (binding) | c-Jun(h) + SIRT1(h) <==> c-Jun(h):SIRT1(h) (binding) | SIRT1(h) --> SIRT1(h) (expression). | FOXO1A(m.s.){aceK} --SIRT1(h)--> FOXO1A(m.s.) + acetyl (deacetylation) | AR-isoform1(h){aceK630}{aceK632}{aceK633} --SIRT1(h)--> AR-isoform1(h) + 3 acetyl (deacetylation) | p53(m.s.){aceK} --SIRT1(h)--> p53(m.s.) + acetyl (deacetylation) | p300(h){aceK1020}{aceK1024} --SIRT1(h)--> p300(h) + 2 acetyl (deacetylation) | SIRT1(h) --> SIRT1(h) (expression). | hsa-miR-34a --/ SIRT1(h) (translational repression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
27 | Phosphoserine. | Swiss-Prot 53.0 | 47 | Phosphoserine. | Swiss-Prot 53.0 | 27 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 47 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr10 |
Promoter: 69312933 - 69314933 | Agilent_014791 |
chr10 |
Promoter: 69312933 - 69314933 | GSE27584 |
chr10 |
Promoter: 69312933 - 69314933 | Agilent_014791_44K |