Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

23411

Name

SIRT1

Synonymous

SIR2|SIR2L1|hSIR2;sirtuin 1;SIRT1;sirtuin 1

Definition

NAD-dependent deacetylase sirtuin-1|NAD-dependent protein deacetylase sirtuin-1|SIR2-like protein 1|SIR2alpha|regulatory protein SIR2 homolog 1|sir2-like 1|sirtuin type 1

Position

10q21.3

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 ARNTNCI_NATURE;

in same component

 BAXNCI_NATURE;

in same component

 EP300NCI_NATURE;

in same component

 EPAS1NCI_NATURE;

in same component

 FHL2NCI_NATURE;

in same component

 FOXO1NCI_NATURE;

in same component

 FOXO3NCI_NATURE;

in same component

 FOXO4NCI_NATURE;

in same component

 HDAC4NCI_NATURE;

in same component

 HIST1H1ENCI_NATURE;

in same component

 KAT2BNCI_NATURE;

in same component

 MEF2DNCI_NATURE;

in same component

 MYOD1NCI_NATURE;

in same component

 PPARGC1ANCI_NATURE;

in same component

 TP53NCI_NATURE;

in same component

 XRCC6NCI_NATURE;

interacts with

 AKIP1BIOGRID;

interacts with

 AKT1INTACT;

interacts with

 ARID4BBIOGRID;

interacts with

 ARNTLBIOGRID;

interacts with

 ARBIOGRID;

interacts with

 ATP1A1MINT;

interacts with

 BCL11ABIOGRID;

interacts with

 BHLHE41BIOGRID;

interacts with

 CLOCKBIOGRID;

interacts with

 CSNK2A1BIOGRID;

interacts with

 CTNNB1BIOGRID;

interacts with

 CTTNBIOGRID;

interacts with

 DBC1BIOGRID;

interacts with

 DDOSTMINT;

interacts with

 DICER1MINT;

interacts with

 DNAJA2MINT;

interacts with

 DOT1LBIOGRID;

interacts with

 DVL1BIOGRID;

interacts with

 DVL2BIOGRID;

interacts with

 E2F1BIOGRID;

interacts with

 EEF1A1MINT;

interacts with

 EIF2B4MINT;

interacts with

 EIF2C1MINT;

interacts with

 EP300HPRD;

interacts with

 EP300INTACT;

interacts with

 ESRRABIOGRID;

interacts with

 EZH2BIOGRID;

interacts with

 FOXO1BIOGRID;

interacts with

 FOXO1HPRD;

interacts with

 FOXO3BIOGRID;

interacts with

 FOXO3HPRD;

interacts with

 FOXO4BIOGRID;

interacts with

 HDAC4BIOGRID;

interacts with

 HES1BIOGRID;

interacts with

 HES1HPRD;

interacts with

 HEY2BIOGRID;

interacts with

 HEY2HPRD;

interacts with

 HIC1BIOGRID;

interacts with

 HIST1H1BHPRD;

interacts with

 HNF4ABIOGRID;

interacts with

 HNF4AHPRD;

interacts with

 HNRNPUL1MINT;

interacts with

 HSF1BIOGRID;

interacts with

 HSP90AB1MINT;

interacts with

 HSPD1MINT;

interacts with

 ING1BIOGRID;

interacts with

 ING2BIOGRID;

interacts with

 IPO9MINT;

interacts with

 JUNBIOGRID;

interacts with

 KAT2BBIOGRID;

interacts with

 KAT5BIOGRID;

interacts with

 MAPK8BIOGRID;

interacts with

 MAPTBIOGRID;

interacts with

 MEF2CBIOGRID;

interacts with

 MLLT1BIOGRID;

interacts with

 MLLT3BIOGRID;

interacts with

 MYOD1BIOGRID;

interacts with

 NBNBIOGRID;

interacts with

 NCOR1BIOGRID;

interacts with

 NEDD8BIOGRID;

interacts with

 NR0B2BIOGRID;

interacts with

 NR1H2BIOGRID;

interacts with

 NR1H2HPRD;

interacts with

 NR1H3BIOGRID;

interacts with

 NR1H3HPRD;

interacts with

 NR1H4BIOGRID;

interacts with

 NUDT21BIOGRID;

interacts with

 PAPOLABIOGRID;

interacts with

 PDCD1MINT;

interacts with

 PPARGC1ABIOGRID;

interacts with

 PPARGC1AHPRD;

interacts with

 PRMT5MINT;

interacts with

 RBP1BIOGRID;

interacts with

 RELABIOGRID;

interacts with

 RELAHPRD;

interacts with

 RPS27LMINT;

interacts with

 RPS3MINT;

interacts with

 RRP8BIOGRID;

interacts with

 RRP8HPRD;

interacts with

 RUVBL2MINT;

interacts with

 SART3MINT;

interacts with

 SETD7BIOGRID;

interacts with

 SIRT2BIOGRID;

interacts with

 SLC25A13MINT;

interacts with

 SLC25A3MINT;

interacts with

 SLC25A5MINT;

interacts with

 SLC25A6MINT;

interacts with

 SMAD7BIOGRID;

interacts with

 SREBF1BIOGRID;

interacts with

 SSR1MINT;

interacts with

 STK4BIOGRID;

interacts with

 SUV39H1BIOGRID;

interacts with

 SUV39H1HPRD;

interacts with

 SUZ12BIOGRID;

interacts with

 TARBP2MINT;

interacts with

 TLE1BIOGRID;

interacts with

 TMEM33MINT;

interacts with

 TP53BIOGRID;

interacts with

 USP22BIOGRID;

interacts with

 VDRBIOGRID;

interacts with

 WDR77MINT;

interacts with

 ZBTB7ABIOGRID;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 E2F1NCI_NATURE;

metabolic catalysis

 TRIM28NCI_NATURE;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 ARNTNCI_NATURE;

reacts with

 BAXNCI_NATURE;

reacts with

 EP300NCI_NATURE;

reacts with

 EPAS1NCI_NATURE;

reacts with

 FHL2NCI_NATURE;

reacts with

 FOXO1NCI_NATURE;

reacts with

 FOXO3NCI_NATURE;

reacts with

 FOXO4NCI_NATURE;

reacts with

 HDAC4NCI_NATURE;

reacts with

 HIST1H1ENCI_NATURE;

reacts with

 KAT2BNCI_NATURE;

reacts with

 MEF2DNCI_NATURE;

reacts with

 MYOD1NCI_NATURE;

reacts with

 PPARGC1ANCI_NATURE;

reacts with

 SIRT1NCI_NATURE;

reacts with

 TP53NCI_NATURE;

reacts with

 XRCC6NCI_NATURE;

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