| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 6850 |
Name | SYK |
Synonym | p72-Syk;spleen tyrosine kinase;SYK;spleen tyrosine kinase |
Definition | tyrosine-protein kinase SYK |
Position | 9q22 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 16032 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | ras-independent pathway in nk cell-mediated cytotoxicity;PID BioCarta;100095 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | GPVI-mediated activation cascade;PID Reactome;500294 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Atypical NF-kappaB pathway;PID Curated;200017 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | il 2 signaling pathway;PID BioCarta;100130 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
|
External Links |
|
Links to Entrez Gene | 6850 |
Links to all GeneRIF Items | 6850 |
Links to iHOP | 6850 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>6850 : length: 1839 atggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatc acccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttg ctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaag gcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcagg acccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtc tgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggcccttt gaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggt caggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctacc acagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaa attgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaac ggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaa gacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagcta gtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaa aaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccat cctgcgtcctcccctgcccaagggaaccggcaagagagtactgtgtcattcaatccgtat gagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagccctacccatg gacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggcccaaggaggtt tacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggtaattttgga actgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggctgtgaaaata ctgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaagcaaatgtc atgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgaggccgagtcc tggatgctggttatggagatggcagaacttggtcccctcaataagtatttgcagcagaac agacatgtcaaggataagaacatcatagaactggttcatcaggtttccatgggcatgaag tacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtgttgctagtt acccaacattacgccaagatcagtgatttcggactttccaaagcactgcgtgctgatgaa aactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgctccggaatgc atcaactactacaagttctccagcaaaagcgatgtctggagctttggagtgttgatgtgg gaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaagtcaccgct atgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagagatgtacgat ctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgcagcagtggaa ctgcggctgcgcaattactactatgacgtggtgaactaa |
Protein Sequence |
>6850 : length: 612 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE LRLRNYYYDVVN |