Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6850

Name

SYK

Synonymous

spleen tyrosine kinase;SYK;spleen tyrosine kinase

Definition

tyrosine-protein kinase SYK

Position

9q22

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.12.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1738G>A; p.D580N; 9:90888599-90888599

 skinmalignant_melanomaSubstitution - Missense

c.1255G>A; p.E419K; 9:90877713-90877713

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.1738G>A; p.D580N; 9:90888599-90888599

 skinmalignant_melanomaSubstitution - Missense

c.988G>A; p.A330T; 9:90874725-90874725

 livercarcinomaSubstitution - Missense

c.988G>A; p.A330T; 9:90874725-90874725

 prostatecarcinomaSubstitution - Missense

c.988G>A; p.A330T; 9:90874725-90874725

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.988G>A; p.A330T; 9:90874725-90874725

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.988G>A; p.A330T; 9:90874725-90874725

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.988G>A; p.A330T; 9:90874725-90874725

 large_intestine; coloncarcinomaSubstitution - Missense

c.988G>A; p.A330T; 9:90874725-90874725

 livercarcinomaSubstitution - Missense

c.988G>A; p.A330T; 9:90874725-90874725

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1811G>A; p.R604H; 9:90895572-90895572

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1043C>T; p.T348M; 9:90874780-90874780

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.82T>G; p.Y28D; 9:90843980-90843980

 breastcarcinomaSubstitution - Missense

c.1432T>C; p.L478L; 9:90878873-90878873

 livercarcinomaSubstitution - coding silent

c.1432T>C; p.L478L; 9:90878873-90878873

 livercarcinomaSubstitution - coding silent

c.131G>T; p.S44I; 9:90844029-90844029

 livercarcinomaSubstitution - Missense

c.1031G>A; p.R344Q; 9:90874768-90874768

 pancreascarcinomaSubstitution - Missense

c.1368C>T; p.S456S; 9:90878809-90878809

 skinmalignant_melanomaSubstitution - coding silent

c.1368C>T; p.S456S; 9:90878809-90878809

 skinmalignant_melanomaSubstitution - coding silent

c.975C>T; p.Y325Y; 9:90874712-90874712

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.437C>G; p.A146G; 9:90845453-90845453

 breastcarcinomaSubstitution - Missense

c.66G>A; p.R22R; 9:90843964-90843964

 central_nervous_system; braingliomaSubstitution - coding silent

c.1546T>A; p.Y516N; 9:90887782-90887782

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.1828G>A; p.V610M; 9:90895589-90895589

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1367C>T; p.S456F; 9:90878808-90878808

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1637G>T; p.G546V; 9:90887873-90887873

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1241G>A; p.G414E; 9:90877699-90877699

 skinmalignant_melanomaSubstitution - Missense

c.602G>A; p.G201D; 9:90862229-90862229

 livercarcinomaSubstitution - Missense

c.1014G>T; p.K338N; 9:90874751-90874751

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1465G>A; p.D489N; 9:90878906-90878906

 skinmalignant_melanomaSubstitution - Missense

c.1737C>T; p.Y579Y; 9:90888598-90888598

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1372G>A; p.G458S; 9:90878813-90878813

 skinmalignant_melanomaSubstitution - Missense

c.313A>G; p.K105E; 9:90844211-90844211

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.702C>T; p.F234F; 9:90862329-90862329

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.702C>T; p.F234F; 9:90862329-90862329

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.702C>T; p.F234F; 9:90862329-90862329

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1121A>C; p.K374T; 9:90877579-90877579

 livercarcinomaSubstitution - Missense

c.922G>T; p.A308S; 9:90874279-90874279

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.583C>T; p.R195*; 9:90862210-90862210

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1470C>T; p.F490F; 9:90878911-90878911

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1105A>C; p.M369L; 9:90874842-90874842

 livercarcinomaSubstitution - Missense

c.1105A>C; p.M369L; 9:90874842-90874842

 livercarcinomaSubstitution - Missense

c.960G>A; p.M320I; 9:90874697-90874697

 skinmalignant_melanomaSubstitution - Missense

c.1738G>C; p.D580H; 9:90888599-90888599

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1584C>T; p.S528S; 9:90887820-90887820

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.877A>T; p.S293C; 9:90874234-90874234

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.655G>A; p.D219N; 9:90862282-90862282

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.267C>T; p.C89C; 9:90844165-90844165

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.913G>A; p.A305T; 9:90874270-90874270

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1407C>G; p.H469Q; 9:90878848-90878848

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; polycythaemia_veraSubstitution - Missense

c.1428T>C; p.N476N; 9:90878869-90878869

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.1664G>A; p.G555E; 9:90888525-90888525

 skinmalignant_melanomaSubstitution - Missense

c.1428T>C; p.N476N; 9:90878869-90878869

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1664G>A; p.G555E; 9:90888525-90888525

 skinmalignant_melanomaSubstitution - Missense

c.1664G>A; p.G555E; 9:90888525-90888525

 skinmalignant_melanomaSubstitution - Missense

c.1213G>A; p.D405N; 9:90877671-90877671

 skinmalignant_melanomaSubstitution - Missense

c.1635T>G; p.Y545*; 9:90887871-90887871

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1233G>C; p.R411R; 9:90877691-90877691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1655G>A; p.G552E; 9:90888516-90888516

 skinmalignant_melanomaSubstitution - Missense

c.1233G>C; p.R411R; 9:90877691-90877691

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1635T>G; p.Y545*; 9:90887871-90887871

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1213G>A; p.D405N; 9:90877671-90877671

 ovaryother; neoplasmSubstitution - Missense

c.93delG; p.G33fs*2; 9:90843991-90843991

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.717+1G>A; p.?; 9:90862345-90862345

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.315G>T; p.K105N; 9:90844213-90844213

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.936C>A; p.G312G; 9:90874673-90874673

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.965C>G; p.T322R; 9:90874702-90874702

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.958A>T; p.M320L; 9:90874695-90874695

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1120A>G; p.K374E; 9:90877578-90877578

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1092G>T; p.K364N; 9:90874829-90874829

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.457C>T; p.Q153*; 9:90845473-90845473

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1700G>A; p.R567Q; 9:90888561-90888561

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.525G>T; p.R175R; 9:90845541-90845541

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.852C>T; p.S284S; 9:90874209-90874209

 skinmalignant_melanomaSubstitution - coding silent

c.851C>T; p.S284F; 9:90874208-90874208

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.297G>T; p.L99L; 9:90844195-90844195

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1796T>C; p.V599A; 9:90895557-90895557

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.297G>T; p.L99L; 9:90844195-90844195

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.647A>G; p.Y216C; 9:90862274-90862274

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.311A>G; p.K104R; 9:90844209-90844209

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.685C>T; p.P229S; 9:90862312-90862312

 skin; trunkmalignant_melanoma; nodularSubstitution - Missense

c.778C>T; p.Q260*; 9:90864649-90864649

 skinmalignant_melanomaSubstitution - Nonsense

c.465G>A; p.E155E; 9:90845481-90845481

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1535C>T; p.P512L; 9:90887771-90887771

 skinmalignant_melanomaSubstitution - Missense

c.1443C>T; p.T481T; 9:90878884-90878884

 skinmalignant_melanomaSubstitution - coding silent

c.465G>A; p.E155E; 9:90845481-90845481

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.1750C>T; p.L584L; 9:90888611-90888611

 skinmalignant_melanomaSubstitution - coding silent

c.1314G>A; p.Q438Q; 9:90877772-90877772

 skinmalignant_melanomaSubstitution - coding silent

c.1675A>G; p.T559A; 9:90888536-90888536

 pancreascarcinomaSubstitution - Missense

c.1675A>G; p.T559A; 9:90888536-90888536

 pancreascarcinomaSubstitution - Missense

c.154G>A; p.A52T; 9:90844052-90844052

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.274C>T; p.H92Y; 9:90844172-90844172

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.832G>A; p.G278S; 9:90865083-90865083

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.649C>T; p.R217C; 9:90862276-90862276

 skinmalignant_melanomaSubstitution - Missense

c.971T>G; p.V324G; 9:90874708-90874708

 breastcarcinomaSubstitution - Missense

c.254C>T; p.P85L; 9:90844152-90844152

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.259G>T; p.D87Y; 9:90844157-90844157

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.897G>A; p.P299P; 9:90874254-90874254

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.897G>A; p.P299P; 9:90874254-90874254

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1452C>T; p.Y484Y; 9:90878893-90878893

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1452C>T; p.Y484Y; 9:90878893-90878893

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1476T>C; p.L492L; 9:90878917-90878917

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1669G>A; p.E557K; 9:90888530-90888530

 skinmalignant_melanomaSubstitution - Missense

c.92_93insG; p.M34fs*3; 9:90843990-90843991

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.92_93insG; p.M34fs*3; 9:90843990-90843991

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.1048G>T; p.E350*; 9:90874785-90874785

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1113-7C>G; p.?; 9:90877564-90877564

 livercarcinoma; hepatocellular_carcinomaUnknown

c.1269G>A; p.L423L; 9:90877727-90877727

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1512G>T; p.K504N; 9:90878953-90878953

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1269G>A; p.L423L; 9:90877727-90877727

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.862G>A; p.G288R; 9:90874219-90874219

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.76G>A; p.E26K; 9:90843974-90843974

 livercarcinomaSubstitution - Missense

c.76G>A; p.E26K; 9:90843974-90843974

 livercarcinomaSubstitution - Missense

c.76G>A; p.E26K; 9:90843974-90843974

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1248C>G; p.C416W; 9:90877706-90877706

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1651C>T; p.R551*; 9:90887887-90887887

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1799A>G; p.E600G; 9:90895560-90895560

 breastcarcinomaSubstitution - Missense

c.1651C>T; p.R551*; 9:90887887-90887887

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1097A>G; p.Y366C; 9:90874834-90874834

 livercarcinomaSubstitution - Missense

c.1097A>G; p.Y366C; 9:90874834-90874834

 livercarcinomaSubstitution - Missense

c.1144delA; p.N383fs*13; 9:90877602-90877602

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.215G>A; p.G72D; 9:90844113-90844113

 skinmalignant_melanomaSubstitution - Missense

c.108T>C; p.D36D; 9:90844006-90844006

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.737A>G; p.Y246C; 9:90864608-90864608

 stomachcarcinomaSubstitution - Missense

c.153C>T; p.F51F; 9:90844051-90844051

 skinmalignant_melanomaSubstitution - coding silent

c.490_491insA; p.M166fs*14; 9:90845506-90845507

 large_intestine; rectumcarcinoma; adenocarcinomaInsertion - Frameshift

c.125G>A; p.R42H; 9:90844023-90844023

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.973T>C; p.Y325H; 9:90874710-90874710

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.854C>A; p.P285H; 9:90874211-90874211

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1273A>T; p.M425L; 9:90877731-90877731

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1706G>T; p.G569V; 9:90888567-90888567

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.810T>G; p.F270L; 9:90865061-90865061

 skinmalignant_melanomaSubstitution - Missense

c.810T>G; p.F270L; 9:90865061-90865061

 skinmalignant_melanomaSubstitution - Missense

c.944G>A; p.R315K; 9:90874681-90874681

 skinmalignant_melanomaSubstitution - Missense

c.1810C>T; p.R604C; 9:90895571-90895571

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1142T>C; p.L381P; 9:90877600-90877600

 skinmalignant_melanomaSubstitution - Missense

c.134G>A; p.R45H; 9:90844032-90844032

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.962A>G; p.D321G; 9:90874699-90874699

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.534T>C; p.S178S; 9:90845550-90845550

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1596C>G; p.V532V; 9:90887832-90887832

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1469T>G; p.F490C; 9:90878910-90878910

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1239C>T; p.I413I; 9:90877697-90877697

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1113-1G>C; p.?; 9:90877570-90877570

 ovarycarcinoma; serous_carcinomaUnknown

c.921G>T; p.W307C; 9:90874278-90874278

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1700_1701GG>AC; p.R567H; 9:90888561-90888562

 skinmalignant_melanomaSubstitution - Missense

c.1548C>T; p.Y516Y; 9:90887784-90887784

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.1548C>T; p.Y516Y; 9:90887784-90887784

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.1206G>T; p.Q402H; 9:90877664-90877664

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1625C>T; p.A542V; 9:90887861-90887861

 skinmalignant_melanomaSubstitution - Missense

c.176G>A; p.R59K; 9:90844074-90844074

 large_intestine; colonadenomaSubstitution - Missense

c.1625C>T; p.A542V; 9:90887861-90887861

 skinmalignant_melanomaSubstitution - Missense

c.1809G>A; p.L603L; 9:90895570-90895570

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.272A>G; p.Y91C; 9:90844170-90844170

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.173G>A; p.G58E; 9:90844071-90844071

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1283C>T; p.A428V; 9:90877741-90877741

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.996C>T; p.P332P; 9:90874733-90874733

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.298G>T; p.V100F; 9:90844196-90844196

 thyroidother; neoplasmSubstitution - Missense

c.1772A>G; p.E591G; 9:90895533-90895533

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1220C>T; p.P407L; 9:90877678-90877678

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1015G>A; p.E339K; 9:90874752-90874752

 skinmalignant_melanomaSubstitution - Missense

c.702C>A; p.F234L; 9:90862329-90862329

 central_nervous_system; frontal_lobeglioma; astrocytoma_Grade_IVSubstitution - Missense

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