General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information |
|
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Gene ID | 6850 |
Name | SYK |
Synonymous | p72-Syk;spleen tyrosine kinase;SYK;spleen tyrosine kinase |
Definition | tyrosine-protein kinase SYK |
Position | 9q22 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] |
Transcription Factors [Top] |
Regulation From TransFac database |
APS(m){p} + Syk(h) <==> APS(m){p}:Syk(h) (binding) | EpoR(h){pY} + Syk(h) <==> EpoR(h){pY}:Syk(h) (binding) | Fibrinogen(h):alpha IIb-integrin(h):beta3-integrin(h):Src(h){pY419} + Syk(h) <==> Fibrinogen(h):alpha IIb-integrin(h):beta3-integrin(h):Src(h){pY419}:Syk(h) (binding) | beta3-integrin(h) + Syk(h) <==> beta3-integrin(h):Syk(h) (binding) | Fibrinogen(h):alpha IIb-integrin(h):beta3-integrin(h) + Syk(h) <==> Fibrinogen(h):alpha IIb-integrin(h):beta3-integrin(h):Syk(h) (binding) | beta2-integrin(h) + Syk(h) <==> beta2-integrin(h):Syk(h) (binding) | beta1A-integrin(h) + Syk(h) <==> beta1A-integrin(h):Syk(h) (binding) | CD22(h){pY} + Syk(h) <==> CD22(h){pY}:Syk(h) (binding) | Syk(h) + DECTIN1(m) <==> Syk(h):DECTIN1(m) (binding) | Syk(h) + PKCalpha(h) <==> Syk(h):PKCalpha(h) (binding) | Syk(h) --> PKCalpha(h){p} (activation; increase of phosphorylation) | Syk(h) + DDR1(h) <==> Syk(h):DDR1(h) (binding) | DAP12(h){p} + Syk(h) <==> DAP12(h){p}:Syk(h) (binding) | PSCDBP(m.s.){p} + Syk(h) <==> PSCDBP(m.s.){p}:Syk(h) (binding) | PSCDBP(m.s.){p} + Syk(h) + NTP --> PSCDBP(m.s.){p}:Syk(h){p} + NDP (phosphorylation; binding) | Syk(h) --> Fyn(m.s.) (binding) | Syk(h) --> mGluR1(m.s.) (binding) | Syk(h) --> SHP-2(m.s.) (binding) | Syk(h) --> Src(h) (binding) | Syk(h) --> Rac1(h) (activation) | Syk(h) --> LAT(h) (binding) | Syk(h) --> RelA-p65(h){p} (regulation of localization; increase of phosphorylation) | Syk(h) --> PLCgamma1(h) (binding) | Syk(h) + Lyn(h) <==> Syk(h):Lyn(h) (binding) | Src(h) + Syk(h) <==> Src(h):Syk(h) (binding) | FcRgamma(h){pY} + Syk(h) <==> FcRgamma(h){pY}:Syk(h) (binding) | Syk(h) + ATP --> Syk(h){pY} + ADP (phosphorylation; automodification) | Syk(h) + ATP --> Syk(h){p} + ADP (phosphorylation; automodification) | Syk(h) + CrkL(h) <==> Syk(h):CrkL(h) (binding) | Syk(h) + ErbB1-p170(h){pY915}{pY998}{pY1016}{pY1125}{pY1172} <==> Syk(h):ErbB1-p170(h){pY915}{pY998}{pY1016}{pY1125}{pY1172} (binding) | ErbB2(h){pY1023}{pY1139}{pY1196}{pY1221}{pY1222} + Syk(h) <==> ErbB2(h){pY1023}{pY1139}{pY1196}{pY1221}{pY1222}:Syk(h) (binding) | Syk(h) + ErbB3-isoform1(h){pY868}{pY1197}{pY1222}{pY1260}{pY1276}{pY1289} <==> Syk(h):ErbB3-isoform1(h){pY868}{pY1197}{pY1222}{pY1260}{pY1276}{pY1289} (binding) | ErbB4(h){pY1284} + Syk(h) <==> ErbB4(h){pY1284}:Syk(h) (binding) | Syk(h) --> Syk(h) (translocation) | Syk(h) + ErbB1(h) <==> Syk(h):ErbB1(h) (binding) | Syk(h) + TLR9(h) <==> Syk(h):TLR9(h) (binding) | Syk(h) + ATP --> Syk(h){pY} + ADP (phosphorylation) | Syk(h) + ATP --> Syk(h){p} + ADP (phosphorylation) | FCGR2(h) + Syk(h) <==> FCGR2(h):Syk(h) (binding) | FcgammaRI alpha(h) + Syk(h) <==> FcgammaRI alpha(h):Syk(h) (binding) | Syk(h) + IgG1(h):FCgammaRI(h) <==> Syk(h):IgG1(h):FCgammaRI(h) (binding) | IL-5Rbeta(h) + Syk(h) <==> IL-5Rbeta(h):Syk(h) (binding) | Lyn(h) + Syk(h) <==> Syk(h):Lyn(h) (binding) | Syk(h) + ATP --> Syk(h){pY352} + ADP (phosphorylation) | Syk(h) + 2 ATP --> Syk(h){pY525}{pY526} + 2 ADP (phosphorylation) | Syk(h) --> icam1(h) (increase of abundance) | RelA-p65(h) + Syk(h) <==> RelA-p65(h):Syk(h) (binding) | Syk(h) --> IL-1beta(h) (increase of secretion) | Syk(h) --> IL1B(h) (transactivation) | Syk(h) --> Caspase-1-p20(h) (increase of abundance) | SYK(h) --> Syk(h) (expression). | Lck(h) --> Syk(h) (binding) | PSCDBP(m.s.) --> Syk(h) (binding) | ZAP-70(h) --> Syk(h) (binding) | GP6(h) --> Syk(h) (activation) | CD22(h){pY} --> Syk(h) (binding) | SHP-1(h) --> Syk(h) (binding) | Syk(h) --> Syk(h) (translocation) | Syk(h){pY} --> Syk(h) + ATP (dephosphorylation) | APS(m) + NTP --Syk(h)--> APS(m){p} + NDP (phosphorylation) | HS1(h) + ATP --Syk(h)--> HS1(h){p} + ADP (phosphorylation) | SLP-76(h) + ATP --Syk(h)--> SLP-76(h){pY} + ADP (phosphorylation) | SLP-76(h) + 2 ATP --Syk(h)--> SLP-76(h){pY113}{pY128} + 2 ADP (phosphorylation) | SYK(h) --> Syk-isoform2(h) (expression). | Syk-isoform1(h) + 2 ATP --> Syk-isoform1(h){pY348}{pY352} + 2 ADP (phosphorylation) | Syk-isoform1(h) + ATP --> Syk-isoform1(h){p} + ADP (phosphorylation) | SYK(h) --> Syk-isoform1(h) (expression). |
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Post Transcriptional Modification [Top] | |||
Location (AA) |
PTM type |
Literature |
Database |
323 | Phosphotyrosine (by LYN) (By similarity). | Swiss-Prot 53.0 | 348 | Phosphotyrosine. | Swiss-Prot 53.0 | 352 | Phosphotyrosine. | Swiss-Prot 53.0 | 525 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 348 | Phosphotyrosine (Syk) | 8657103;12522270 | Phospho.ELM 6.0 | 352 | Phosphotyrosine (Syk) | 8657103;12522270 | Phospho.ELM 6.0 | 525 | Phosphotyrosine (Syk) | 8657103 | Phospho.ELM 6.0 | 526 | Phosphotyrosine (Syk) | 8657103 | Phospho.ELM 6.0 | 323 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
Chromosome |
Location |
Source |
---|---|---|
chr9 |
Promoter: 92602391 - 92604391 | Agilent_014791 |
chr9 |
Promoter: 92602391 - 92604391 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 92602391 - 92604391 | GSE27584 |
chr9 |
Promoter: 92602391 - 92604391 | Agilent_014791_44K |
chr9 |
Promoter: 92602391 - 92604391 | PMID:20064646 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:11454707 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:15172987 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:15059510 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:15188513 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:17143801 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:16192589 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:16964403 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:16304050 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:15713962 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:14970867 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:16435073 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:15316056 |
chr9 |
Promoter: 92602391 - 92604391 | PMID:17121887 |