Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4089

Name

SMAD4

Synonymous

DPC4|JIP|MADH4|MYHRS;SMAD family member 4;SMAD4;SMAD family member 4

Definition

MAD homolog 4|SMAD, mothers against DPP homolog 4|deleted in pancreatic carcinoma locus 4|deletion target in pancreatic carcinoma 4|mothers against decapentaplegic homolog 4|mothers against decapentaplegic, Drosophila, homolog of, 4

Position

18q21.1

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 ARNTNCI_NATURE;

in same component

 ARNCI_NATURE;

in same component

 ATF2NCI_NATURE;

in same component

 ATF3NCI_NATURE;

in same component

 CBFBNCI_NATURE;

in same component

 CEBPBNCI_NATURE;

in same component

 DCP1ANCI_NATURE;

in same component

 DLX1NCI_NATURE;

in same component

 E2F4CELL_MAP;

in same component

 E2F5CELL_MAP;

in same component

 ESR1NCI_NATURE;

in same component

 FOSNCI_NATURE;

in same component

 FOXG1NCI_NATURE;

in same component

 FOXH1NCI_NATURE;

in same component

 FOXH1REACTOME;

in same component

 FOXO3REACTOME;

in same component

 GATA3NCI_NATURE;

in same component

 HDAC1NCI_NATURE;

in same component

 HDAC2NCI_NATURE;

in same component

 HIF1ANCI_NATURE;

in same component

 HNF4ANCI_NATURE;

in same component

 IRF7NCI_NATURE;

in same component

 JUNNCI_NATURE;

in same component

 MAXNCI_NATURE;

in same component

 MED15NCI_NATURE;

in same component

 MEF2CNCI_NATURE;

in same component

 MYCNCI_NATURE;

in same component

 MYOD1NCI_NATURE;

in same component

 NCOR1NCI_NATURE;

in same component

 NKX2-5NCI_NATURE;

in same component

 NR3C1NCI_NATURE;

in same component

 PIAS4NCI_NATURE;

in same component

 RBBP4NCI_NATURE;

in same component

 RBBP7NCI_NATURE;

in same component

 RBL1CELL_MAP;

in same component

 RBL1NCI_NATURE;

in same component

 RUNX2NCI_NATURE;

in same component

 SAP18NCI_NATURE;

in same component

 SAP30NCI_NATURE;

in same component

 SIN3ANCI_NATURE;

in same component

 SIN3BNCI_NATURE;

in same component

 SKILNCI_NATURE;

in same component

 SKIHUMANCYC;

in same component

 SKIREACTOME;

in same component

 SMAD1NCI_NATURE;

in same component

 SMAD2CELL_MAP;

in same component

 SMAD2NCI_NATURE;

in same component

 SMAD5NCI_NATURE;

in same component

 SMAD9NCI_NATURE;

in same component

 SP1NCI_NATURE;

in same component

 STK11IPNCI_NATURE;

in same component

 STK11NCI_NATURE;

in same component

 TFDP1CELL_MAP;

in same component

 TFDP1NCI_NATURE;

in same component

 TFE3NCI_NATURE;

in same component

 TGFBR1NCI_NATURE;

in same component

 TGFBR2NCI_NATURE;

in same component

 TGFBRAP1NCI_NATURE;

in same component

 TGIF2NCI_NATURE;

in same component

 UBE2INCI_NATURE;

in same component

 VDRNCI_NATURE;

in same component

 ZBTB17NCI_NATURE;

in same component

 ZFYVE16NCI_NATURE;

interacts with

 ACVR1BHPRD;

interacts with

 AKT1BIOGRID;

interacts with

 AKT1HPRD;

interacts with

 Ap2b1BIOGRID;

interacts with

 AP2B1HPRD;

interacts with

 Apbb2BIOGRID;

interacts with

 Arfrp1BIOGRID;

interacts with

 Arhgef7BIOGRID;

interacts with

 Arl5bBIOGRID;

interacts with

 ARL5BHPRD;

interacts with

 ARBIOGRID;

interacts with

 ARCELL_MAP;

interacts with

 ARHPRD;

interacts with

 ATF2BIOGRID;

interacts with

 ATF2CELL_MAP;

interacts with

 ATF2HPRD;

interacts with

 ATF7IPMINT;

interacts with

 BTRCBIOGRID;

interacts with

 BTRCCELL_MAP;

interacts with

 C16orf57HPRD;

interacts with

 C16orf57MINT;

interacts with

 CAMK2GBIOGRID;

interacts with

 CAMK2GHPRD;

interacts with

 CD59HPRD;

interacts with

 CD59MINT;

interacts with

 CEBPABIOGRID;

interacts with

 CEBPBBIOGRID;

interacts with

 CEBPBHPRD;

interacts with

 CEBPBMINT;

interacts with

 CEBPDBIOGRID;

interacts with

 Chek1BIOGRID;

interacts with

 CHEK1HPRD;

interacts with

 Chek1MINT;

interacts with

 CITED1BIOGRID;

interacts with

 CITED1CELL_MAP;

interacts with

 CITED1HPRD;

interacts with

 CNKSR1MINT;

interacts with

 COPS5BIOGRID;

interacts with

 COPS5CELL_MAP;

interacts with

 COPS5HPRD;

interacts with

 COPS5INTACT;

interacts with

 CREBBPHPRD;

interacts with

 CSH1HPRD;

interacts with

 CSH1MINT;

interacts with

 CTCFCELL_MAP;

interacts with

 CTCFHPRD;

interacts with

 CTNNB1BIOGRID;

interacts with

 CTNNB1CELL_MAP;

interacts with

 CTNNB1HPRD;

interacts with

 DACH1HPRD;

interacts with

 DAXXBIOGRID;

interacts with

 DCP1ABIOGRID;

interacts with

 DCP1AHPRD;

interacts with

 DCP1AMINT;

interacts with

 DCP1BHPRD;

interacts with

 DCP1BMINT;

interacts with

 DLX1BIOGRID;

interacts with

 DLX1HPRD;

interacts with

 DNAJB2HPRD;

interacts with

 DNAJB2MINT;

interacts with

 DVL1BIOGRID;

interacts with

 Dvl1CELL_MAP;

interacts with

 DVL1HPRD;

interacts with

 E2F4CELL_MAP;

interacts with

 E2F4HPRD;

interacts with

 E2F5CELL_MAP;

interacts with

 E2F5HPRD;

interacts with

 ECSITHPRD;

interacts with

 EEF1A1HPRD;

interacts with

 EEF1A1MINT;

interacts with

 EID2BIOGRID;

interacts with

 EID2CELL_MAP;

interacts with

 EID2HPRD;

interacts with

 Eif2ak4BIOGRID;

interacts with

 EIF2AK4HPRD;

interacts with

 EP300BIOGRID;

interacts with

 EP300CELL_MAP;

interacts with

 EP300HPRD;

interacts with

 ERBB2IPBIOGRID;

interacts with

 ERBB2IPHPRD;

interacts with

 ESR1CELL_MAP;

interacts with

 ESR1HPRD;

interacts with

 ESR2HPRD;

interacts with

 EWSR1BIOGRID;

interacts with

 FBLN1HPRD;

interacts with

 FBLN1MINT;

interacts with

 FBXO30HPRD;

interacts with

 Fbxo30MINT;

interacts with

 FBXO34HPRD;

interacts with

 FOSBHPRD;

interacts with

 FOSCELL_MAP;

interacts with

 FOXG1HPRD;

interacts with

 FOXH1BIOGRID;

interacts with

 FOXH1HPRD;

interacts with

 FOXO1BIOGRID;

interacts with

 FOXO1CELL_MAP;

interacts with

 FOXO1HPRD;

interacts with

 FOXO3BIOGRID;

interacts with

 FOXO3CELL_MAP;

interacts with

 FOXO3HPRD;

interacts with

 FOXO4BIOGRID;

interacts with

 FOXO4CELL_MAP;

interacts with

 FOXO4HPRD;

interacts with

 FSTL3HPRD;

interacts with

 GATA2BIOGRID;

interacts with

 GLI3HPRD;

interacts with

 GPNMBHPRD;

interacts with

 GPNMBMINT;

interacts with

 HDAC1BIOGRID;

interacts with

 HdgfBIOGRID;

interacts with

 HDLBPHPRD;

interacts with

 HDLBPMINT;

interacts with

 HMG20AHPRD;

interacts with

 HMG20AMINT;

interacts with

 HNF4AHPRD;

interacts with

 HOXA9BIOGRID;

interacts with

 HOXA9CELL_MAP;

interacts with

 HOXA9HPRD;

interacts with

 HOXC8BIOGRID;

interacts with

 HOXC8HPRD;

interacts with

 IlkapBIOGRID;

interacts with

 ItkBIOGRID;

interacts with

 ITKHPRD;

interacts with

 JUNBBIOGRID;

interacts with

 JUNBCELL_MAP;

interacts with

 JUNBHPRD;

interacts with

 JUNBMINT;

interacts with

 JUNDCELL_MAP;

interacts with

 JUNDHPRD;

interacts with

 JUNCELL_MAP;

interacts with

 JUNHPRD;

interacts with

 KDM6BBIOGRID;

interacts with

 KPNB1BIOGRID;

interacts with

 LEF1BIOGRID;

interacts with

 LEF1CELL_MAP;

interacts with

 Map2k3BIOGRID;

interacts with

 MAPK13HPRD;

interacts with

 MAPK13MINT;

interacts with

 MAPK1HPRD;

interacts with

 MAXBIOGRID;

interacts with

 MAXHPRD;

interacts with

 MDM4BIOGRID;

interacts with

 MECOMBIOGRID;

interacts with

 MED15MINT;

interacts with

 MEF2AHPRD;

interacts with

 MEX3BHPRD;

interacts with

 MYOD1HPRD;

interacts with

 MYOD1MINT;

interacts with

 NAT8HPRD;

interacts with

 Nat8MINT;

interacts with

 Nek6BIOGRID;

interacts with

 NEK6HPRD;

interacts with

 NF1BIOGRID;

interacts with

 NKX3-2BIOGRID;

interacts with

 NOTCH4HPRD;

interacts with

 NRASHPRD;

interacts with

 Nuak2BIOGRID;

interacts with

 NUAK2HPRD;

interacts with

 NUP214CELL_MAP;

interacts with

 NUP214HPRD;

interacts with

 OclnBIOGRID;

interacts with

 OCLNHPRD;

interacts with

 ODZ3HPRD;

interacts with

 ODZ3MINT;

interacts with

 PAK1HPRD;

interacts with

 PAPPA2MINT;

interacts with

 PARD3BBIOGRID;

interacts with

 PbkBIOGRID;

interacts with

 PBKHPRD;

interacts with

 PbkMINT;

interacts with

 PIAS1HPRD;

interacts with

 PIAS1MINT;

interacts with

 PIAS2HPRD;

interacts with

 PIAS3BIOGRID;

interacts with

 PIAS3HPRD;

interacts with

 PIAS4BIOGRID;

interacts with

 PIAS4HPRD;

interacts with

 PKHD1HPRD;

interacts with

 Plk4BIOGRID;

interacts with

 PLK4HPRD;

interacts with

 Plk4MINT;

interacts with

 PRKAR1BCELL_MAP;

interacts with

 PRKAR1BHPRD;

interacts with

 PRKAR2ACELL_MAP;

interacts with

 PRKAR2AHPRD;

interacts with

 PRKG1MINT;

interacts with

 PRPF40AHPRD;

interacts with

 PRPF40AMINT;

interacts with

 PSG2HPRD;

interacts with

 PSG2MINT;

interacts with

 PSG9HPRD;

interacts with

 PSG9MINT;

interacts with

 PSMD11HPRD;

interacts with

 PSMD11MINT;

interacts with

 Rab13BIOGRID;

interacts with

 RAB13HPRD;

interacts with

 Rab13MINT;

interacts with

 RAB25HPRD;

interacts with

 Rab2bBIOGRID;

interacts with

 Rab34BIOGRID;

interacts with

 RAB34HPRD;

interacts with

 Rab38BIOGRID;

interacts with

 RAB38HPRD;

interacts with

 Rab3bBIOGRID;

interacts with

 RAB3BHPRD;

interacts with

 Rab3bMINT;

interacts with

 Rac2BIOGRID;

interacts with

 RAC2HPRD;

interacts with

 RALAHPRD;

interacts with

 RALAMINT;

interacts with

 Rasd2BIOGRID;

interacts with

 RASD2HPRD;

interacts with

 RASL12HPRD;

interacts with

 RBL1BIOGRID;

interacts with

 RBL1CELL_MAP;

interacts with

 RBL1HPRD;

interacts with

 RFX1HPRD;

interacts with

 RFX1MINT;

interacts with

 RHEBL1HPRD;

interacts with

 Rhebl1MINT;

interacts with

 RhodBIOGRID;

interacts with

 RHODHPRD;

interacts with

 RhodMINT;

interacts with

 RhogBIOGRID;

interacts with

 RhojBIOGRID;

interacts with

 RHOJHPRD;

interacts with

 Ripk2BIOGRID;

interacts with

 RIPK2HPRD;

interacts with

 RMND5BHPRD;

interacts with

 RMND5BMINT;

interacts with

 Rnf138BIOGRID;

interacts with

 Rnf14BIOGRID;

interacts with

 RPL28MINT;

interacts with

 Rras2BIOGRID;

interacts with

 RTDR1HPRD;

interacts with

 SASH3HPRD;

interacts with

 Sash3MINT;

interacts with

 SKILBIOGRID;

interacts with

 SKILCELL_MAP;

interacts with

 SKILHPRD;

interacts with

 SKILMINT;

interacts with

 SKIBIOGRID;

interacts with

 SKICELL_MAP;

interacts with

 SKIHPRD;

interacts with

 SKIMINT;

interacts with

 SKP2BIOGRID;

interacts with

 Smad1BIOGRID;

interacts with

 SMAD1BIOGRID;

interacts with

 SMAD1HPRD;

interacts with

 SMAD1MINT;

interacts with

 Smad2BIOGRID;

interacts with

 SMAD2BIOGRID;

interacts with

 SMAD2CELL_MAP;

interacts with

 SMAD2HPRD;

interacts with

 SMAD2MINT;

interacts with

 SMAD5BIOGRID;

interacts with

 SMAD5HPRD;

interacts with

 SMAD5MINT;

interacts with

 SMAD6BIOGRID;

interacts with

 SMAD7BIOGRID;

interacts with

 SMAD9BIOGRID;

interacts with

 SMAD9HPRD;

interacts with

 SMAD9MINT;

interacts with

 SMURF1BIOGRID;

interacts with

 SNIP1BIOGRID;

interacts with

 SNIP1CELL_MAP;

interacts with

 SNIP1HPRD;

interacts with

 SNRNP70HPRD;

interacts with

 SNRNP70MINT;

interacts with

 SNW1BIOGRID;

interacts with

 SP1BIOGRID;

interacts with

 SP1CELL_MAP;

interacts with

 SP1HPRD;

interacts with

 SPTBN1HPRD;

interacts with

 Sqstm1BIOGRID;

interacts with

 SQSTM1HPRD;

interacts with

 STK11IPBIOGRID;

interacts with

 STK11IPCELL_MAP;

interacts with

 STK11IPHPRD;

interacts with

 Stk11CELL_MAP;

interacts with

 Stk35BIOGRID;

interacts with

 STK35HPRD;

interacts with

 STUB1HPRD;

interacts with

 TCTAHPRD;

interacts with

 TCTAMINT;

interacts with

 TDGHPRD;

interacts with

 TDGMINT;

interacts with

 TFDP1CELL_MAP;

interacts with

 TFDP1HPRD;

interacts with

 TFE3BIOGRID;

interacts with

 TFE3HPRD;

interacts with

 TGFB1HPRD;

interacts with

 TGFBR1BIOGRID;

interacts with

 TGFBR2HPRD;

interacts with

 TGFBRAP1BIOGRID;

interacts with

 TGFBRAP1CELL_MAP;

interacts with

 TGFBRAP1HPRD;

interacts with

 TH1LHPRD;

interacts with

 TH1LMINT;

interacts with

 TM9SF2HPRD;

interacts with

 TM9SF2MINT;

interacts with

 TOB1BIOGRID;

interacts with

 TOB1HPRD;

interacts with

 TRAP1HPRD;

interacts with

 TRIM33BIOGRID;

interacts with

 TRIM33HPRD;

interacts with

 Trim35BIOGRID;

interacts with

 Tssk3BIOGRID;

interacts with

 TSSK3HPRD;

interacts with

 Uba52BIOGRID;

interacts with

 UBE2IBIOGRID;

interacts with

 UBE2IHPRD;

interacts with

 UBE2IMINT;

interacts with

 UBE2L3HPRD;

interacts with

 UBE2ZHPRD;

interacts with

 Uhmk1BIOGRID;

interacts with

 UHRF2HPRD;

interacts with

 UHRF2MINT;

interacts with

 XPO5HPRD;

interacts with

 XPO5MINT;

interacts with

 YY1BIOGRID;

interacts with

 ZBED5HPRD;

interacts with

 ZBED5MINT;

interacts with

 ZMYM2HPRD;

interacts with

 ZMYM2MINT;

interacts with

 ZNF423BIOGRID;

interacts with

 ZNF423HPRD;

interacts with

 ZNF521HPRD;

Metabolic Interaction   [Top]

There is no record for SMAD4

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 ARNTNCI_NATURE;

reacts with

 ARNCI_NATURE;

reacts with

 ATF2NCI_NATURE;

reacts with

 CBFBNCI_NATURE;

reacts with

 CEBPBNCI_NATURE;

reacts with

 DCP1ANCI_NATURE;

reacts with

 DLX1NCI_NATURE;

reacts with

 E2F4CELL_MAP;

reacts with

 E2F5CELL_MAP;

reacts with

 ESR1NCI_NATURE;

reacts with

 FOSNCI_NATURE;

reacts with

 FOXG1NCI_NATURE;

reacts with

 FOXH1NCI_NATURE;

reacts with

 FOXH1REACTOME;

reacts with

 FOXO3REACTOME;

reacts with

 GATA3NCI_NATURE;

reacts with

 HDAC1NCI_NATURE;

reacts with

 HDAC2NCI_NATURE;

reacts with

 HIF1ANCI_NATURE;

reacts with

 HNF4ANCI_NATURE;

reacts with

 IRF7NCI_NATURE;

reacts with

 JUNNCI_NATURE;

reacts with

 MAXNCI_NATURE;

reacts with

 MED15NCI_NATURE;

reacts with

 MEF2CNCI_NATURE;

reacts with

 MYCNCI_NATURE;

reacts with

 MYOD1NCI_NATURE;

reacts with

 NCOA2NCI_NATURE;

reacts with

 NCOR1NCI_NATURE;

reacts with

 NKX2-5NCI_NATURE;

reacts with

 NR3C1NCI_NATURE;

reacts with

 PIAS4NCI_NATURE;

reacts with

 RBBP4NCI_NATURE;

reacts with

 RBBP7NCI_NATURE;

reacts with

 RBL1CELL_MAP;

reacts with

 RUNX2NCI_NATURE;

reacts with

 SAP18NCI_NATURE;

reacts with

 SAP30NCI_NATURE;

reacts with

 SIN3ANCI_NATURE;

reacts with

 SIN3BNCI_NATURE;

reacts with

 SKILNCI_NATURE;

reacts with

 SKIHUMANCYC;

reacts with

 SKIREACTOME;

reacts with

 SMAD1NCI_NATURE;

reacts with

 SMAD2CELL_MAP;

reacts with

 SMAD2NCI_NATURE;

reacts with

 SMAD4CELL_MAP;

reacts with

 SMAD4HUMANCYC;

reacts with

 SMAD4NCI_NATURE;

reacts with

 SMAD4REACTOME;

reacts with

 SMAD5NCI_NATURE;

reacts with

 SMAD6NCI_NATURE;

reacts with

 SMAD9NCI_NATURE;

reacts with

 SP1NCI_NATURE;

reacts with

 STK11IPNCI_NATURE;

reacts with

 STK11NCI_NATURE;

reacts with

 TCF3NCI_NATURE;

reacts with

 TFDP1CELL_MAP;

reacts with

 TFE3NCI_NATURE;

reacts with

 TGFBR1NCI_NATURE;

reacts with

 TGFBR2NCI_NATURE;

reacts with

 TGFBRAP1NCI_NATURE;

reacts with

 TGIF2NCI_NATURE;

reacts with

 UBE2INCI_NATURE;

reacts with

 VDRNCI_NATURE;

reacts with

 ZBTB17NCI_NATURE;

reacts with

 ZFYVE16NCI_NATURE;

state change

 BTRCCELL_MAP;

state change

 Camk2aCELL_MAP;

state change

 Camk2bCELL_MAP;

state change

 Camk2dCELL_MAP;

state change

 CITED1NCI_NATURE;

state change

 COPS5CELL_MAP;

state change

 CTBP1NCI_NATURE;

state change

 DRAP1REACTOME;

state change

 EP300NCI_NATURE;

state change

 FOXH1REACTOME;

state change

 HDAC1NCI_NATURE;

state change

 HDAC2NCI_NATURE;

state change

 HSPA8NCI_NATURE;

state change

 KAT2BNCI_NATURE;

state change

 KPNA2NCI_NATURE;

state change

 KPNB1NCI_NATURE;

state change

 NCOA1NCI_NATURE;

state change

 NCOR1NCI_NATURE;

state change

 NUP153NCI_NATURE;

state change

 NUP214NCI_NATURE;

state change

 Pias1CELL_MAP;

state change

 Pias2CELL_MAP;

state change

 PIAS3NCI_NATURE;

state change

 RBBP4NCI_NATURE;

state change

 RBBP7NCI_NATURE;

state change

 SAP18NCI_NATURE;

state change

 SAP30NCI_NATURE;

state change

 SIN3ANCI_NATURE;

state change

 SIN3BNCI_NATURE;

state change

 SKINCI_NATURE;

state change

 SMAD1NCI_NATURE;

state change

 SMURF1NCI_NATURE;

state change

 SNIP1NCI_NATURE;

state change

 TGIF1NCI_NATURE;

state change

 UBE2D3HUMANCYC;

state change

 UBE2E1CELL_MAP;

state change

 UBE2L3CELL_MAP;

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