Entrez Gene

Basic Information
Gene ID	4089
Name	SMAD4
Synonymous	DPC4\|JIP\|MADH4\|MYHRS;SMAD family member 4;SMAD4;SMAD family member 4
Definition	MAD homolog 4\|SMAD, mothers against DPP homolog 4\|deleted in pancreatic carcinoma locus 4\|deletion target in pancreatic carcinoma 4\|mothers against decapentaplegic homolog 4\|mothers against decapentaplegic, Drosophila, homolog of, 4
Position	18q21.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Experimentally validated miRNA-TS gene regulation information.

Regulation From TransFac database
Transcription Factors [Top]
Smad2-L(h) + smad4(h) --TGFbetaR-I(h)--> Smad2-L(h):smad4(h) (binding)
smad4(h) + importin-beta(h) <==> smad4(h):importin-beta(h) (binding)
Smad2-L(h) + smad4(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad2-L(h):smad4(h) (binding)
Smad3(h) + smad4(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad3(h):smad4(h) (binding)
Smad8(r) + smad4(h) --ActR-I(x)--> Smad8(r):smad4(h) (binding)
Smad3(h) + smad4(h) --TGFbetaR-I(h)--> Smad3(h):smad4(h) (binding)
smad4(h) + Smad6(h) <==> smad4(h):Smad6(h) (binding)
Smad1(h) + smad4(h) <==> Smad1(h):smad4(h) (binding)
Smad2-L(h){p} + smad4(h) <==> Smad2-L(h){p}:smad4(h) (binding)
smad4(h) --> Mix.2(x) (DNA binding).
smad4(h) --> MMP1(h) (DNA binding).
smad4(h) --> JUN(h) (DNA binding).
smad4(h) --> SERPINE1(h) (DNA binding).
smad4(h) --> Junb(m) (DNA binding).
smad4(h) --> vent-2(x) (DNA binding).
p62Dok-1(m) + smad4(h) <==> p62Dok-1(m):smad4(h) (binding)
beta-catenin(h) + smad4(h) <==> beta-catenin(h):smad4(h) (binding)
LEF-1(m) + smad4(h) <==> LEF-1(m):smad4(h) (binding)
Smad3(h) + smad4(h) <==> Smad3(h):smad4(h) (binding)
smad4(h) --> twin(x) (DNA binding; transactivation).
HNF-4alpha(h) + smad4(h) <==> HNF-4alpha(h):smad4(h) (binding).
HNF-4alpha(r) + smad4(h) <==> HNF-4alpha(r):smad4(h) (binding).
smad4(h) + Smad2(h) <==> smad4(h):Smad2(h) (binding)
smad4(h) + CRI2(h) <==> smad4(h):CRI2(h) (binding)
smad4(h) + FOXO1A(h) <==> smad4(h):FOXO1A(h) (binding)
FOXO3a(h) + smad4(h) <==> FOXO3a(h):smad4(h) (binding)
smad4(h) + foxo4(h) <==> smad4(h):foxo4(h) (binding)
Smad2-L(h) + smad4(h) <==> Smad2-L(h):smad4(h) (binding)
EIF4ENIF1(m.s.) + smad4(h) <==> EIF4ENIF1(m.s.):smad4(h) (binding)
ZNF198(m.s.) + smad4(h) <==> ZNF198(m.s.):smad4(h) (binding)
PEX6(m.s.) + smad4(h) <==> PEX6(m.s.):smad4(h) (binding)
SF3B2(m.s.) + smad4(h) <==> SF3B2(m.s.):smad4(h) (binding)
smad4(h) + p68(m) <==> smad4(h):p68(m) (binding)
smad4(h) + Erbin(m.s.) <==> smad4(h):Erbin(m.s.) (binding)
Dvl-1(m.s.) + smad4(h) <==> Dvl-1(m.s.):smad4(h) (binding)
smad4(h) + Par3(m.s.) <==> smad4(h):Par3(m.s.) (binding)
smad4(h) + col1a2(m.s.) <==> smad4(h):col1a2(m.s.) (binding)
COL3A1(m.s.) + smad4(h) <==> COL3A1(m.s.):smad4(h) (binding)
COL5A2(m.s.) + smad4(h) <==> COL5A2(m.s.):smad4(h) (binding)
smad4(h) + Smad1(h) + RbAp48(h) + RbAp46(h) + sin3a(h) + HDAC1(h) + Nkx3-2(c) <==> smad4(h):Smad1(h):RbAp48(h):RbAp46(h):sin3a(h):HDAC1(h):Nkx3-2(c) (binding)
Daxx(h) + smad4(h) <==> Daxx(h):smad4(h) (binding)
Ubc9(h) + smad4(h) <==> Ubc9(h):smad4(h) (binding)
Daxx(h) + smad4(h) <==> Daxx(h):smad4(h) (binding)
smad4(h) + ATP --PDK1(h)--> smad4(h){p} + ADP (phosphorylation)
smad4(h) --> TGFB2(h) (DNA binding).
smad4(h) --> SERPINB5(h) (DNA binding).
smad4(h) --> Gast(m) (DNA binding; transactivation).
smad4(h) --> ELN(h) (DNA binding).
EWS(h) + smad4(h) <==> EWS(h):smad4(h) (binding)
smad4(h) + Smad8(h) <==> smad4(h):Smad8(h) (binding)
smad4(h) --> SMAD7(h) (DNA binding).
smad4(h) --> Il10(m) (DNA binding).
smad4(h) --> MMP13(h) (DNA binding).
smad4(h) --/ SEPP1(h) (DNA binding; transrepression).
smad4(h) --> c-myc(h) (DNA binding).
c-Ski(h) + Smad2(h) + Smad4(h) <==> c-Ski(h):Smad2(h):Smad4(h) (binding)
Smad4(h) --/ Pax-3(h) (decrease of abundance)
Smad4(h) --> PDGFB(h) (DNA binding).
SMAD4(h) --> smad4(h) (expression).
SMAD4(h) --> smad4delta3(h) (expression).
SMAD4(h) --> smad4delta4(h) (expression).
SMAD4(h) --> smad4delta6(h) (expression).
SMAD4(h) --> smad4delta5-6(h) (expression).
SMAD4(h) --> smad4delta4-6(h) (expression).
SMAD4(h) --> smad4delta4-7(h) (expression).
TCF-4(h) + Smad4(h) <==> TCF-4(h):Smad4(h) (binding)
Smad4(h) --> Skil(m) (DNA binding).
Smad4(h) --> Gnrhr(m) (DNA binding).
SMAD4(h) --> Smad4(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
277	Phosphothreonine (MAP2K2)	12801888	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr18	Promoter: 46809111 - 46811111	Agilent_014791
chr18	Promoter: 46809111 - 46811111	GoldenGate_Methylation_Cancer_Panel_I
chr18	Promoter: 46809111 - 46811111	GSE27584
chr18	Promoter: 46809111 - 46811111	Agilent_014791

Experimentally verified miRNA from miRTarBase [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]