Entrez Gene

Basic Information
Gene ID	11200
Name	CHEK2
Synonymous	checkpoint kinase 2;CHEK2;checkpoint kinase 2
Definition	CHK2 checkpoint homolog\|cds1 homolog\|checkpoint-like protein CHK2\|serine/threonine-protein kinase Chk2
Position	22q12.1
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.03.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1460A>G; p.Q487R; 22:28694033-28694033	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.410G>A; p.R137Q; 22:28725277-28725277	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.134C>T; p.T45M; 22:28734588-28734588	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1015C>T; p.H339Y; 22:28696981-28696981	urinary_tract; bladder	carcinoma	Substitution - Missense
c.229G>C; p.D77H; 22:28734493-28734493	breast	carcinoma	Substitution - Missense
c.330T>C; p.N110N; 22:28725357-28725357	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1036C>A; p.R346S; 22:28696960-28696960	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.430T>C; p.F144L; 22:28725257-28725257	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1036C>A; p.R346S; 22:28696960-28696960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.430T>C; p.F144L; 22:28725257-28725257	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1233G>A; p.W411*; 22:28695736-28695736	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.429C>G; p.H143Q; 22:28725258-28725258	thyroid	carcinoma	Substitution - Missense
c.451G>A; p.G151S; 22:28725118-28725118	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.688G>A; p.A230T; 22:28712013-28712013	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; essential_thrombocythaemia	Substitution - Missense
c.1060T>G; p.L354V; 22:28696936-28696936	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.592+2T>C; p.?; 22:28724975-28724975	stomach	carcinoma; adenocarcinoma	Unknown
c.945_946insG; p.N316fs*2; 22:28699900-28699901	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.753C>G; p.I251M; 22:28711948-28711948	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.753C>G; p.I251M; 22:28711948-28711948	urinary_tract; bladder	carcinoma	Substitution - Missense
c.544C>T; p.P182S; 22:28725025-28725025	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.30_31insG; p.Q11fs*66; 22:28734691-28734692	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1604G>A; p.R535H; 22:28687925-28687925	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1075G>A; p.E359K; 22:28696921-28696921	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.764A>G; p.K255R; 22:28711937-28711937	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1170C>G; p.Y390*; 22:28695799-28695799	thyroid	carcinoma	Substitution - Nonsense
c.1591G>T; p.E531*; 22:28687938-28687938	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.587A>T; p.N196I; 22:28724982-28724982	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.673delA; p.T225fs*10; 22:28719405-28719405	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1210T>G; p.Y404D; 22:28695759-28695759	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1210T>G; p.Y404D; 22:28695759-28695759	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.404A>C; p.K135T; 22:28725283-28725283	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.470T>C; p.I157T; 22:28725099-28725099	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1042T>C; p.L348L; 22:28696954-28696954	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1210T>G; p.Y404D; 22:28695759-28695759	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1169A>G; p.Y390C; 22:28695800-28695800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.739G>A; p.A247T; 22:28711962-28711962	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.441C>T; p.F147F; 22:28725246-28725246	skin	malignant_melanoma	Substitution - coding silent
c.394delA; p.R132fs*29; 22:28725293-28725293	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.804C>T; p.L268L; 22:28710048-28710048	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1115C>A; p.S372Y; 22:28695854-28695854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.400G>T; p.D134Y; 22:28725287-28725287	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.539G>A; p.R180H; 22:28725030-28725030	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>TG; p.K373E; 22:28695852-28695853	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1037G>A; p.R346H; 22:28696959-28696959	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.827T>G; p.I276S; 22:28710025-28710025	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.326T>G; p.V109G; 22:28725361-28725361	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.711T>G; p.A237A; 22:28711990-28711990	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1556G>A; p.R519Q; 22:28687973-28687973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.564A>T; p.E188D; 22:28725005-28725005	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; polycythaemia_vera	Substitution - Missense
c.461A>G; p.N154S; 22:28725108-28725108	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.736G>T; p.V246L; 22:28711965-28711965	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.740C>A; p.A247D; 22:28711961-28711961	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1116C>T; p.S372S; 22:28695853-28695853	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.740C>A; p.A247D; 22:28711961-28711961	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.740C>A; p.A247D; 22:28711961-28711961	large_intestine; colon	carcinoma	Substitution - Missense
c.1116C>T; p.S372S; 22:28695853-28695853	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.740C>A; p.A247D; 22:28711961-28711961	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1116C>T; p.S372S; 22:28695853-28695853	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	central_nervous_system; brain	glioma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 22:28695853-28695853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.823G>T; p.E275*; 22:28710029-28710029	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.717G>A; p.E239E; 22:28711984-28711984	breast	carcinoma	Substitution - coding silent
c.1095+2T>C; p.?; 22:28696899-28696899	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.685G>T; p.G229C; 22:28712016-28712016	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1384C>A; p.L462I; 22:28694109-28694109	thyroid	carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; angioimmunoblastic_T_cell_lymphoma	Substitution - Missense
c.1555C>G; p.R519G; 22:28687974-28687974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1149C>T; p.T383T; 22:28695820-28695820	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1149C>T; p.T383T; 22:28695820-28695820	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.718A>T; p.R240W; 22:28711983-28711983	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.459A>C; p.K153N; 22:28725110-28725110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1067C>A; p.S356*; 22:28696929-28696929	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1297C>G; p.Q433E; 22:28695205-28695205	urinary_tract; bladder	carcinoma	Substitution - Missense
c.192G>A; p.E64E; 22:28734530-28734530	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.961G>T; p.E321*; 22:28699885-28699885	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.961G>T; p.E321*; 22:28699885-28699885	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.961G>T; p.E321*; 22:28699885-28699885	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.192G>A; p.E64E; 22:28734530-28734530	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1064T>C; p.L355P; 22:28696932-28696932	large_intestine; colon	carcinoma	Substitution - Missense
c.1064T>C; p.L355P; 22:28696932-28696932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1211A>G; p.Y404C; 22:28695758-28695758	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.491G>A; p.S164N; 22:28725078-28725078	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.53G>C; p.C18S; 22:28734669-28734669	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1036C>T; p.R346C; 22:28696960-28696960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1036C>T; p.R346C; 22:28696960-28696960	breast	carcinoma	Substitution - Missense
c.931G>C; p.D311H; 22:28699915-28699915	urinary_tract; bladder	carcinoma	Substitution - Missense
c.73G>A; p.V25I; 22:28734649-28734649	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1622C>G; p.A541G; 22:28687907-28687907	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1087C>T; p.L363F; 22:28696909-28696909	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1087C>T; p.L363F; 22:28696909-28696909	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.545C>A; p.P182H; 22:28725024-28725024	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1421G>A; p.R474H; 22:28694072-28694072	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1180G>A; p.E394K; 22:28695789-28695789	skin; subungual	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.1038T>C; p.R346R; 22:28696958-28696958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1038T>C; p.R346R; 22:28696958-28696958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1180G>A; p.E394K; 22:28695789-28695789	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.553A>T; p.N185Y; 22:28725016-28725016	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.146C>T; p.S49F; 22:28734576-28734576	liver	carcinoma	Substitution - Missense
c.146C>T; p.S49F; 22:28734576-28734576	liver	carcinoma	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1141A>G; p.M381V; 22:28695828-28695828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.412A>G; p.T138A; 22:28725275-28725275	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.992T>C; p.M331T; 22:28699854-28699854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.154T>C; p.S52P; 22:28734568-28734568	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.268C>T; p.P90S; 22:28734454-28734454	skin	malignant_melanoma	Substitution - Missense
c.836A>C; p.K279T; 22:28710016-28710016	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.540C>A; p.R180R; 22:28725029-28725029	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1365C>T; p.V455V; 22:28695137-28695137	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1543-1G>T; p.?; 22:28687987-28687987	ovary	carcinoma; serous_carcinoma	Unknown
c.335A>T; p.N112I; 22:28725352-28725352	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>T; p.P536L; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.305G>T; p.G102V; 22:28734417-28734417	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.914A>G; p.E305G; 22:28699932-28699932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.557A>G; p.N186S; 22:28725012-28725012	thyroid	carcinoma	Substitution - Missense
c.278G>T; p.W93L; 22:28734444-28734444	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1173G>T; p.L391F; 22:28695796-28695796	thyroid	carcinoma	Substitution - Missense
c.267C>T; p.T89T; 22:28734455-28734455	skin	malignant_melanoma	Substitution - coding silent
c.1568G>A; p.R523H; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1568G>A; p.R523H; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1568G>A; p.R523H; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.629C>A; p.S210*; 22:28719449-28719449	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1568G>A; p.R523H; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1558_1559delAA; p.K520fs*4; 22:28687970-28687971	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1561C>T; p.R521W; 22:28687968-28687968	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1561C>T; p.R521W; 22:28687968-28687968	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1259+1G>C; p.?; 22:28695709-28695709	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Unknown
c.1259+1G>C; p.?; 22:28695709-28695709	urinary_tract; bladder	carcinoma	Unknown
c.980A>G; p.Y327C; 22:28699866-28699866	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Substitution - Missense
c.1438G>A; p.A480T; 22:28694055-28694055	central_nervous_system; brain	glioma	Substitution - Missense
c.922G>C; p.E308Q; 22:28699924-28699924	breast	carcinoma	Substitution - Missense
c.1568G>C; p.R523P; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1568G>C; p.R523P; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1568G>C; p.R523P; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1583A>T; p.E528V; 22:28687946-28687946	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1568G>C; p.R523P; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1568G>C; p.R523P; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1568G>C; p.R523P; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1568G>C; p.R523P; 22:28687961-28687961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.916G>A; p.G306R; 22:28699930-28699930	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1175C>T; p.A392V; 22:28695794-28695794	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1116_1117CA>GT; p.S372>?; 22:28695852-28695853	lung	carcinoma; adenocarcinoma	Complex
c.1116_1117CA>GT; p.S372>?; 22:28695852-28695853	lung	carcinoma; adenocarcinoma	Complex
c.694G>C; p.G232R; 22:28712007-28712007	oesophagus	carcinoma	Substitution - Missense
c.1116_1117CA>GT; p.S372>?; 22:28695852-28695853	lung	carcinoma; adenocarcinoma	Complex
c.1114T>C; p.S372P; 22:28695855-28695855	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1036C>G; p.R346G; 22:28696960-28696960	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1174G>T; p.A392S; 22:28695795-28695795	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.869A>C; p.N290T; 22:28703544-28703544	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.703A>C; p.K235Q; 22:28711998-28711998	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.326T>C; p.V109A; 22:28725361-28725361	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.609T>G; p.D203E; 22:28719469-28719469	breast	carcinoma	Substitution - Missense
c.1175C>A; p.A392E; 22:28695794-28695794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.398C>A; p.T133K; 22:28725289-28725289	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.1053G>T; p.E351D; 22:28696943-28696943	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.508G>A; p.V170I; 22:28725061-28725061	salivary_gland; mouth_floor	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1628T>C; p.L543S; 22:28687901-28687901	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1176G>T; p.A392A; 22:28695793-28695793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.252A>G; p.E84E; 22:28734470-28734470	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.395G>T; p.R132I; 22:28725292-28725292	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1233G>C; p.W411C; 22:28695736-28695736	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1186C>G; p.L396V; 22:28695783-28695783	breast	carcinoma	Substitution - Missense
c.476A>G; p.Y159C; 22:28725093-28725093	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1193C>G; p.S398C; 22:28695776-28695776	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1193C>G; p.S398C; 22:28695776-28695776	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1193C>G; p.S398C; 22:28695776-28695776	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1193C>G; p.S398C; 22:28695776-28695776	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1193C>G; p.S398C; 22:28695776-28695776	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1193C>G; p.S398C; 22:28695776-28695776	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1193C>G; p.S398C; 22:28695776-28695776	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1542+1G>T; p.?; 22:28689134-28689134	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.461_462insA; p.N154fs*32; 22:28725107-28725108	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1129G>A; p.E377K; 22:28695840-28695840	urinary_tract; bladder	carcinoma	Substitution - Missense
c.480A>G; p.I160M; 22:28725089-28725089	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1607C>A; p.P536Q; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1607C>A; p.P536Q; 22:28687922-28687922	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	skin	malignant_melanoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	stomach	carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1283C>T; p.S428F; 22:28695219-28695219	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	skin	malignant_melanoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	skin	malignant_melanoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1117A>G; p.K373E; 22:28695852-28695852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.106C>T; p.Q36*; 22:28734616-28734616	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1111C>T; p.H371Y; 22:28695858-28695858	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.275C>T; p.P92L; 22:28734447-28734447	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.524T>C; p.V175A; 22:28725045-28725045	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1580C>T; p.A527V; 22:28687949-28687949	skin	malignant_melanoma	Substitution - Missense
c.1037G>T; p.R346L; 22:28696959-28696959	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.526G>T; p.G176W; 22:28725043-28725043	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1566C>T; p.P522P; 22:28687963-28687963	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]