Entrez Gene

Basic Information
Gene ID	3014
Name	H2AFX
Synonymous	H2A.X\|H2A/X\|H2AX;H2A histone family, member X;H2AFX;H2A histone family, member X
Definition	H2AX histone\|histone H2A.x\|histone H2AX
Position	11q23.3
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
h2ax(h) + ATP --> h2ax(h){pS140} + ADP (phosphorylation)
h2ax(h) + ATP --> h2ax(h){p} + ADP (phosphorylation)
H2AFX(h) --> h2ax(h) (expression).
H2AFX(h) --> h2ax(h) (expression).
h2ax(h){pS140} --Wip1(m.s.)--> h2ax(h) + p (dephosphorylation)
h2ax(h){pS140} --> h2ax(h) + p (dephosphorylation)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
2	N-acetylserine (By similarity).		Swiss-Prot 53.0
2	Phosphoserine (By similarity).		Swiss-Prot 53.0
140	Phosphoserine (by ATM, ATR and PRKDC).		Swiss-Prot 53.0
120	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin) (Bysimilarity).		Swiss-Prot 53.0
139	Phosphoserine (ATM)	11571274	Phospho.ELM 6.0
120	Phosphothreonine	16083285	Phospho.ELM 6.0
123	Phosphothreonine	16083285	Phospho.ELM 6.0