Entrez Gene

Basic Information
Gene ID	5925
Name	RB1
Synonymous	OSRC\|PPP1R130\|RB\|p105-Rb\|pRb\|pp110;retinoblastoma 1;RB1;retinoblastoma 1
Definition	prepro-retinoblastoma-associated protein\|protein phosphatase 1, regulatory subunit 130\|retinoblastoma suspectibility protein\|retinoblastoma-associated protein
Position	13q14.2
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Experimentally validated miRNA-TS gene regulation information.

Regulation From TransFac database
Transcription Factors [Top]
E1A(12S)(AD12) + p107(h) + p130(h) + pRb(h) + p300(h) <==> E1A(12S)(AD12):p300(h):pRb(h):p130(h):p107(h) (binding)
pRb(h) + ATP --cyclinD(m):Cdk4(m)--> pRb(h){p} + ADP (phosphorylation)
pRb(h) + ATP --cyclinD2(m):Cdk6(m)--> pRb(h){p} + ADP (phosphorylation)
pRb(h) + ATP --cyclinD1(m):Cdk4(m)--> pRb(h){p} + ADP (phosphorylation)
pRb(h) + p21Cip1(h) <==> pRb(h):p21Cip1(h) (binding)
pRb(h) + p57Kip2(m) <==> pRb(h):p57Kip2(m) (binding)
pRb(h) + ATP --cyclinD3(m):Cdk4(m)--> pRb(h){p} + ADP (phosphorylation)
pRb(h) + ATP --cyclinD1(h):Cdk6(h){pT177}--> pRb(h){p} + ADP (phosphorylation)
pRb(h) + ATP --cyclinE(h):Cdk2(h)--> pRb(h){p} + ADP (phosphorylation)
pRb(h) + ATP --cyclinA(h):Cdk2(h)--> pRb(h){p} + ADP (phosphorylation)
pRb(h) + Abl(m) <==> pRb(h):Abl(m) (binding)
pRb(h) + ATP --cyclinB(h):Cdk1(h)--> pRb(h){p} + ADP (phosphorylation)
E2F-1(h) + pRb(h) <==> E2F-1(h):pRb(h) (binding)
E2F-1(h) + DP-1(h) + pRb(h) <==> E2F-1(h):DP-1(h):pRb(h) (binding)
E2F-1(h) + DP-2(h) + pRb(h) <==> E2F-1(h):DP-2(h):pRb(h) (binding)
E2F-2(h) + DP-2(h) + pRb(h) <==> E2F-2(h):DP-2(h):pRb(h) (binding)
E2F-2(h) + DP-1(h) + pRb(h) <==> E2F-2(h):DP-1(h):pRb(h) (binding)
E2F-3(h) + DP-1(h) + pRb(h) <==> E2F-3(h):DP-1(h):pRb(h) (binding)
E2F-3(h) + DP-2(h) + pRb(h) <==> E2F-3(h):DP-2(h):pRb(h) (binding)
E2F-4(h) + pRb(h) <==> E2F-4(h):pRb(h) (binding)
pRb(h) + T-Ag(SV) <==> pRb(h):T-Ag(SV) (binding)
pRb(h) + PP1-alpha2(h) <==> pRb(h):PP1-alpha2(h) (binding)
pRb(h) + PP1-alpha1(h) <==> pRb(h):PP1-alpha1(h) (binding)
c-Myc(h) + pRb(h) <==> c-Myc(h):pRb(h) (binding).
pRb(h) + ATF-2-xbb4(h) <==> pRb(h):ATF-2-xbb4(h) (binding).
C/EBPbeta(h) + pRb(h) <==> C/EBPbeta(h):pRb(h) (binding).
SPI1(c) + pRb(h) <==> SPI1(c):pRb(h) (binding).
E2F-2(h) + pRb(h) <==> E2F-2(h):pRb(h) (binding).
E2F-3(h) + pRb(h) <==> E2F-3(h):pRb(h) (binding).
TAF(II)250-isoform2(h) + pRb(h) <==> TAF(II)250-isoform2(h):pRb(h) (binding).
E1A 12S protein(AD) + pRb(h) <==> E1A 12S protein(AD):pRb(h) (binding).
Elf-1(h) + pRb(h) <==> Elf-1(h):pRb(h) (binding).
Id2(h) + pRb(h) <==> Id2(h):pRb(h) (binding).
N-Myc(m) + pRb(h) <==> N-Myc(m):pRb(h) (binding).
RBP60(h) + pRb(h) <==> RBP60(h):pRb(h) (binding).
pRb(h) + MyoD(m) <==> pRb(h):MyoD(m) (binding)
pRb(h) + Myogenin(h) <==> pRb(h):Myogenin(h) (binding)
Raf-1(h) + pRb(h) <==> Raf-1(h):pRb(h) (binding)
E2F(h):DP(h) + pRb(h) + Raf-1(h) <==> E2F(h):DP(h):pRb(h):Raf-1(h) (binding)
pRb(h) --Caspase-3(h)--> protein remnants (processing)
CLIM2(h) + E2A(h) + RBTN2-isoform1(h) + Tal-1(h) + pRb(h) <==> CLIM2(h):E2A(h):RBTN2-isoform1(h):Tal-1(h):pRb(h) (binding)
pRb(h) + Tal-1(h) <==> pRb(h):Tal-1(h) (binding)
pRb(h) + E2A(h) <==> pRb(h):E2A(h) (binding)
pRb(h) + RBTN2-isoform1(h) <==> pRb(h):RBTN2-isoform1(h) (binding)
pRb(h) + CLIM2(h) <==> pRb(h):CLIM2(h) (binding)
AhR(h) + pRb(h) <==> AhR(h):pRb(h) (binding)
E2F(h):DP(h) + pRb(h) <==> E2F(h):DP(h):pRb(h) (binding).
SPI1(h) + pRb(h) <==> SPI1(h):pRb(h) (binding).
SPI1(m) + pRb(h) <==> SPI1(m):pRb(h) (binding).
E1A 13S protein(AD2) + pRb(h) <==> E1A 13S protein(AD2):pRb(h) (binding).
Hec1(h){p} + pRb(h) <==> Hec1(h){p}:pRb(h) (binding)
pRb(h) + E1A(AD) <==> pRb(h):E1A(AD) (binding)
pRb(h) + E7(HPV16) <==> pRb(h):E7(HPV16) (binding)
RACK1(h) + pRb(h) <==> RACK1(h):pRb(h) (binding)
pRb(h) + MTB-Zf(h) <==> pRb(h):MTB-Zf(h) (binding)
ER-alpha(h) + pRb(h) + MTB-Zf(h) <==> ER-alpha(h):pRb(h):MTB-Zf(h) (binding)
MRFAP1(h) + pRb(h) <==> MRFAP1(h):pRb(h) (binding)
pRb(h) + AML3(m) <==> pRb(h):AML3(m) (binding)
HES-1(h) + pRb(h) <==> HES-1(h):pRb(h) (binding)
pRb(h) + CRI1(h) <==> pRb(h):CRI1(h) (binding)
pRb(h) + SUMO2(h) --> pRb(h){sumo2} (sumoylation)
pRb(h) + sumo3(m.s.) --> pRb(h){sumo3} (sumoylation)
pRb(h) + HCV-NS5B-1B-Japanese(HCV1BJapan) <==> pRb(h):HCV-NS5B-1B-Japanese(HCV1BJapan) (binding)
pRb(h) + ATP --> pRb(h){p} + ADP (phosphorylation)
pRb(h) + neurofibromin1(h) <==> pRb(h):neurofibromin1(h) (binding)
Sp1(h) + pRb(h) <==> Sp1(h):pRb(h) (binding)
HDAC1(h) + pRb(h) <==> HDAC1(h):pRb(h) (binding)
hdac2(h) + pRb(h) <==> hdac2(h):pRb(h) (binding)
HDAC3(h) + pRb(h) <==> HDAC3(h):pRb(h) (binding)
RBBP1(h) + pRb(h) <==> RBBP1(h):pRb(h) (binding)
pRb(h) + MNAR(h) <==> pRb(h):MNAR(h) (binding)
HDAC1(h) + E2F-1(h) + pRb(h) + Dnmt1(h) <==> HDAC1(h):E2F-1(h):pRb(h):Dnmt1(h) (binding)
pRb(h) + Dnmt1(h) <==> pRb(h):Dnmt1(h) (binding)
pRb(h) + ATP --> pRb(h){pS780} + ADP (phosphorylation)
pRb(h) + ATP --> pRb(h){pS807} + ADP (phosphorylation)
pRb(h) + mcm7(h) <==> pRb(h):mcm7(h) (binding)
hdac2(h){p} + pRb(h) <==> hdac2(h){p}:pRb(h) (binding)
BMP2A(h) --/ pRb(h) (inhibition)
RB1(h) --> pRb(h) (expression).
TFF1(h) --> pRb(h) (activation)
IKK-alpha(h) --> pRb(h) (increase of abundance)
E2F-1(h) --> pRb(h) (increase of abundance)
p75NTR(m.s.) --> pRb(h) (increase of abundance)
Cdx-2(h) --/ pRb(h) (decrease of abundance)
pRb(h) --> EIIaE1(AD) (DNA binding).
CRI1(h) + pRb(h) <==> CRI1(h):pRb(h) (binding)
pRb(h) + 2 acetyl-CoA --p300(h)--> pRb(h){aceK873}{aceK874} + 2 CoA (acetylation)
E2F-1(h) + pRb(h) <==> E2F-1(h):pRb(h) (binding)
E2F-1(m.s.) + pRb(h) <==> E2F-1(m.s.):pRb(h) (binding)
pRb(h) --/ RBL1(h) (transrepression)
pRb(h) + 2 ATP --> pRb(h){pS807}{pS811} + 2 ADP (phosphorylation)
RB1(h) --> pRb(h) (expression).

Location (AA)	PTM type	Database
Post Transcriptional Modification [Top]
249	Phosphoserine (by CDC2).	Swiss-Prot 53.0
252	Phosphothreonine (by CDC2).	Swiss-Prot 53.0
373	Phosphothreonine (by CDC2).	Swiss-Prot 53.0
807	Phosphoserine (by CDC2).	Swiss-Prot 53.0
811	Phosphoserine (by CDC2).	Swiss-Prot 53.0
826	Phosphothreonine (By similarity).	Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr13	Promoter: 47774384 - 47776384	Agilent_014791
chr13	Promoter: 47774384 - 47776384	GSE27584
chr13	Promoter: 47774384 - 47776384	Agilent_014791_44K
chr13	Promoter: 47774384 - 47776384	Agilent_014791
chr13	Promoter: 47774384 - 47776384	PMID:20064646
chr13	Promoter: 47774384 - 47776384	PMID:12447702
chr13	Promoter: 47774384 - 47776384	PMID:16353169
chr13	Promoter: 47774384 - 47776384	PMID:15365725
chr13	Promoter: 47774384 - 47776384	PMID:15892004
chr13	Promoter: 47774384 - 47776384	PMID:12579314
chr13	Promoter: 47774384 - 47776384	PMID:11204276
chr13	Promoter: 47774384 - 47776384	PMID:17216555
chr13	Promoter: 47774384 - 47776384	PMID:16391867
chr13	Promoter: 47774384 - 47776384	PMID:14654541
chr13	Promoter: 47774384 - 47776384	PMID:11487055
chr13	Promoter: 47774384 - 47776384	PMID:11522621
chr13	Promoter: 47774384 - 47776384	PMID:12660028
chr13	Promoter: 47774384 - 47776384	PMID:16858686
chr13	Promoter: 47774384 - 47776384	PMID:12149142
chr13	Promoter: 47774384 - 47776384	PMID:11943705
chr13	Promoter: 47774384 - 47776384	PMID:12845670
chr13	Promoter: 47774384 - 47776384	PMID:12143052
chr13	Promoter: 47774384 - 47776384	PMID:17034532
chr13	Promoter: 47774384 - 47776384	PMID:12947553
chr13	Promoter: 47774384 - 47776384	PMID:12942643
chr13	Promoter: 47774384 - 47776384	PMID:15975525
chr13	Promoter: 47774384 - 47776384	PMID:14714493
chr13	Promoter: 47774384 - 47776384	PMID:15892297
chr13	Promoter: 47774384 - 47776384	PMID:12826052
chr13	Promoter: 47774384 - 47776384	PMID:16682076
chr13	Promoter: 47774384 - 47776384	PMID:15695118

Experimentally verified miRNA from miRTarBase [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]