| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 835 |
Name | CASP2 |
Synonymous | CASP-2|ICH1|NEDD-2|NEDD2|PPP1R57;caspase 2, apoptosis-related cysteine peptidase;CASP2;caspase 2, apoptosis-related cysteine peptidase |
Definition | caspase-2|neural precursor cell expressed developmentally down-regulated protein 2|protease ICH-1|protein phosphatase 1, regulatory subunit 57 |
Position | 7q34-q35 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
proCaspase-2-1S(h) --Caspase-3(h)--> Caspase-2(h) (processing) | CRADD(h) + proCaspase-2-1S(h) <==> CRADD(h):proCaspase-2-1S(h) (binding) | proCaspase-2-1S(h) --Caspase-2(h)--> Caspase-2-p34(h) + protein remnants (processing) | TNFR1(h):TRADD(h):CRADD(h):RIP(h) + proCaspase-2-1S(h) <==> TNFR1(h):TRADD(h):CRADD(h):RIP(h):proCaspase-2-1S(h) (binding) | proCaspase-2-1S(h) + RIP3(h) <==> proCaspase-2-1S(h):RIP3(h) (binding) | proCaspase-2-1S(h) --Caspase-2(h)--> Caspase-2-p34(h) + Caspase-2-p14(h) + protein remnants (processing) | proCaspase-2-1S(h) --Caspase-3(h)--> Caspase-2-p34(h) + Caspase-2-p14(h) + protein remnants (processing) | proCaspase-2-1S(h) --Caspase-10(h)--> Caspase-2-p34(h) + Caspase-2-p14(h) + protein remnants (processing) | proCaspase-2-1S(h) --Caspase-8(h)--> Caspase-2-p34(h) + Caspase-2-p14(h) + protein remnants (processing) | proCaspase-2-1S(h) --Caspase-3(h)--> Caspase-2-p12(h) + protein remnants (cleavage) | CASP2(h) --> proCaspase-2-1S(h) (expression). | CRADD(h) + proCaspase-2L-Pro(h) <==> CRADD(h):proCaspase-2L-Pro(h) (binding) | CASP2(h) --> proCaspase-2L-Pro(h) (expression). | CASP2(h) --> proCaspase-2S-Pro(h) (expression). | proCaspase-2(h) + CKII-alpha(h) <==> proCaspase-2(h):CKII-alpha(h) (binding) | proCaspase-2(h) + ATP --CKII-alpha(h)--> proCaspase-2(h){pS} + ADP (phosphorylation) | proCaspase-2(h) --> Caspase-2-p18(h) + protein remnants (cleavage) | proCaspase-2(h) + TRAF2(h) + RIP(h) <==> proCaspase-2(h):TRAF2(h):RIP(h) (binding) | proCaspase-2(h) --> Caspase-2-p33(h) + protein remnants (processing) | Fas(h) + proCaspase-2(h) + Caspase-8-p43(h) <==> Fas(h):proCaspase-2(h):Caspase-8-p43(h) (binding) | Fas(h) + FADD(h) + proCaspase-2(h) + Caspase-8-p43(h) <==> Fas(h):FADD(h):proCaspase-2(h):Caspase-8-p43(h) (binding) | FADD(h) + proCaspase-2(h) <==> FADD(h):proCaspase-2(h) (binding) | Fas(h) + proCaspase-2(h) + proCaspase-8(h) <==> Fas(h):proCaspase-2(h):proCaspase-8(h) (binding) | proCaspase-2(h) + sumo1(h) --> proCaspase-2(h){sumo} (sumoylation) | PIDD(h) + proCaspase-2(h) + CRADD(h) <==> PIDD(h):proCaspase-2(h):CRADD(h) (binding) | PIDD-isoform-1(h) + proCaspase-2(h) + CRADD(h) <==> PIDD-isoform-1(h):proCaspase-2(h):CRADD(h) (binding) | proCaspase-2(h) --> Caspase-2-p19(h) + protein remnants (cleavage) | proCaspase-2(h) --> Caspase-2-p31(h) + protein remnants (cleavage) | CRADD(h) + proCaspase-2(h) <==> CRADD(h):proCaspase-2(h) (binding) | proCaspase-2(h) + CRADD(h) <==> proCaspase-2(h):CRADD(h) (binding) | proCaspase-2(h) --> Caspase-2-p15(h) + protein remnants (cleavage) | proCaspase-2(h) --> Caspase-2-p25(h) + Caspase-2-p15(h) + protein remnants (cleavage) | proCaspase-2(h) --> Caspase-2-p13(h) + protein remnants (cleavage) | proCaspase-2(h) --> Caspase-2-p12(h) + protein remnants (cleavage) | proCaspase-2(h) --proCaspase-2-1L(h)--> Caspase-2-p33(h) + protein remnants (cleavage) | proCaspase-2(h) --proCaspase-2-1L(h)--> Caspase-2-p30(h) + protein remnants (cleavage) | proCaspase-2(h) --proCaspase-2-1L(h)--> Caspase-2-p19(h) + protein remnants (cleavage) | proCaspase-2(h) --> Caspase-2-p34(h) + protein remnants (cleavage) | proCaspase-2(h) + GMEB-1(h) <==> proCaspase-2(h):GMEB-1(h) (binding) | proCaspase-2(h) + GMEB1-xbb2(h) <==> proCaspase-2(h):GMEB1-xbb2(h) (binding) | proCaspase-2(h) + proCaspase-9(h) + Apaf-1(h) + proCaspase-3(h) <==> proCaspase-2(h):proCaspase-9(h):Apaf-1(h):proCaspase-3(h) (binding) | proCaspase-2(h) --> protein remnants (cleavage) | proCaspase-2(h) --> Caspase-2-p32(h) + protein remnants (processing) | proCaspase-2(h) --> Caspase-2-p37(h) + protein remnants (processing) | proCaspase-2(h) --> Caspase-2-p14(h) + protein remnants (processing) | proCaspase-2(h) --> Caspase-2-p30(h) + protein remnants (processing) | CASP2(h) --> proCaspase-2(h) (expression). | NADE-isoform1(m) --> proCaspase-2(h) (increase of cleavage) | CASP2(h) --> proCaspase-2-1L(h) (expression). | proCaspase-2(h) --proCaspase-2-1L(h)--> Caspase-2-p33(h) + protein remnants (cleavage) | proCaspase-2(h) --proCaspase-2-1L(h)--> Caspase-2-p30(h) + protein remnants (cleavage) | proCaspase-2(h) --proCaspase-2-1L(h)--> Caspase-2-p19(h) + protein remnants (cleavage) |
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Post Transcriptional Modification [Top] | |||
There is no record for CASP2 | |||
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 142502623 - 142502667 | Agilent_014791 |
chr7 |
Promoter: 142694024 - 142696024 | Agilent_014791 |
chr7 |
Promoter: 142694024 - 142696024 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 142694024 - 142696024 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 142694024 - 142696024 | GSE27584 |
chr7 |
Promoter: 142694024 - 142696024 | GSE27584 |