|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1111 |
Name | CHEK1 |
Synonym | CHK1;checkpoint kinase 1;CHEK1;checkpoint kinase 1 |
Definition | CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1|cell cycle checkpoint kinase|checkpoint kinase-1|serine/threonine-protein kinase Chk1 |
Position | 11q24.2 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 2 PubMed records as below. |
|
Evidence Status |
Description |
potential | "Thus, our study suggests that LOH11CR2A, PIG8 and CHEK1 are candidate tumor suppressor genes associated with breast carcinoma and have significant clinical as well as prognostic importance." |
reviewed | "The haploinsufficient tumor suppressor Chk1 is essential for embryonic cells, but the consequences of Chk1 loss in adult tissues are unknown." |
| More detail of all 2 literatures about CHEK1 | |
|
Pathways and Diseases |
|
Pathway | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PID Reactome;500938 |
Pathway | cell cycle: g2/m checkpoint;PID BioCarta;100159 |
Pathway | Activation of ATR in response to replication stress;PID Reactome;500319 |
Pathway | Circadian rhythm pathway;PID Curated;200068 |
Pathway | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;PID Reactome;500318 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234 |
Pathway | G2/M DNA damage checkpoint;PID Reactome;500952 |
Pathway | regulation of cell cycle progression by plk3;PID BioCarta;100068 |
Pathway | cdc25 and chk1 regulatory pathway in response to dna damage;PID BioCarta;100212 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | atm signaling pathway;PID BioCarta;100235 |
Pathway | rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046 |
Pathway | G2/M Checkpoints;PID Reactome;500874 |
Pathway | p53 pathway;PID Curated;200175 |
Disease | CANCER;GAD |
Disease | Cancer;FunDO |
Disease | Fanconi's anemia;FunDO |
Disease | colorectal cancer;GAD |
|
External Links |
|
Links to Entrez Gene | 1111 |
Links to all GeneRIF Items | 1111 |
Links to iHOP | 1111 |
|
Sequence Information |
|
Nucleotide Sequence |
>1111 : length: 1431 atggcagtgccctttgtggaagactgggacttggtgcaaaccctgggagaaggtgcctat ggagaagttcaacttgctgtgaatagagtaactgaagaagcagtcgcagtgaagattgta gatatgaagcgtgccgtagactgtccagaaaatattaagaaagagatctgtatcaataaa atgctaaatcatgaaaatgtagtaaaattctatggtcacaggagagaaggcaatatccaa tatttatttctggagtactgtagtggaggagagctttttgacagaatagagccagacata ggcatgcctgaaccagatgctcagagattcttccatcaactcatggcaggggtggtttat ctgcatggtattggaataactcacagggatattaaaccagaaaatcttctgttggatgaa agggataacctcaaaatctcagactttggcttggcaacagtatttcggtataataatcgt gagcgtttgttgaacaagatgtgtggtactttaccatatgttgctccagaacttctgaag agaagagaatttcatgcagaaccagttgatgtttggtcctgtggaatagtacttactgca atgctcgctggagaattgccatgggaccaacccagtgacagctgtcaggagtattctgac tggaaagaaaaaaaaacatacctcaacccttggaaaaaaatcgattctgctcctctagct ctgctgcataaaatcttagttgagaatccatcagcaagaattaccattccagacatcaaa aaagatagatggtacaacaaacccctcaagaaaggggcaaaaaggccccgagtcacttca ggtggtgtgtcagagtctcccagtggattttctaagcacattcaatccaatttggacttc tctccagtaaacagtgcttctagtgaagaaaatgtgaagtactccagttctcagccagaa ccccgcacaggtctttccttatgggataccagcccctcatacattgataaattggtacaa gggatcagcttttcccagcccacatgtcctgatcatatgcttttgaatagtcagttactt ggcaccccaggatcctcacagaacccctggcagcggttggtcaaaagaatgacacgattc tttaccaaattggatgcagacaaatcttatcaatgcctgaaagagacttgtgagaagttg ggctatcaatggaagaaaagttgtatgaatcaggttactatatcaacaactgataggaga aacaataaactcattttcaaagtgaatttgttagaaatggatgataaaatattggttgac ttccggctttctaagggtgatggattggagttcaagagacacttcctgaagattaaaggg aagctgattgatattgtgagcagccagaagatttggcttcctgccacatga |
Protein Sequence |
>1111 : length: 476 MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT |