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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 1111 |
Name | CHEK1 |
Synonymous | CHK1;checkpoint kinase 1;CHEK1;checkpoint kinase 1 |
Definition | CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1|cell cycle checkpoint kinase|checkpoint kinase-1|serine/threonine-protein kinase Chk1 |
Position | 11q24.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Chk1(h) + ATP --ATR(h)--> Chk1(h){p} + ADP (phosphorylation) | Cdc25A(h) + Chk1(h) <==> Cdc25A(h):Chk1(h) (binding) | Cdc25B(h) + Chk1(h) <==> Cdc25B(h):Chk1(h) (binding) | Cdc25C(h) + Chk1(h) <==> Cdc25C(h):Chk1(h) (binding) | brca1(h) + Chk1(h) <==> brca1(h):Chk1(h) (binding) | Chk1(h) + p73alpha(h) <==> Chk1(h):p73alpha(h) (binding) | Chk1(h) + p73beta(h) <==> Chk1(h):p73beta(h) (binding) | Wip1(h) + Chk1(h) <==> Wip1(h):Chk1(h) (binding) | BLM(h) + Chk1(h) <==> BLM(h):Chk1(h) (binding) | Chk1(h) + ATP --> Chk1(h){pS317} + ADP (phosphorylation) | Chk1(h) + ATP --> Chk1(h){pS345} + ADP (phosphorylation) | Chk1(h) + ATP --ATR(h)--> Chk1(h){pS345} + ADP (phosphorylation) | Chk1(h) + Claspin(h){p}n <==> Chk1(h):Claspin(h){p}n (binding) | Chk1(h) + ATP --> Chk1(h){p} + ADP (phosphorylation) | Chk1(h) --/ Cdc25A(h) (inhibition; decrease of abundance) | Cdc25C(h):Chk1(h) + ATP --> Cdc25C(h){pS216} + Chk1(h) + ADP (phosphorylation; dissociation) | Cdc25B(h):Chk1(h) + ATP --> Cdc25B(h){p} + Chk1(h) + ADP (phosphorylation; dissociation) | Cdc25A(h):Chk1(h) + ATP --> Cdc25A(h){p} + Chk1(h) + ADP (phosphorylation; dissociation) | CHEK1(h) --> Chk1(h) (expression). | Chk1(h){pS345} --Wip1(h)--> p + Chk1(h) (dephosphorylation) | Chk1(h){pS345} --> Chk1(h) + p (dephosphorylation) | HAUSP(h) --> Chk1(h) (activation) | Cdc25(h) + ATP --Chk1(h)--> Cdc25(h){p} + ADP (phosphorylation) | p53(h) + ATP --Chk1(h)--> p53(h){pS15} + ADP (phosphorylation) | p53(h) + ATP --Chk1(h)--> p53(h){pS20} + ADP (phosphorylation) | p53(h) + ATP --Chk1(h)--> p53(h){pS37} + ADP (phosphorylation) | Cdc25B3(h) + ATP --Chk1(h)--> Cdc25B3(h){p} + ADP (phosphorylation) | p73alpha(h) + ATP --Chk1(h)--> p73alpha(h){pS47} + ADP (phosphorylation) | BLM(h) + ATP --Chk1(h)--> BLM(h){pS} + ADP (phosphorylation) | Mdm4(h) + ATP --Chk1(h)--> Mdm4(h){pS367} + ADP (phosphorylation) | Cdc25C(m.s.) + ATP --Chk1(h)--> Cdc25C(m.s.){pS216} + ADP (phosphorylation) | Chk1(h) + 2 ATP --ATM(m.s.)--> Chk1(h){pS317}{pS345} + 2 ADP (phosphorylation) | Chk1(h) + 2 ATP --ATR(m.s.)--> Chk1(h){pS317}{pS345} + 2 ADP (phosphorylation) | Chk1(h) + 2 ATP --DNA-PK(m.s.)--> Chk1(h){pS317}{pS345} + 2 ADP (phosphorylation) | Chk1(h) --> Cdc25A(h){ub(n)} (increase of ubiquitination) | CHEK1(h) --> Chk1(h) (expression). | Chk1(h){pS345} --Wip1(m.s.)--> Chk1(h) + p (dephosphorylation) | Aurora-B(h) + ATP --Chk1(h)--> Aurora-B(h){p} + ADP (phosphorylation) | Cdc25C(h) + ATP --Chk1(h)--> Cdc25C(h){p} + ADP (phosphorylation) | Cdc25C-isoform1(h) + ATP --Chk1(h)--> Cdc25C-isoform1(h){pS216} + ADP (phosphorylation) | Cdc25A(h) + ATP --Chk1(h)--> Cdc25A(h){pS76} + ADP (phosphorylation) |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
280 | Phosphoserine (by PKB/AKT1) (Bysimilarity). | Swiss-Prot 53.0 | 296 | Phosphoserine. | Swiss-Prot 53.0 | 317 | Phosphoserine (by ATM and ATR). | Swiss-Prot 53.0 | 345 | Phosphoserine (by ATM and ATR). | Swiss-Prot 53.0 | 317 | Phosphoserine (ATM;ATR) | 11252893;11390642 | Phospho.ELM 6.0 | 345 | Phosphoserine (ATM;ATR) | 11390642;10859164;15533933;15674326 | Phospho.ELM 6.0 | 296 | Phosphoserine | 15975956 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr11 |
Promoter: 125000047 - 125002047 | Agilent_014791 |
chr11 |
Promoter: 125000047 - 125002047 | GSE27584 |
chr11 |
Promoter: 125000047 - 125002047 | Agilent_014791_44K |
chr11 |
Promoter: 125000047 - 125002047 | Agilent_014791 |