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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1630 |
Name | DCC |
Synonym | CRC18|CRCR1|IGDCC1;deleted in colorectal carcinoma;DCC;deleted in colorectal carcinoma |
Definition | colorectal cancer suppressor|colorectal tumor suppressor|deleted in colorectal cancer protein|immunoglobulin superfamily DCC subclass member 1|immunoglobulin superfamily, DCC subclass, member 1|netrin receptor DCC|tumor suppressor protein DCC |
Position | 18q21.3 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,Generif,UniProt |
Literature support | Count: 5 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. |
reviewed | the transcriptionally active TAp73alpha tumor suppressor is implicated in the apoptosis induced by netrin-1 in a p53-independent and DCC/ubiquitin-proteasome dependent manner. |
potential | Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. |
reviewed | Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with beta-catenin levels and outcome in patients with epithelial ovarian cancer. |
reviewed | "Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells." |
| More detail of all 5 literatures about DCC | |
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Pathways and Diseases |
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Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Axon guidance mediated by netrin;PANTHER;P00009 |
Pathway | DCC mediated attractive signaling;PID Reactome;500089 |
Pathway | Axon guidance mediated by Slit/Robo;PANTHER;P00008 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Netrin-1 signaling;PID Reactome;500088 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Role of second messengers in netrin-1 signaling;PID Reactome;500091 |
Pathway | Role of DCC in regulating apoptosis;PID Reactome;500280 |
Pathway | Netrin mediated repulsion signals;PID Reactome;500090 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Disease | Cancers;KEGG DISEASE |
Disease | Mirror movements, congenital;OMIM |
Disease | Gastric cancer;KEGG DISEASE;H00018 |
Disease | Colorectal cancer;OMIM |
Disease | Cancer;FunDO |
Disease | Cancer of the anal canal;KEGG DISEASE;H00044 |
Disease | Cancers of the digestive system;KEGG DISEASE |
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External Links |
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Links to Entrez Gene | 1630 |
Links to all GeneRIF Items | 1630 |
Links to iHOP | 1630 |
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Sequence Information |
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Nucleotide Sequence |
>1630 : length: 4344 atggagaatagtcttagatgtgtttgggtacccaagctggcttttgtactcttcggagct tccttgttcagcgcgcatcttcaagtaaccggttttcaaattaaagctttcacagcactg cgcttcctctcagaaccttctgatgccgtcacaatgcggggaggaaatgtcctcctcgac tgctccgcggagtccgaccgaggagttccagtgatcaagtggaagaaagatggcattcat ctggccttgggaatggatgaaaggaagcagcaactttcaaatgggtctctgctgatacaa aacatacttcattccagacaccacaagccagatgagggactttaccaatgtgaggcatct ttaggagattctggctcaattattagtcggacagcaaaagttgcagtagcaggaccactg aggttcctttcacagacagaatctgtcacagccttcatgggagacacagtgctactcaag tgtgaagtcattggggagcccatgccaacaatccactggcagaagaaccaacaagacctg actccaatcccaggtgactcccgagtggtggtcttgccctctggagcattgcagatcagc cgactccaaccgggggacattggaatttaccgatgctcagctcgaaatccagccagctca agaacaggaaatgaagcagaagtcagaattttatcagatccaggactgcatagacagctg tattttctgcaaagaccatccaatgtagtagccattgaaggaaaagatgctgtcctggaa tgttgtgtttctggctatcctccaccaagttttacctggttacgaggcgaggaagtcatc caactcaggtctaaaaagtattctttattgggtggaagcaacttgcttatctccaatgtg acagatgatgacagtggaatgtatacctgtgttgtcacatataaaaatgagaatattagt gcctctgcagagctcacagtcttggttccgccatggtttttaaatcatccttccaacctg tatgcctatgaaagcatggatattgagtttgaatgtacagtctctggaaagcctgtgccc actgtgaattggatgaagaatggagatgtggtcattcctagtgattattttcagatagtg ggaggaagcaacttacggatacttggggtggtgaagtcagatgaaggcttttatcaatgt gtggctgaaaatgaggctggaaatgcccagaccagtgcacagctcattgtccctaagcct gctatcccaagctccagtgtcctcccttcggctcccagagatgtggtccctgtcttggtt tccagccgatttgtccgtctcagctggcgcccacctgcagaagcgaaagggaacattcaa actttcacggtctttttctccagagaaggtgacaacagggaacgagcattgaatacaaca cagcctgggtcccttcagctcactgtgggaaacctgaagccagaagccatgtacaccttt cgagttgtggcttacaatgaatggggaccgggagagagttctcaacccatcaaggtggcc acacagcctgagttgcaagttccagggccagtagaaaacctgcaagctgtatctacctca cctacctcaattcttattacctgggaaccccctgcctatgcaaacggtccagtccaaggt tacagattgttctgcactgaggtgtccacaggaaaagaacagaatatagaggttgatgga ctatcttataaactggaaggcctgaaaaaattcaccgaatatagtcttcgattcttagct tataatcgctatggtccgggcgtctctactgatgatataacagtggttacactttctgac gtgccaagtgccccgcctcagaacgtctccctggaagtggtcaattcaagaagtatcaaa gttagctggctgcctcctccatcaggaacacaaaatggatttattaccggctataaaatt cgacacagaaagacgacccgcaggggtgagatggaaacactggagccaaacaacctctgg tacctattcacaggactggagaaaggaagtcagtacagtttccaggtgtcagccatgaca gtcaatggtactggaccaccttccaactggtatactgcagagactccagagaatgatcta gatgaatctcaagttcctgatcaaccaagctctcttcatgtgaggccccagactaactgc atcatcatgagttggactcctcccttgaacccaaacatcgtggtgcgaggttatattatc ggttatggcgttgggagcccttacgctgagacagtgcgtgtggacagcaagcagcgatat tattccattgagaggttagagtcaagttcccattatgtaatctccctaaaagcttttaac aatgccggagaaggagttcctctttatgaaagtgccaccaccaggtctataaccgatccc actgacccagttgattattatcctttgcttgatgatttccccacctcggtcccagatctc tccacccccatgctcccaccagtaggtgtacaggctgtggctcttacccatgatgctgtg agggtcagctgggcagacaactctgtccctaagaaccaaaagacgtctgaggtgcgactt tacaccgtccggtggagaaccagcttttctgcaagtgcaaaatacaagtcagaagacaca acatctctaagttacacagcaacaggcctcaaaccaaacacaatgtatgaattctcggtc atggtaacaaaaaacagaaggtccagtacttggagcatgactgcacatgccaccacgtat gaagcagcccccacctctgctcccaaggacttgacagtcattactagggaagggaagcct cgtgccgtcattgtgagttggcagcctcccttggaagccaatgggaaaattactgcttac atcttattttataccttggacaagaacatcccaattgatgactggattatggaaacaatc agtggtgataggcttactcatcaaatcatggatctcaaccttgatactatgtattacttt cgaattcaagcacgaaattcaaaaggagtggggccactctctgatcctatcctcttcagg actctgaaagtggaacaccctgacaaaatggctaatgaccaaggtcgtcatggagatgga ggttattggccagttgatactaatttgattgatagaagcaccctaaatgagccgccaatt ggacaaatgcaccccccgcatggcagtgtcactcctcagaagaacagcaacctgcttgtg atcattgtggtcaccgttggtgtcatcacagtgctggtagtggtcatcgtggctgtgatt tgcacccgacgctcttcagcccagcagagaaagaaacgggccacccacagtgctggcaaa aggaagggcagccagaaggacctccgaccccctgatctttggatccatcatgaagaaatg gagatgaaaaatattgaaaagccatctggcactgaccctgcaggaagggactctcccatc caaagttgccaagacctcacaccagtcagccacagccagtcagaaacccaactgggaagc aaaagcacctctcattcaggtcaagacactgaggaagcagggagctctatgtccactctg gagaggtcgctggctgcacgccgagccccccgggccaagctcatgattcccatggatgcc cagtccaacaatcctgctgtcgtgagcgccatcccggtgccaacgctagaaagtgcccag tacccaggaatcctcccgtctcccacctgtggatatccccacccgcagttcactctccgg cctgtgccattcccaacactctcagtggaccgaggtttcggagcaggaagaagtcagtca gtgagtgaaggaccaactacccaacaaccacctatgctgcccccatctcagcctgagcat tctagcagcgaggaggcaccaagcagaaccatccccacagcttgtgttcgaccaactcac ccactccgcagctttgctaatcctttgctacctccaccaatgagtgcaatagaaccgaaa gtcccttacacaccacttttgtctcagccagggcccactcttcctaagacccatgtgaaa acagcctcccttgggttggctggaaaagcaagatcccctttgcttcctgtgtctgtgcca acagcccctgaagtgtctgaggagagccacaaaccaacagaggattcagccaatgtgtat gaacaggatgatctgagtgaacaaatggcaagtttggaaggactcatgaagcagcttaat gccatcacaggctcagccttttaa |
Protein Sequence |
>1630 : length: 1447 MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLD CSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEAS LGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDL TPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQL YFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNV TDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP TVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP AIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTT QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTS PTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLA YNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDL STPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDT TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP RAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF RIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPI GQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGK RKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGS KSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQ YPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEH SSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVK TASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLN AITGSAF |