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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 317 |
Name | APAF1 |
Synonym | APAF-1|CED4;apoptotic peptidase activating factor 1;APAF1;apoptotic peptidase activating factor 1 |
Definition | apoptotic protease-activating factor 1 |
Position | 12q23 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
reviewed | These data point to a role for Apaf-1 as a bona fide tumor suppressor. |
| More detail of all 1 literatures about APAF1 | |
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Pathways and Diseases |
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Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Formation of apoptosome;PID Reactome;500886 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | apoptotic signaling in response to dna damage;PID BioCarta;100204 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | stress induction of hsp regulation;PID BioCarta;100142 |
Pathway | Amyotrophic lateral sclerosis (ALS);KEGG PATHWAY;hsa05014 |
Pathway | west nile virus;PID BioCarta;100001 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | role of mitochondria in apoptotic signaling;PID BioCarta;100106 |
Pathway | caspase cascade in apoptosis;PID BioCarta;100218 |
Pathway | regulation of cell cycle progression by plk3;PID BioCarta;100068 |
Pathway | Huntington disease;PANTHER;P00029 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Parkinson's disease;KEGG PATHWAY;hsa05012 |
Disease | Cancer;FunDO |
Disease | Depression;FunDO |
Disease | Intestinal disease;FunDO |
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External Links |
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Links to Entrez Gene | 317 |
Links to all GeneRIF Items | 317 |
Links to iHOP | 317 |
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Sequence Information |
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Nucleotide Sequence |
>317 : length: 3585 atggatgcaaaagctcgaaattgtttgcttcaacatagagaagctctggaaaaggacatc aagacatcctacatcatggatcacatgattagtgatggatttttaacaatatcagaagag gaaaaagtaagaaatgagcccactcaacagcaaagagcagctatgctgattaaaatgata cttaaaaaagataatgattcctacgtatcattctacaatgctctactacatgaaggatat aaagatcttgctgcccttctccatgatggcattcctgttgtctcttcttccagtgtaagg acagtcctgtgtgaaggtggagtaccacagaggccagttgtttttgtcacaaggaagaag ctggtgaatgcaattcagcagaagctctccaaattgaaaggtgaaccaggatgggtcacc atacatggaatggcaggctgtgggaagtctgtattagctgcagaagctgttagagatcat tcccttttagaaggttgtttcccagggggagtgcattgggtttcagttgggaaacaagac aaatctgggcttctgatgaaactgcagaatctttgcacacggttggatcaggatgagagt ttttcccagaggcttccacttaatattgaagaggctaaagaccgtctccgcattctgatg cttcgcaaacacccaaggtctctcttgatcttggatgatgtttgggactcttgggtgttg aaagcttttgacagtcagtgtcagattcttcttacaaccagagacaagagtgttacagat tcagtaatgggtcctaaatatgtagtccctgtggagagttccttaggaaaggaaaaagga cttgaaattttatccctttttgttaatatgaagaaggcagatttgccagaacaagctcat agtattataaaagaatgtaaaggctctccccttgtagtatctttaattggtgcactttta cgtgattttcccaatcgctgggagtactacctcaaacagcttcagaataagcagtttaag agaataaggaaatcttcgtcttatgattatgaggctctagatgaagccatgtctataagt gttgaaatgctcagagaagacatcaaagattattacacagatctttccatccttcagaag gacgttaaggtgcctacaaaggtgttatgtattctctgggacatggaaactgaagaagtt gaagacatactgcaggagtttgtaaataagtctcttttattctgtgatcggaatggaaag tcgtttcgttattatttacatgatcttcaagtagattttcttacagagaagaattgcagc cagcttcaggatctacataagaagataatcactcagtttcagagatatcaccagccgcat actctttcaccagatcaggaagactgtatgtattggtacaactttctggcctatcacatg gccagtgccaagatgcacaaggaactttgtgctttaatgttttccctggattggattaaa gcaaaaacagaacttgtaggccctgctcatctgattcatgaatttgtggaatacagacat atactagatgaaaaggattgtgcagtcagtgagaattttcaggagtttttatctttaaat ggacaccttcttggacgacagccatttcctaatattgtacaactgggtctctgtgagccg gaaacttcagaagtttatcagcaagctaagctgcaggccaagcaggaggtcgataatgga atgctttacctggaatggataaacaaaaaaaacatcacgaatctttcccgcttagttgtc cgcccccacacagatgctgtttaccatgcctgcttttctgaggatggtcagagaatagct tcttgtggagctgataaaaccttacaggtgttcaaagctgaaacaggagagaaacttcta gaaatcaaggctcatgaggatgaagtgctttgttgtgcattctctacagatgacagattt atagcaacctgctcagtggataaaaaagtgaagatttggaattctatgactggggaacta gtacacacctatgatgagcactcagagcaagtcaattgctgccatttcaccaacagtagt catcatcttctcttagccactgggtcaagtgactgcttcctcaaactttgggatttgaat caaaaagaatgtcgaaataccatgtttggtcatacaaattcagtcaatcactgcagattt tcaccagatgataagcttttggctagttgttcagctgatggaaccttaaagctttgggat gcgacatcagcaaatgagaggaaaagcattaatgtgaaacagttcttcctaaatttggag gaccctcaagaggatatggaagtgatagtgaagtgttgttcgtggtctgctgatggtgca aggataatggtggcagcaaaaaataaaatctttttgtggaatacagactcacgttcaaag gtggctgattgcagaggacatttaagttgggttcatggtgtgatgttttctcctgatgga tcatcatttttgacatcttctgatgaccagacaatcaggctctgggagacaaagaaagta tgtaagaactctgctgtaatgttaaagcaagaagtagatgttgtgtttcaagaaaatgaa gtgatggtccttgcagttgaccatataagacgtctgcaactcattaatggaagaacaggt cagattgattatctgactgaagctcaagttagctgctgttgcttaagtccacatcttcag tacattgcatttggagatgaaaatggagccattgagattttagaacttgtaaacaataga atcttccagtccaggtttcagcacaagaaaactgtatggcacatccagttcacagccgat gagaagactcttatttcaagttctgatgatgctgaaattcaggtatggaattggcaattg gacaaatgtatctttctacgaggccatcaggaaacagtgaaagactttagactcttgaaa aattcaagactgctttcttggtcatttgatggaacagtgaaggtatggaatattattact ggaaataaagaaaaagactttgtctgtcaccagggtacagtactttcttgtgacatttct cacgatgctaccaagttttcatctacctctgctgacaagactgcaaagatctggagtttt gatctccttttgccacttcatgaattgaggggccacaacggctgtgtgcgctgctctgcc ttctctgtggacagtaccctgctggcaacgggagatgacaatggagaaatcaggatatgg aatgtctcaaacggtgagcttcttcatttgtgtgctccgctttcagaagaaggagctgct acccatggaggctgggtgactgacctttgcttttctccagatggcaaaatgcttatctct gctggaggatatattaagtggtggaacgttgtcactggggaatcctcacagaccttctac acaaatggaaccaatcttaagaaaatacacgtgtcccctgacttcaaaacatatgtgact gtggataatcttggtattttatatattttacagactttagaataa |
Protein Sequence |
>317 : length: 1194 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG SSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD EKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS AGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE |