Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

317

Name

APAF1

Synonym

APAF-1|CED4;apoptotic peptidase activating factor 1;APAF1;apoptotic peptidase activating factor 1

Definition

apoptotic protease-activating factor 1

Position

12q23

Gene Type

protein-coding

Source

Count: 2; TAG,Generif

Literature support

Count: 1 PubMed records as below.

Evidence Status

Description

reviewed

These data point to a role for Apaf-1 as a bona fide tumor suppressor.
More detail of all 1 literatures about APAF1

Pathways and Diseases

Pathway

Apoptosis;Reactome;REACT:578

Pathway

Small cell lung cancer;KEGG PATHWAY;hsa05222

Pathway

Formation of apoptosome;PID Reactome;500886

Pathway

Direct p53 effectors;PID Curated;200101

Pathway

Alzheimer's disease;KEGG PATHWAY;hsa05010

Pathway

Huntington's disease;KEGG PATHWAY;hsa05016

Pathway

trefoil factors initiate mucosal healing;PID BioCarta;100018

Pathway

apoptotic signaling in response to dna damage;PID BioCarta;100204

Pathway

Apoptosis;KEGG PATHWAY;hsa04210

Pathway

hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144

Pathway

stress induction of hsp regulation;PID BioCarta;100142

Pathway

Amyotrophic lateral sclerosis (ALS);KEGG PATHWAY;hsa05014

Pathway

west nile virus;PID BioCarta;100001

Pathway

E2F transcription factor network;PID Curated;200027

Pathway

p53 pathway;PANTHER;P00059

Pathway

role of mitochondria in apoptotic signaling;PID BioCarta;100106

Pathway

caspase cascade in apoptosis;PID BioCarta;100218

Pathway

regulation of cell cycle progression by plk3;PID BioCarta;100068

Pathway

Huntington disease;PANTHER;P00029

Pathway

Apoptosis signaling pathway;PANTHER;P00006

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Pathway

Parkinson's disease;KEGG PATHWAY;hsa05012

Disease

Cancer;FunDO

Disease

Depression;FunDO

Disease

Intestinal disease;FunDO

External Links

Links to Entrez Gene

317

Links to all GeneRIF Items

317

Links to iHOP

317

Sequence Information

Nucleotide Sequence

>317 : length: 3585
atggatgcaaaagctcgaaattgtttgcttcaacatagagaagctctggaaaaggacatc
aagacatcctacatcatggatcacatgattagtgatggatttttaacaatatcagaagag
gaaaaagtaagaaatgagcccactcaacagcaaagagcagctatgctgattaaaatgata
cttaaaaaagataatgattcctacgtatcattctacaatgctctactacatgaaggatat
aaagatcttgctgcccttctccatgatggcattcctgttgtctcttcttccagtgtaagg
acagtcctgtgtgaaggtggagtaccacagaggccagttgtttttgtcacaaggaagaag
ctggtgaatgcaattcagcagaagctctccaaattgaaaggtgaaccaggatgggtcacc
atacatggaatggcaggctgtgggaagtctgtattagctgcagaagctgttagagatcat
tcccttttagaaggttgtttcccagggggagtgcattgggtttcagttgggaaacaagac
aaatctgggcttctgatgaaactgcagaatctttgcacacggttggatcaggatgagagt
ttttcccagaggcttccacttaatattgaagaggctaaagaccgtctccgcattctgatg
cttcgcaaacacccaaggtctctcttgatcttggatgatgtttgggactcttgggtgttg
aaagcttttgacagtcagtgtcagattcttcttacaaccagagacaagagtgttacagat
tcagtaatgggtcctaaatatgtagtccctgtggagagttccttaggaaaggaaaaagga
cttgaaattttatccctttttgttaatatgaagaaggcagatttgccagaacaagctcat
agtattataaaagaatgtaaaggctctccccttgtagtatctttaattggtgcactttta
cgtgattttcccaatcgctgggagtactacctcaaacagcttcagaataagcagtttaag
agaataaggaaatcttcgtcttatgattatgaggctctagatgaagccatgtctataagt
gttgaaatgctcagagaagacatcaaagattattacacagatctttccatccttcagaag
gacgttaaggtgcctacaaaggtgttatgtattctctgggacatggaaactgaagaagtt
gaagacatactgcaggagtttgtaaataagtctcttttattctgtgatcggaatggaaag
tcgtttcgttattatttacatgatcttcaagtagattttcttacagagaagaattgcagc
cagcttcaggatctacataagaagataatcactcagtttcagagatatcaccagccgcat
actctttcaccagatcaggaagactgtatgtattggtacaactttctggcctatcacatg
gccagtgccaagatgcacaaggaactttgtgctttaatgttttccctggattggattaaa
gcaaaaacagaacttgtaggccctgctcatctgattcatgaatttgtggaatacagacat
atactagatgaaaaggattgtgcagtcagtgagaattttcaggagtttttatctttaaat
ggacaccttcttggacgacagccatttcctaatattgtacaactgggtctctgtgagccg
gaaacttcagaagtttatcagcaagctaagctgcaggccaagcaggaggtcgataatgga
atgctttacctggaatggataaacaaaaaaaacatcacgaatctttcccgcttagttgtc
cgcccccacacagatgctgtttaccatgcctgcttttctgaggatggtcagagaatagct
tcttgtggagctgataaaaccttacaggtgttcaaagctgaaacaggagagaaacttcta
gaaatcaaggctcatgaggatgaagtgctttgttgtgcattctctacagatgacagattt
atagcaacctgctcagtggataaaaaagtgaagatttggaattctatgactggggaacta
gtacacacctatgatgagcactcagagcaagtcaattgctgccatttcaccaacagtagt
catcatcttctcttagccactgggtcaagtgactgcttcctcaaactttgggatttgaat
caaaaagaatgtcgaaataccatgtttggtcatacaaattcagtcaatcactgcagattt
tcaccagatgataagcttttggctagttgttcagctgatggaaccttaaagctttgggat
gcgacatcagcaaatgagaggaaaagcattaatgtgaaacagttcttcctaaatttggag
gaccctcaagaggatatggaagtgatagtgaagtgttgttcgtggtctgctgatggtgca
aggataatggtggcagcaaaaaataaaatctttttgtggaatacagactcacgttcaaag
gtggctgattgcagaggacatttaagttgggttcatggtgtgatgttttctcctgatgga
tcatcatttttgacatcttctgatgaccagacaatcaggctctgggagacaaagaaagta
tgtaagaactctgctgtaatgttaaagcaagaagtagatgttgtgtttcaagaaaatgaa
gtgatggtccttgcagttgaccatataagacgtctgcaactcattaatggaagaacaggt
cagattgattatctgactgaagctcaagttagctgctgttgcttaagtccacatcttcag
tacattgcatttggagatgaaaatggagccattgagattttagaacttgtaaacaataga
atcttccagtccaggtttcagcacaagaaaactgtatggcacatccagttcacagccgat
gagaagactcttatttcaagttctgatgatgctgaaattcaggtatggaattggcaattg
gacaaatgtatctttctacgaggccatcaggaaacagtgaaagactttagactcttgaaa
aattcaagactgctttcttggtcatttgatggaacagtgaaggtatggaatattattact
ggaaataaagaaaaagactttgtctgtcaccagggtacagtactttcttgtgacatttct
cacgatgctaccaagttttcatctacctctgctgacaagactgcaaagatctggagtttt
gatctccttttgccacttcatgaattgaggggccacaacggctgtgtgcgctgctctgcc
ttctctgtggacagtaccctgctggcaacgggagatgacaatggagaaatcaggatatgg
aatgtctcaaacggtgagcttcttcatttgtgtgctccgctttcagaagaaggagctgct
acccatggaggctgggtgactgacctttgcttttctccagatggcaaaatgcttatctct
gctggaggatatattaagtggtggaacgttgtcactggggaatcctcacagaccttctac
acaaatggaaccaatcttaagaaaatacacgtgtcccctgacttcaaaacatatgtgact
gtggataatcttggtattttatatattttacagactttagaataa

Protein Sequence

>317 : length: 1194
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK
LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL
KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH
SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS
VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK
SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM
ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN
GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV
RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF
IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN
QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE
DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG
SSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG
QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD
EKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT
GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA
FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS
AGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE



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