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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 317 |
Name | APAF1 |
Synonymous | APAF-1|CED4;apoptotic peptidase activating factor 1;APAF1;apoptotic peptidase activating factor 1 |
Definition | apoptotic protease-activating factor 1 |
Position | 12q23 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
interacts with |
APIP | BIOGRID; PUBMED:15262985; |
interacts with |
NLRP1 | BIOGRID; PUBMED:11113115; |
interacts with |
CASP4 | BIOGRID; PUBMED:9539746; |
interacts with |
AVEN | BIOGRID; PUBMED:10949025; |
interacts with |
BCL2L1 | BIOGRID; PUBMED:9488720; |
interacts with |
BCL2L1 | BIOGRID; PUBMED:9539746; |
interacts with |
HSP90AA1 | BIOGRID; PUBMED:10934467; |
interacts with |
HSPA4 | BIOGRID; PUBMED:10934467; |
interacts with |
CASP8 | BIOGRID; PUBMED:9539746; |
interacts with |
CASP9 | BIOGRID; PUBMED:11113115; |
interacts with |
CASP9 | BIOGRID; PUBMED:15262985; |
interacts with |
CASP9 | BIOGRID; PUBMED:9390557; |
interacts with |
CASP9 | BIOGRID; PUBMED:9488720; |
interacts with |
CASP9 | BIOGRID; PUBMED:9539746; |
interacts with |
CYCS | BIOGRID; PUBMED:9267021; |
interacts with |
APIP | HPRD; PUBMED:15262985; |
interacts with |
CASP4 | HPRD; PUBMED:9539746; |
interacts with |
AVEN | HPRD; PUBMED:10949025; |
interacts with |
BCL2L1 | HPRD; PUBMED:9539746; |
interacts with |
BCL2L10 | HPRD; PUBMED:9829980; |
interacts with |
BCL2L10 | HPRD; PUBMED:9878060; |
interacts with |
HIP1 | HPRD; PUBMED:16979168; |
interacts with |
FEM1B | HPRD; PUBMED:10764728; |
interacts with |
CASP8 | HPRD; PUBMED:9539746; |
interacts with |
CASP3 | HPRD; PUBMED:11230124; |
interacts with |
CASP3 | HPRD; PUBMED:11550094; |
interacts with |
CASP9 | HPRD; PUBMED:10206961; |
interacts with |
CASP9 | HPRD; PUBMED:11230124; |
interacts with |
CASP9 | HPRD; PUBMED:16979168; |
interacts with |
CASP9 | HPRD; PUBMED:9488720; |
interacts with |
CASP9 | HPRD; PUBMED:9878060; |
interacts with |
CYCS | HPRD; PUBMED:10206961; |
interacts with |
CYCS | HPRD; PUBMED:9267021; |
interacts with |
PPP1CA | HPRD; PUBMED:17274640; |
interacts with |
XIAP | HPRD; PUBMED:11230124; |
interacts with |
TRIAP1 | HPRD; PUBMED:15735003; |
interacts with |
MED1 | INTACT; PUBMED:19377461; |
interacts with |
MAP3K1 | INTACT; PUBMED:19377461; |
interacts with |
MLL5 | INTACT; PUBMED:19377461; |
interacts with |
TAF5L | INTACT; PUBMED:19377461; |
interacts with |
NCOR1 | INTACT; PUBMED:19377461; |
interacts with |
NCOR2 | INTACT; PUBMED:19377461; |
interacts with |
NSD1 | INTACT; PUBMED:19377461; |
interacts with |
LATS2 | INTACT; PUBMED:19377461; |
interacts with |
LMO7 | INTACT; PUBMED:19377461; |
interacts with |
PHKA1 | INTACT; PUBMED:19377461; |
interacts with |
BAZ1B | INTACT; PUBMED:19377461; |
interacts with |
ARMC1 | INTACT; PUBMED:19377461; |
interacts with |
ASXL1 | INTACT; PUBMED:19377461; |
interacts with |
ERBB4 | INTACT; PUBMED:19377461; |
interacts with |
BAG3 | INTACT; PUBMED:19377461; |
interacts with |
BAZ2B | INTACT; PUBMED:19377461; |
interacts with |
BDP1 | INTACT; PUBMED:19377461; |
interacts with |
GRHL2 | INTACT; PUBMED:19377461; |
interacts with |
DNMT1 | INTACT; PUBMED:19377461; |
interacts with |
FANCC | INTACT; PUBMED:19377461; |
interacts with |
CASP3 | INTACT; PUBMED:21827945; |
interacts with |
CASP9 | INTACT; PUBMED:21827945; |
interacts with |
DHX30 | INTACT; PUBMED:19377461; |
interacts with |
JAK2 | INTACT; PUBMED:19377461; |
interacts with |
KAT2A | INTACT; PUBMED:19377461; |
interacts with |
ITCH | INTACT; PUBMED:19377461; |
interacts with |
RARA | INTACT; PUBMED:19377461; |
interacts with |
JAK1 | INTACT; PUBMED:19377461; |
interacts with |
ANKRD11 | INTACT; PUBMED:19377461; |
interacts with |
ACACA | INTACT; PUBMED:19377461; |
interacts with |
PIK3CG | INTACT; PUBMED:19377461; |
interacts with |
PKD1L3 | INTACT; PUBMED:19377461; |
interacts with |
PPEF2 | INTACT; PUBMED:19377461; |
interacts with |
ZBTB40 | INTACT; PUBMED:19377461; |
interacts with |
WDR7 | INTACT; PUBMED:19377461; |
interacts with |
TSHZ1 | INTACT; PUBMED:19377461; |
interacts with |
TRIP11 | INTACT; PUBMED:19377461; |
interacts with |
RSF1 | INTACT; PUBMED:19377461; |
interacts with |
SETD2 | INTACT; PUBMED:19377461; |
interacts with |
PARP1 | INTACT; PUBMED:19377461; |
interacts with |
Bcl2l10 | MINT; PUBMED:9829980; |
interacts with |
AVEN | MINT; PUBMED:10949025; |
interacts with |
CASP3 | MINT; PUBMED:11550094; |
interacts with |
CASP9 | MINT; PUBMED:10376594; |
interacts with |
CASP9 | MINT; PUBMED:19494828; |
interacts with |
CASP9 | MINT; PUBMED:9390557; |
Metabolic Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
metabolic catalysis |
E2F1 | NCI_NATURE; PUBMED:15897886;PUBMED:15133492;PUBMED:11389439; |
metabolic catalysis |
TP53 | NCI_NATURE; PUBMED:11559530; |
Signaling Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
reacts with |
ANP32A | IMID; PUBMED:12522243; |
reacts with |
APAF1 | IMID; PUBMED:10364241;PUBMED:9390557; |
reacts with |
APAF1 | IMID; PUBMED:12522243; |
reacts with |
APAF1 | IMID; PUBMED:9390557;PUBMED:9267021; |
reacts with |
COX5B | IMID; PUBMED:9390557;PUBMED:9267021; |
reacts with |
CASP9 | REACTOME; PUBMED:9390557; |
state change |
CASP9 | REACTOME; PUBMED:9390557; |
reacts with |
CYCS | REACTOME; PUBMED:9267021; |
reacts with |
CYCS | REACTOME; PUBMED:9390557; |
state change |
CYCS | REACTOME; PUBMED:9390557; |
reacts with |
APAF1 | REACTOME; PUBMED:9267021; |
reacts with |
APAF1 | REACTOME; PUBMED:9390557; |
state change |
APAF1 | REACTOME; PUBMED:9390557; |