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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 317 |
Name | APAF1 |
Synonymous | APAF-1|CED4;apoptotic peptidase activating factor 1;APAF1;apoptotic peptidase activating factor 1 |
Definition | apoptotic protease-activating factor 1 |
Position | 12q23 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Cytochrome C(h) + Apaf-1(h) + Caspase-9(h) + dATP <==> Cytochrome C(h):Apaf-1(h):Caspase-9(h):dATP (binding) | Bcl-X(h) + Apaf-1(h) <==> Bcl-X(h):Apaf-1(h) (binding) | Apaf-1(h) + Caspase-4(h) <==> Apaf-1(h):Caspase-4(h) (binding) | Apaf-1(h) + CED-3(ce) <==> Apaf-1(h):CED-3(ce) (binding) | Apaf-1(h) + proCaspase-9(h) <==> Apaf-1(h):proCaspase-9(h) (binding) | Apaf-1(h) + proCaspase-8(h) <==> Apaf-1(h):proCaspase-8(h) (binding) | Boo(m) + Apaf-1(h) <==> Boo(m):Apaf-1(h) (binding) | Aven(h) + Apaf-1(h) <==> Aven(h):Apaf-1(h) (binding) | Apaf-1(h) + ATP <==> Apaf-1(h):ATP (binding) | 2 Apaf-1(h) <==> Apaf-1(h):Apaf-1(h) (oligomerization) | Hsp70-1(h) + Apaf-1(h) <==> Hsp70-1(h):Apaf-1(h) (binding) | Hsp90(h) + Apaf-1(h) <==> Hsp90(h):Apaf-1(h) (binding) | NAC-beta(h) + Apaf-1(h) <==> NAC-beta(h):Apaf-1(h) (binding) | Apaf-1(h) --Caspase-8(h)--> Apaf-1-p84(h) + protein remnants (processing) | Apaf-1(h) + proCaspase-9(h) + proCaspase-3(h) <==> Apaf-1(h):proCaspase-9(h):proCaspase-3(h) (binding) | Apaf-1(h) --Caspase-3(h)--> Apaf-1-p84(h) + protein remnants (processing) | proCaspase-3(h) + XIAP(h) + Cytochrome C(h) + Apaf-1(h) + proCaspase-9(h) <==> proCaspase-3(h):XIAP(h):Cytochrome C(h):Apaf-1(h):proCaspase-9(h) (binding) | Cytochrome C(h) + Apaf-1(h) <==> Cytochrome C(h):Apaf-1(h) (binding) | Apaf-1(h) + Hsp70(h) <==> Apaf-1(h):Hsp70(h) (binding) | proCaspase-2(h) + proCaspase-9(h) + Apaf-1(h) + proCaspase-3(h) <==> proCaspase-2(h):proCaspase-9(h):Apaf-1(h):proCaspase-3(h) (binding) | Apaf-1(h) + Caspase-9-p35(h) <==> Apaf-1(h):Caspase-9-p35(h) (binding) | Caspase-9-p35(h) + Apaf-1(h) + XIAP(h) <==> Caspase-9-p35(h):Apaf-1(h):XIAP(h) (binding) | HSPC132(m.s.) + Apaf-1(h) <==> HSPC132(m.s.):Apaf-1(h) (binding) | Apaf-1(h) + HSPC132(h) <==> Apaf-1(h):HSPC132(h) (binding) | APAF1(h) --> Apaf-1(h) (expression). | proCaspase-9(h) --Apaf-1(h)--> Caspase-9(h) (processing) | Hsp70-1(h) + Apaf-1L(h) <==> Hsp70-1(h):Apaf-1L(h) (binding) | Cytochrome C(m.s.) + 8 Apaf-1L(h) <==> Cytochrome C(m.s.):(Apaf-1L(h))8 (binding) | 8 Apaf-1L(h) + proCaspase-9(m.s.) <==> (Apaf-1L(h))8:proCaspase-9(m.s.) (binding) | 2 Apaf-1L(h) <==> (Apaf-1L(h))2 (binding) | Cytochrome C(m.s.) + Apaf-1L(h) <==> Cytochrome C(m.s.):Apaf-1L(h) (binding) | APAF1(h) --> Apaf-1L(h) (expression). | APAF1(h) --> Apaf-1S(h) (expression). | APAF1(h) --> Apaf-1XL(h) (expression). | APAF1(h) --> Apaf-1M(h) (expression). | APAF1(h) --> Apaf-1XS(h) (expression). | APAF1(h) --> Apaf-1ALT(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
204 | Phosphothreonine. | Swiss-Prot 53.0 | 238 | Phosphoserine. | Swiss-Prot 53.0 | 248 | Phosphoserine. | Swiss-Prot 53.0 | 204 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 238 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 248 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
|
Chromosome |
Location |
Source |
|---|---|---|
chr12 |
Promoter: 97561709 - 97563709 | GSE27584 |
chr12 |
Promoter: 97561709 - 97563709 | GSE27584 |
chr12 |
Promoter: 97561709 - 97563709 | GSE27584 |
chr12 |
Promoter: 97561709 - 97563709 | GSE27584 |
chr12 |
Promoter: 97561709 - 97563709 | GSE27584 |
chr12 |
Promoter: 97561709 - 97563709 | Agilent_014791_44K |
chr12 |
Promoter: 97561709 - 97563709 | Agilent_014791 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15198948 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15198948 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15198948 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15198948 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15198948 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16192589 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16192589 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16192589 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16192589 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16192589 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15972851 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15972851 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15972851 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15972851 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:15972851 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16697107 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16697107 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16697107 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16697107 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16697107 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:17133271 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:17133271 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:17133271 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:17133271 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:17133271 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16642478 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16642478 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16642478 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16642478 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16642478 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16951219 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16951219 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16951219 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16951219 |
chr12 |
Promoter: 97561709 - 97563709 | PMID:16951219 |