Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

3661

Name

IRF3

Synonym

-;interferon regulatory factor 3;IRF3;interferon regulatory factor 3

Definition

-

Position

19q13.3-q13.4

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 1 PubMed records as below.

Evidence Status

Description

potential

"hIRF3 inhibited cell growth, blocked DNA synthesis, and induced apoptosis, while a dominant negative mutant transformed 3T3 cells, implying that IRF3 may function as a tumor suppressor and its dominant negative mutant may have a role in tumorigenesis."
More detail of all 1 literatures about IRF3

Pathways and Diseases

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620

Pathway

RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622

Pathway

TRAM Cascade;PID Reactome;500465

Pathway

Cytosolic DNA-sensing pathway;KEGG PATHWAY;hsa04623

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

Toll receptor signaling pathway;PANTHER;P00054

Disease

esophageal cancer;GAD

Disease

Infection;FunDO

Disease

Rheumatoid arthritis;FunDO

Disease

Lymphoma;FunDO

Disease

CANCER;GAD

Disease

cervical intraepithelial neoplasia grade 3;GAD

Disease

Hemorrhagic fevers, Viral;FunDO

Disease

Respiratory tract disease;FunDO

External Links

Links to Entrez Gene

3661

Links to all GeneRIF Items

3661

Links to iHOP

3661

Sequence Information

Nucleotide Sequence

>3661 : length: 1359
atgggaaccccaaagccacggatcctgccctggctggtgtcgcagctggacctggggcaa
ctggagggcgtggcctgggtgaacaagagccgcacgcgcttccgcatcccttggaagcac
ggcctacggcaggatgcacagcaggaggatttcggaatcttccaggcctgggccgaggcc
actggtgcatatgttcccgggagggataagccagacctgccaacctggaagaggaatttc
cgctctgccctcaaccgcaaagaagggttgcgtttagcagaggaccggagcaaggaccct
cacgacccacataaaatctacgagtttgtgaactcaggagttggggacttttcccagcca
gacacctctccggacaccaatggtggaggcagtacttctgatacccaggaagacattctg
gatgagttactgggtaacatggtgttggccccactcccagatccgggacccccaagcctg
gctgtagcccctgagccctgccctcagcccctgcggagccccagcttggacaatcccact
cccttcccaaacctggggccctctgagaacccactgaagcggctgttggtgccgggggaa
gagtgggagttcgaggtgacagccttctaccggggccgccaagtcttccagcagaccatc
tcctgcccggagggcctgcggctggtggggtccgaagtgggagacaggacgctgcctgga
tggccagtcacactgccagaccctggcatgtccctgacagacaggggagtgatgagctac
gtgaggcatgtgctgagctgcctgggtgggggactggctctctggcgggccgggcagtgg
ctctgggcccagcggctggggcactgccacacatactgggcagtgagcgaggagctgctc
cccaacagcgggcatgggcctgatggcgaggtccccaaggacaaggaaggaggcgtgttt
gacctggggcccttcattgtaggctcctgggcccccagatctgattaccttcacggaagg
aagcggacgctcaccacgctatgccctctggttctgtgtgggggagtcatggccccagga
ccagccgtggaccaagaggctcgtgatggtcaaggttgtgcccacgtgcctcagggcctt
ggtagaaatggcccgggtagggggtgcctcctccctggagaatactgtggacctgcacat
ttccaacagccacccactctccctcacctccgaccagtacaaggcctacctgcaggactt
ggtggagggcatggatttccagggccctggggagagctgagccctcgctcctcatggtgt
gcctccaacccccctgttccccaccacctcaaccaataa

Protein Sequence

>3661 : length: 452
MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA
TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP
DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT
PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG
WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL
PNSGHGPDGEVPKDKEGGVFDLGPFIVGSWAPRSDYLHGRKRTLTTLCPLVLCGGVMAPG
PAVDQEARDGQGCAHVPQGLGRNGPGRGCLLPGEYCGPAHFQQPPTLPHLRPVQGLPAGL
GGGHGFPGPWGELSPRSSWCASNPPVPHHLNQ



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