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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3661 |
Name | IRF3 |
Synonym | -;interferon regulatory factor 3;IRF3;interferon regulatory factor 3 |
Definition | - |
Position | 19q13.3-q13.4 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | "hIRF3 inhibited cell growth, blocked DNA synthesis, and induced apoptosis, while a dominant negative mutant transformed 3T3 cells, implying that IRF3 may function as a tumor suppressor and its dominant negative mutant may have a role in tumorigenesis." |
| More detail of all 1 literatures about IRF3 | |
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Pathways and Diseases |
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Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | TRAM Cascade;PID Reactome;500465 |
Pathway | Cytosolic DNA-sensing pathway;KEGG PATHWAY;hsa04623 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Disease | esophageal cancer;GAD |
Disease | Infection;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | Lymphoma;FunDO |
Disease | CANCER;GAD |
Disease | cervical intraepithelial neoplasia grade 3;GAD |
Disease | Hemorrhagic fevers, Viral;FunDO |
Disease | Respiratory tract disease;FunDO |
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External Links |
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Links to Entrez Gene | 3661 |
Links to all GeneRIF Items | 3661 |
Links to iHOP | 3661 |
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Sequence Information |
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Nucleotide Sequence |
>3661 : length: 1359 atgggaaccccaaagccacggatcctgccctggctggtgtcgcagctggacctggggcaa ctggagggcgtggcctgggtgaacaagagccgcacgcgcttccgcatcccttggaagcac ggcctacggcaggatgcacagcaggaggatttcggaatcttccaggcctgggccgaggcc actggtgcatatgttcccgggagggataagccagacctgccaacctggaagaggaatttc cgctctgccctcaaccgcaaagaagggttgcgtttagcagaggaccggagcaaggaccct cacgacccacataaaatctacgagtttgtgaactcaggagttggggacttttcccagcca gacacctctccggacaccaatggtggaggcagtacttctgatacccaggaagacattctg gatgagttactgggtaacatggtgttggccccactcccagatccgggacccccaagcctg gctgtagcccctgagccctgccctcagcccctgcggagccccagcttggacaatcccact cccttcccaaacctggggccctctgagaacccactgaagcggctgttggtgccgggggaa gagtgggagttcgaggtgacagccttctaccggggccgccaagtcttccagcagaccatc tcctgcccggagggcctgcggctggtggggtccgaagtgggagacaggacgctgcctgga tggccagtcacactgccagaccctggcatgtccctgacagacaggggagtgatgagctac gtgaggcatgtgctgagctgcctgggtgggggactggctctctggcgggccgggcagtgg ctctgggcccagcggctggggcactgccacacatactgggcagtgagcgaggagctgctc cccaacagcgggcatgggcctgatggcgaggtccccaaggacaaggaaggaggcgtgttt gacctggggcccttcattgtaggctcctgggcccccagatctgattaccttcacggaagg aagcggacgctcaccacgctatgccctctggttctgtgtgggggagtcatggccccagga ccagccgtggaccaagaggctcgtgatggtcaaggttgtgcccacgtgcctcagggcctt ggtagaaatggcccgggtagggggtgcctcctccctggagaatactgtggacctgcacat ttccaacagccacccactctccctcacctccgaccagtacaaggcctacctgcaggactt ggtggagggcatggatttccagggccctggggagagctgagccctcgctcctcatggtgt gcctccaacccccctgttccccaccacctcaaccaataa |
Protein Sequence |
>3661 : length: 452 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL PNSGHGPDGEVPKDKEGGVFDLGPFIVGSWAPRSDYLHGRKRTLTTLCPLVLCGGVMAPG PAVDQEARDGQGCAHVPQGLGRNGPGRGCLLPGEYCGPAHFQQPPTLPHLRPVQGLPAGL GGGHGFPGPWGELSPRSSWCASNPPVPHHLNQ |