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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 3661 |
Name | IRF3 |
Synonymous | -;interferon regulatory factor 3;IRF3;interferon regulatory factor 3 |
Definition | - |
Position | 19q13.3-q13.4 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
IRF-3(h) + IRF-5(h) <==> IRF-3(h):IRF-5(h) (binding). | IRF-3(h) --> CCL5(h) (DNA binding). | TRIF(h) + IRF-3(h) <==> TRIF(h):IRF-3(h) (binding) | TRAM(h) + IRF-3(h) <==> TRAM(h):IRF-3(h) (binding) | TBK1(h) + IRF-3(h) <==> TBK1(h):IRF-3(h) (binding) | IKK-i(h) + IRF-3(h) <==> IKK-i(h):IRF-3(h) (binding) | IRF-3(h) + ATP --IKK-i(h){p}--> IRF-3(h){p} + ADP (phosphorylation) | IRF-3(h) + ATP --TBK1(h)--> IRF-3(h){p} + ADP (phosphorylation) | TIRAP(v.s.) + IRF-3(h) <==> TIRAP(v.s.):IRF-3(h) (binding) | IRF-3(h) + ATP --IKK-beta(h)--> IRF-3(h){p} + ADP (phosphorylation) | 2 IRF-3(h) <==> (IRF-3(h))2 (binding; oligomerization) | IRF-3(h) + p300(h) <==> IRF-3(h):p300(h) (binding) | IRF-3(h) + CBP(m) <==> IRF-3(h):CBP(m) (binding) | IRF-3(h) + CBP(h) <==> IRF-3(h):CBP(h) (binding) | IRF-3(h) --> IFNA1(h) (DNA binding; transregulation). | IRF-3(h) + ATP --> IRF-3(h){p} + ADP (phosphorylation) | TBK1(h) + IRF-3(h) <==> TBK1(h):IRF-3(h) (binding) | IRF-3(h) --> IRF-3(h) (translocation) | IRF-3(h) + ATP --> IRF-3(h){pS386} + ADP (phosphorylation) | IRF-3(h) + ATP --> IRF-3(h){pS396} + ADP (phosphorylation) | CBP(h) + IRF-3(h) <==> CBP(h):IRF-3(h) (binding) | IRF-3(h) + Prdx1(h) <==> IRF-3(h):Prdx1(h) (binding) | IRF-3(h) --> CCL19(h) (DNA binding). | IRF-3(h) + Ro52(h) <==> IRF-3(h):Ro52(h) (binding) | IRF-3(h) + n ubiquitin(h) --> IRF-3(h){ub}n (ubiquitination) | IRF-3(h) --> protein remnants (degradation) | IRF-3(h) + n ATP --> IRF-3(h){p}n + n ADP (phosphorylation) | Pin1(h) + IRF-3(h) <==> Pin1(h):IRF-3(h) (binding) | Pin1(m.s.) + IRF-3(h) <==> Pin1(m.s.):IRF-3(h) (binding) | IRF-3(h) + n ubiquitin(m.s.) --> IRF-3(h){ub}n (ubiquitination) | IRF-3(h) --> NOS2(h) (DNA binding). | IRF-3(h) --> ABCC2(h) (DNA binding; transactivation). | IRF-3(h) + ATP --> IRF-3(h){pS398} + ADP (phosphorylation) | IRF-3(h) --> ISG15(h) (DNA binding). | IRF-3(h) --> IFNB1(h) (DNA binding). | IRF-3(h) --> IFNA14(h) (DNA binding). | IRF-3(h) --> IL12A(h) (DNA binding). | IRF-3(h) --> IL28B(h) (DNA binding). | IRF-3(h) --> IL29(h) (DNA binding). | IRF3(h) --> IRF-3(h) (expression). | HCV-NS5A(HCV) --> IRF-3(h) (increase of abundance) | HCV-NS3-1A(HCV1A):HCV-NS4A-1A(HCV1A) --> IRF-3(h) (decrease of transport) | IRF-3(h) --> IRF-3(h) (translocation) | IRF-3(h) --> IFNA1(h) (DNA binding; transactivation). | IRF-3(h) --> IFNB1(h) (DNA binding; transactivation). | IRF-3(h) --/ IFNA4(m) (DNA binding; transrepression). | IRF-3(h) --> ISG15(h) (DNA binding; transactivation). | IRF-3(h) --> IRF7(h) (DNA binding). | IRF-3(h) --> Ifnb1(m) (transactivation) | IRF-3(h) + ATP --> IRF-3(h){pS339} + ADP (phosphorylation) | IRF-3(h) + 2 ATP --> IRF-3(h){pS339}{pS396} + 2 ADP (phosphorylation) | IRF-3(h) + 2 ATP --IKK-i(m.s.):TBK1(m.s.)--> IRF-3(h){pS339}{pS396} + 2 ADP (phosphorylation) | 2 IRF-3(h) <==> (IRF-3(h))2 (binding; oligomerization) | IRF-3(h) + ATP --TBK1(m.s.)--> IRF-3(h){pS386} + ADP (phosphorylation) | IRF-3(h) + n ATP --TBK1(m.s.)--> IRF-3(h){p}n + ADP (phosphorylation) | IRF3(h) --> IRF-3(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
385 | Phosphoserine (IKK-epsilon;) | 9463386;14703513 | Phospho.ELM 6.0 | 396 | Phosphoserine | 12524442 | Phospho.ELM 6.0 | 398 | Phosphoserine | 9566918 | Phospho.ELM 6.0 | 402 | Phosphoserine | 9566918 | Phospho.ELM 6.0 | 404 | Phosphothreonine | 9566918 | Phospho.ELM 6.0 | 405 | Phosphoserine | 9566918 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr19 |
Promoter: 54860426 - 54862426 | Agilent_014791 |
chr19 |
Promoter: 54860426 - 54862426 | GSE27584 |