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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 3678 |
Name | ITGA5 |
Synonym | CD49e|FNRA|VLA5A;integrin, alpha 5 (fibronectin receptor, alpha polypeptide);ITGA5;integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Definition | CD49 antigen-like family member E|VLA-5|fibronectin receptor subunit alpha|fibronectin receptor, alpha subunit|integrin alpha-5|integrin alpha-F|very late activation protein 5, alpha subunit |
Position | 12q11-q13 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling. |
| More detail of all 1 literatures about ITGA5 | |
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Pathways and Diseases |
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Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | Syndecan-4-mediated signaling events;PID Curated;200115 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | VEGFR3 signaling in lymphatic endothelium;PID Curated;200188 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | Cell surface interactions at the vascular wall;PID Reactome;500305 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
Pathway | Hematopoietic cell lineage;KEGG PATHWAY;hsa04640 |
Pathway | Dilated cardiomyopathy;KEGG PATHWAY;hsa05414 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | Hypertrophic cardiomyopathy (HCM);KEGG PATHWAY;hsa05410 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Pathway | ECM-receptor interaction;KEGG PATHWAY;hsa04512 |
Disease | Colon cancer;FunDO |
Disease | Squamous cell cancer;FunDO |
Disease | Aortic aneurysm;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Malignant glioma;FunDO |
Disease | Lung cancer;FunDO |
Disease | Ovarian cancer;FunDO |
Disease | Pertussis;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Bone metastases;FunDO |
Disease | Cervical cancer;FunDO |
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External Links |
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Links to Entrez Gene | 3678 |
Links to all GeneRIF Items | 3678 |
Links to iHOP | 3678 |
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Sequence Information |
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Nucleotide Sequence |
>3678 : length: 3150 atggggagccggacgccagagtcccctctccacgccgtgcagctgcgctggggcccccgg cgccgacccccgctgctgccgctgctgttgctgctgctgccgccgccacccagggtcggg ggcttcaacttagacgcggaggccccagcagtactctcggggcccccgggctccttcttc ggattctcagtggagttttaccggccgggaacagacggggtcagtgtgctggtgggagca cccaaggctaataccagccagccaggagtgctgcagggtggtgctgtctacctctgtcct tggggtgccagccccacacagtgcacccccattgaatttgacagcaaaggctctcggctc ctggagtcctcactgtccagctcagagggagaggagcctgtggagtacaagtccttgcag tggttcggggcaacagttcgagcccatggctcctccatcttggcatgcgctccactgtac agctggcgcacagagaaggagccactgagcgaccccgtgggcacctgctacctctccaca gataacttcacccgaattctggagtatgcaccctgccgctcagatttcagctgggcagca ggacagggttactgccaaggaggcttcagtgccgagttcaccaagactggccgtgtggtt ttaggtggaccaggaagctatttctggcaaggccagatcctgtctgccactcaggagcag attgcagaatcttattaccccgagtacctgatcaacctggttcaggggcagctgcagact cgccaggccagttccatctatgatgacagctacctaggatactctgtggctgttggtgaa ttcagtggtgatgacacagaagactttgttgctggtgtgcccaaagggaacctcacttac ggctatgtcaccatccttaatggctcagacattcgatccctctacaacttctcaggggaa cagatggcctcctactttggctatgcagtggccgccacagacgtcaatggggacgggctg gatgacttgctggtgggggcacccctgctcatggatcggacccctgacgggcggcctcag gaggtgggcagggtctacgtctacctgcagcacccagccggcatagagcccacgcccacc cttaccctcactggccatgatgagtttggccgatttggcagctccttgacccccctgggg gacctggaccaggatggctacaatgatgtggccatcggggctccctttggtggggagacc cagcagggagtagtgtttgtatttcctgggggcccaggagggctgggctctaagccttcc caggttctgcagcccctgtgggcagccagccacaccccagacttctttggctctgccctt cgaggaggccgagacctggatggcaatggatatcctgatctgattgtggggtcctttggt gtggacaaggctgtggtatacaggggccgccccatcgtgtccgctagtgcctccctcacc atcttccccgccatgttcaacccagaggagcggagctgcagcttagaggggaaccctgtg gcctgcatcaaccttagcttctgcctcaatgcttctggaaaacacgttgctgactccatt ggtttcacagtggaacttcagctggactggcagaagcagaagggaggggtacggcgggca ctgttcctggcctccaggcaggcaaccctgacccagaccctgctcatccagaatggggct cgagaggattgcagagagatgaagatctacctcaggaacgagtcagaatttcgagacaaa ctctcgccgattcacatcgctctcaacttctccttggacccccaagccccagtggacagc cacggcctcaggccagccctacattatcagagcaagagccggatagaggacaaggctcag atcttgctggactgtggagaagacaacatctgtgtgcctgacctgcagctggaagtgttt ggggagcagaaccatgtgtacctgggtgacaagaatgccctgaacctcactttccatgcc cagaatgtgggtgagggtggcgcctatgaggctgagcttcgggtcaccgcccctccagag gctgagtactcaggactcgtcagacacccagggaacttctccagcctgagctgtgactac tttgccgtgaaccagagccgcctgctggtgtgtgacctgggcaaccccatgaaggcagga gccagtctgtggggtggccttcggtttacagtccctcatctccgggacactaagaaaacc atccagtttgacttccagatcctcagcaagaatctcaacaactcgcaaagcgacgtggtt tcctttcggctctccgtggaggctcaggcccaggtcaccctgaacggtgtctccaagcct gaggcagtgctattcccagtaagcgactggcatccccgagaccagcctcagaaggaggag gacctgggacctgctgtccaccatgtctatgagctcatcaaccaaggccccagctccatt agccagggtgtgctggaactcagctgtccccaggctctggaaggtcagcagctcctatat gtgaccagagttacgggactcaactgcaccaccaatcaccccattaacccaaagggcctg gagttggatcccgagggttccctgcaccaccagcaaaaacgggaagctccaagccgcagc tctgcttcctcgggacctcagatcctgaaatgcccggaggctgagtgtttcaggctgcgc tgtgagctcgggcccctgcaccaacaagagagccaaagtctgcagttgcatttccgagtc tgggccaagactttcttgcagcgggagcaccagccatttagcctgcagtgtgaggctgtg tacaaagccctgaagatgccctaccgaatcctgcctcggcagctgccccaaaaagagcgt caggtggccacagctgtgcaatggaccaaggcagaaggcagctatggcgtcccactgtgg atcatcatcctagccatcctgtttggcctcctgctcctaggtctactcatctacatcctc tacaagcttggattcttcaaacgctccctcccatatggcaccgccatggaaaaagctcag ctcaagcctccagccacctctgatgcctga |
Protein Sequence |
>3678 : length: 1049 MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFF GFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRL LESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLST DNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQ IAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTY GYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQ EVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGET QQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFG VDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSI GFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDK LSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVF GEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDY FAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVV SFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSI SQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRS SASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAV YKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYIL YKLGFFKRSLPYGTAMEKAQLKPPATSDA |