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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4851 |
Name | NOTCH1 |
Synonym | TAN1|hN1;notch 1;NOTCH1;notch 1 |
Definition | Notch homolog 1, translocation-associated|neurogenic locus notch homolog protein 1|translocation-associated notch protein TAN-1 |
Position | 9q34.3 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 9 PubMed records as below. |
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Evidence Status |
Description |
potential | "identified mutations in FBXW7 and NOTCH in head and neck squamous cell carcinoma; nearly 40% of mutations in NOTCH1 predicted to truncate the gene product, suggesting NOTCH1 may function as tumor suppressor gene rather than oncogene in this tumor type". |
reviewed | "Notch1 signal activation can inhibit the proliferation and neuroendocrine marker expression in small cell lung cancer cells, and may behave as a tumor suppressor." |
reviewed | Notch 1 is a tumor suppressor gene under direct p53 control. Review. |
reviewed | "arsenite, by decreasing generation of the tumor suppressor Notch1, contributes to skin carcinogenesis". |
reviewed | "in UV-related squamous cell photocarcinogenesis Notch 1 downregulation could mirror a tumor suppressor function of the receptor, in sun-protected squamous cell carcinomas Notch 1 was upregulated". |
reviewed | "Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies." |
potential | "Loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC." |
potential | "In the, Notch1 deletion leads to tumor formation, suggesting that Notch1 is a ""tumor suppressor"" within this context." |
reviewed | "Notch signaling, and more specifically Notch1, acts as a tumor suppressor in mouse skin. Review." |
reviewed | Notch1 functions as a tumor suppressor in mouse skin. |
| More detail of all 9 literatures about NOTCH1 | |
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Pathways and Diseases |
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Pathway | Notch signaling pathway;PANTHER;P00045 |
Pathway | Transport of Notch receptor precursor to golgi;PID Reactome;500111 |
Pathway | Mature Notch receptor trafficks to plasma membrane;PID Reactome;500113 |
Pathway | Signaling by Notch;PID Reactome;500110 |
Pathway | Prion diseases;KEGG PATHWAY;hsa05020 |
Pathway | Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor;PID Reactome;500115 |
Pathway | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;PID Reactome;500520 |
Pathway | A third proteolytic cleavage releases NICD;PID Reactome;500116 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Presenilin action in Notch and Wnt signaling;PID Curated;200052 |
Pathway | Notch signaling pathway;KEGG PATHWAY;hsa04330 |
Pathway | Notch-mediated HES/HEY network;PID Curated;200196 |
Pathway | NICD trafficks to nucleus;PID Reactome;500117 |
Pathway | Gene Expression;Reactome;REACT:71 |
Pathway | Signaling by Notch;Reactome;REACT:299 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Notch signaling pathway;PID Curated;200013 |
Pathway | Maturation of Notch precursor via proteolytic cleavage;PID Reactome;500112 |
Pathway | Dorso-ventral axis formation;KEGG PATHWAY;hsa04320 |
Pathway | proteolysis and signaling pathway of notch;PID BioCarta;100091 |
Disease | Cancers;KEGG DISEASE |
Disease | leukemia;GAD |
Disease | Acute lymphoblastic leukemia (ALL) (Precursor T lymphoblastic leukemia);KEGG DISEASE;H00002 |
Disease | Leukemia, T-cell acute lymphoblastic;OMIM |
Disease | Aortic valve disease;OMIM |
Disease | Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE |
Disease | CANCER;GAD |
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External Links |
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Links to Entrez Gene | 4851 |
Links to all GeneRIF Items | 4851 |
Links to iHOP | 4851 |
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Sequence Information |
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Nucleotide Sequence |
>4851 : length: 7668 atgccgccgctcctggcgcccctgctctgcctggcgctgctgcccgcgctcgccgcacga ggcccgcgatgctcccagcccggtgagacctgcctgaatggcgggaagtgtgaagcggcc aatggcacggaggcctgcgtctgtggcggggccttcgtgggcccgcgatgccaggacccc aacccgtgcctcagcaccccctgcaagaacgccgggacatgccacgtggtggaccgcaga ggcgtggcagactatgcctgcagctgtgccctgggcttctctgggcccctctgcctgaca cccctggacaatgcctgcctcaccaacccctgccgcaacgggggcacctgcgacctgctc acgctgacggagtacaagtgccgctgcccgcccggctggtcagggaaatcgtgccagcag gctgacccgtgcgcctccaacccctgcgccaacggtggccagtgcctgcccttcgaggcc tcctacatctgccactgcccacccagcttccatggccccacctgccggcaggatgtcaac gagtgtggccagaagcccgggctttgccgccacggaggcacctgccacaacgaggtcggc tcctaccgctgcgtctgccgcgccacccacactggccccaactgcgagcggccctacgtg ccctgcagcccctcgccctgccagaacgggggcacctgccgccccacgggcgacgtcacc cacgagtgtgcctgcctgccaggcttcaccggccagaactgtgaggaaaatatcgacgat tgtccaggaaacaactgcaagaacgggggtgcctgtgtggacggcgtgaacacctacaac tgccgctgcccgccagagtggacaggtcagtactgtaccgaggatgtggacgagtgccag ctgatgccaaatgcctgccagaacggcgggacctgccacaacacccacggtggctacaac tgcgtgtgtgtcaacggctggactggtgaggactgcagcgagaacattgatgactgtgcc agcgccgcctgcttccacggcgccacctgccatgaccgtgtggcctccttctactgcgag tgtccccatggccgcacaggtctgctgtgccacctcaacgacgcatgcatcagcaacccc tgtaacgagggctccaactgcgacaccaaccctgtcaatggcaaggccatctgcacctgc ccctcggggtacacgggcccggcctgcagccaggacgtggatgagtgctcgctgggtgcc aacccctgcgagcatgcgggcaagtgcatcaacacgctgggctccttcgagtgccagtgt ctgcagggctacacgggcccccgatgcgagatcgacgtcaacgagtgcgtctcgaacccg tgccagaacgacgccacctgcctggaccagattggggagttccagtgcatctgcatgccc ggctacgagggtgtgcactgcgaggtcaacacagacgagtgtgccagcagcccctgcctg cacaatggccgctgcctggacaagatcaatgagttccagtgcgagtgccccacgggcttc actgggcatctgtgccagtacgatgtggacgagtgtgccagcaccccctgcaagaatggt gccaagtgcctggacggacccaacacttacacctgtgtgtgcacggaagggtacacgggg acgcactgcgaggtggacatcgatgagtgcgaccccgacccctgccactacggctcctgc aaggacggcgtcgccaccttcacctgcctctgccgcccaggctacacgggccaccactgc gagaccaacatcaacgagtgctccagccagccctgccgccacgggggcacctgccaggac cgcgacaacgcctacctctgcttctgcctgaaggggaccacaggacccaactgcgagatc aacctggatgactgtgccagcagcccctgcgactcgggcacctgtctggacaagatcgat ggctacgagtgtgcctgtgagccgggctacacagggagcatgtgtaacatcaacatcgat gagtgtgcgggcaacccctgccacaacgggggcacctgcgaggacggcatcaatggcttc acctgccgctgccccgagggctaccacgaccccacctgcctgtctgaggtcaatgagtgc aacagcaacccctgcgtccacggggcctgccgggacagcctcaacgggtacaagtgcgac tgtgaccctgggtggagtgggaccaactgtgacatcaacaacaatgagtgtgaatccaac ccttgtgtcaacggcggcacctgcaaagacatgaccagtggctacgtgtgcacctgccgg gagggcttcagcggtcccaactgccagaccaacatcaacgagtgtgcgtccaacccatgt ctgaaccagggcacgtgtattgacgacgttgccgggtacaagtgcaactgcctgctgccc tacacaggtgccacgtgtgaggtggtgctggccccgtgtgcccccagcccctgcagaaac ggcggggagtgcaggcaatccgaggactatgagagcttctcctgtgtctgccccacgggc tggcaagggcagacctgtgaggtcgacatcaacgagtgcgttctgagcccgtgccggcac ggcgcatcctgccagaacacccacggcggctaccgctgccactgccaggccggctacagt gggcgcaactgcgagaccgacatcgacgactgccggcccaacccgtgtcacaacgggggc tcctgcacagacggcatcaacacggccttctgcgactgcctgcccggcttccggggcact ttctgtgaggaggacatcaacgagtgtgccagtgacccctgccgcaacggggccaactgc acggactgcgtggacagctacacgtgcacctgccccgcaggcttcagcgggatccactgt gagaacaacacgcctgactgcacagagagctcctgcttcaacggtggcacctgcgtggac ggcatcaactcgttcacctgcctgtgtccacccggcttcacgggcagctactgccagcac gatgtcaatgagtgcgactcacagccctgcctgcatggcggcacctgtcaggacggctgc ggctcctacaggtgcacctgcccccagggctacactggccccaactgccagaaccttgtg cactggtgtgactcctcgccctgcaagaacggcggcaaatgctggcagacccacacccag taccgctgcgagtgccccagcggctggaccggcctttactgcgacgtgcccagcgtgtcc tgtgaggtggctgcgcagcgacaaggtgttgacgttgcccgcctgtgccagcatggaggg ctctgtgtggacgcgggcaacacgcaccactgccgctgccaggcgggctacacaggcagc tactgtgaggacctggtggacgagtgctcacccagcccctgccagaacggggccacctgc acggactacctgggcggctactcctgcaagtgcgtggccggctaccacggggtgaactgc tctgaggagatcgacgagtgcctctcccacccctgccagaacgggggcacctgcctcgac ctccccaacacctacaagtgctcctgcccacggggcactcagggtgtgcactgtgagatc aacgtggacgactgcaatccccccgttgaccccgtgtcccggagccccaagtgctttaac aacggcacctgcgtggaccaggtgggcggctacagctgcacctgcccgccgggcttcgtg ggtgagcgctgtgagggggatgtcaacgagtgcctgtccaatccctgcgacgcccgtggc acccagaactgcgtgcagcgcgtcaatgacttccactgcgagtgccgtgctggtcacacc gggcgccgctgcgagtccgtcatcaatggctgcaaaggcaagccctgcaagaatgggggc acctgcgccgtggcctccaacaccgcccgcgggttcatctgcaagtgccctgcgggcttc gagggcgccacgtgtgagaatgacgctcgtacctgcggcagcctgcgctgcctcaacggc ggcacatgcatctccggcccgcgcagccccacctgcctgtgcctgggccccttcacgggc cccgaatgccagttcccggccagcagcccctgcctgggcggcaacccctgctacaaccag gggacctgtgagcccacatccgagagccccttctaccgttgcctgtgccccgccaaattc aacgggctcttgtgccacatcctggactacagcttcgggggtggggccgggcgcgacatc cccccgccgctgatcgaggaggcgtgcgagctgcccgagtgccaggaggacgcgggcaac aaggtctgcagcctgcagtgcaacaaccacgcgtgcggctgggacggcggtgactgctcc ctcaacttcaatgacccctggaagaactgcacgcagtctctgcagtgctggaagtacttc agtgacggccactgtgacagccagtgcaactcagccggctgcctcttcgacggctttgac tgccagcgtgcggaaggccagtgcaaccccctgtacgaccagtactgcaaggaccacttc agcgacgggcactgcgaccagggctgcaacagcgcggagtgcgagtgggacgggctggac tgtgcggagcatgtacccgagaggctggcggccggcacgctggtggtggtggtgctgatg ccgccggagcagctgcgcaacagctccttccacttcctgcgggagctcagccgcgtgctg cacaccaacgtggtcttcaagcgtgacgcacacggccagcagatgatcttcccctactac ggccgcgaggaggagctgcgcaagcaccccatcaagcgtgccgccgagggctgggccgca cctgacgccctgctgggccaggtgaaggcctcgctgctccctggtggcagcgagggtggg cggcggcggagggagctggaccccatggacgtccgcggctccatcgtctacctggagatt gacaaccggcagtgtgtgcaggcctcctcgcagtgcttccagagtgccaccgacgtggcc gcattcctgggagcgctcgcctcgctgggcagcctcaacatcccctacaagatcgaggcc gtgcagagtgagaccgtggagccgcccccgccggcgcagctgcacttcatgtacgtggcg gcggccgcctttgtgcttctgttcttcgtgggctgcggggtgctgctgtcccgcaagcgc cggcggcagcatggccagctctggttccctgagggcttcaaagtgtctgaggccagcaag aagaagcggcgggagcccctcggcgaggactccgtgggcctcaagcccctgaagaacgct tcagacggtgccctcatggacgacaaccagaatgagtggggggacgaggacctggagacc aagaagttccggttcgaggagcccgtggttctgcctgacctggacgaccagacagaccac cggcagtggactcagcagcacctggatgccgctgacctgcgcatgtctgccatggccccc acaccgccccagggtgaggttgacgccgactgcatggacgtcaatgtccgcgggcctgat ggcttcaccccgctcatgatcgcctcctgcagcgggggcggcctggagacgggcaacagc gaggaagaggaggacgcgccggccgtcatctccgacttcatctaccagggcgccagcctg cacaaccagacagaccgcacgggcgagaccgccttgcacctggccgcccgctactcacgc tctgatgccgccaagcgcctgctggaggccagcgcagatgccaacatccaggacaacatg ggccgcaccccgctgcatgcggctgtgtctgccgacgcacaaggtgtcttccagatcctg atccggaaccgagccacagacctggatgcccgcatgcatgatggcacgacgccactgatc ctggctgcccgcctggccgtggagggcatgctggaggacctcatcaactcacacgccgac gtcaacgccgtagatgacctgggcaagtccgccctgcactgggccgccgccgtgaacaat gtggatgccgcagttgtgctcctgaagaacggggctaacaaagatatgcagaacaacagg gaggagacacccctgtttctggccgcccgggagggcagctacgagaccgccaaggtgctg ctggaccactttgccaaccgggacatcacggatcatatggaccgcctgccgcgcgacatc gcacaggagcgcatgcatcacgacatcgtgaggctgctggacgagtacaacctggtgcgc agcccgcagctgcacggagccccgctggggggcacgcccaccctgtcgcccccgctctgc tcgcccaacggctacctgggcagcctcaagcccggcgtgcagggcaagaaggtccgcaag cccagcagcaaaggcctggcctgtggaagcaaggaggccaaggacctcaaggcacggagg aagaagtcccaggacggcaagggctgcctgctggacagctccggcatgctctcgcccgtg gactccctggagtcaccccatggctacctgtcagacgtggcctcgccgccactgctgccc tccccgttccagcagtctccgtccgtgcccctcaaccacctgcctgggatgcccgacacc cacctgggcatcgggcacctgaacgtggcggccaagcccgagatggcggcgctgggtggg ggcggccggctggcctttgagactggcccacctcgtctctcccacctgcctgtggcctct ggcaccagcaccgtcctgggctccagcagcggaggggccctgaatttcactgtgggcggg tccaccagtttgaatggtcaatgcgagtggctgtcccggctgcagagcggcatggtgccg aaccaatacaaccctctgcgggggagtgtggcaccaggccccctgagcacacaggccccc tccctgcagcatggcatggtaggcccgctgcacagtagccttgctgccagcgccctgtcc cagatgatgagctaccagggcctgcccagcacccggctggccacccagcctcacctggtg cagacccagcaggtgcagccacaaaacttacagatgcagcagcagaacctgcagccagca aacatccagcagcagcaaagcctgcagccgccaccaccaccaccacagccgcaccttggc gtgagctcagcagccagcggccacctgggccggagcttcctgagtggagagccgagccag gcagacgtgcagccactgggccccagcagcctggcggtgcacactattctgccccaggag agccccgccctgcccacgtcgctgccatcctcgctggtcccacccgtgaccgcagcccag ttcctgacgcccccctcgcagcacagctactcctcgcctgtggacaacacccccagccac cagctacaggtgcctgagcaccccttcctcaccccgtcccctgagtcccctgaccagtgg tccagctcgtccccgcattccaacgtctccgactggtccgagggcgtctccagccctccc accagcatgcagtcccagatcgcccgcattccggaggccttcaagtaa |
Protein Sequence |
>4851 : length: 2555 MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDP NPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLL TLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVT HECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQ LMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGA NPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMP GYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHC ETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKID GYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCR EGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRN GGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANC TDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQH DVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGS YCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLD LPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGG TCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTG PECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYF SDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLD CAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEI DNRQCVQASSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPPPPAQLHFMYVA AAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNA SDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAADLRMSAMAP TPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASL HNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQIL IRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNN VDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDI AQERMHHDIVRLLDEYNLVRSPQLHGAPLGGTPTLSPPLCSPNGYLGSLKPGVQGKKVRK PSSKGLACGSKEAKDLKARRKKSQDGKGCLLDSSGMLSPVDSLESPHGYLSDVASPPLLP SPFQQSPSVPLNHLPGMPDTHLGIGHLNVAAKPEMAALGGGGRLAFETGPPRLSHLPVAS GTSTVLGSSSGGALNFTVGGSTSLNGQCEWLSRLQSGMVPNQYNPLRGSVAPGPLSTQAP SLQHGMVGPLHSSLAASALSQMMSYQGLPSTRLATQPHLVQTQQVQPQNLQMQQQNLQPA NIQQQQSLQPPPPPPQPHLGVSSAASGHLGRSFLSGEPSQADVQPLGPSSLAVHTILPQE SPALPTSLPSSLVPPVTAAQFLTPPSQHSYSSPVDNTPSHQLQVPEHPFLTPSPESPDQW SSSSPHSNVSDWSEGVSSPPTSMQSQIARIPEAFK |