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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 4851 |
Name | NOTCH1 |
Synonymous | TAN1|hN1;notch 1;NOTCH1;notch 1 |
Definition | Notch homolog 1, translocation-associated|neurogenic locus notch homolog protein 1|translocation-associated notch protein TAN-1 |
Position | 9q34.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Notch1(h) --/ E47(h) (decrease of abundance) | Notch1(h) --> ERK1(m){p} (increase of phosphorylation) | Notch1(h) --> ERK2(m){p} (increase of phosphorylation) | Notch1(h) --> E47(h){ub(n)} (increase of ubiquitination) | Notch1(h) --> E47(h){p}:Skp2(h) (increase of binding) | Notch1(h) --> ERK1(h){p} (increase of phosphorylation) | Notch1(h) --> ERK2(h){p} (increase of phosphorylation) | Notch1(h) --/ E2A(m) (decrease of abundance) | Notch1(h) --/ E2A(h) (decrease of abundance) | Notch1(h) --> Notch1-p82(h) + protein remnants (cleavage) | Notch1(h) --> Notch1-p77(h) + protein remnants (cleavage) | Notch1(h) --> Notch1-p70(h) + protein remnants (cleavage) | Notch1(h) --> Notch1-p48(h) + protein remnants (cleavage) | Notch1(h) --> Notch1-p45(h) + protein remnants (cleavage) | Notch1(h) --> Notch1-p40(h) + protein remnants (cleavage) | Notch1(h) --> Notch1-p32(h) + protein remnants (cleavage) | Notch1(h) --> Notch1-p28(h) + protein remnants (cleavage) | Notch1(h) --> Notch1-p22(h) + protein remnants (cleavage) | Notch1(h) --> KRT1(h) (transactivation) | NOTCH1(h) --> Notch1(h) (expression). | Jagged1(h) --/ Notch1(h) (decrease of abundance) | EGF(m.s.) --/ Notch1(h) (decrease of abundance) | ErbB1(h) --/ Notch1(h) (decrease of abundance) | c-Jun(h) --/ Notch1(h) (decrease of abundance) | Notch1(h) --> NICD1(h) + protein remnants (cleavage) | Notch1(h) --> Notch1TM(h) + Notch1EC(h) (cleavage) | Notch1(h) --> PTEN(h) (DNA binding; transactivation). | NOTCH1(h) --> Notch1(h) (expression). | NOTCH1(h) --> NOTCH1(h) (expression). | hsa-miR-134 --/ NOTCH1(h) (predicted) | hsa-miR-34a --/ NOTCH1(h) (predicted) | hsa-miR-34c --/ NOTCH1(h) (predicted) |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
41 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 960 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1180 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1242 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1490 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1588 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr9 |
Promoter: 138559559 - 138561559 | Agilent_014791 |
chr9 |
Promoter: 138559559 - 138561559 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 138559559 - 138561559 | GSE27584 |
chr9 |
Promoter: 138559559 - 138561559 | Agilent_014791_44K |