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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4851 |
Name | NOTCH1 |
Synonymous | TAN1|hN1;notch 1;NOTCH1;notch 1 |
Definition | Notch homolog 1, translocation-associated|neurogenic locus notch homolog protein 1|translocation-associated notch protein TAN-1 |
Position | 9q34.3 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
interacts with |
MAML3 | BIOGRID; PUBMED:12370315; |
interacts with |
MAML1 | BIOGRID; PUBMED:11101851; |
interacts with |
MAML1 | BIOGRID; PUBMED:12370315; |
interacts with |
RELA | BIOGRID; PUBMED:8642313; |
interacts with |
NUMB | BIOGRID; PUBMED:8755477; |
interacts with |
NOV | BIOGRID; PUBMED:12050162; |
interacts with |
NFKB1 | BIOGRID; PUBMED:11418662; |
interacts with |
NFKB1 | BIOGRID; PUBMED:8642313; |
interacts with |
LCK | BIOGRID; PUBMED:14583609; |
interacts with |
LEF1 | BIOGRID; PUBMED:11604490; |
interacts with |
GSK3B | BIOGRID; PUBMED:12123574; |
interacts with |
FBXW7 | BIOGRID; PUBMED:11425854; |
interacts with |
FBXW7 | BIOGRID; PUBMED:17646408; |
interacts with |
DTX1 | BIOGRID; PUBMED:11564735; |
interacts with |
DTX1 | BIOGRID; PUBMED:20208568; |
interacts with |
EP300 | BIOGRID; PUBMED:19838210; |
interacts with |
DLL1 | BIOGRID; PUBMED:11006133; |
interacts with |
CTNNB1 | BIOGRID; PUBMED:19000719; |
interacts with |
CBL | BIOGRID; PUBMED:11777909; |
interacts with |
JAG2 | BIOGRID; PUBMED:11006133; |
interacts with |
ITCH | BIOGRID; PUBMED:10940313; |
interacts with |
AKT1 | BIOGRID; PUBMED:18440314; |
interacts with |
JAG1 | BIOGRID; PUBMED:11006133; |
interacts with |
PIK3CA | BIOGRID; PUBMED:14583609; |
interacts with |
PSEN1 | BIOGRID; PUBMED:10077672; |
interacts with |
RBPJ | BIOGRID; PUBMED:12644465; |
interacts with |
RBPJ | BIOGRID; PUBMED:9111040; |
interacts with |
SNW1 | BIOGRID; PUBMED:10713164; |
interacts with |
SNW1 | BIOGRID; PUBMED:11404076; |
interacts with |
XRCC6 | BIOGRID; PUBMED:16169070; |
interacts with |
YY1 | BIOGRID; PUBMED:12913000; |
interacts with |
Itch | BIOGRID; PUBMED:18628966; |
interacts with |
CNTN1 | BIOGRID; PUBMED:14567914; |
interacts with |
MAML3 | HPRD; PUBMED:12370315; |
interacts with |
MEF2C | HPRD; PUBMED:10082551; |
interacts with |
MFNG | HPRD; PUBMED:10935626; |
interacts with |
MAML1 | HPRD; PUBMED:12644465; |
interacts with |
RELA | HPRD; PUBMED:8642313; |
interacts with |
NUMB | HPRD; PUBMED:12682059; |
interacts with |
NOV | HPRD; PUBMED:12050162; |
interacts with |
NUMBL | HPRD; PUBMED:9169836; |
interacts with |
NFKB1 | HPRD; PUBMED:8642313; |
interacts with |
LCK | HPRD; PUBMED:14583609; |
interacts with |
LFNG | HPRD; PUBMED:10935626; |
interacts with |
BLOC1S1 | HPRD; PUBMED:10747963; |
interacts with |
GSK3B | HPRD; PUBMED:12123574; |
interacts with |
FBXW7 | HPRD; PUBMED:11585921; |
interacts with |
FURIN | HPRD; PUBMED:9653148; |
interacts with |
GFI1B | HPRD; PUBMED:16713569; |
interacts with |
DTX1 | HPRD; PUBMED:11226752; |
interacts with |
DTX2 | HPRD; PUBMED:11226752; |
interacts with |
EP300 | HPRD; PUBMED:11604511; |
interacts with |
DLL1 | HPRD; PUBMED:11006133; |
interacts with |
DLL4 | HPRD; PUBMED:10837024; |
interacts with |
CBL | HPRD; PUBMED:11777909; |
interacts with |
KAT2B | HPRD; PUBMED:10747963; |
interacts with |
KAT2A | HPRD; PUBMED:10747963; |
interacts with |
JAG2 | HPRD; PUBMED:11006133; |
interacts with |
ITCH | HPRD; PUBMED:12682059; |
interacts with |
REL | HPRD; PUBMED:16319921; |
interacts with |
ADAM17 | HPRD; PUBMED:10882063; |
interacts with |
APBA1 | HPRD; PUBMED:14756819; |
interacts with |
PSEN1 | HPRD; PUBMED:10077672; |
interacts with |
PSEN2 | HPRD; PUBMED:11518718; |
interacts with |
RBPJ | HPRD; PUBMED:8749394; |
interacts with |
SNW1 | HPRD; PUBMED:10713164; |
interacts with |
XIAP | HPRD; PUBMED:17318174; |
interacts with |
XRCC6 | HPRD; PUBMED:16169070; |
interacts with |
WDR12 | HPRD; PUBMED:11827460; |
interacts with |
YY1 | HPRD; PUBMED:12913000; |
interacts with |
POFUT1 | HPRD; PUBMED:12697902; |
interacts with |
CNTN1 | HPRD; PUBMED:14567914; |
interacts with |
NFKB1 | MINT; PUBMED:16319921; |
interacts with |
GFI1B | MINT; PUBMED:16713569; |
interacts with |
REL | MINT; PUBMED:16319921; |
interacts with |
XIAP | MINT; PUBMED:17318174; |
interacts with |
XRCC6 | MINT; PUBMED:16169070; |
Metabolic Interaction | | Top | |
There is no record for NOTCH1 |
Signaling Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
state change |
MFAP5 | NCI_NATURE; PUBMED:18417156;PUBMED:17296795; |
reacts with |
SPEN | NCI_NATURE; PUBMED:17392792;PUBMED:8749394;PUBMED:16287852;PUBMED:12374742; |
reacts with |
SPEN | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:11604511;PUBMED:12374742; |
state change |
NUMB | NCI_NATURE; PUBMED:10940313;PUBMED:19567869;PUBMED:12682059;PUBMED:18628966; |
state change |
NCSTN | NCI_NATURE; PUBMED:10882062; |
state change |
NCSTN | NCI_NATURE; PUBMED:14567914;PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
NCSTN | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
NCSTN | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:15965470;PUBMED:10593990;PUBMED:14566063; |
state change |
NCSTN | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:15082708;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:10593990;PUBMED:14566063; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:10940313;PUBMED:19567869;PUBMED:12682059;PUBMED:18628966; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:11150244; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:11604511; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:12794186; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:12913000; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:14567914; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:14567914;PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:15082708; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:15965470;PUBMED:10593990;PUBMED:14566063; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:15082708;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:10593990;PUBMED:14566063; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:15652348; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:15965470; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:16492672; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:16682003; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:17296795; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:17296795;PUBMED:16492672; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:17392792;PUBMED:8749394;PUBMED:16287852;PUBMED:12374742; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:18417156;PUBMED:17296795; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:11604511;PUBMED:12374742; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:11604511;PUBMED:9694793; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:9694793; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:8923452; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:9171444; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:9244302;PUBMED:9653148; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:9315665;PUBMED:11006133; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:9315665;PUBMED:16144902;PUBMED:17296795;PUBMED:11006133; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:9315665;PUBMED:9244302;PUBMED:16144902;PUBMED:11006133;PUBMED:17296795; |
reacts with |
NOTCH1 | NCI_NATURE; PUBMED:9315665;PUBMED:9244302;PUBMED:18676613;PUBMED:16144902;PUBMED:11006133;PUBMED:17296795; |
reacts with |
KDM1A | NCI_NATURE; PUBMED:17392792;PUBMED:8749394;PUBMED:16287852;PUBMED:12374742; |
state change |
DNM1 | NCI_NATURE; PUBMED:17296795; |
reacts with |
HDAC1 | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:11604511;PUBMED:9694793; |
reacts with |
HDAC1 | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:9694793; |
reacts with |
HES1 | NCI_NATURE; PUBMED:16682003; |
reacts with |
HEY1 | NCI_NATURE; PUBMED:16682003; |
state change |
FURIN | NCI_NATURE; PUBMED:9244302;PUBMED:9653148; |
reacts with |
DTX1 | NCI_NATURE; PUBMED:12794186; |
state change |
EPS15 | NCI_NATURE; PUBMED:17296795; |
reacts with |
EP300 | NCI_NATURE; PUBMED:11604511; |
reacts with |
EP300 | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:11604511;PUBMED:12374742; |
reacts with |
EP300 | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:11604511;PUBMED:9694793; |
reacts with |
DLL1 | NCI_NATURE; PUBMED:12794186; |
reacts with |
DLL1 | NCI_NATURE; PUBMED:17296795; |
reacts with |
DLL1 | NCI_NATURE; PUBMED:8923452; |
reacts with |
DLL1 | NCI_NATURE; PUBMED:9315665;PUBMED:9244302;PUBMED:16144902;PUBMED:11006133;PUBMED:17296795; |
reacts with |
DLL1 | NCI_NATURE; PUBMED:9315665;PUBMED:9244302;PUBMED:18676613;PUBMED:16144902;PUBMED:11006133;PUBMED:17296795; |
reacts with |
DLK1 | NCI_NATURE; PUBMED:15652348; |
reacts with |
CTBP1 | NCI_NATURE; PUBMED:17392792;PUBMED:8749394;PUBMED:16287852;PUBMED:12374742; |
reacts with |
DNER | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:15965470;PUBMED:10593990;PUBMED:14566063; |
reacts with |
DNER | NCI_NATURE; PUBMED:15965470; |
state change |
DLL3 | NCI_NATURE; PUBMED:9315665;PUBMED:16144902;PUBMED:17296795;PUBMED:11006133; |
state change |
DLL3 | NCI_NATURE; PUBMED:9315665;PUBMED:9244302;PUBMED:16144902;PUBMED:11006133;PUBMED:17296795; |
state change |
DLL3 | NCI_NATURE; PUBMED:9315665;PUBMED:9244302;PUBMED:18676613;PUBMED:16144902;PUBMED:11006133;PUBMED:17296795; |
reacts with |
JAG2 | NCI_NATURE; PUBMED:17296795; |
reacts with |
JAG2 | NCI_NATURE; PUBMED:9315665;PUBMED:11006133; |
state change |
ITCH | NCI_NATURE; PUBMED:10940313;PUBMED:19567869;PUBMED:12682059;PUBMED:18628966; |
state change |
APH1A | NCI_NATURE; PUBMED:10882062; |
state change |
APH1A | NCI_NATURE; PUBMED:14567914;PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
APH1A | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
APH1A | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:15965470;PUBMED:10593990;PUBMED:14566063; |
state change |
APH1A | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:15082708;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:10593990;PUBMED:14566063; |
state change |
ADAM10 | NCI_NATURE; PUBMED:12794186; |
state change |
APH1B | NCI_NATURE; PUBMED:10882062; |
state change |
APH1B | NCI_NATURE; PUBMED:14567914;PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
APH1B | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
APH1B | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:15965470;PUBMED:10593990;PUBMED:14566063; |
state change |
APH1B | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:15082708;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:10593990;PUBMED:14566063; |
reacts with |
JAG1 | NCI_NATURE; PUBMED:11150244; |
reacts with |
JAG1 | NCI_NATURE; PUBMED:17296795; |
reacts with |
JAG1 | NCI_NATURE; PUBMED:18417156;PUBMED:17296795; |
reacts with |
JAG1 | NCI_NATURE; PUBMED:9315665;PUBMED:16144902;PUBMED:17296795;PUBMED:11006133; |
state change |
PSENEN | NCI_NATURE; PUBMED:10882062; |
state change |
PSENEN | NCI_NATURE; PUBMED:14567914;PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
PSENEN | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
PSENEN | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:15965470;PUBMED:10593990;PUBMED:14566063; |
state change |
PSENEN | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:15082708;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:10593990;PUBMED:14566063; |
state change |
PSEN1 | NCI_NATURE; PUBMED:10882062; |
state change |
PSEN1 | NCI_NATURE; PUBMED:14567914;PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
PSEN1 | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
state change |
PSEN1 | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:15965470;PUBMED:10593990;PUBMED:14566063; |
state change |
PSEN1 | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:15082708;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:10593990;PUBMED:14566063; |
reacts with |
RBPJ | NCI_NATURE; PUBMED:11604511; |
reacts with |
RBPJ | NCI_NATURE; PUBMED:16682003; |
reacts with |
RBPJ | NCI_NATURE; PUBMED:17392792;PUBMED:8749394;PUBMED:16287852;PUBMED:12374742; |
reacts with |
RBPJ | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:11604511;PUBMED:12374742; |
reacts with |
RBPJ | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:11604511;PUBMED:9694793; |
reacts with |
RBPJ | NCI_NATURE; PUBMED:8749394;PUBMED:12370315;PUBMED:11101851;PUBMED:9694793; |
reacts with |
RBPJ | NCI_NATURE; PUBMED:9171444; |
reacts with |
YY1 | NCI_NATURE; PUBMED:12913000; |
reacts with |
CNTN1 | NCI_NATURE; PUBMED:14567914; |
reacts with |
CNTN1 | NCI_NATURE; PUBMED:14567914;PUBMED:15274632;PUBMED:10206645;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:14566063;PUBMED:10593990; |
reacts with |
CNTN6 | NCI_NATURE; PUBMED:15082708; |
reacts with |
CNTN6 | NCI_NATURE; PUBMED:15274632;PUBMED:10206645;PUBMED:15082708;PUBMED:12297508;PUBMED:10882062;PUBMED:11459941;PUBMED:9620803;PUBMED:8643690;PUBMED:11518718;PUBMED:10593990;PUBMED:14566063; |
reacts with |
RBBP8 | NCI_NATURE; PUBMED:17392792;PUBMED:8749394;PUBMED:16287852;PUBMED:12374742; |
reacts with |
NOTCH1 | REACTOME; PUBMED:10079256;PUBMED:12794186;PUBMED:10958687; |
reacts with |
NOTCH1 | REACTOME; PUBMED:10882063;PUBMED:12794186;PUBMED:10958687; |
reacts with |
NOTCH1 | REACTOME; PUBMED:11135303;PUBMED:9244302; |
reacts with |
NOTCH1 | REACTOME; PUBMED:9244302;PUBMED:9653148; |