Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5071

Name

PARK2

Synonym

AR-JP|LPRS2|PDJ|PRKN;parkinson protein 2, E3 ubiquitin protein ligase (parkin);PARK2;parkinson protein 2, E3 ubiquitin protein ligase (parkin)

Definition

E3 ubiquitin ligase|E3 ubiquitin-protein ligase parkin|Parkinson disease (autosomal recessive, juvenile) 2, parkin|parkin 2|parkinson disease protein 2|parkinson juvenile disease protein 2

Position

6q25.2-q27

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 7 PubMed records as below.

Evidence Status

Description

reviewed

Parkin as a tumor suppressor gene for hepatocellular carcinoma.

reviewed

Parkin is a tumor suppressor gene whose inactivation may play an important role in non-small cell lung cancer tumorigenesis.

reviewed

"Allelic loss of 6q25-27, the PARKIN tumor suppressor gene locus, in cervical carcinoma."

reviewed

Data strongly point to PARK2 as a tumor suppressor on 6q25.2-q27.

potential

"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm".

potential

analysis of Parkin protein expression with antibodies revealed that most of the ovarian cancer cell lines and primary tumors had diminished or absent Parkin expression and it is suggested it may be a tumor suppressor gene.

potential

"Parkin, implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27 in breast asnd ovarian cancers."
More detail of all 7 literatures about PARK2

Pathways and Diseases

Pathway

alpha-synuclein and parkin-mediated proteolysis in parkinson`s disease;PID BioCarta;100080

Pathway

Parkinson disease;PANTHER;P00049

Pathway

Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120

Pathway

role of parkin in ubiquitin-proteasomal pathway;PID BioCarta;100081

Pathway

Alpha-synuclein signaling;PID Curated;200187

Pathway

Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141

Pathway

Parkinson's disease;KEGG PATHWAY;hsa05012

Disease

Primary tumor;FunDO

Disease

Serum metabolites;NHGRI

Disease

Pancreatic cancer;NHGRI

Disease

Nervous system diseases;KEGG DISEASE

Disease

Breast cancer;FunDO

Disease

Liver cancer;FunDO

Disease

Leprosy, susceptibility to;OMIM

Disease

Leprosy;FunDO

Disease

Parkinson's disease;GAD

Disease

Leprosy;GAD

Disease

serum metabolites;GAD

Disease

Leukemia;FunDO

Disease

METABOLIC;GAD

Disease

INFECTION;GAD

Disease

Adenocarcinoma of lung, somatic;OMIM

Disease

Tuberculosis;FunDO

Disease

Adenocarcinoma, ovarian, somatic;OMIM

Disease

Movement disorder;FunDO

Disease

CNS metastases;FunDO

Disease

NEUROLOGICAL;GAD

Disease

Parkinson's disease;KEGG DISEASE;H00057

Disease

Parkinson disease, juvenile, type 2;OMIM

Disease

Ovarian cancer;FunDO

Disease

Congenital abnormality;FunDO

Disease

Neurodegenerative diseases;KEGG DISEASE

External Links

Links to Entrez Gene

5071

Links to all GeneRIF Items

5071

Links to iHOP

5071

Sequence Information

Nucleotide Sequence

>5071 : length: 1398
atgatagtgtttgtcaggttcaactccagccatggtttcccagtggaggtcgattctgac
accagcatcttccagctcaaggaggtggttgctaagcgacagggggttccggctgaccag
ttgcgtgtgattttcgcagggaaggagctgaggaatgactggactgtgcagaattgtgac
ctggatcagcagagcattgttcacattgtgcagagaccgtggagaaaaggtcaagaaatg
aatgcaactggaggcgacgaccccagaaacgcggcgggaggctgtgagcgggagccccag
agcttgactcgggtggacctcagcagctcagtcctcccaggagactctgtggggctggct
gtcattctgcacactgacagcaggaaggactcaccaccagctggaagtccagcaggtaga
tcaatctacaacagcttttatgtgtattgcaaaggcccctgtcaaagagtgcagccggga
aaactcagggtacagtgcagcacctgcaggcaggcaacgctcaccttgacccagggtcca
tcttgctgggatgatgttttaattccaaaccggatgagtggtgaatgccaatccccacac
tgccctgggactagtgcagaatttttctttaaatgtggagcacaccccacctctgacaag
gaaacatcagtagctttgcacctgatcgcaacaaatagtcggaacatcacttgcattacg
tgcacagacgtcaggagccccgtcctggttttccagtgcaactcccgccacgtgatttgc
ttagactgtttccacttatactgtgtgacaagactcaatgatcggcagtttgttcacgac
cctcaacttggctactccctgccttgtgtggctggctgtcccaactccttgattaaagag
ctccatcacttcaggattctgggagaagagcagtacaaccggtaccagcagtatggtgca
gaggagtgtgtcctgcagatggggggcgtgttatgcccccgccctggctgtggagcgggg
ctgctgccggagcctgaccagaggaaagtcacctgcgaagggggcaatggcctgggctgt
gggtttgccttctgccgggaatgtaaagaagcgtaccatgaaggggagtgcagtgccgta
tttgaagcctcaggaacaactactcaggcctacagagtcgatgaaagagccgccgagcag
gctcgttgggaagcagcctccaaagaaaccatcaagaaaaccaccaagccctgtccccgc
tgccatgtaccagtggaaaaaaatggaggctgcatgcacatgaagtgtccgcagccccag
tgcaggctcgagtggtgctggaactgtggctgcgagtggaaccgcgtctgcatgggggac
cactggttcgacgtgtag

Protein Sequence

>5071 : length: 465
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD
LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA
VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP
SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT
CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE
LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC
GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR
CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV



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