Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5071

Name

PARK2

Synonymous

AR-JP|LPRS2|PDJ|PRKN;parkinson protein 2, E3 ubiquitin protein ligase (parkin);PARK2;parkinson protein 2, E3 ubiquitin protein ligase (parkin)

Definition

E3 ubiquitin ligase|E3 ubiquitin-protein ligase parkin|Parkinson disease (autosomal recessive, juvenile) 2, parkin|parkin 2|parkinson disease protein 2|parkinson juvenile disease protein 2

Position

6q25.2-q27

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

parkin(h) + UbcH7(h) <==> parkin(h):UbcH7(h) (binding)
parkin(h) + NACP(h){gly} <==> parkin(h):NACP(h){gly} (binding)
parkin(h) + NO --> parkin(h){no} (nitrosylation)
parkin(h) + n ubiquitin(v.s.) --> parkin(h){ub(n)} (ubiquitination)
parkin(h) + n ubiquitin(v.s.) --E1(v.s.),UbcH7(h),ATP--> parkin(h){ub(n)} (ubiquitination)
parkin(h) --Caspase-1(m)--> protein remnants (degradation)
parkin(h) --Caspase-3(m)--> protein remnants (degradation)
parkin(h) --Caspase-8(m)--> protein remnants (degradation)
parkin(h) --Caspase-8(h)--> protein remnants (degradation)
parkin(h) + UbcH8(h) <==> parkin(h):UbcH8(h) (binding)
parkin(h) + Septin5(m) <==> parkin(h):Septin5(m) (binding)
parkin(h) + synaptotagmin-11(h) <==> parkin(h):synaptotagmin-11(h) (binding)
parkin(h) + Hsc70(h) <==> parkin(h):Hsc70(h) (binding)
parkin(h) + Hsp70-1(h) <==> parkin(h):Hsp70-1(h) (binding)
parkin(h) + TCP-1beta(h) <==> parkin(h):TCP-1beta(h) (binding)
parkin(h) + TCP-1alpha(h) <==> parkin(h):TCP-1alpha(h) (binding)
Glup(h) + parkin(h) <==> Glup(h):parkin(h) (binding)
parkin(h) + S8(h) <==> parkin(h):S8(h) (binding)
parkin(h) + 26S proteasome(b) <==> parkin(h):26S proteasome(b) (binding)
parkin(h) + CHIP(h) <==> parkin(h):CHIP(h) (binding)
parkin(h) + Pael-R(h) <==> parkin(h):Pael-R(h) (binding)
parkin(h) + HSJ2(h) <==> parkin(h):HSJ2(h) (binding)
parkin(h) + CHIP(m) <==> parkin(h):CHIP(m) (binding)
parkin(h) + Pael-R(h){ub(n)} <==> parkin(h):Pael-R(h){ub(n)} (binding)
parkin(h) + vimentin(mo) <==> parkin(h):vimentin(mo) (binding)
parkin(h) + Hsp70(mo) <==> parkin(h):Hsp70(mo) (binding)
parkin(h) + Hsp40(mo) <==> parkin(h):Hsp40(mo) (binding)
parkin(h) + GRP78(mo) <==> parkin(h):GRP78(mo) (binding)
parkin(h) + NACP(mo) <==> parkin(h):NACP(mo) (binding)
parkin(h) + synphilin-1(mo) <==> parkin(h):synphilin-1(mo) (binding)
parkin(h) + Fbw7(h) <==> parkin(h):Fbw7(h) (binding)
parkin(h) + n ubiquitin(v.s.) --UbcH7(h),Fbw7(h)--> parkin(h){ub(n)} (ubiquitination)
Cul-1(h) + parkin(h) <==> Cul-1(h):parkin(h) (binding)
Cul-1(v.s.) + parkin(h) <==> Cul-1(v.s.):parkin(h) (binding)
parkin(h) + cyclinE(v.s.) <==> parkin(h):cyclinE(v.s.) (binding)
parkin(h) + n ubiquitin(h) --> parkin(h){ub(n)} (ubiquitination)
BAG5(h) + parkin(h) <==> BAG5(h):parkin(h) (binding; decrease of ubiquitination)
Pael-R(m.s.) + parkin(h) <==> Pael-R(m.s.):parkin(h) (binding)
parkin(h) + ETB(m.s.) <==> parkin(h):ETB(m.s.) (binding)
parkin(h) + Ubc7(h) <==> parkin(h):Ubc7(h) (binding)
Ubc6(h) + parkin(h) <==> Ubc6(h):parkin(h) (binding)
parkin(h) + Septin4-isoform1(h) <==> parkin(h):Septin4-isoform1(h) (binding)
parkin(h) + RanBP2(h) <==> parkin(h):RanBP2(h) (binding)
parkin(h) + RanBP2(h) <==> parkin(h):RanBP2(h) (binding)
parkin(h) + HDAC4(m.s.) <==> parkin(h):HDAC4(m.s.) (binding)
parkin(h) + NRDP1(h) <==> parkin(h):NRDP1(h) (binding)
parkin(h) + 14-3-3eta(h) <==> parkin(h):14-3-3eta(h) (binding)
parkin(h) + S5a(m) <==> parkin(h):S5a(m) (binding)
parkin(h) + JTV-1(h) <==> parkin(h):JTV-1(h) (binding)
FBP-Isoform 1(h) + parkin(h) <==> FBP-Isoform 1(h):parkin(h) (binding)
parkin(h) + ATP --> parkin(h){p} + ADP (phosphorylation)
parkin(h) + IKK-gamma(h) <==> parkin(h):IKK-gamma(h) (binding)
parkin(h) + TRAF2(h) <==> parkin(h):TRAF2(h) (binding)
parkin(h) --> JNK1(h){pT183}{pY185} (decrease of phosphorylation)
parkin(h) --> JNK2(h){pT183}{pY185} (decrease of phosphorylation)
parkin(h) --> c-Jun(h){pS63} (decrease of phosphorylation)
parkin(h) --> c-Jun(h){pS73} (decrease of phosphorylation)
Pink1(h) + parkin(h) <==> Pink1(h):parkin(h) (binding)
parkin(h) --> PARP-p89(h) (decrease of cleavage)
parkin(h) --> Caspase-3-p17(h) (decrease of cleavage)
parkin(h) --> Caspase-3-p19(h) (decrease of cleavage)
parkin(h) + DJ-1(h) <==> parkin(h):DJ-1(h) (binding)
parkin(h) + DAT(m) <==> parkin(h):DAT(m) (binding)
parkin(h) --> parkin-p38(h) + protein remnants (cleavage)
parkin(h) --> parkin-p12(h) + parkin-p38(h) + protein remnants (cleavage)
parkin(h) + TRIP-13(h) <==> parkin(h):TRIP-13(h) (binding)
PARK2(h) --> parkin(h) (expression).
NACP(h){gly} + n ubiquitin(v.s.) --E1(v.s.),UbcH7(h),parkin(h),ATP--> NACP(h){gly}{ub(n)} (ubiquitination)
synphilin-1(v.s.) + n ubiquitin(v.s.) --parkin(h)--> synphilin-1(v.s.){ub(n)} (ubiquitination)
Septin5(m) + ubiquitin(v.s.) --parkin(h)--> Septin5(m){ub} (ubiquitination)
synaptotagmin-11(h) + n ubiquitin(v.s.) --parkin(h)--> synaptotagmin-11(h){ub(n)} (ubiquitination)
Pael-R(h) + n ubiquitin(v.s.) --E1(h),UbcH7(h),parkin(h)--> Pael-R(h){ub(n)} (ubiquitination)
cyclinE(v.s.) + n ubiquitin(v.s.) --E1(y),UbcH7(h),parkin(h)--> cyclinE(v.s.){ub(n)} (ubiquitination)
Pael-R(m.s.) + ubiquitin(m.s.) --parkin(h),E1(m.s.),UbcH7(m.s.)--> Pael-R(m.s.){ub} (ubiquitination)
FBP-Isoform 1(h) + ubiquitin(h) --parkin(h)--> FBP-Isoform 1(h){ub} (ubiquitination)
ubiquitin(h) + Hsp70-1(h) --parkin(h)--> Hsp70-1(h){ub(1)} (ubiquitination)
Hsp70-1(h) + 2 ubiquitin(h) --parkin(h)--> Hsp70-1(h){ub(2)} (ubiquitination)
DAT(m) + ubiquitin(m) --parkin(h)--> DAT(m){ub} (ubiquitination)
parkin-isoform1(h) + sumo1(m.s.) <==> parkin-isoform1(h):sumo1(m.s.) (binding)
parkin-isoform1(h) + ubiquitin(h) --> parkin-isoform1(h){ub} (ubiquitination; automodification)
JTV-1(h) + parkin-isoform1(h) <==> JTV-1(h):parkin-isoform1(h) (binding)
parkin-isoform1(h) + JTV1(h) <==> JTV1(h):parkin-isoform1(h) (binding)
sim2(h) + parkin-isoform1(h) <==> sim2(h):parkin-isoform1(h) (binding)
parkin-isoform1(h) + ARIH1(h) <==> parkin-isoform1(h):ARIH1(h) (binding)
UbcH7(m.s.) + parkin-isoform1(h) <==> UbcH7(m.s.):parkin-isoform1(h) (binding)
parkin-isoform1(h) + 14-3-3eta(m.s.) <==> parkin-isoform1(h):14-3-3eta(m.s.) (binding)
parkin-isoform1(h) + Synphilin-1(m.s.) <==> parkin-isoform1(h):Synphilin-1(m.s.) (binding)
parkin-isoform1(h) + XAPC7(h) <==> parkin-isoform1(h):XAPC7(h) (binding)
parkin-isoform1(h) + XAPC7-isoform1(h) <==> parkin-isoform1(h):XAPC7-isoform1(h) (binding)
LIMK1-isoform1(h) + parkin-isoform1(h) <==> LIMK1-isoform1(h):parkin-isoform1(h) (binding)
parkin-isoform1(h) + LIMK1-isoform1(h) + CHIP(h) <==> parkin-isoform1(h):LIMK1-isoform1(h):CHIP(h) (binding)
Hsp70-1(h) + parkin-isoform1(h) <==> Hsp70-1(h):parkin-isoform1(h) (binding)
parkin-isoform1(h) + ubiquitin(h) --E1(h),UbcH7(h),parkin-isoform1(h)--> parkin-isoform1(h){ub} (ubiquitination)
parkin-isoform1(h) + ubiquitin(h) --parkin-isoform1(h)--> parkin-isoform1(h){ub} (ubiquitination)
parkin-isoform1(h) + 5 ATP --> parkin-isoform1(h){pS101}{pS131}{pS136}{pS296}{pS378} + 5 ADP (phosphorylation)
parkin-isoform1(h) + 2 ATP --CKI-delta(r)--> parkin-isoform1(h){pS101}{pS378} + 2 ADP (phosphorylation)
parkin-isoform1(h) + ATP --PKAc(b)--> parkin-isoform1(h){pS} + ADP (phosphorylation)
parkin-isoform1(h) + ATP --PKC(r)--> parkin-isoform1(h){p} + ADP (phosphorylation)
parkin-isoform1(h) + IKK-gamma(h) <==> parkin-isoform1(h):IKK-gamma(h) (binding)
parkin-isoform1(h) + TRAF2(m.s.) <==> parkin-isoform1(h):TRAF2(m.s.) (binding)
parkin-isoform1(h) + NACP(m.s.) <==> parkin-isoform1(h):NACP(m.s.) (binding)
parkin-isoform1(h) --> PARP-p32(r) (increase of cleavage)
parkin-isoform1(h) + 2 NO --> parkin-isoform1(h){noC253}{noC368} (nitrosylation)
PARK2(h) --> parkin-isoform1(h) (expression).
JTV-1(h) + ubiquitin(h) --parkin-isoform1(h)--> JTV-1(h){ub} (ubiquitination)
Synphilin-1(m.s.) + ubiquitin(m.s.) --parkin-isoform1(h)--> Synphilin-1(m.s.){ub{K63}(n)} (ubiquitination)
JTV1(h) + ubiquitin(h) --parkin-isoform1(h)--> JTV1(h){ub} (ubiquitination)
LIMK1-isoform1(h) + ubiquitin(h) --parkin-isoform1(h)--> LIMK1-isoform1(h){ub} (ubiquitination)
LIMK1-isoform1(h) + ubiquitin(h) --E1(h),UbcH7(h),parkin-isoform1(h)--> LIMK1-isoform1(h){ub} (ubiquitination)
parkin-isoform1(h) + ubiquitin(h) --E1(h),UbcH7(h),parkin-isoform1(h)--> parkin-isoform1(h){ub} (ubiquitination)
parkin-isoform1(h) + ubiquitin(h) --parkin-isoform1(h)--> parkin-isoform1(h){ub} (ubiquitination)
PARK2(h) --> parkin-isoform2(h) (expression).
PARK2(h) --> parkin-isoform3(h) (expression).
PARK2(h) --> parkin-isoform4(h) (expression).
PARK2(h) --> parkin-isoform5(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

101Phosphoserine (CK1 alpha)15557340Phospho.ELM 6.0
378Phosphoserine (CK1 alpha)15557340Phospho.ELM 6.0
136Phosphoserine15557340Phospho.ELM 6.0
296Phosphoserine15557340Phospho.ELM 6.0
131Phosphoserine15557340Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr6

 Promoter: 163068290 - 163070290Agilent_014791

chr6

 Promoter: 163068290 - 163070290GSE27584

chr6

 Promoter: 163068290 - 163070290GSE27584

chr6

 Promoter: 163068290 - 163070290GSE27584

chr6

 Promoter: 163068290 - 163070290PMID:16287063

chr6

 Promoter: 163068290 - 163070290PMID:16287063

chr6

 Promoter: 163068290 - 163070290PMID:16287063

chr6

 Promoter: 163068290 - 163070290PMID:15198948

chr6

 Promoter: 163068290 - 163070290PMID:15198948

chr6

 Promoter: 163068290 - 163070290PMID:15198948

chr6

 Promoter: 163068290 - 163070290PMID:16192589

chr6

 Promoter: 163068290 - 163070290PMID:16192589

chr6

 Promoter: 163068290 - 163070290PMID:16192589

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