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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 55294 |
Name | FBXW7 |
Synonym | AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10;F-box and WD repeat domain containing 7;FBXW7;F-box and WD repeat domain containing 7 |
Definition | F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)|F-box protein FBW7|F-box protein FBX30|F-box protein SEL-10|F-box/WD repeat-containing protein 7|hAgo|hCdc4|homolog of C elegans sel-10 |
Position | 4q31.3 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 9 PubMed records as below. |
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Evidence Status |
Description |
reviewed | The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. |
reviewed | F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. |
reviewed | tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradation. |
reviewed | The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation. |
reviewed | The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. |
reviewed | The Fbxw7/hCdc4 tumor suppressor in human cancer. |
reviewed | FBXW7/hCDC4 is a general tumor suppressor in human cancer. |
potential | "FBW7 is a novel tumor suppressor in T cell leukemia, and its loss may be a potential mechanism of drug resistance in T-ALL". |
reviewed | The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. |
| More detail of all 9 literatures about FBXW7 | |
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Pathways and Diseases |
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Pathway | Notch signaling pathway;PANTHER;P00045 |
Pathway | Metabolism of proteins;Reactome;REACT:17015 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | C-MYC pathway;PID Curated;200093 |
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External Links |
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Links to Entrez Gene | 55294 |
Links to all GeneRIF Items | 55294 |
Links to iHOP | 55294 |
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Sequence Information |
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Nucleotide Sequence |
>55294 : length: 1770 atgtcaaaaccgggaaaacctactctaaaccatggcttggttcctgttgatcttaaaagt gcaaaagagcctctaccacatcaaactgtgatgaagatatttagcattagcatcattgcc caaggcctccctttttgtcgaagacggatgaaaagaaagttggaccatggttctgaggtc cgctctttttctttgggaaagaaaccatgcaaagtctcagaatatacaagtaccactggg cttgtaccatgttcagcaacaccaacaacttttggggacctcagagcagccaatggccaa gggcaacaacgacgccgaattacatctgtccagccacctacaggcctccaggaatggcta aaaatgtttcagagctggagtggaccagagaaattgcttgctttagatgaactcattgat agttgtgaaccaacacaagtaaaacatatgatgcaagtgatagaaccccagtttcaacga gacttcatttcattgctccctaaagagttggcactctatgtgctttcattcctggaaccc aaagacctgctacaagcagctcagacatgtcgctactggagaattttggctgaagacaac cttctctggagagagaaatgcaaagaagaggggattgatgaaccattgcacatcaagaga agaaaagtaataaaaccaggtttcatacacagtccatggaaaagtgcatacatcagacag cacagaattgatactaactggaggcgaggagaactcaaatctcctaaggtgctgaaagga catgatgatcatgtgatcacatgcttacagttttgtggtaaccgaatagttagtggttct gatgacaacactttaaaagtttggtcagcagtcacaggcaaatgtctgagaacattagtg ggacatacaggtggagtatggtcatcacaaatgagagacaacatcatcattagtggatct acagatcggacactcaaagtgtggaatgcagagactggagaatgtatacacaccttatat gggcatacttccactgtgcgttgtatgcatcttcatgaaaaaagagttgttagcggttct cgagatgccactcttagggtttgggatattgagacaggccagtgtttacatgttttgatg ggtcatgttgcagcagtccgctgtgttcaatatgatggcaggagggttgttagtggagca tatgattttatggtaaaggtgtgggatccagagactgaaacctgtctacacacgttgcag gggcatactaatagagtctattcattacagtttgatggtatccatgtggtgagtggatct cttgatacatcaatccgtgtttgggatgtggagacagggaattgcattcacacgttaaca gggcaccagtcgttaacaagtggaatggaactcaaagacaatattcttgtctctgggaat gcagattctacagttaaaatctgggatatcaaaacaggacagtgtttacaaacattgcaa ggtcccaacaagcatcagagtgctgtgacctgtttacagttcaacaagaactttgtaatt accagctcagatgatggaactgtaaaactatgggacttgaaaacgggtgaatttattcga aacctagtcacattggagagtggggggagtgggggagttgtgtggcggatcagagcctca aacacaaagctggtgtgtgcagttgggagtcggaatgggactgaagaaaccaagctgctg gtgctggactttgatgtggacatgaagtga |
Protein Sequence |
>55294 : length: 589 MSKPGKPTLNHGLVPVDLKSAKEPLPHQTVMKIFSISIIAQGLPFCRRRMKRKLDHGSEV RSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWL KMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEP KDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQ HRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGS RDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQ GHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGN ADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR NLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK |