Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

55294

Name

FBXW7

Synonymous

AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10;F-box and WD repeat domain containing 7;FBXW7;F-box and WD repeat domain containing 7

Definition

F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)|F-box protein FBW7|F-box protein FBX30|F-box protein SEL-10|F-box/WD repeat-containing protein 7|hAgo|hCdc4|homolog of C elegans sel-10

Position

4q31.3

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

Skp1(h) + Fbw7(h) <==> Skp1(h):Fbw7(h) (binding)
Cul-1(h) + Fbw7(h) <==> Cul-1(h):Fbw7(h) (binding)
cyclinE(m) + Fbw7(h) <==> cyclinE(m):Fbw7(h) (binding)
parkin(h) + Fbw7(h) <==> parkin(h):Fbw7(h) (binding)
Fbw7(h) + Skp1(v.s.) <==> Fbw7(h):Skp1(v.s.) (binding)
Fbw7(h) + cyclinE(v.s.) <==> Fbw7(h):cyclinE(v.s.) (binding)
Fbw7(h) + cyclinA1(v.s.) <==> Fbw7(h):cyclinA1(v.s.) (binding)
shprh(h) + Fbw7(h) <==> shprh(h):Fbw7(h) (binding)
Fbxw7(h) --> Fbw7(h) (expression).
parkin(h) + n ubiquitin(v.s.) --UbcH7(h),Fbw7(h)--> parkin(h){ub(n)} (ubiquitination)
Fbxw7(h) --> Fbw7-110k(h) (expression).

Post Transcriptional Modification From dbPTM

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There is no record for FBXW7

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr4

Promoter: 153675122 - 153677122Agilent_014791

chr4

Promoter: 153493060 - 153495060GSE27584

chr4

Promoter: 153675122 - 153677122GSE27584


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