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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5728 |
Name | PTEN |
Synonym | 10q23del|BZS|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1;phosphatase and tensin homolog;PTEN;phosphatase and tensin homolog |
Definition | MMAC1 phosphatase and tensin homolog deleted on chromosome 10|mutated in multiple advanced cancers 1|phosphatase and tensin-like protein|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
Position | 10q23.3 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,Generif,UniProt |
Literature support | Count: 136 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas." |
reviewed | Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. |
reviewed | "Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN." |
reviewed | "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate." |
reviewed | Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. |
reviewed | "these results provide further support for the existence of a DNA damage-inducible size checkpoint that is regulated by a major tumor suppressor, and they provide a novel Akt-independent mechanism by which PTEN controls cell size." |
reviewed | Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells. |
| More detail of all 136 literatures about PTEN | |
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Pathways and Diseases |
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Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism;BioCyc;PWY-6358 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | RhoA signaling pathway;PID Curated;200007 |
Pathway | mtor signaling pathway;PID BioCarta;100101 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway;PID BioCarta;100137 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | ctcf: first multivalent nuclear factor;PID BioCarta;100194 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Hypoxia response via HIF activation;PANTHER;P00030 |
Pathway | Inositol phosphate metabolism;KEGG PATHWAY;hsa00562 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | AP-1 transcription factor network;PID Curated;200118 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | D-myo-inositol (1,3,4)-trisphosphate biosynthesis;BioCyc;PWY-6364 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | 3-phosphoinositide degradation;BioCyc;PWY-6368 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | regulation of eif-4e and p70s6 kinase;PID BioCarta;100178 |
Disease | Cancers of the lung and pleura;KEGG DISEASE |
Disease | PTEN hamartoma tumor syndrome;OMIM |
Disease | Meningioma;OMIM |
Disease | Skin cancers;KEGG DISEASE |
Disease | glioblastoma multiforme;GAD |
Disease | Vulvar cancer;KEGG DISEASE;H00029 |
Disease | VATER association with macrocephaly and ventriculomegaly;OMIM |
Disease | anaplastic astrocytoma;GAD |
Disease | Macrocephaly/autism syndrome;OMIM |
Disease | brain cancer;GAD |
Disease | prostate cancer;GAD |
Disease | METABOLIC;GAD |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Breast cancer;KEGG DISEASE;H00031 |
Disease | diabetes, type 2;GAD |
Disease | CHEMDEPENDENCY;GAD |
Disease | Glioma susceptibility 2;OMIM |
Disease | Hepatocellular carcinoma;KEGG DISEASE;H00048 |
Disease | Prostate cancer, somatic;OMIM |
Disease | CANCER;GAD |
Disease | Endometrial cancer;KEGG DISEASE;H00026 |
Disease | nicotine dependence;GAD |
Disease | smoking behavior;GAD |
Disease | Cancers of the breast and female genital organs;KEGG DISEASE |
Disease | Cancers of the nervous system;KEGG DISEASE |
Disease | Cancers;KEGG DISEASE |
Disease | Small cell lung cancer;KEGG DISEASE;H00013 |
Disease | Glioma;KEGG DISEASE;H00042 |
Disease | Cancers of the urinary system and male genital organs;KEGG DISEASE |
Disease | Malignant melanoma;KEGG DISEASE;H00038 |
Disease | Prostate cancer;KEGG DISEASE;H00024 |
Disease | Bannayan-Riley-Ruvalcaba syndrome;OMIM |
Disease | Cowden disease;OMIM |
Disease | ovarian cancer;GAD |
Disease | Lhermitte-Duclos syndrome;OMIM |
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External Links |
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Links to Entrez Gene | 5728 |
Links to all GeneRIF Items | 5728 |
Links to iHOP | 5728 |
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Sequence Information |
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Nucleotide Sequence |
>5728 : length: 1212 atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaagaggatgga ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag cataaaaaccattacaagatatacaatctttgtgctgaaagacattatgacaccgccaaa tttaattgcagagttgcacaatatccttttgaagaccataacccaccacagctagaactt atcaaacccttttgtgaagatcttgaccaatggctaagtgaagatgacaatcatgttgca gcaattcactgtaaagctggaaagggacgaactggtgtaatgatatgtgcatatttatta catcggggcaaatttttaaaggcacaagaggccctagatttctatggggaagtaaggacc agagacaaaaagggagtaactattcccagtcagaggcgctatgtgtattattatagctac ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagcta aaggtgaagatatattcctccaattcaggacccacacgacgggaagacaagttcatgtac tttgagttccctcagccgttacctgtgtgtggtgatatcaaagtagagttcttccacaaa cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaatacattcttcata ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctatgtgatcaagaaatc gatagcatttgcagtatagagcgtgcagataatgacaaggaatatctagtacttacttta acaaaaaatgatcttgacaaagcaaataaagacaaagccaaccgatacttttctccaaat tttaaggtgaagctgtacttcacaaaaacagtagaggagccgtcaaatccagaggctagc agttcaacttctgtaacaccagatgttagtgacaatgaacctgatcattatagatattct gacaccactgactctgatccagagaatgaaccttttgatgaagatcagcatacacaaatt acaaaagtctga |
Protein Sequence |
>5728 : length: 403 MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV |