Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5728

Name

PTEN

Synonym

10q23del|BZS|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1;phosphatase and tensin homolog;PTEN;phosphatase and tensin homolog

Definition

MMAC1 phosphatase and tensin homolog deleted on chromosome 10|mutated in multiple advanced cancers 1|phosphatase and tensin-like protein|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Position

10q23.3

Gene Type

protein-coding

Source

Count: 4; Pubmed_search,TAG,Generif,UniProt

Literature support

Count: 136 PubMed records as below.

Evidence Status

Description

reviewed

"tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas."

reviewed

Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.

reviewed

"Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN."

reviewed

"The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate."

reviewed

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.

reviewed

"these results provide further support for the existence of a DNA damage-inducible size checkpoint that is regulated by a major tumor suppressor, and they provide a novel Akt-independent mechanism by which PTEN controls cell size."

reviewed

Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells.
More detail of all 136 literatures about PTEN

Pathways and Diseases

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Tight junction;KEGG PATHWAY;hsa04530

Pathway

superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism;BioCyc;PWY-6358

Pathway

Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070

Pathway

Small cell lung cancer;KEGG PATHWAY;hsa05222

Pathway

Direct p53 effectors;PID Curated;200101

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

RhoA signaling pathway;PID Curated;200007

Pathway

mtor signaling pathway;PID BioCarta;100101

Pathway

PDGFR-beta signaling pathway;PID Curated;200127

Pathway

Class I PI3K signaling events;PID Curated;200098

Pathway

BCR signaling pathway;PID Curated;200005

Pathway

TCR signaling in naive CD4+ T cells;PID Curated;200022

Pathway

pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

skeletal muscle hypertrophy is regulated via akt-mtor pathway;PID BioCarta;100137

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

PI3 kinase pathway;PANTHER;P00048

Pathway

ctcf: first multivalent nuclear factor;PID BioCarta;100194

Pathway

p53 pathway;PANTHER;P00059

Pathway

Hypoxia response via HIF activation;PANTHER;P00030

Pathway

Inositol phosphate metabolism;KEGG PATHWAY;hsa00562

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

AP-1 transcription factor network;PID Curated;200118

Pathway

Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

D-myo-inositol (1,3,4)-trisphosphate biosynthesis;BioCyc;PWY-6364

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

3-phosphoinositide degradation;BioCyc;PWY-6368

Pathway

p53 pathway feedback loops 2;PANTHER;P04398

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

regulation of eif-4e and p70s6 kinase;PID BioCarta;100178

Disease

Cancers of the lung and pleura;KEGG DISEASE

Disease

PTEN hamartoma tumor syndrome;OMIM

Disease

Meningioma;OMIM

Disease

Skin cancers;KEGG DISEASE

Disease

glioblastoma multiforme;GAD

Disease

Vulvar cancer;KEGG DISEASE;H00029

Disease

VATER association with macrocephaly and ventriculomegaly;OMIM

Disease

anaplastic astrocytoma;GAD

Disease

Macrocephaly/autism syndrome;OMIM

Disease

brain cancer;GAD

Disease

prostate cancer;GAD

Disease

METABOLIC;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Breast cancer;KEGG DISEASE;H00031

Disease

diabetes, type 2;GAD

Disease

CHEMDEPENDENCY;GAD

Disease

Glioma susceptibility 2;OMIM

Disease

Hepatocellular carcinoma;KEGG DISEASE;H00048

Disease

Prostate cancer, somatic;OMIM

Disease

CANCER;GAD

Disease

Endometrial cancer;KEGG DISEASE;H00026

Disease

nicotine dependence;GAD

Disease

smoking behavior;GAD

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

Cancers of the nervous system;KEGG DISEASE

Disease

Cancers;KEGG DISEASE

Disease

Small cell lung cancer;KEGG DISEASE;H00013

Disease

Glioma;KEGG DISEASE;H00042

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

Malignant melanoma;KEGG DISEASE;H00038

Disease

Prostate cancer;KEGG DISEASE;H00024

Disease

Bannayan-Riley-Ruvalcaba syndrome;OMIM

Disease

Cowden disease;OMIM

Disease

ovarian cancer;GAD

Disease

Lhermitte-Duclos syndrome;OMIM

External Links

Links to Entrez Gene

5728

Links to all GeneRIF Items

5728

Links to iHOP

5728

Sequence Information

Nucleotide Sequence

>5728 : length: 1212
atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaagaggatgga
ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa
agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag
cataaaaaccattacaagatatacaatctttgtgctgaaagacattatgacaccgccaaa
tttaattgcagagttgcacaatatccttttgaagaccataacccaccacagctagaactt
atcaaacccttttgtgaagatcttgaccaatggctaagtgaagatgacaatcatgttgca
gcaattcactgtaaagctggaaagggacgaactggtgtaatgatatgtgcatatttatta
catcggggcaaatttttaaaggcacaagaggccctagatttctatggggaagtaaggacc
agagacaaaaagggagtaactattcccagtcagaggcgctatgtgtattattatagctac
ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt
gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagcta
aaggtgaagatatattcctccaattcaggacccacacgacgggaagacaagttcatgtac
tttgagttccctcagccgttacctgtgtgtggtgatatcaaagtagagttcttccacaaa
cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaatacattcttcata
ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctatgtgatcaagaaatc
gatagcatttgcagtatagagcgtgcagataatgacaaggaatatctagtacttacttta
acaaaaaatgatcttgacaaagcaaataaagacaaagccaaccgatacttttctccaaat
tttaaggtgaagctgtacttcacaaaaacagtagaggagccgtcaaatccagaggctagc
agttcaacttctgtaacaccagatgttagtgacaatgaacctgatcattatagatattct
gacaccactgactctgatccagagaatgaaccttttgatgaagatcagcatacacaaatt
acaaaagtctga

Protein Sequence

>5728 : length: 403
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV



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