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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 5728 |
Name | PTEN |
Synonymous | 10q23del|BZS|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1;phosphatase and tensin homolog;PTEN;phosphatase and tensin homolog |
Definition | MMAC1 phosphatase and tensin homolog deleted on chromosome 10|mutated in multiple advanced cancers 1|phosphatase and tensin-like protein|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
Position | 10q23.3 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
interacts with |
MAGI3 | BIOGRID; PUBMED:10748157; |
interacts with |
MVP | BIOGRID; PUBMED:12177006; |
interacts with |
NEDD4 | BIOGRID; PUBMED:18498243; |
interacts with |
ESR1 | BIOGRID; PUBMED:15205473; |
interacts with |
HBA1 | BIOGRID; PUBMED:16169070; |
interacts with |
CAV1 | BIOGRID; PUBMED:12176037; |
interacts with |
PTK2 | BIOGRID; PUBMED:10400703; |
interacts with |
PTK2 | BIOGRID; PUBMED:11857088; |
interacts with |
CSNK2A1 | BIOGRID; PUBMED:12297295; |
interacts with |
COPS6 | BIOGRID; PUBMED:16169070; |
interacts with |
CSNK2A2 | BIOGRID; PUBMED:12297295; |
interacts with |
ANG | BIOGRID; PUBMED:16169070; |
interacts with |
AR | BIOGRID; PUBMED:15205473; |
interacts with |
UTP14A | BIOGRID; PUBMED:16169070; |
interacts with |
UBE2I | BIOGRID; PUBMED:12620973; |
interacts with |
UBE2L3 | BIOGRID; PUBMED:12620973; |
interacts with |
CHGB | BIOGRID; PUBMED:16169070; |
interacts with |
TP53 | BIOGRID; PUBMED:12620407; |
interacts with |
PXN | BIOGRID; PUBMED:11857088; |
interacts with |
AR | CELL_MAP; PUBMED:15205473; |
interacts with |
MAST3 | HPRD; PUBMED:15951562; |
interacts with |
MAST1 | HPRD; PUBMED:15951562; |
interacts with |
MAGI3 | HPRD; PUBMED:10748157; |
interacts with |
MAGI2 | HPRD; PUBMED:10760291; |
interacts with |
MAST2 | HPRD; PUBMED:15951562; |
interacts with |
SLC9A3R2 | HPRD; PUBMED:16456542; |
interacts with |
MVP | HPRD; PUBMED:12177006; |
interacts with |
SLC9A3R1 | HPRD; PUBMED:16456542; |
interacts with |
HBA1 | HPRD; PUBMED:16169070; |
interacts with |
CAV1 | HPRD; PUBMED:12176037; |
interacts with |
CSNK2A1 | HPRD; PUBMED:12297295; |
interacts with |
COPS6 | HPRD; PUBMED:16169070; |
interacts with |
CSNK2A2 | HPRD; PUBMED:12297295; |
interacts with |
DLG1 | HPRD; PUBMED:10646847; |
interacts with |
ANG | HPRD; PUBMED:16169070; |
interacts with |
AR | HPRD; PUBMED:15205473; |
interacts with |
AKT1 | HPRD; PUBMED:12077256; |
interacts with |
PDGFRB | HPRD; PUBMED:16456542; |
interacts with |
PPP1CA | HPRD; PUBMED:17274640; |
interacts with |
STK11 | HPRD; PUBMED:15987703; |
interacts with |
UTP14A | HPRD; PUBMED:16169070; |
interacts with |
UBE2I | HPRD; PUBMED:12620973; |
interacts with |
UBE2L3 | HPRD; PUBMED:12620973; |
interacts with |
CHGB | HPRD; PUBMED:16169070; |
interacts with |
PXN | HPRD; PUBMED:11857088; |
interacts with |
CDC27 | INTACT; PUBMED:21241890; |
interacts with |
ANAPC7 | INTACT; PUBMED:21241890; |
interacts with |
ANAPC4 | INTACT; PUBMED:21241890; |
interacts with |
ANAPC5 | INTACT; PUBMED:21241890; |
interacts with |
MAGI3 | MINT; PUBMED:10748157; |
interacts with |
SLC9A3R2 | MINT; PUBMED:16456542; |
interacts with |
SLC9A3R1 | MINT; PUBMED:16456542; |
interacts with |
HBA1 | MINT; PUBMED:16169070; |
interacts with |
CAV1 | MINT; PUBMED:12176037; |
interacts with |
Slc9a3r2 | MINT; PUBMED:16456542; |
interacts with |
COPS6 | MINT; PUBMED:16169070; |
interacts with |
PRDX1 | MINT; DOI:10.1038/emboj.2009.101; |
interacts with |
PDGFRB | MINT; PUBMED:16456542; |
interacts with |
UTP14A | MINT; PUBMED:16169070; |
interacts with |
CHGB | MINT; PUBMED:16169070; |
Metabolic Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
metabolic catalysis |
JUN | NCI_NATURE; PUBMED:16676006; |
metabolic catalysis |
TP53 | NCI_NATURE; PUBMED:11545734;PUBMED:17409411; |
Signaling Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
reacts with |
PTEN | NCI_NATURE; PUBMED:16456542; |
reacts with |
PDGFRB | NCI_NATURE; PUBMED:16456542; |
reacts with |
PDGFB | NCI_NATURE; PUBMED:16456542; |