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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 5728 |
Name | PTEN |
Synonymous | 10q23del|BZS|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1;phosphatase and tensin homolog;PTEN;phosphatase and tensin homolog |
Definition | MMAC1 phosphatase and tensin homolog deleted on chromosome 10|mutated in multiple advanced cancers 1|phosphatase and tensin-like protein|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
Position | 10q23.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
|
Regulation From TransFac database |
MVP(h) + PTEN(h) <==> MVP(h):PTEN(h) (binding) | PTEN(h) + 2 ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> PTEN(h){pS370}{pS385} + 2 ADP (phosphorylation) | CKII-alpha(h) + PTEN(h) <==> CKII-alpha(h):PTEN(h) (binding) | PTEN(h) + 5 ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> PTEN(h){pS370}{pS380}{pT382}{pT383}{pS385} + 5 ADP (phosphorylation) | PTEN(h) + 5 ATP --CKII(mo)--> PTEN(h){pS370}{pS380}{pT382}{pT383}{pS385} + 5 ADP (phosphorylation) | p300(h) + PTEN(h) <==> p300(h):PTEN(h) (binding) | p53(h) + PTEN(h) <==> p53(h):PTEN(h) (binding) | PTEN(h) + 3 ATP --> PTEN(h){pS380}{pT381}{pT382} + 3 ADP (phosphorylation) | PTEN(h) + ubiquitin(h) --> PTEN(h){ub} (ubiquitination) | PTEN(h) --> AKT-1(h){pT308}{pS473} (decrease of phosphorylation) | PTEN(h) --> p21Cip1(h) (increase of abundance) | PTEN(h) --/ Skp2(h) (decrease of abundance) | PTEN(h) --> AKT-1(h){pS473} (decrease of phosphorylation) | HAUSP(h) + PTEN(h) <==> HAUSP(h):PTEN(h) (binding) | PTEN(h) + HAUSP(m.s.) <==> PTEN(h):HAUSP(m.s.) (binding) | PTEN(h) --> PTEN(h) (expression). | estradiol --/ PTEN(h) (decrease of abundance) | p53(h) --> PTEN(h) (increase of abundance) | p53(m.s.) --> PTEN(h) (increase of abundance) | mdm2(m.s.) --/ PTEN(h) (decrease of abundance) | p16INK4a(m.s.) --> PTEN(h) (increase of abundance) | estradiol --> PTEN(h) (increase of abundance) | Fzr(h) --/ PTEN(h) (decrease of abundance) | PTEN(h){ub} --HAUSP(m.s.)--> PTEN(h) + ubiquitin(h) (deubiquitination) | PIP3 --PTEN(h)--> PIP2 + p (dephosphorylation) | PtdIns(3,4)P2 --PTEN(h)--> PtdIns(4)P + p (dephosphorylation) | PtdIns(3)P --PTEN(h)--> PtdIns + p (dephosphorylation) | Ins(1,3,4,5)P4 --PTEN(h)--> IP3 + p (dephosphorylation) | PTEN(h) --> p38(m.s.){p} (decrease of phosphorylation) | PTEN(h) --> PTEN(h) (expression). | PTEN(h) --> PTEN(h) (expression). | hsa-miR-19a --/ PTEN(h) (predicted) | hsa-miR-19b --/ PTEN(h) (predicted) | hsa-miR-214 --/ PTEN(h) (translational repression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
366 | Phosphothreonine. | Swiss-Prot 53.0 | 370 | Phosphoserine (by CK2). | Swiss-Prot 53.0 | 385 | Phosphoserine (by CK2). | Swiss-Prot 53.0 | 401 | Phosphothreonine. | Swiss-Prot 53.0 | 383 | Phosphothreonine | 10866658 | Phospho.ELM 6.0 | 380 | Phosphoserine (CK2 alpha;PK) | 12077256;10866658;11035045 | Phospho.ELM 6.0 | 382 | Phosphothreonine (CK2 alpha) | 10866658;11035045 | Phospho.ELM 6.0 | 240 | Phosphotyrosine (Lck) | 11948419 | Phospho.ELM 6.0 | 315 | Phosphotyrosine (Lck) | 11948419 | Phospho.ELM 6.0 | 229 | Phosphoserine (ROCK1) | 15793569 | Phospho.ELM 6.0 | 232 | Phosphothreonine (ROCK1) | 15793569 | Phospho.ELM 6.0 | 362 | Phosphoserine (GSK-3beta) | 16107342 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr10 |
Promoter: 89611675 - 89613675 | Agilent_014791 |
chr10 |
Promoter: 89611675 - 89613675 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 89611675 - 89613675 | GSE27584 |
chr10 |
Promoter: 89611675 - 89613675 | Agilent_014791 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:16889486 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15196854 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:16928264 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15198948 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:16192589 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:17177027 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15389252 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15126336 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:16818626 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15596045 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:16258501 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15891996 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:11896207 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15382065 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15662588 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:12660822 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:16739377 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15975525 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:16983315 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:12006535 |
chr10 |
Promoter: 89611675 - 89613675 | PMID:15547698 |