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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 675 |
Name | BRCA2 |
Synonym | BRCC2|BROVCA2|FACD|FAD|FAD1|FANCB|FANCD|FANCD1|GLM3|PNCA2;breast cancer 2, early onset;BRCA2;breast cancer 2, early onset |
Definition | BRCA1/BRCA2-containing complex, subunit 2|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer susceptibility protein BRCA2|breast cancer type 2 susceptibility protein|fanconi anemia group D1 protein |
Position | 13q12.3 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,Generif,UniProt |
Literature support | Count: 11 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. |
reviewed | A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor. |
reviewed | The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. |
reviewed | Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection. |
reviewed | Evidence that the tumor-suppressor protein BRCA2 does not regulate cytokinesis in human cells. |
reviewed | CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. |
reviewed | "These observations are consistent with the idea that BRCA2, but not BRCA1, is a tumor suppressor of prostate cancer." |
reviewed | Molecular genetic analysis of the BRCA2 tumor suppressor gene region in cutaneous squamous cell carcinomas. |
reviewed | risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. |
reviewed | Phytoestrogen-rich diets modulate expression of Brca1 and Brca2 tumor suppressor genes in mammary glands of female Wistar rats. |
| More detail of all 11 literatures about BRCA2 | |
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Pathways and Diseases |
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Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Fanconi Anemia pathway;PID Reactome;500068 |
Pathway | Homologous recombination;KEGG PATHWAY;hsa03440 |
Pathway | Presynaptic phase of homologous DNA pairing and strand exchange;PID Reactome;501013 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Disease | Prostate cancer;OMIM |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | Breast-ovarian cancer, familial, 2;OMIM |
Disease | Pancreatic cancer;KEGG DISEASE;H00019 |
Disease | Glioblastoma 3;OMIM |
Disease | Pancreatic cancer;OMIM |
Disease | breast cancer, male;GAD |
Disease | Cancer;FunDO |
Disease | Fanconi anemia, complementation group D1;OMIM |
Disease | Wilms tumor;OMIM |
Disease | prenatal viability;GAD |
Disease | Medulloblastoma;OMIM |
Disease | Fanconi's anemia;FunDO |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | lung cancer;GAD |
Disease | prophylactic breast surgery;GAD |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Infertility, Male;FunDO |
Disease | Neoplasms;GAD |
Disease | Breast cancer;KEGG DISEASE;H00031 |
Disease | Fanconi anemia;KEGG DISEASE;H00238 |
Disease | Ovarian cancer;KEGG DISEASE;H00027 |
Disease | CANCER;GAD |
Disease | Cancers of the breast and female genital organs;KEGG DISEASE |
Disease | Endometriosis;FunDO |
Disease | Breast cancer, male, susceptibility to;OMIM |
Disease | Cancers;KEGG DISEASE |
Disease | Oligospermia;FunDO |
Disease | Pre-B-cell acute lymphoblastic leukemia;OMIM |
Disease | Abortion;FunDO |
Disease | Prostate cancer;FunDO |
Disease | breast cancer;GAD |
Disease | Azoospermia;FunDO |
Disease | breast cancer risk and prenatal viability;GAD |
Disease | ovarian cancer;GAD |
Disease | stomach cancer;GAD |
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External Links |
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Links to Entrez Gene | 675 |
Links to all GeneRIF Items | 675 |
Links to iHOP | 675 |
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Sequence Information |
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Nucleotide Sequence |
>675 : length: 10257 atgcctattggatccaaagagaggccaacattttttgaaatttttaagacacgctgcaac aaagcagatttaggaccaataagtcttaattggtttgaagaactttcttcagaagctcca ccctataattctgaacctgcagaagaatctgaacataaaaacaacaattacgaaccaaac ctatttaaaactccacaaaggaaaccatcttataatcagctggcttcaactccaataata ttcaaagagcaagggctgactctgccgctgtaccaatctcctgtaaaagaattagataaa ttcaaattagacttaggaaggaatgttcccaatagtagacataaaagtcttcgcacagtg aaaactaaaatggatcaagcagatgatgtttcctgtccacttctaaattcttgtcttagt gaaagtcctgttgttctacaatgtacacatgtaacaccacaaagagataagtcagtggta tgtgggagtttgtttcatacaccaaagtttgtgaagggtcgtcagacaccaaaacatatt tctgaaagtctaggagctgaggtggatcctgatatgtcttggtcaagttctttagctaca ccacccacccttagttctactgtgctcatagtcagaaatgaagaagcatctgaaactgta tttcctcatgatactactgctaatgtgaaaagctatttttccaatcatgatgaaagtctg aagaaaaatgatagatttatcgcttctgtgacagacagtgaaaacacaaatcaaagagaa gctgcaagtcatggatttggaaaaacatcagggaattcatttaaagtaaatagctgcaaa gaccacattggaaagtcaatgccaaatgtcctagaagatgaagtatatgaaacagttgta gatacctctgaagaagatagtttttcattatgtttttctaaatgtagaacaaaaaatcta caaaaagtaagaactagcaagactaggaaaaaaattttccatgaagcaaacgctgatgaa tgtgaaaaatctaaaaaccaagtgaaagaaaaatactcatttgtatctgaagtggaacca aatgatactgatccattagattcaaatgtagcaaatcagaagccctttgagagtggaagt gacaaaatctccaaggaagttgtaccgtctttggcctgtgaatggtctcaactaaccctt tcaggtctaaatggagcccagatggagaaaatacccctattgcatatttcttcatgtgac caaaatatttcagaaaaagacctattagacacagagaacaaaagaaagaaagattttctt acttcagagaattctttgccacgtatttctagcctaccaaaatcagagaagccattaaat gaggaaacagtggtaaataagagagatgaagagcagcatcttgaatctcatacagactgc attcttgcagtaaagcaggcaatatctggaacttctccagtggcttcttcatttcagggt atcaaaaagtctatattcagaataagagaatcacctaaagagactttcaatgcaagtttt tcaggtcatatgactgatccaaactttaaaaaagaaactgaagcctctgaaagtggactg gaaatacatactgtttgctcacagaaggaggactccttatgtccaaatttaattgataat ggaagctggccagccaccaccacacagaattctgtagctttgaagaatgcaggtttaata tccactttgaaaaagaaaacaaataagtttatttatgctatacatgatgaaacatcttat aaaggaaaaaaaataccgaaagaccaaaaatcagaactaattaactgttcagcccagttt gaagcaaatgcttttgaagcaccacttacatttgcaaatgctgattcaggtttattgcat tcttctgtgaaaagaagctgttcacagaatgattctgaagaaccaactttgtccttaact agctcttttgggacaattctgaggaaatgttctagaaatgaaacatgttctaataataca gtaatctctcaggatcttgattataaagaagcaaaatgtaataaggaaaaactacagtta tttattaccccagaagctgattctctgtcatgcctgcaggaaggacagtgtgaaaatgat ccaaaaagcaaaaaagtttcagatataaaagaagaggtcttggctgcagcatgtcaccca gtacaacattcaaaagtggaatacagtgatactgactttcaatcccagaaaagtctttta tatgatcatgaaaatgccagcactcttattttaactcctacttccaaggatgttctgtca aacctagtcatgatttctagaggcaaagaatcatacaaaatgtcagacaagctcaaaggt aacaattatgaatctgatgttgaattaaccaaaaatattcccatggaaaagaatcaagat gtatgtgctttaaatgaaaattataaaaacgttgagctgttgccacctgaaaaatacatg agagtagcatcaccttcaagaaaggtacaattcaaccaaaacacaaatctaagagtaatc caaaaaaatcaagaagaaactacttcaatttcaaaaataactgtcaatccagactctgaa gaacttttctcagacaatgagaataattttgtcttccaagtagctaatgaaaggaataat cttgctttaggaaatactaaggaacttcatgaaacagacttgacttgtgtaaacgaaccc attttcaagaactctaccatggttttatatggagacacaggtgataaacaagcaacccaa gtgtcaattaaaaaagatttggtttatgttcttgcagaggagaacaaaaatagtgtaaag cagcatataaaaatgactctaggtcaagatttaaaatcggacatctccttgaatatagat aaaataccagaaaaaaataatgattacatgaacaaatgggcaggactcttaggtccaatt tcaaatcacagttttggaggtagcttcagaacagcttcaaataaggaaatcaagctctct gaacataacattaagaagagcaaaatgttcttcaaagatattgaagaacaatatcctact agtttagcttgtgttgaaattgtaaataccttggcattagataatcaaaagaaactgagc aagcctcagtcaattaatactgtatctgcacatttacagagtagtgtagttgtttctgat tgtaaaaatagtcatataacccctcagatgttattttccaagcaggattttaattcaaac cataatttaacacctagccaaaaggcagaaattacagaactttctactatattagaagaa tcaggaagtcagtttgaatttactcagtttagaaaaccaagctacatattgcagaagagt acatttgaagtgcctgaaaaccagatgactatcttaaagaccacttctgaggaatgcaga gatgctgatcttcatgtcataatgaatgccccatcgattggtcaggtagacagcagcaag caatttgaaggtacagttgaaattaaacggaagtttgctggcctgttgaaaaatgactgt aacaaaagtgcttctggttatttaacagatgaaaatgaagtggggtttaggggcttttat tctgctcatggcacaaaactgaatgtttctactgaagctctgcaaaaagctgtgaaactg tttagtgatattgagaatattagtgaggaaacttctgcagaggtacatccaataagttta tcttcaagtaaatgtcatgattctgttgtttcaatgtttaagatagaaaatcataatgat aaaactgtaagtgaaaaaaataataaatgccaactgatattacaaaataatattgaaatg actactggcacttttgttgaagaaattactgaaaattacaagagaaatactgaaaatgaa gataacaaatatactgctgccagtagaaattctcataacttagaatttgatggcagtgat tcaagtaaaaatgatactgtttgtattcataaagatgaaacggacttgctatttactgat cagcacaacatatgtcttaaattatctggccagtttatgaaggagggaaacactcagatt aaagaagatttgtcagatttaacttttttggaagttgcgaaagctcaagaagcatgtcat ggtaatacttcaaataaagaacagttaactgctactaaaacggagcaaaatataaaagat tttgagacttctgatacattttttcagactgcaagtgggaaaaatattagtgtcgccaaa gagtcatttaataaaattgtaaatttctttgatcagaaaccagaagaattgcataacttt tccttaaattctgaattacattctgacataagaaagaacaaaatggacattctaagttat gaggaaacagacatagttaaacacaaaatactgaaagaaagtgtcccagttggtactgga aatcaactagtgaccttccagggacaacccgaacgtgatgaaaagatcaaagaacctact ctattgggttttcatacagctagcgggaaaaaagttaaaattgcaaaggaatctttggac aaagtgaaaaacctttttgatgaaaaagagcaaggtactagtgaaatcaccagttttagc catcaatgggcaaagaccctaaagtacagagaggcctgtaaagaccttgaattagcatgt gagaccattgagatcacagctgccccaaagtgtaaagaaatgcagaattctctcaataat gataaaaaccttgtttctattgagactgtggtgccacctaagctcttaagtgataattta tgtagacaaactgaaaatctcaaaacatcaaaaagtatctttttgaaagttaaagtacat gaaaatgtagaaaaagaaacagcaaaaagtcctgcaacttgttacacaaatcagtcccct tattcagtcattgaaaattcagccttagctttttacacaagttgtagtagaaaaacttct gtgagtcagacttcattacttgaagcaaaaaaatggcttagagaaggaatatttgatggt caaccagaaagaataaatactgcagattatgtaggaaattatttgtatgaaaataattca aacagtactatagctgaaaatgacaaaaatcatctctccgaaaaacaagatacttattta agtaacagtagcatgtctaacagctattcctaccattctgatgaggtatataatgattca ggatatctctcaaaaaataaacttgattctggtattgagccagtattgaagaatgttgaa gatcaaaaaaacactagtttttccaaagtaatatccaatgtaaaagatgcaaatgcatac ccacaaactgtaaatgaagatatttgcgttgaggaacttgtgactagctcttcaccctgc aaaaataaaaatgcagccattaaattgtccatatctaatagtaataattttgaggtaggg ccacctgcatttaggatagccagtggtaaaatcgtttgtgtttcacatgaaacaattaaa aaagtgaaagacatatttacagacagtttcagtaaagtaattaaggaaaacaacgagaat aaatcaaaaatttgccaaacgaaaattatggcaggttgttacgaggcattggatgattca gaggatattcttcataactctctagataatgatgaatgtagcacgcattcacataaggtt tttgctgacattcagagtgaagaaattttacaacataaccaaaatatgtctggattggag aaagtttctaaaatatcaccttgtgatgttagtttggaaacttcagatatatgtaaatgt agtatagggaagcttcataagtcagtctcatctgcaaatacttgtgggatttttagcaca gcaagtggaaaatctgtccaggtatcagatgcttcattacaaaacgcaagacaagtgttt tctgaaatagaagatagtaccaagcaagtcttttccaaagtattgtttaaaagtaacgaa cattcagaccagctcacaagagaagaaaatactgctatacgtactccagaacatttaata tcccaaaaaggcttttcatataatgtggtaaattcatctgctttctctggatttagtaca gcaagtggaaagcaagtttccattttagaaagttccttacacaaagttaagggagtgtta gaggaatttgatttaatcagaactgagcatagtcttcactattcacctacgtctagacaa aatgtatcaaaaatacttcctcgtgttgataagagaaacccagagcactgtgtaaactca gaaatggaaaaaacctgcagtaaagaatttaaattatcaaataacttaaatgttgaaggt ggttcttcagaaaataatcactctattaaagtttctccatatctctctcaatttcaacaa gacaaacaacagttggtattaggaaccaaagtgtcacttgttgagaacattcatgttttg ggaaaagaacaggcttcacctaaaaacgtaaaaatggaaattggtaaaactgaaactttt tctgatgttcctgtgaaaacaaatatagaagtttgttctacttactccaaagattcagaa aactactttgaaacagaagcagtagaaattgctaaagcttttatggaagatgatgaactg acagattctaaactgccaagtcatgccacacattctctttttacatgtcccgaaaatgag gaaatggttttgtcaaattcaagaattggaaaaagaagaggagagccccttatcttagtg ggagaaccctcaatcaaaagaaacttattaaatgaatttgacaggataatagaaaatcaa gaaaaatccttaaaggcttcaaaaagcactccagatggcacaataaaagatcgaagattg tttatgcatcatgtttctttagagccgattacctgtgtaccctttcgcacaactaaggaa cgtcaagagatacagaatccaaattttaccgcacctggtcaagaatttctgtctaaatct catttgtatgaacatctgactttggaaaaatcttcaagcaatttagcagtttcaggacat ccattttatcaagtttctgctacaagaaatgaaaaaatgagacacttgattactacaggc agaccaaccaaagtctttgttccaccttttaaaactaaatcacattttcacagagttgaa cagtgtgttaggaatattaacttggaggaaaacagacaaaagcaaaacattgatggacat ggctctgatgatagtaaaaataagattaatgacaatgagattcatcagtttaacaaaaac aactccaatcaagcagcagctgtaactttcacaaagtgtgaagaagaacctttagattta attacaagtcttcagaatgccagagatatacaggatatgcgaattaagaagaaacaaagg caacgcgtctttccacagccaggcagtctgtatcttgcaaaaacatccactctgcctcga atctctctgaaagcagcagtaggaggccaagttccctctgcgtgttctcataaacagctg tatacgtatggcgtttctaaacattgcataaaaattaacagcaaaaatgcagagtctttt cagtttcacactgaagattattttggtaaggaaagtttatggactggaaaaggaatacag ttggctgatggtggatggctcataccctccaatgatggaaaggctggaaaagaagaattt tatagggctctgtgtgacactccaggtgtggatccaaagcttatttctagaatttgggtt tataatcactatagatggatcatatggaaactggcagctatggaatgtgcctttcctaag gaatttgctaatagatgcctaagcccagaaagggtgcttcttcaactaaaatacagatat gatacggaaattgatagaagcagaagatcggctataaaaaagataatggaaagggatgac acagctgcaaaaacacttgttctctgtgtttctgacataatttcattgagcgcaaatata tctgaaacttctagcaataaaactagtagtgcagatacccaaaaagtggccattattgaa cttacagatgggtggtatgctgttaaggcccagttagatcctcccctcttagctgtctta aagaatggcagactgacagttggtcagaagattattcttcatggagcagaactggtgggc tctcctgatgcctgtacacctcttgaagccccagaatctcttatgttaaagatttctgct aacagtactcggcctgctcgctggtataccaaacttggattctttcctgaccctagacct tttcctctgcccttatcatcgcttttcagtgatggaggaaatgttggttgtgttgatgta attattcaaagagcataccctatacagtggatggagaagacatcatctggattatacata tttcgcaatgaaagagaggaagaaaaggaagcagcaaaatatgtggaggcccaacaaaag agactagaagccttattcactaaaattcaggaggaatttgaagaacatgaagaaaacaca acaaaaccatatttaccatcacgtgcactaacaagacagcaagttcgtgctttgcaagat ggtgcagagctttatgaagcagtgaagaatgcagcagacccagcttaccttgagggttat ttcagtgaagagcagttaagagccttgaataatcacaggcaaatgttgaatgataagaaa caagctcagatccagttggaaattaggaaggccatggaatctgctgaacaaaaggaacaa ggtttatcaagggatgtcacaaccgtgtggaagttgcgtattgtaagctattcaaaaaaa gaaaaagattcagttatactgagtatttggcgtccatcatcagatttatattctctgtta acagaaggaaagagatacagaatttatcatcttgcaacttcaaaatctaaaagtaaatct gaaagagctaacatacagttagcagcgacaaaaaaaactcagtatcaacaactaccggtt tcagatgaaattttatttcagatttaccagccacgggagccccttcacttcagcaaattt ttagatccagactttcagccatcttgttctgaggtggacctaataggatttgtcgtttct gttgtgaaaaaaacaggacttgcccctttcgtctatttgtcagacgaatgttacaattta ctggcaataaagttttggatagaccttaatgaggacattattaagcctcatatgttaatt gctgcaagcaacctccagtggcgaccagaatccaaatcaggccttcttactttatttgct ggagatttttctgtgttttctgctagtccaaaagagggccactttcaagagacattcaac aaaatgaaaaatactgttgagaatattgacatactttgcaatgaagcagaaaacaagctt atgcatatactgcatgcaaatgatcccaagtggtccaccccaactaaagactgtacttca gggccgtacactgctcaaatcattcctggtacaggaaacaagcttctgatgtcttctcct aattgtgagatatattatcaaagtcctttatcactttgtatggccaaaaggaagtctgtt tccacacctgtctcagcccagatgacttcaaagtcttgtaaaggggagaaagagattgat gaccaaaagaactgcaaaaagagaagagccttggatttcttgagtagactgcctttacct ccacctgttagtcccatttgtacatttgtttctccggctgcacagaaggcatttcagcca ccaaggagttgtggcaccaaatacgaaacacccataaagaaaaaagaactgaattctcct cagatgactccatttaaaaaattcaatgaaatttctcttttggaaagtaattcaatagct gacgaagaacttgcattgataaatacccaagctcttttgtctggttcaacaggagaaaaa caatttatatctgtcagtgaatccactaggactgctcccaccagttcagaagattatctc agactgaaacgacgttgtactacatctctgatcaaagaacaggagagttcccaggccagt acggaagaatgtgagaaaaataagcaggacacaattacaactaaaaaatatatctaa |
Protein Sequence |
>675 : length: 3418 MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPN LFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTV KTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHI SESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESL KKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVV DTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEP NDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCD QNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDC ILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGL EIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSY KGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLT SSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCEND PKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLS NLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYM RVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNN LALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVK QHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLS EHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSD CKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKS TFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDC NKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISL SSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENE DNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQI KEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAK ESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTG NQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFS HQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNL CRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTS VSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYL SNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAY PQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIK KVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKV FADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFST ASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLI SQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQ NVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQ DKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSE NYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILV GEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKE RQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTG RPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKN NSNQAAAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPR ISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQ LADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK EFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANI SETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVG SPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDV IIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT TKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKK QAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLL TEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKF LDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLI AASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKL MHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSV STPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQP PRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEK QFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI |