Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

675

Name

BRCA2

Synonym

BRCC2|BROVCA2|FACD|FAD|FAD1|FANCB|FANCD|FANCD1|GLM3|PNCA2;breast cancer 2, early onset;BRCA2;breast cancer 2, early onset

Definition

BRCA1/BRCA2-containing complex, subunit 2|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer susceptibility protein BRCA2|breast cancer type 2 susceptibility protein|fanconi anemia group D1 protein

Position

13q12.3

Gene Type

protein-coding

Source

Count: 4; Pubmed_search,TAG,Generif,UniProt

Literature support

Count: 11 PubMed records as below.

Evidence Status

Description

reviewed

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.

reviewed

A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.

reviewed

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

reviewed

Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection.

reviewed

Evidence that the tumor-suppressor protein BRCA2 does not regulate cytokinesis in human cells.

reviewed

CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.

reviewed

"These observations are consistent with the idea that BRCA2, but not BRCA1, is a tumor suppressor of prostate cancer."

reviewed

Molecular genetic analysis of the BRCA2 tumor suppressor gene region in cutaneous squamous cell carcinomas.

reviewed

risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2.

reviewed

Phytoestrogen-rich diets modulate expression of Brca1 and Brca2 tumor suppressor genes in mammary glands of female Wistar rats.
More detail of all 11 literatures about BRCA2

Pathways and Diseases

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

Fanconi Anemia pathway;PID Reactome;500068

Pathway

Homologous recombination;KEGG PATHWAY;hsa03440

Pathway

Presynaptic phase of homologous DNA pairing and strand exchange;PID Reactome;501013

Pathway

DNA Repair;Reactome;REACT:216

Pathway

role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234

Pathway

FOXM1 transcription factor network;PID Curated;200120

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Disease

Prostate cancer;OMIM

Disease

Hematologic diseases;KEGG DISEASE

Disease

Breast-ovarian cancer, familial, 2;OMIM

Disease

Pancreatic cancer;KEGG DISEASE;H00019

Disease

Glioblastoma 3;OMIM

Disease

Pancreatic cancer;OMIM

Disease

breast cancer, male;GAD

Disease

Cancer;FunDO

Disease

Fanconi anemia, complementation group D1;OMIM

Disease

Wilms tumor;OMIM

Disease

prenatal viability;GAD

Disease

Medulloblastoma;OMIM

Disease

Fanconi's anemia;FunDO

Disease

Circulatory system diseases;KEGG DISEASE

Disease

lung cancer;GAD

Disease

prophylactic breast surgery;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Infertility, Male;FunDO

Disease

Neoplasms;GAD

Disease

Breast cancer;KEGG DISEASE;H00031

Disease

Fanconi anemia;KEGG DISEASE;H00238

Disease

Ovarian cancer;KEGG DISEASE;H00027

Disease

CANCER;GAD

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

Endometriosis;FunDO

Disease

Breast cancer, male, susceptibility to;OMIM

Disease

Cancers;KEGG DISEASE

Disease

Oligospermia;FunDO

Disease

Pre-B-cell acute lymphoblastic leukemia;OMIM

Disease

Abortion;FunDO

Disease

Prostate cancer;FunDO

Disease

breast cancer;GAD

Disease

Azoospermia;FunDO

Disease

breast cancer risk and prenatal viability;GAD

Disease

ovarian cancer;GAD

Disease

stomach cancer;GAD

External Links

Links to Entrez Gene

675

Links to all GeneRIF Items

675

Links to iHOP

675

Sequence Information

Nucleotide Sequence

>675 : length: 10257
atgcctattggatccaaagagaggccaacattttttgaaatttttaagacacgctgcaac
aaagcagatttaggaccaataagtcttaattggtttgaagaactttcttcagaagctcca
ccctataattctgaacctgcagaagaatctgaacataaaaacaacaattacgaaccaaac
ctatttaaaactccacaaaggaaaccatcttataatcagctggcttcaactccaataata
ttcaaagagcaagggctgactctgccgctgtaccaatctcctgtaaaagaattagataaa
ttcaaattagacttaggaaggaatgttcccaatagtagacataaaagtcttcgcacagtg
aaaactaaaatggatcaagcagatgatgtttcctgtccacttctaaattcttgtcttagt
gaaagtcctgttgttctacaatgtacacatgtaacaccacaaagagataagtcagtggta
tgtgggagtttgtttcatacaccaaagtttgtgaagggtcgtcagacaccaaaacatatt
tctgaaagtctaggagctgaggtggatcctgatatgtcttggtcaagttctttagctaca
ccacccacccttagttctactgtgctcatagtcagaaatgaagaagcatctgaaactgta
tttcctcatgatactactgctaatgtgaaaagctatttttccaatcatgatgaaagtctg
aagaaaaatgatagatttatcgcttctgtgacagacagtgaaaacacaaatcaaagagaa
gctgcaagtcatggatttggaaaaacatcagggaattcatttaaagtaaatagctgcaaa
gaccacattggaaagtcaatgccaaatgtcctagaagatgaagtatatgaaacagttgta
gatacctctgaagaagatagtttttcattatgtttttctaaatgtagaacaaaaaatcta
caaaaagtaagaactagcaagactaggaaaaaaattttccatgaagcaaacgctgatgaa
tgtgaaaaatctaaaaaccaagtgaaagaaaaatactcatttgtatctgaagtggaacca
aatgatactgatccattagattcaaatgtagcaaatcagaagccctttgagagtggaagt
gacaaaatctccaaggaagttgtaccgtctttggcctgtgaatggtctcaactaaccctt
tcaggtctaaatggagcccagatggagaaaatacccctattgcatatttcttcatgtgac
caaaatatttcagaaaaagacctattagacacagagaacaaaagaaagaaagattttctt
acttcagagaattctttgccacgtatttctagcctaccaaaatcagagaagccattaaat
gaggaaacagtggtaaataagagagatgaagagcagcatcttgaatctcatacagactgc
attcttgcagtaaagcaggcaatatctggaacttctccagtggcttcttcatttcagggt
atcaaaaagtctatattcagaataagagaatcacctaaagagactttcaatgcaagtttt
tcaggtcatatgactgatccaaactttaaaaaagaaactgaagcctctgaaagtggactg
gaaatacatactgtttgctcacagaaggaggactccttatgtccaaatttaattgataat
ggaagctggccagccaccaccacacagaattctgtagctttgaagaatgcaggtttaata
tccactttgaaaaagaaaacaaataagtttatttatgctatacatgatgaaacatcttat
aaaggaaaaaaaataccgaaagaccaaaaatcagaactaattaactgttcagcccagttt
gaagcaaatgcttttgaagcaccacttacatttgcaaatgctgattcaggtttattgcat
tcttctgtgaaaagaagctgttcacagaatgattctgaagaaccaactttgtccttaact
agctcttttgggacaattctgaggaaatgttctagaaatgaaacatgttctaataataca
gtaatctctcaggatcttgattataaagaagcaaaatgtaataaggaaaaactacagtta
tttattaccccagaagctgattctctgtcatgcctgcaggaaggacagtgtgaaaatgat
ccaaaaagcaaaaaagtttcagatataaaagaagaggtcttggctgcagcatgtcaccca
gtacaacattcaaaagtggaatacagtgatactgactttcaatcccagaaaagtctttta
tatgatcatgaaaatgccagcactcttattttaactcctacttccaaggatgttctgtca
aacctagtcatgatttctagaggcaaagaatcatacaaaatgtcagacaagctcaaaggt
aacaattatgaatctgatgttgaattaaccaaaaatattcccatggaaaagaatcaagat
gtatgtgctttaaatgaaaattataaaaacgttgagctgttgccacctgaaaaatacatg
agagtagcatcaccttcaagaaaggtacaattcaaccaaaacacaaatctaagagtaatc
caaaaaaatcaagaagaaactacttcaatttcaaaaataactgtcaatccagactctgaa
gaacttttctcagacaatgagaataattttgtcttccaagtagctaatgaaaggaataat
cttgctttaggaaatactaaggaacttcatgaaacagacttgacttgtgtaaacgaaccc
attttcaagaactctaccatggttttatatggagacacaggtgataaacaagcaacccaa
gtgtcaattaaaaaagatttggtttatgttcttgcagaggagaacaaaaatagtgtaaag
cagcatataaaaatgactctaggtcaagatttaaaatcggacatctccttgaatatagat
aaaataccagaaaaaaataatgattacatgaacaaatgggcaggactcttaggtccaatt
tcaaatcacagttttggaggtagcttcagaacagcttcaaataaggaaatcaagctctct
gaacataacattaagaagagcaaaatgttcttcaaagatattgaagaacaatatcctact
agtttagcttgtgttgaaattgtaaataccttggcattagataatcaaaagaaactgagc
aagcctcagtcaattaatactgtatctgcacatttacagagtagtgtagttgtttctgat
tgtaaaaatagtcatataacccctcagatgttattttccaagcaggattttaattcaaac
cataatttaacacctagccaaaaggcagaaattacagaactttctactatattagaagaa
tcaggaagtcagtttgaatttactcagtttagaaaaccaagctacatattgcagaagagt
acatttgaagtgcctgaaaaccagatgactatcttaaagaccacttctgaggaatgcaga
gatgctgatcttcatgtcataatgaatgccccatcgattggtcaggtagacagcagcaag
caatttgaaggtacagttgaaattaaacggaagtttgctggcctgttgaaaaatgactgt
aacaaaagtgcttctggttatttaacagatgaaaatgaagtggggtttaggggcttttat
tctgctcatggcacaaaactgaatgtttctactgaagctctgcaaaaagctgtgaaactg
tttagtgatattgagaatattagtgaggaaacttctgcagaggtacatccaataagttta
tcttcaagtaaatgtcatgattctgttgtttcaatgtttaagatagaaaatcataatgat
aaaactgtaagtgaaaaaaataataaatgccaactgatattacaaaataatattgaaatg
actactggcacttttgttgaagaaattactgaaaattacaagagaaatactgaaaatgaa
gataacaaatatactgctgccagtagaaattctcataacttagaatttgatggcagtgat
tcaagtaaaaatgatactgtttgtattcataaagatgaaacggacttgctatttactgat
cagcacaacatatgtcttaaattatctggccagtttatgaaggagggaaacactcagatt
aaagaagatttgtcagatttaacttttttggaagttgcgaaagctcaagaagcatgtcat
ggtaatacttcaaataaagaacagttaactgctactaaaacggagcaaaatataaaagat
tttgagacttctgatacattttttcagactgcaagtgggaaaaatattagtgtcgccaaa
gagtcatttaataaaattgtaaatttctttgatcagaaaccagaagaattgcataacttt
tccttaaattctgaattacattctgacataagaaagaacaaaatggacattctaagttat
gaggaaacagacatagttaaacacaaaatactgaaagaaagtgtcccagttggtactgga
aatcaactagtgaccttccagggacaacccgaacgtgatgaaaagatcaaagaacctact
ctattgggttttcatacagctagcgggaaaaaagttaaaattgcaaaggaatctttggac
aaagtgaaaaacctttttgatgaaaaagagcaaggtactagtgaaatcaccagttttagc
catcaatgggcaaagaccctaaagtacagagaggcctgtaaagaccttgaattagcatgt
gagaccattgagatcacagctgccccaaagtgtaaagaaatgcagaattctctcaataat
gataaaaaccttgtttctattgagactgtggtgccacctaagctcttaagtgataattta
tgtagacaaactgaaaatctcaaaacatcaaaaagtatctttttgaaagttaaagtacat
gaaaatgtagaaaaagaaacagcaaaaagtcctgcaacttgttacacaaatcagtcccct
tattcagtcattgaaaattcagccttagctttttacacaagttgtagtagaaaaacttct
gtgagtcagacttcattacttgaagcaaaaaaatggcttagagaaggaatatttgatggt
caaccagaaagaataaatactgcagattatgtaggaaattatttgtatgaaaataattca
aacagtactatagctgaaaatgacaaaaatcatctctccgaaaaacaagatacttattta
agtaacagtagcatgtctaacagctattcctaccattctgatgaggtatataatgattca
ggatatctctcaaaaaataaacttgattctggtattgagccagtattgaagaatgttgaa
gatcaaaaaaacactagtttttccaaagtaatatccaatgtaaaagatgcaaatgcatac
ccacaaactgtaaatgaagatatttgcgttgaggaacttgtgactagctcttcaccctgc
aaaaataaaaatgcagccattaaattgtccatatctaatagtaataattttgaggtaggg
ccacctgcatttaggatagccagtggtaaaatcgtttgtgtttcacatgaaacaattaaa
aaagtgaaagacatatttacagacagtttcagtaaagtaattaaggaaaacaacgagaat
aaatcaaaaatttgccaaacgaaaattatggcaggttgttacgaggcattggatgattca
gaggatattcttcataactctctagataatgatgaatgtagcacgcattcacataaggtt
tttgctgacattcagagtgaagaaattttacaacataaccaaaatatgtctggattggag
aaagtttctaaaatatcaccttgtgatgttagtttggaaacttcagatatatgtaaatgt
agtatagggaagcttcataagtcagtctcatctgcaaatacttgtgggatttttagcaca
gcaagtggaaaatctgtccaggtatcagatgcttcattacaaaacgcaagacaagtgttt
tctgaaatagaagatagtaccaagcaagtcttttccaaagtattgtttaaaagtaacgaa
cattcagaccagctcacaagagaagaaaatactgctatacgtactccagaacatttaata
tcccaaaaaggcttttcatataatgtggtaaattcatctgctttctctggatttagtaca
gcaagtggaaagcaagtttccattttagaaagttccttacacaaagttaagggagtgtta
gaggaatttgatttaatcagaactgagcatagtcttcactattcacctacgtctagacaa
aatgtatcaaaaatacttcctcgtgttgataagagaaacccagagcactgtgtaaactca
gaaatggaaaaaacctgcagtaaagaatttaaattatcaaataacttaaatgttgaaggt
ggttcttcagaaaataatcactctattaaagtttctccatatctctctcaatttcaacaa
gacaaacaacagttggtattaggaaccaaagtgtcacttgttgagaacattcatgttttg
ggaaaagaacaggcttcacctaaaaacgtaaaaatggaaattggtaaaactgaaactttt
tctgatgttcctgtgaaaacaaatatagaagtttgttctacttactccaaagattcagaa
aactactttgaaacagaagcagtagaaattgctaaagcttttatggaagatgatgaactg
acagattctaaactgccaagtcatgccacacattctctttttacatgtcccgaaaatgag
gaaatggttttgtcaaattcaagaattggaaaaagaagaggagagccccttatcttagtg
ggagaaccctcaatcaaaagaaacttattaaatgaatttgacaggataatagaaaatcaa
gaaaaatccttaaaggcttcaaaaagcactccagatggcacaataaaagatcgaagattg
tttatgcatcatgtttctttagagccgattacctgtgtaccctttcgcacaactaaggaa
cgtcaagagatacagaatccaaattttaccgcacctggtcaagaatttctgtctaaatct
catttgtatgaacatctgactttggaaaaatcttcaagcaatttagcagtttcaggacat
ccattttatcaagtttctgctacaagaaatgaaaaaatgagacacttgattactacaggc
agaccaaccaaagtctttgttccaccttttaaaactaaatcacattttcacagagttgaa
cagtgtgttaggaatattaacttggaggaaaacagacaaaagcaaaacattgatggacat
ggctctgatgatagtaaaaataagattaatgacaatgagattcatcagtttaacaaaaac
aactccaatcaagcagcagctgtaactttcacaaagtgtgaagaagaacctttagattta
attacaagtcttcagaatgccagagatatacaggatatgcgaattaagaagaaacaaagg
caacgcgtctttccacagccaggcagtctgtatcttgcaaaaacatccactctgcctcga
atctctctgaaagcagcagtaggaggccaagttccctctgcgtgttctcataaacagctg
tatacgtatggcgtttctaaacattgcataaaaattaacagcaaaaatgcagagtctttt
cagtttcacactgaagattattttggtaaggaaagtttatggactggaaaaggaatacag
ttggctgatggtggatggctcataccctccaatgatggaaaggctggaaaagaagaattt
tatagggctctgtgtgacactccaggtgtggatccaaagcttatttctagaatttgggtt
tataatcactatagatggatcatatggaaactggcagctatggaatgtgcctttcctaag
gaatttgctaatagatgcctaagcccagaaagggtgcttcttcaactaaaatacagatat
gatacggaaattgatagaagcagaagatcggctataaaaaagataatggaaagggatgac
acagctgcaaaaacacttgttctctgtgtttctgacataatttcattgagcgcaaatata
tctgaaacttctagcaataaaactagtagtgcagatacccaaaaagtggccattattgaa
cttacagatgggtggtatgctgttaaggcccagttagatcctcccctcttagctgtctta
aagaatggcagactgacagttggtcagaagattattcttcatggagcagaactggtgggc
tctcctgatgcctgtacacctcttgaagccccagaatctcttatgttaaagatttctgct
aacagtactcggcctgctcgctggtataccaaacttggattctttcctgaccctagacct
tttcctctgcccttatcatcgcttttcagtgatggaggaaatgttggttgtgttgatgta
attattcaaagagcataccctatacagtggatggagaagacatcatctggattatacata
tttcgcaatgaaagagaggaagaaaaggaagcagcaaaatatgtggaggcccaacaaaag
agactagaagccttattcactaaaattcaggaggaatttgaagaacatgaagaaaacaca
acaaaaccatatttaccatcacgtgcactaacaagacagcaagttcgtgctttgcaagat
ggtgcagagctttatgaagcagtgaagaatgcagcagacccagcttaccttgagggttat
ttcagtgaagagcagttaagagccttgaataatcacaggcaaatgttgaatgataagaaa
caagctcagatccagttggaaattaggaaggccatggaatctgctgaacaaaaggaacaa
ggtttatcaagggatgtcacaaccgtgtggaagttgcgtattgtaagctattcaaaaaaa
gaaaaagattcagttatactgagtatttggcgtccatcatcagatttatattctctgtta
acagaaggaaagagatacagaatttatcatcttgcaacttcaaaatctaaaagtaaatct
gaaagagctaacatacagttagcagcgacaaaaaaaactcagtatcaacaactaccggtt
tcagatgaaattttatttcagatttaccagccacgggagccccttcacttcagcaaattt
ttagatccagactttcagccatcttgttctgaggtggacctaataggatttgtcgtttct
gttgtgaaaaaaacaggacttgcccctttcgtctatttgtcagacgaatgttacaattta
ctggcaataaagttttggatagaccttaatgaggacattattaagcctcatatgttaatt
gctgcaagcaacctccagtggcgaccagaatccaaatcaggccttcttactttatttgct
ggagatttttctgtgttttctgctagtccaaaagagggccactttcaagagacattcaac
aaaatgaaaaatactgttgagaatattgacatactttgcaatgaagcagaaaacaagctt
atgcatatactgcatgcaaatgatcccaagtggtccaccccaactaaagactgtacttca
gggccgtacactgctcaaatcattcctggtacaggaaacaagcttctgatgtcttctcct
aattgtgagatatattatcaaagtcctttatcactttgtatggccaaaaggaagtctgtt
tccacacctgtctcagcccagatgacttcaaagtcttgtaaaggggagaaagagattgat
gaccaaaagaactgcaaaaagagaagagccttggatttcttgagtagactgcctttacct
ccacctgttagtcccatttgtacatttgtttctccggctgcacagaaggcatttcagcca
ccaaggagttgtggcaccaaatacgaaacacccataaagaaaaaagaactgaattctcct
cagatgactccatttaaaaaattcaatgaaatttctcttttggaaagtaattcaatagct
gacgaagaacttgcattgataaatacccaagctcttttgtctggttcaacaggagaaaaa
caatttatatctgtcagtgaatccactaggactgctcccaccagttcagaagattatctc
agactgaaacgacgttgtactacatctctgatcaaagaacaggagagttcccaggccagt
acggaagaatgtgagaaaaataagcaggacacaattacaactaaaaaatatatctaa

Protein Sequence

>675 : length: 3418
MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPN
LFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTV
KTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHI
SESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESL
KKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVV
DTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEP
NDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCD
QNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDC
ILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGL
EIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSY
KGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLT
SSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCEND
PKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLS
NLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYM
RVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNN
LALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVK
QHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLS
EHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSD
CKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKS
TFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDC
NKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISL
SSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENE
DNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQI
KEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAK
ESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTG
NQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFS
HQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNL
CRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTS
VSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYL
SNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAY
PQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIK
KVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKV
FADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFST
ASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLI
SQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQ
NVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQ
DKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSE
NYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILV
GEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKE
RQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTG
RPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKN
NSNQAAAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPR
ISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQ
LADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK
EFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANI
SETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVG
SPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDV
IIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT
TKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKK
QAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLL
TEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKF
LDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLI
AASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKL
MHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSV
STPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQP
PRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEK
QFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI



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