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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 675 |
Name | BRCA2 |
Synonymous | BRCC2|BROVCA2|FACD|FAD|FAD1|FANCB|FANCD|FANCD1|GLM3|PNCA2;breast cancer 2, early onset;BRCA2;breast cancer 2, early onset |
Definition | BRCA1/BRCA2-containing complex, subunit 2|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer susceptibility protein BRCA2|breast cancer type 2 susceptibility protein|fanconi anemia group D1 protein |
Position | 13q12.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
BRCA2(h) + 3 ATP --plk1(m)--> BRCA2(h){pS193}{p}2 + 3 ADP (phosphorylation) | BRCA2(h) + ATP --Cdk1(h)--> BRCA2(h){p} + ADP (phosphorylation) | Palb2(h) + BRCA2(h) + Rad51(h) <==> Palb2(h):BRCA2(h):Rad51(h) (binding) | Palb2(h) + BRCA2(h) <==> Palb2(h):BRCA2(h) (binding) | BRCA2(h) + Skp2(h) <==> BRCA2(h):Skp2(h) (binding) | BRCA2(h) + ubiquitin(h) --Skp2(h)--> BRCA2(h){ub} (ubiquitination) | BRCA2(h) --> protein remnants (degradation) | BRE(h) + BRCC36(h) + Rad51(h) + BRCA2(h) + brca1(h) + BARD1(m.s.) <==> BARD1(m.s.):brca1(h):BRCA2(h):BRCC36(h):BRE(h):Rad51(h) (binding) | BRCA2(h) + BARD1(h) + brca1(h) <==> BRCA2(h):BARD1(h):brca1(h) (binding) | BRE(h) + BRCA2(h) + brca1(h) + BARD1(m.s.) + BRCC36(m.s.) <==> BRE(h):BRCA2(h):brca1(h):BARD1(m.s.):BRCC36(m.s.) (binding) | BARD1(h) + BRCA2(h) + brca1(h) + Bach1(h) + MLH1(h) + tubulin(h) + CtIP(h) <==> BARD1(h):BRCA2(h):brca1(h):Bach1(h):MLH1(h):tubulin(h):CtIP(h) (binding) | BRCA2(h) + brca1(h) + BARD1(h) <==> BRCA2(h):brca1(h):BARD1(h) (binding) | BARD1(h) + Bach1(h) + brca1(h) + BRCA2(h) <==> BARD1(h):Bach1(h):brca1(h):BRCA2(h) (binding) | BRCC36(h) + BRE(h) + Bach1(h) + BRCA2(h) + brca1(h) + BARD1(m.s.) <==> BRCC36(h):BRE(h):Bach1(h):BRCA2(h):brca1(h):BARD1(m.s.) (binding) | BRCA2(h) + STAT5A(h) <==> BRCA2(h):STAT5A(h) (binding) | BRCA2(h) + DSS1(h) <==> BRCA2(h):DSS1(h) (binding) | BRCA2(h) + DSS1(m.s.) <==> BRCA2(h):DSS1(m.s.) (binding) | BRCA2(h) --> BRCA2(h) (expression). | PI3K(h) --> BRCA2(h) (decrease of abundance) | BARD1(h) + BRCA2(h) + brca1(h) + BRCC36(m.s.) + BRE(h) <==> BARD1(h):BRCA2(h):brca1(h):BRCC36(m.s.):BRE(h) (binding) | BRCA2(h) + ATP --ATR(m.s.)--> BRCA2(h){pS2156} + ADP (phosphorylation) | STAT5A(m.s.) + BRCA2(h) <==> STAT5A(m.s.):BRCA2(h) (binding) | BRCA2(h) + DSS1(h) <==> BRCA2(h):DSS1(h) (binding) | BRCA2(h) + Rad51(h) <==> BRCA2(h):Rad51(h) (binding) | BRCA2(h) + DSS1(h) <==> BRCA2(h):DSS1(h) (binding) | BRCA2(h) --> BRCA2(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
193 | Phosphoserine (PLK1) | 12815053 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr13 |
Promoter: 31786117 - 31788117 | Agilent_014791 |
chr13 |
Promoter: 31786117 - 31788117 | GSE27584 |
chr13 |
Promoter: 31786117 - 31788117 | Agilent_014791_44K |
chr13 |
Promoter: 31786117 - 31788117 | Agilent_014791 |
chr13 |
Promoter: 31786117 - 31788117 | PMID:15574200 |
chr13 |
Promoter: 31786117 - 31788117 | PMID:12237285 |
chr13 |
Promoter: 31786117 - 31788117 | PMID:17289874 |