Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

675

Name

BRCA2

Synonymous

BRCC2|BROVCA2|FACD|FAD|FAD1|FANCB|FANCD|FANCD1|GLM3|PNCA2;breast cancer 2, early onset;BRCA2;breast cancer 2, early onset

Definition

BRCA1/BRCA2-containing complex, subunit 2|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer susceptibility protein BRCA2|breast cancer type 2 susceptibility protein|fanconi anemia group D1 protein

Position

13q12.3

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction

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Interaction Type

Interactor

Data Source

interacts with

MORF4L1BIOGRID; PUBMED:20332121;

interacts with

MCPH1BIOGRID; PUBMED:19549900;

interacts with

MCPH1BIOGRID; PUBMED:20107607;

interacts with

KIF4ABIOGRID; PUBMED:18604178;

interacts with

BUB1BBIOGRID; PUBMED:10749118;

interacts with

ATMBIOGRID; PUBMED:15199141;

interacts with

BARD1BIOGRID; PUBMED:14636569;

interacts with

BARD1BIOGRID; PUBMED:17664283;

interacts with

BARD1BIOGRID; PUBMED:19176389;

interacts with

AURKBBIOGRID; PUBMED:19176389;

interacts with

SHFM1BIOGRID; PUBMED:10373512;

interacts with

SHFM1BIOGRID; PUBMED:12228710;

interacts with

BRCA1BIOGRID; PUBMED:11477095;

interacts with

BRCA1BIOGRID; PUBMED:14499622;

interacts with

BRCA1BIOGRID; PUBMED:14636569;

interacts with

BRCA1BIOGRID; PUBMED:17664283;

interacts with

BRCA1BIOGRID; PUBMED:21135251;

interacts with

BRCA1BIOGRID; PUBMED:9774970;

interacts with

BRCC3BIOGRID; PUBMED:14636569;

interacts with

BRCC3BIOGRID; PUBMED:17664283;

interacts with

BREBIOGRID; PUBMED:14636569;

interacts with

BCCIPBIOGRID; PUBMED:11313963;

interacts with

BACH1BIOGRID; PUBMED:17664283;

interacts with

ATRBIOGRID; PUBMED:10608806;

interacts with

EMSYBIOGRID; PUBMED:14651845;

interacts with

Rad51BIOGRID; PUBMED:9126738;

interacts with

H2AFXBIOGRID; PUBMED:18406329;

interacts with

H2AFXBIOGRID; PUBMED:20936109;

interacts with

HMG20BBIOGRID; PUBMED:11207365;

interacts with

HMG20BBIOGRID; PUBMED:12032298;

interacts with

FANCEBIOGRID; PUBMED:15199141;

interacts with

FANCGBIOGRID; PUBMED:12915460;

interacts with

FANCGBIOGRID; PUBMED:16621732;

interacts with

FANCGBIOGRID; PUBMED:18212739;

interacts with

FANCGBIOGRID; PUBMED:20450923;

interacts with

FANCD2BIOGRID; PUBMED:15115758;

interacts with

FANCD2BIOGRID; PUBMED:15199141;

interacts with

FANCD2BIOGRID; PUBMED:18212739;

interacts with

FANCD2BIOGRID; PUBMED:18263878;

interacts with

FANCD2BIOGRID; PUBMED:20450923;

interacts with

FLNABIOGRID; PUBMED:11602572;

interacts with

KAT2BBIOGRID; PUBMED:12815053;

interacts with

KAT2BBIOGRID; PUBMED:9824164;

interacts with

RAD51BIOGRID; PUBMED:11313963;

interacts with

RAD51BIOGRID; PUBMED:11477095;

interacts with

RAD51BIOGRID; PUBMED:12442171;

interacts with

RAD51BIOGRID; PUBMED:12815053;

interacts with

RAD51BIOGRID; PUBMED:14580352;

interacts with

RAD51BIOGRID; PUBMED:14636569;

interacts with

RAD51BIOGRID; PUBMED:15065660;

interacts with

RAD51BIOGRID; PUBMED:15671039;

interacts with

RAD51BIOGRID; PUBMED:16793542;

interacts with

RAD51BIOGRID; PUBMED:16914443;

interacts with

RAD51BIOGRID; PUBMED:9126738;

interacts with

RAD51BIOGRID; PUBMED:9405383;

interacts with

RAD51BIOGRID; PUBMED:9523196;

interacts with

RAD51BIOGRID; PUBMED:9560268;

interacts with

RAD51BIOGRID; PUBMED:9774970;

interacts with

RAD51BIOGRID; PUBMED:9811893;

interacts with

RPA1BIOGRID; PUBMED:12527904;

interacts with

PLK1BIOGRID; PUBMED:12815053;

interacts with

PLK1BIOGRID; PUBMED:14647413;

interacts with

PMS2BIOGRID; PUBMED:17148452;

interacts with

PMS1BIOGRID; PUBMED:17148452;

interacts with

SKP2BIOGRID; PUBMED:16754685;

interacts with

STAT5ABIOGRID; PUBMED:12459499;

interacts with

SMAD2BIOGRID; PUBMED:12165866;

interacts with

SP1BIOGRID; PUBMED:18769160;

interacts with

XRCC3BIOGRID; PUBMED:16621732;

interacts with

XRCC3BIOGRID; PUBMED:18212739;

interacts with

XRCC3BIOGRID; PUBMED:20450923;

interacts with

USP11BIOGRID; PUBMED:15314155;

interacts with

UQCCBIOGRID; PUBMED:19578754;

interacts with

SERPINH1BIOGRID; PUBMED:19578754;

interacts with

PALB2BIOGRID; PUBMED:16793542;

interacts with

PALB2BIOGRID; PUBMED:17200672;

interacts with

PALB2BIOGRID; PUBMED:19268590;

interacts with

PALB2BIOGRID; PUBMED:19553677;

interacts with

PALB2BIOGRID; PUBMED:19584259;

interacts with

PALB2BIOGRID; PUBMED:20332121;

interacts with

TP53BIOGRID; PUBMED:14636569;

interacts with

TP53BIOGRID; PUBMED:9811893;

interacts with

CHEK2BIOGRID; PUBMED:17525332;

interacts with

TACC1HPRD; PUBMED:19176389;

interacts with

CDK2HPRD; PUBMED:15800651;

interacts with

BUB1BHPRD; PUBMED:10749118;

interacts with

BARD1HPRD; PUBMED:19176389;

interacts with

AURKBHPRD; PUBMED:19176389;

interacts with

SHFM1HPRD; PUBMED:12228710;

interacts with

BCCIPHPRD; PUBMED:11313963;

interacts with

EMSYHPRD; PUBMED:14651845;

interacts with

HMG20BHPRD; PUBMED:11207365;

interacts with

FANCEHPRD; PUBMED:15199141;

interacts with

FANCD2HPRD; PUBMED:15115758;

interacts with

FLNAHPRD; PUBMED:11602572;

interacts with

KAT2BHPRD; PUBMED:9824164;

interacts with

RAD51HPRD; PUBMED:9126738;

interacts with

RPA1HPRD; PUBMED:12527904;

interacts with

CCNA2HPRD; PUBMED:15800651;

interacts with

PLK1HPRD; PUBMED:12815053;

interacts with

CCNE1HPRD; PUBMED:15800651;

interacts with

STAT5AHPRD; PUBMED:12459499;

interacts with

WDR16HPRD; PUBMED:15967112;

interacts with

PALB2HPRD; PUBMED:16793542;

interacts with

HMG20BINTACT; PUBMED:21399666;

interacts with

RAD51INTACT; PUBMED:21399666;

interacts with

FYNMINT; PUBMED:17474147;

interacts with

DMC1MINT; PUBMED:17541404;

interacts with

RAD51MINT; PUBMED:17541404;

interacts with

RAD23AMINT; PUBMED:16712842;

interacts with

ABL1MINT; PUBMED:17474147;

interacts with

PALB2MINT; PUBMED:19609323;

Metabolic Interaction

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There is no record for BRCA2

Signaling Interaction

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Interaction Type

Interactor

Data Source

reacts with

BRCA2NCI_NATURE; PUBMED:15115758;PUBMED:12915460;PUBMED:16621732;PUBMED:18212739;

reacts with

BRCA2NCI_NATURE; PUBMED:15115758;PUBMED:17200672;PUBMED:15199141;PUBMED:16793542;

reacts with

BRCA2NCI_NATURE; PUBMED:18317453;PUBMED:15665856;

reacts with

FANCGNCI_NATURE; PUBMED:15115758;PUBMED:12915460;PUBMED:16621732;PUBMED:18212739;

reacts with

FANCD2NCI_NATURE; PUBMED:15115758;PUBMED:12915460;PUBMED:16621732;PUBMED:18212739;

reacts with

FANCD2NCI_NATURE; PUBMED:15115758;PUBMED:17200672;PUBMED:15199141;PUBMED:16793542;

reacts with

FANCINCI_NATURE; PUBMED:15115758;PUBMED:17200672;PUBMED:15199141;PUBMED:16793542;

reacts with

RAD51NCI_NATURE; PUBMED:18317453;PUBMED:15665856;

reacts with

XRCC3NCI_NATURE; PUBMED:15115758;PUBMED:12915460;PUBMED:16621732;PUBMED:18212739;

reacts with

PALB2NCI_NATURE; PUBMED:15115758;PUBMED:17200672;PUBMED:15199141;PUBMED:16793542;

state change

CHEK1NCI_NATURE; PUBMED:18317453;PUBMED:15665856;

reacts with

MSH4REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

MSH4REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

MLH1REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

MLH3REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

state change

MND1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16407260;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

MSH5REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

MSH5REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

state change

TEX15REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18283110;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

TOP3AREACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

TOP3AREACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

CDK2REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

ATMREACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

ATMREACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

ATMREACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

ATMREACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

ATMREACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

BRCA2REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

BRCA2REACTOME; PUBMED:12606939;

reacts with

BRCA2REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

BRCA2REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

BRCA2REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

BRCA2REACTOME; PUBMED:19369211;PUBMED:17549079;PUBMED:16793542;

state change

BRCA2REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

BLMREACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

BLMREACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

BRCA1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

BRCA1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

BRCA1REACTOME; PUBMED:19369211;PUBMED:17549079;PUBMED:16793542;

state change

BRCA1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

HIST3H3REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

HIST3H3REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

HIST3H3REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

HIST3H3REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

H2AFXREACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

H2AFXREACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

H2AFXREACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

H2AFXREACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

PSMC3IPREACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16407260;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

DMC1REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

DMC1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

DMC1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

DMC1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

CDK4REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

CDK4REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

CDK4REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

CDK4REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

CDK4REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

RAD51REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

RAD51REACTOME; PUBMED:12606939;

reacts with

RAD51REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

RAD51REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

RAD51REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

RPA1REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

RPA1REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

RPA1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

RPA1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

RPA1REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

RAD51CREACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:17312021;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

RPA2REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

RPA2REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

RPA2REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

RPA2REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

RPA2REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

RPA3REACTOME; PUBMED:10029069;PUBMED:10734115;PUBMED:17977839;PUBMED:15304223;PUBMED:16123081;PUBMED:10728666;

reacts with

RPA3REACTOME; PUBMED:16322221;PUBMED:10928988;PUBMED:11292842;PUBMED:9781043;PUBMED:16123081;

reacts with

RPA3REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:20062530;PUBMED:18535008;PUBMED:9311981;PUBMED:9826763;PUBMED:16123081;PUBMED:10562567;PUBMED:9008167;PUBMED:17541404;

reacts with

RPA3REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

state change

RPA3REACTOME; PUBMED:17981954;PUBMED:15164066;PUBMED:9450758;PUBMED:18256600;PUBMED:9311981;PUBMED:16123081;PUBMED:10562567;PUBMED:10438626;PUBMED:8929543;

reacts with

PALB2REACTOME; PUBMED:19369211;PUBMED:17549079;PUBMED:16793542;


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