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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6850 |
Name | SYK |
Synonym | -;spleen tyrosine kinase;SYK;spleen tyrosine kinase |
Definition | tyrosine-protein kinase SYK |
Position | 9q22 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion. |
potential | "Syk has a role in limiting proliferation and invasion of epithelial cells during normal morphogenesis, and is a tumor suppressor for breast cancer". |
potential | Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human oral squamous cell carcinoma. |
potential | Syk tyrosine kinase is downregulated by methylation and functions as a tumor suppressor in malignant melanoma. |
| More detail of all 4 literatures about SYK | |
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Pathways and Diseases |
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Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | ras-independent pathway in nk cell-mediated cytotoxicity;PID BioCarta;100095 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | GPVI-mediated activation cascade;PID Reactome;500294 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Atypical NF-kappaB pathway;PID Curated;200017 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | il 2 signaling pathway;PID BioCarta;100130 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
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External Links |
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Links to Entrez Gene | 6850 |
Links to all GeneRIF Items | 6850 |
Links to iHOP | 6850 |
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Sequence Information |
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Nucleotide Sequence |
>6850 : length: 1839 atggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatc acccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttg ctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaag gcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcagg acccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtc tgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggcccttt gaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggt caggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctacc acagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaa attgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaac ggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaa gacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagcta gtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaa aaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccat cctgcgtcctcccctgcccaagggaaccggcaagagagtactgtgtcattcaatccgtat gagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagccctacccatg gacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggcccaaggaggtt tacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggtaattttgga actgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggctgtgaaaata ctgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaagcaaatgtc atgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgaggccgagtcc tggatgctggttatggagatggcagaacttggtcccctcaataagtatttgcagcagaac agacatgtcaaggataagaacatcatagaactggttcatcaggtttccatgggcatgaag tacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtgttgctagtt acccaacattacgccaagatcagtgatttcggactttccaaagcactgcgtgctgatgaa aactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgctccggaatgc atcaactactacaagttctccagcaaaagcgatgtctggagctttggagtgttgatgtgg gaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaagtcaccgct atgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagagatgtacgat ctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgcagcagtggaa ctgcggctgcgcaattactactatgacgtggtgaactaa |
Protein Sequence |
>6850 : length: 612 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE LRLRNYYYDVVN |