Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

6850

Name

SYK

Synonymous

-;spleen tyrosine kinase;SYK;spleen tyrosine kinase

Definition

tyrosine-protein kinase SYK

Position

9q22

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

APS(m){p} + Syk(h) <==> APS(m){p}:Syk(h) (binding)
EpoR(h){pY} + Syk(h) <==> EpoR(h){pY}:Syk(h) (binding)
Fibrinogen(h):alpha IIb-integrin(h):beta3-integrin(h):Src(h){pY419} + Syk(h) <==> Fibrinogen(h):alpha IIb-integrin(h):beta3-integrin(h):Src(h){pY419}:Syk(h) (binding)
beta3-integrin(h) + Syk(h) <==> beta3-integrin(h):Syk(h) (binding)
Fibrinogen(h):alpha IIb-integrin(h):beta3-integrin(h) + Syk(h) <==> Fibrinogen(h):alpha IIb-integrin(h):beta3-integrin(h):Syk(h) (binding)
beta2-integrin(h) + Syk(h) <==> beta2-integrin(h):Syk(h) (binding)
beta1A-integrin(h) + Syk(h) <==> beta1A-integrin(h):Syk(h) (binding)
CD22(h){pY} + Syk(h) <==> CD22(h){pY}:Syk(h) (binding)
Syk(h) + DECTIN1(m) <==> Syk(h):DECTIN1(m) (binding)
Syk(h) + PKCalpha(h) <==> Syk(h):PKCalpha(h) (binding)
Syk(h) --> PKCalpha(h){p} (activation; increase of phosphorylation)
Syk(h) + DDR1(h) <==> Syk(h):DDR1(h) (binding)
DAP12(h){p} + Syk(h) <==> DAP12(h){p}:Syk(h) (binding)
PSCDBP(m.s.){p} + Syk(h) <==> PSCDBP(m.s.){p}:Syk(h) (binding)
PSCDBP(m.s.){p} + Syk(h) + NTP --> PSCDBP(m.s.){p}:Syk(h){p} + NDP (phosphorylation; binding)
Syk(h) --> Fyn(m.s.) (binding)
Syk(h) --> mGluR1(m.s.) (binding)
Syk(h) --> SHP-2(m.s.) (binding)
Syk(h) --> Src(h) (binding)
Syk(h) --> Rac1(h) (activation)
Syk(h) --> LAT(h) (binding)
Syk(h) --> RelA-p65(h){p} (regulation of localization; increase of phosphorylation)
Syk(h) --> PLCgamma1(h) (binding)
Syk(h) + Lyn(h) <==> Syk(h):Lyn(h) (binding)
Src(h) + Syk(h) <==> Src(h):Syk(h) (binding)
FcRgamma(h){pY} + Syk(h) <==> FcRgamma(h){pY}:Syk(h) (binding)
Syk(h) + ATP --> Syk(h){pY} + ADP (phosphorylation; automodification)
Syk(h) + ATP --> Syk(h){p} + ADP (phosphorylation; automodification)
Syk(h) + CrkL(h) <==> Syk(h):CrkL(h) (binding)
Syk(h) + ErbB1-p170(h){pY915}{pY998}{pY1016}{pY1125}{pY1172} <==> Syk(h):ErbB1-p170(h){pY915}{pY998}{pY1016}{pY1125}{pY1172} (binding)
ErbB2(h){pY1023}{pY1139}{pY1196}{pY1221}{pY1222} + Syk(h) <==> ErbB2(h){pY1023}{pY1139}{pY1196}{pY1221}{pY1222}:Syk(h) (binding)
Syk(h) + ErbB3-isoform1(h){pY868}{pY1197}{pY1222}{pY1260}{pY1276}{pY1289} <==> Syk(h):ErbB3-isoform1(h){pY868}{pY1197}{pY1222}{pY1260}{pY1276}{pY1289} (binding)
ErbB4(h){pY1284} + Syk(h) <==> ErbB4(h){pY1284}:Syk(h) (binding)
Syk(h) --> Syk(h) (translocation)
Syk(h) + ErbB1(h) <==> Syk(h):ErbB1(h) (binding)
Syk(h) + TLR9(h) <==> Syk(h):TLR9(h) (binding)
Syk(h) + ATP --> Syk(h){pY} + ADP (phosphorylation)
Syk(h) + ATP --> Syk(h){p} + ADP (phosphorylation)
FCGR2(h) + Syk(h) <==> FCGR2(h):Syk(h) (binding)
FcgammaRI alpha(h) + Syk(h) <==> FcgammaRI alpha(h):Syk(h) (binding)
Syk(h) + IgG1(h):FCgammaRI(h) <==> Syk(h):IgG1(h):FCgammaRI(h) (binding)
IL-5Rbeta(h) + Syk(h) <==> IL-5Rbeta(h):Syk(h) (binding)
Lyn(h) + Syk(h) <==> Syk(h):Lyn(h) (binding)
Syk(h) + ATP --> Syk(h){pY352} + ADP (phosphorylation)
Syk(h) + 2 ATP --> Syk(h){pY525}{pY526} + 2 ADP (phosphorylation)
Syk(h) --> icam1(h) (increase of abundance)
RelA-p65(h) + Syk(h) <==> RelA-p65(h):Syk(h) (binding)
Syk(h) --> IL-1beta(h) (increase of secretion)
Syk(h) --> IL1B(h) (transactivation)
Syk(h) --> Caspase-1-p20(h) (increase of abundance)
SYK(h) --> Syk(h) (expression).
Lck(h) --> Syk(h) (binding)
PSCDBP(m.s.) --> Syk(h) (binding)
ZAP-70(h) --> Syk(h) (binding)
GP6(h) --> Syk(h) (activation)
CD22(h){pY} --> Syk(h) (binding)
SHP-1(h) --> Syk(h) (binding)
Syk(h) --> Syk(h) (translocation)
Syk(h){pY} --> Syk(h) + ATP (dephosphorylation)
APS(m) + NTP --Syk(h)--> APS(m){p} + NDP (phosphorylation)
HS1(h) + ATP --Syk(h)--> HS1(h){p} + ADP (phosphorylation)
SLP-76(h) + ATP --Syk(h)--> SLP-76(h){pY} + ADP (phosphorylation)
SLP-76(h) + 2 ATP --Syk(h)--> SLP-76(h){pY113}{pY128} + 2 ADP (phosphorylation)
SYK(h) --> Syk-isoform2(h) (expression).
Syk-isoform1(h) + 2 ATP --> Syk-isoform1(h){pY348}{pY352} + 2 ADP (phosphorylation)
Syk-isoform1(h) + ATP --> Syk-isoform1(h){p} + ADP (phosphorylation)
SYK(h) --> Syk-isoform1(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

323Phosphotyrosine (by LYN) (By similarity).Swiss-Prot 53.0
348Phosphotyrosine.Swiss-Prot 53.0
352Phosphotyrosine.Swiss-Prot 53.0
525Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
348Phosphotyrosine (Syk)8657103;12522270Phospho.ELM 6.0
352Phosphotyrosine (Syk)8657103;12522270Phospho.ELM 6.0
525Phosphotyrosine (Syk)8657103Phospho.ELM 6.0
526Phosphotyrosine (Syk)8657103Phospho.ELM 6.0
323Phosphotyrosine16497976Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr9

 Promoter: 92602391 - 92604391Agilent_014791

chr9

 Promoter: 92602391 - 92604391GoldenGate_Methylation_Cancer_Panel_I

chr9

 Promoter: 92602391 - 92604391GSE27584

chr9

 Promoter: 92602391 - 92604391Agilent_014791_44K

chr9

 Promoter: 92602391 - 92604391PMID:20064646

chr9

 Promoter: 92602391 - 92604391PMID:11454707

chr9

 Promoter: 92602391 - 92604391PMID:15172987

chr9

 Promoter: 92602391 - 92604391PMID:15059510

chr9

 Promoter: 92602391 - 92604391PMID:15188513

chr9

 Promoter: 92602391 - 92604391PMID:17143801

chr9

 Promoter: 92602391 - 92604391PMID:16192589

chr9

 Promoter: 92602391 - 92604391PMID:16964403

chr9

 Promoter: 92602391 - 92604391PMID:16304050

chr9

 Promoter: 92602391 - 92604391PMID:15713962

chr9

 Promoter: 92602391 - 92604391PMID:14970867

chr9

 Promoter: 92602391 - 92604391PMID:16435073

chr9

 Promoter: 92602391 - 92604391PMID:15316056

chr9

 Promoter: 92602391 - 92604391PMID:17121887

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