Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

6850

Name

SYK

Synonymous

-;spleen tyrosine kinase;SYK;spleen tyrosine kinase

Definition

tyrosine-protein kinase SYK

Position

9q22

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction

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Interaction Type

Interactor

Data Source

interacts with

LYNBIOGRID; PUBMED:7831290;

interacts with

TUBA1ABIOGRID; PUBMED:10862713;

interacts with

TRAF6BIOGRID; PUBMED:11418661;

interacts with

RPS6KB1BIOGRID; PUBMED:16640565;

interacts with

PRKD1BIOGRID; PUBMED:8885868;

interacts with

LCKBIOGRID; PUBMED:7539035;

interacts with

LATBIOGRID; PUBMED:11368773;

interacts with

RPS6KB2BIOGRID; PUBMED:16640565;

interacts with

CD4BIOGRID; PUBMED:7539035;

interacts with

HDAC9BIOGRID; PUBMED:16288017;

interacts with

HDAC3BIOGRID; PUBMED:16288017;

interacts with

HDAC2BIOGRID; PUBMED:16288017;

interacts with

HDAC1BIOGRID; PUBMED:16288017;

interacts with

HDAC6BIOGRID; PUBMED:16288017;

interacts with

HDAC4BIOGRID; PUBMED:16288017;

interacts with

MS4A2BIOGRID; PUBMED:8071371;

interacts with

PTK2BBIOGRID; PUBMED:10747947;

interacts with

FCGR2ABIOGRID; PUBMED:11141335;

interacts with

FCGR2ABIOGRID; PUBMED:9268059;

interacts with

PTK2BIOGRID; PUBMED:9169439;

interacts with

PTK2BIOGRID; PUBMED:9342235;

interacts with

FCRL3BIOGRID; PUBMED:12051764;

interacts with

FYNBIOGRID; PUBMED:9535867;

interacts with

FGRBIOGRID; PUBMED:11672534;

interacts with

FCER1GBIOGRID; PUBMED:8071371;

interacts with

EPORBIOGRID; PUBMED:9852052;

interacts with

CD3EBIOGRID; PUBMED:7761456;

interacts with

CD79ABIOGRID; PUBMED:7500027;

interacts with

CD19BIOGRID; PUBMED:9120258;

interacts with

CD22BIOGRID; PUBMED:8627166;

interacts with

CRKLBIOGRID; PUBMED:11313252;

interacts with

CSF3RBIOGRID; PUBMED:8197119;

interacts with

CBLBIOGRID; PUBMED:11331248;

interacts with

CBLBIOGRID; PUBMED:11742985;

interacts with

CBLBIOGRID; PUBMED:12435267;

interacts with

CBLBIOGRID; PUBMED:15577829;

interacts with

CBLBIOGRID; PUBMED:9857068;

interacts with

SH3BP2BIOGRID; PUBMED:9846481;

interacts with

ITGB2BIOGRID; PUBMED:10961871;

interacts with

PLCG2BIOGRID; PUBMED:10981967;

interacts with

PTPN6BIOGRID; PUBMED:10072516;

interacts with

PTPN6BIOGRID; PUBMED:10747947;

interacts with

PLCG1BIOGRID; PUBMED:7831290;

interacts with

SRCBIOGRID; PUBMED:7513017;

interacts with

CTTNBIOGRID; PUBMED:8636079;

interacts with

SP1BIOGRID; PUBMED:16288017;

interacts with

SLABIOGRID; PUBMED:10449770;

interacts with

VAV1BIOGRID; PUBMED:11331248;

interacts with

VAV1BIOGRID; PUBMED:8900182;

interacts with

VAV1BIOGRID; PUBMED:8986718;

interacts with

CD79BBIOGRID; PUBMED:7500027;

interacts with

SIRPB1BIOGRID; PUBMED:10940905;

interacts with

SIT1BIOGRID; PUBMED:10209036;

interacts with

CBLBBIOGRID; PUBMED:10022120;

interacts with

PAG1BIOGRID; PUBMED:10790433;

interacts with

PXNBIOGRID; PUBMED:9590268;

interacts with

CD72BIOGRID; PUBMED:9590210;

interacts with

MAP4K1HPRD; PUBMED:11514608;

interacts with

LYNHPRD; PUBMED:10469124;

interacts with

LYNHPRD; PUBMED:7831290;

interacts with

MAPK3HPRD; PUBMED:9218456;

interacts with

TUBA1AHPRD; PUBMED:10862713;

interacts with

TRAF6HPRD; PUBMED:11418661;

interacts with

TNFRSF1AHPRD; PUBMED:16291755;

interacts with

TUBA4AHPRD; PUBMED:8617742;

interacts with

NFAM1HPRD; PUBMED:15143214;

interacts with

PRKD1HPRD; PUBMED:8885868;

interacts with

LCKHPRD; PUBMED:7539035;

interacts with

LAX1HPRD; PUBMED:12359715;

interacts with

LATHPRD; PUBMED:10469124;

interacts with

LATHPRD; PUBMED:9891970;

interacts with

PRKCAHPRD; PUBMED:12881490;

interacts with

RPS6KA1HPRD; PUBMED:9218456;

interacts with

LCP2HPRD; PUBMED:10469124;

interacts with

LCP2HPRD; PUBMED:15388330;

interacts with

SLC4A1HPRD; PUBMED:1998697;

interacts with

BLNKHPRD; PUBMED:10981967;

interacts with

BTKHPRD; PUBMED:11226282;

interacts with

PIK3AP1HPRD; PUBMED:11163197;

interacts with

HCLS1HPRD; PUBMED:9104825;

interacts with

HNRNPUHPRD; PUBMED:7831290;

interacts with

DUSP3HPRD; PUBMED:12447358;

interacts with

FCGR1AHPRD; PUBMED:11141335;

interacts with

GAB2HPRD; PUBMED:11895767;

interacts with

MS4A2HPRD; PUBMED:8071371;

interacts with

PTK2BHPRD; PUBMED:10747947;

interacts with

FCGR2AHPRD; PUBMED:8756631;

interacts with

FYNHPRD; PUBMED:9535867;

interacts with

FCER1GHPRD; PUBMED:10469124;

interacts with

FCER1GHPRD; PUBMED:8071371;

interacts with

EPORHPRD; PUBMED:9852052;

interacts with

CD3EHPRD; PUBMED:7761456;

interacts with

CD79AHPRD; PUBMED:7500027;

interacts with

CD19HPRD; PUBMED:9120258;

interacts with

CRKLHPRD; PUBMED:11313252;

interacts with

CRKLHPRD; PUBMED:15556646;

interacts with

CSF3RHPRD; PUBMED:8197119;

interacts with

DBNLHPRD; PUBMED:9891087;

interacts with

CBLHPRD; PUBMED:15556646;

interacts with

CBLHPRD; PUBMED:8621719;

interacts with

IL2RBHPRD; PUBMED:7600304;

interacts with

IL15RAHPRD; PUBMED:11714793;

interacts with

RASA1HPRD; PUBMED:9218456;

interacts with

CSF2RBHPRD; PUBMED:8666899;

interacts with

JAK1HPRD; PUBMED:10825200;

interacts with

SH3BP2HPRD; PUBMED:9846481;

interacts with

ITGB2HPRD; PUBMED:12885943;

interacts with

PLCG2HPRD; PUBMED:10469124;

interacts with

PLCG2HPRD; PUBMED:12470302;

interacts with

PTPN6HPRD; PUBMED:10072516;

interacts with

SNCAHPRD; PUBMED:12096713;

interacts with

STAT5AHPRD; PUBMED:10825200;

interacts with

STAT3HPRD; PUBMED:10825200;

interacts with

SRCHPRD; PUBMED:7513017;

interacts with

CTTNHPRD; PUBMED:8636079;

interacts with

STAT1HPRD; PUBMED:15467722;

interacts with

SLAHPRD; PUBMED:10449770;

interacts with

TYROBPHPRD; PUBMED:9490415;

interacts with

VAV1HPRD; PUBMED:8986718;

interacts with

VAV2HPRD; PUBMED:15345594;

interacts with

CD79BHPRD; PUBMED:7538118;

interacts with

SHC1HPRD; PUBMED:10482988;

interacts with

SH2B2HPRD; PUBMED:10872802;

interacts with

SIT1HPRD; PUBMED:10209036;

interacts with

SELPLGHPRD; PUBMED:12387735;

interacts with

CBLBHPRD; PUBMED:10022120;

interacts with

POU2AF1HPRD; PUBMED:16713566;

interacts with

PAG1HPRD; PUBMED:10790433;

interacts with

PIK3R2HPRD; PUBMED:15536084;

interacts with

PIK3R2HPRD; PUBMED:15556646;

interacts with

PXNHPRD; PUBMED:9590268;

interacts with

PIK3R1HPRD; PUBMED:15536084;

interacts with

PIK3R1HPRD; PUBMED:15556646;

interacts with

MSNMINT; PUBMED:12387735;

interacts with

LCKMINT; PUBMED:15536084;

interacts with

LCKMINT; PUBMED:8621719;

interacts with

LCKMINT; PUBMED:8798676;

interacts with

BLNKMINT; PUBMED:18369315;

interacts with

ERBB4MINT; PUBMED:16273093;

interacts with

EGFRMINT; PUBMED:16273093;

interacts with

FCGR2AMINT; PUBMED:7487883;

interacts with

FGRMINT; PUBMED:15536084;

interacts with

FCER1GMINT; PUBMED:8810294;

interacts with

ERBB3MINT; PUBMED:16273093;

interacts with

ERBB2MINT; PUBMED:16273093;

interacts with

CD3EMINT; PUBMED:7761456;

interacts with

CD3EMINT; PUBMED:9698567;

interacts with

Nfam1MINT; PUBMED:15143214;

interacts with

Fcer1gMINT; PUBMED:7623809;

interacts with

CBLMINT; DOI:10.1182/blood-2003-08-2965;

interacts with

CBLMINT; PUBMED:15556646;

interacts with

CBLMINT; PUBMED:18273061;

interacts with

CBLMINT; PUBMED:8621719;

interacts with

SH3BP2MINT; DOI:10.1182/blood-2003-08-2965;

interacts with

PLCG1MINT; DOI:10.1182/blood-2003-08-2965;

interacts with

PLCG1MINT; PUBMED:8657103;

interacts with

VAV1MINT; DOI:10.1182/blood-2003-08-2965;

interacts with

VAV2MINT; DOI:10.1182/blood-2003-08-2965;

interacts with

PIK3R2MINT; PUBMED:15536084;

interacts with

PIK3R1MINT; PUBMED:15536084;

Metabolic Interaction

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There is no record for SYK

Signaling Interaction

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Interaction Type

Interactor

Data Source

reacts with

LYNIMID; PUBMED:7831290;

reacts with

SYKIMID; PUBMED:15173175;

reacts with

SYKIMID; PUBMED:7831290;

state change

SRCIMID; PUBMED:7513017;

reacts with

LYNNCI_NATURE; PUBMED:10820378;

reacts with

LYNNCI_NATURE; PUBMED:11226282;PUBMED:11577348;PUBMED:12780340;PUBMED:10339589;

reacts with

LYNNCI_NATURE; PUBMED:11356834;

reacts with

LYNNCI_NATURE; PUBMED:11465115;

reacts with

LYNNCI_NATURE; PUBMED:11909947;

reacts with

LYNNCI_NATURE; PUBMED:14757742;

reacts with

LYNNCI_NATURE; PUBMED:8666899;

reacts with

LYNNCI_NATURE; PUBMED:9058799;

reacts with

FASLGNCI_NATURE; PUBMED:20153221;PUBMED:16033886;

reacts with

FASNCI_NATURE; PUBMED:20153221;PUBMED:16033886;

reacts with

SYKNCI_NATURE; PUBMED:10820378;

reacts with

SYKNCI_NATURE; PUBMED:11226282;PUBMED:11577348;PUBMED:12780340;PUBMED:10339589;

reacts with

SYKNCI_NATURE; PUBMED:11356834;

reacts with

SYKNCI_NATURE; PUBMED:11465115;

reacts with

SYKNCI_NATURE; PUBMED:11909947;

reacts with

SYKNCI_NATURE; PUBMED:12393431;PUBMED:7600304;PUBMED:10825200;

reacts with

SYKNCI_NATURE; PUBMED:14757742;

reacts with

SYKNCI_NATURE; PUBMED:20153221;PUBMED:16033886;

reacts with

SYKNCI_NATURE; PUBMED:8666899;

reacts with

SYKNCI_NATURE; PUBMED:9058799;

state change

KLRG1NCI_NATURE; PUBMED:11465115;

reacts with

LCKNCI_NATURE; PUBMED:12393431;PUBMED:7600304;PUBMED:10825200;

reacts with

BLNKNCI_NATURE; PUBMED:10820378;

reacts with

BLNKNCI_NATURE; PUBMED:11226282;PUBMED:11577348;PUBMED:12780340;PUBMED:10339589;

reacts with

BLNKNCI_NATURE; PUBMED:11356834;

reacts with

BLNKNCI_NATURE; PUBMED:11909947;

reacts with

BTKNCI_NATURE; PUBMED:10820378;

reacts with

BTKNCI_NATURE; PUBMED:11226282;PUBMED:11577348;PUBMED:12780340;PUBMED:10339589;

reacts with

BTKNCI_NATURE; PUBMED:11356834;

reacts with

MS4A2NCI_NATURE; PUBMED:11465115;

reacts with

MS4A2NCI_NATURE; PUBMED:14757742;

reacts with

FCER1GNCI_NATURE; PUBMED:11465115;

reacts with

FCER1GNCI_NATURE; PUBMED:14757742;

reacts with

FCER1ANCI_NATURE; PUBMED:11465115;

reacts with

FCER1ANCI_NATURE; PUBMED:14757742;

reacts with

CD79ANCI_NATURE; PUBMED:10820378;

reacts with

CD79ANCI_NATURE; PUBMED:11226282;PUBMED:11577348;PUBMED:12780340;PUBMED:10339589;

reacts with

CD79ANCI_NATURE; PUBMED:11356834;

reacts with

CD79ANCI_NATURE; PUBMED:11909947;

reacts with

CD79ANCI_NATURE; PUBMED:9058799;

reacts with

CSF2NCI_NATURE; PUBMED:8666899;

reacts with

CSF2RANCI_NATURE; PUBMED:8666899;

state change

ITGB3NCI_NATURE; PUBMED:11940607;PUBMED:14624447;

reacts with

IL2RANCI_NATURE; PUBMED:12393431;PUBMED:7600304;PUBMED:10825200;

reacts with

IL2RBNCI_NATURE; PUBMED:12393431;PUBMED:7600304;PUBMED:10825200;

reacts with

IL2RGNCI_NATURE; PUBMED:12393431;PUBMED:7600304;PUBMED:10825200;

state change

IBTKNCI_NATURE; PUBMED:11226282;PUBMED:11577348;PUBMED:12780340;PUBMED:10339589;

reacts with

CSF2RBNCI_NATURE; PUBMED:8666899;

reacts with

JAK1NCI_NATURE; PUBMED:12393431;PUBMED:7600304;PUBMED:10825200;

reacts with

JAK3NCI_NATURE; PUBMED:12393431;PUBMED:7600304;PUBMED:10825200;

state change

SH3BP5NCI_NATURE; PUBMED:11226282;PUBMED:11577348;PUBMED:12780340;PUBMED:10339589;

reacts with

IGHENCI_NATURE; PUBMED:11465115;

reacts with

IGHENCI_NATURE; PUBMED:14757742;

state change

ITGAVNCI_NATURE; PUBMED:11940607;PUBMED:14624447;

reacts with

IL2NCI_NATURE; PUBMED:12393431;PUBMED:7600304;PUBMED:10825200;

reacts with

PLCG2NCI_NATURE; PUBMED:10820378;

reacts with

PLCG2NCI_NATURE; PUBMED:11226282;PUBMED:11577348;PUBMED:12780340;PUBMED:10339589;

reacts with

PLCG2NCI_NATURE; PUBMED:11356834;

reacts with

PTPN6NCI_NATURE; PUBMED:11356834;

state change

PTPN6NCI_NATURE; PUBMED:9058799;

state change

PTPN11NCI_NATURE; PUBMED:11465115;

reacts with

SRCNCI_NATURE; PUBMED:20153221;PUBMED:16033886;

reacts with

WIPF1NCI_NATURE; PUBMED:14757742;

reacts with

CD79BNCI_NATURE; PUBMED:10820378;

reacts with

CD79BNCI_NATURE; PUBMED:11226282;PUBMED:11577348;PUBMED:12780340;PUBMED:10339589;

reacts with

CD79BNCI_NATURE; PUBMED:11356834;

reacts with

CD79BNCI_NATURE; PUBMED:11909947;

reacts with

CD79BNCI_NATURE; PUBMED:9058799;

state change

SPP1NCI_NATURE; PUBMED:11940607;PUBMED:14624447;

reacts with

CD72NCI_NATURE; PUBMED:10820378;

reacts with

CD72NCI_NATURE; PUBMED:11356834;

reacts with

LYNREACTOME; PUBMED:10669724;

reacts with

LYNREACTOME; PUBMED:9099676;PUBMED:18689684;PUBMED:8617742;

reacts with

LYNREACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

state change

LYNREACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

reacts with

TLN1REACTOME; PUBMED:12171941;PUBMED:11940607;PUBMED:15205259;PUBMED:9351824;PUBMED:17055557;

reacts with

TLN1REACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

state change

TLN1REACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

reacts with

SYKREACTOME; PUBMED:10669724;

reacts with

SYKREACTOME; PUBMED:10825200;

reacts with

SYKREACTOME; PUBMED:11007481;PUBMED:8986718;PUBMED:11262396;PUBMED:17054426;

reacts with

SYKREACTOME; PUBMED:12171941;PUBMED:11940607;PUBMED:15205259;PUBMED:9351824;PUBMED:17055557;

reacts with

SYKREACTOME; PUBMED:7600304;

reacts with

SYKREACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

reacts with

SYKREACTOME; PUBMED:9099676;PUBMED:18689684;PUBMED:8617742;

reacts with

SYKREACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

state change

SYKREACTOME; PUBMED:10825200;

state change

SYKREACTOME; PUBMED:11007481;PUBMED:8986718;PUBMED:11262396;PUBMED:17054426;

state change

SYKREACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

state change

SYKREACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

reacts with

LCP2REACTOME; PUBMED:12555096;PUBMED:16493428;PUBMED:11050236;PUBMED:9884330;PUBMED:8702662;PUBMED:10026222;PUBMED:11901197;

reacts with

GP6REACTOME; PUBMED:10669724;

reacts with

GP6REACTOME; PUBMED:9099676;PUBMED:18689684;PUBMED:8617742;

reacts with

GP6REACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

state change

GP6REACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

reacts with

FYNREACTOME; PUBMED:10669724;

reacts with

FYNREACTOME; PUBMED:9099676;PUBMED:18689684;PUBMED:8617742;

reacts with

FYNREACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

state change

FYNREACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

reacts with

FCER1GREACTOME; PUBMED:10669724;

reacts with

FCER1GREACTOME; PUBMED:9099676;PUBMED:18689684;PUBMED:8617742;

reacts with

FCER1GREACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

state change

FCER1GREACTOME; PUBMED:9099676;PUBMED:1874735;PUBMED:11481033;PUBMED:18818202;PUBMED:19409513;

reacts with

ITGB3REACTOME; PUBMED:12171941;PUBMED:11940607;PUBMED:15205259;PUBMED:9351824;PUBMED:17055557;

reacts with

ITGB3REACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

state change

ITGB3REACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

reacts with

IL2RAREACTOME; PUBMED:10825200;

reacts with

IL2RAREACTOME; PUBMED:7600304;

state change

IL2RAREACTOME; PUBMED:10825200;

reacts with

IL2RBREACTOME; PUBMED:10825200;

reacts with

IL2RBREACTOME; PUBMED:7600304;

state change

IL2RBREACTOME; PUBMED:10825200;

reacts with

IL2RGREACTOME; PUBMED:10825200;

reacts with

IL2RGREACTOME; PUBMED:7600304;

state change

IL2RGREACTOME; PUBMED:10825200;

reacts with

JAK1REACTOME; PUBMED:10825200;

reacts with

JAK1REACTOME; PUBMED:7600304;

state change

JAK1REACTOME; PUBMED:10825200;

reacts with

JAK3REACTOME; PUBMED:10825200;

reacts with

JAK3REACTOME; PUBMED:7600304;

state change

JAK3REACTOME; PUBMED:10825200;

reacts with

APBB1IPREACTOME; PUBMED:12171941;PUBMED:11940607;PUBMED:15205259;PUBMED:9351824;PUBMED:17055557;

reacts with

APBB1IPREACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

state change

APBB1IPREACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

reacts with

ITGA2BREACTOME; PUBMED:12171941;PUBMED:11940607;PUBMED:15205259;PUBMED:9351824;PUBMED:17055557;

reacts with

ITGA2BREACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

state change

ITGA2BREACTOME; PUBMED:7961845;PUBMED:9351824;PUBMED:7513017;

reacts with

IL2REACTOME; PUBMED:10825200;

reacts with

IL2REACTOME; PUBMED:7600304;

state change

IL2REACTOME; PUBMED:10825200;

reacts with

PIK3CBREACTOME; PUBMED:19700402;PUBMED:9852111;PUBMED:19515725;

reacts with

PIK3CGREACTOME; PUBMED:19700402;PUBMED:9852111;PUBMED:19515725;


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