Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

7490

Name

WT1

Synonym

AWT1|EWS-WT1|GUD|NPHS4|WAGR|WIT-2|WT33;Wilms tumor 1;WT1;Wilms tumor 1

Definition

Wilms tumor protein|amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1

Position

11p13

Gene Type

protein-coding

Source

Count: 3; Pubmed_search,Generif,UniProt

Literature support

Count: 68 PubMed records as below.

Evidence Status

Description

reviewed

Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition.

reviewed

Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1.

reviewed

Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.

reviewed

"A novel mutation H373Y in the Wilms' tumor suppressor gene, WT1, associated with Denys-Drash syndrome."

reviewed

"A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1."

reviewed

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor.

reviewed

The Wilms' tumor suppressor gene WT1 is negatively autoregulated.

reviewed

Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.

reviewed

"Analysis of the Wilms' tumor suppressor gene (WT1) in patients 46,XY disorders of sex development."

reviewed

tumor suppressor menin represses paired box gene 2 expression via Wilms tumor suppressor protein-polycomb group complex.
More detail of all 68 literatures about WT1

Pathways and Diseases

Pathway

chaperones modulate interferon signaling pathway;PID BioCarta;100016

Pathway

overview of telomerase protein component gene htert transcriptional regulation;PID BioCarta;100019

Pathway

Regulation of Telomerase;PID Curated;200072

Disease

Denys-Drash syndrome;GAD

Disease

Nephrotic syndrome, typ 4;OMIM

Disease

Alzheimer's disease;GAD

Disease

Cancer;FunDO

Disease

WAGR Syndrome;GAD

Disease

DEVELOPMENTAL;GAD

Disease

glomerulosclerosis, focal;GAD

Disease

Pleural effusion, Malignant;FunDO

Disease

Meacham syndrome;OMIM

Disease

Frasier syndrome;OMIM

Disease

Wilm's tumor;GAD

Disease

Aplastic anemia;FunDO

Disease

Yersinia infection;FunDO

Disease

Cirrhosis;FunDO

Disease

Alzheimer's disease;FunDO

Disease

wilms' tumor and congenital male genitourinary malformation;GAD

Disease

Nephritis;FunDO

Disease

Proteinuria;FunDO

Disease

Wilms tumor, type 1;OMIM

Disease

CANCER;GAD

Disease

hypospadias;GAD

Disease

Endometriosis;FunDO

Disease

NEUROLOGICAL;GAD

Disease

abnormal urogenital development;GAD

Disease

Hyperparathyroidism;FunDO

Disease

nephrotic syndrome;GAD

Disease

Urogenital abnormalities;FunDO

Disease

Denys-Drash syndrome;OMIM

Disease

RENAL;GAD

External Links

Links to Entrez Gene

7490

Links to all GeneRIF Items

7490

Links to iHOP

7490

Sequence Information

Nucleotide Sequence

>7490 : length: 1494
ctgcaggacccggcttccacgtgtgtcccggagccggcgtctcagcacacgctccgctcc
gggcctgggtgcctacagcagccagagcagcagggagtccgggacccgggcggcatctgg
gccaagttaggcgccgccgaggccagcgctgaacgtctccagggccggaggagccgcggg
gcgtccgggtctgagccgcagcaaatgggctccgacgtgcgggacctgaacgcgctgctg
cccgccgtcccctccctgggtggcggcggcggctgtgccctgcctgtgagcggcgcggcg
cagtgggcgccggtgctggactttgcgcccccgggcgcttcggcttacgggtcgttgggc
ggccccgcgccgccaccggctccgccgccacccccgccgccgccgcctcactccttcatc
aaacaggagccgagctggggcggcgcggagccgcacgaggagcagtgcctgagcgccttc
actgtccacttttccggccagttcactggcacagccggagcctgtcgctacgggcccttc
ggtcctcctccgcccagccaggcgtcatccggccaggccaggatgtttcctaacgcgccc
tacctgcccagctgcctcgagagccagcccgctattcgcaatcagggttacagcacggtc
accttcgacgggacgcccagctacggtcacacgccctcgcaccatgcggcgcagttcccc
aaccactcattcaagcatgaggatcccatgggccagcagggctcgctgggtgagcagcag
tactcggtgccgcccccggtctatggctgccacacccccaccgacagctgcaccggcagc
caggctttgctgctgaggacgccctacagcagtgacaatttataccaaatgacatcccag
cttgaatgcatgacctggaatcagatgaacttaggagccaccttaaagggccacagcaca
gggtacgagagcgataaccacacaacgcccatcctctgcggagcccaatacagaatacac
acgcacggtgtcttcagaggcattcaggatgtgcgacgtgtgcctggagtagccccgact
cttgtacggtcggcatctgagaccagtgagaaacgccccttcatgtgtgcttacccaggc
tgcaataagagatattttaagctgtcccacttacagatgcacagcaggaagcacactggt
gagaaaccataccagtgtgacttcaaggactgtgaacgaaggttttctcgttcagaccag
ctcaaaagacaccaaaggagacatacaggtgtgaaaccattccagtgtaaaacttgtcag
cgaaagttctcccggtccgaccacctgaagacccacaccaggactcatacaggtgaaaag
cccttcagctgtcggtggccaagttgtcagaaaaagtttgcccggtcagatgaattagtc
cgccatcacaacatgcatcagagaaacatgaccaaactccagctggcgctttga

Protein Sequence

>7490 : length: 497
MQDPASTCVPEPASQHTLRSGPGCLQQPEQQGVRDPGGIWAKLGAAEASAERLQGRRSRG
ASGSEPQQMGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLG
GPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPF
GPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFP
NHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQ
LECMTWNQMNLGATLKGHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPT
LVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQ
LKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELV
RHHNMHQRNMTKLQLAL



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