General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	7490
Name	WT1
Synonymous	AWT1\|EWS-WT1\|GUD\|NPHS4\|WAGR\|WIT-2\|WT33;Wilms tumor 1;WT1;Wilms tumor 1
Definition	Wilms tumor protein\|amino-terminal domain of EWS\|last three zinc fingers of the DNA-binding domain of WT1
Position	11p13
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database
pawr(h) + WT1(h) <==> pawr(h):WT1(h) (binding)
WT1(h) --> Egr1(m) (DNA binding).
WT1(h) --> IGF2(h) (DNA binding).
WT1(h) --> PDGFA(h) (DNA binding).
WT1(h) --> IGF-1 receptor(r) (DNA binding).
WT1(h) --> FOXD1(h) (DNA binding).
WT1(h) + p53(r) <==> WT1(h):p53(r) (binding)
WT1(h) + p53(h) <==> WT1(h):p53(h) (binding).
p73alpha(mo) + WT1(h) <==> p73alpha(mo):WT1(h) (binding)
WT1(h) --/ IGF-1 receptor(r) (transrepression)
WT1(h) --> WT1(h) (expression).
WT1 I -KTS(h) --> IGF-1 receptor(r) (DNA binding).
p73alpha(mo) + WT1 I -KTS(h) <==> p73alpha(mo):WT1 I -KTS(h) (binding)
p73beta(mo) + WT1 I -KTS(h) <==> p73beta(mo):WT1 I -KTS(h) (binding)
p53(h) + WT1 I -KTS(h) <==> p53(h):WT1 I -KTS(h) (binding)
p63(r) + WT1 I -KTS(h) <==> p63(r):WT1 I -KTS(h) (binding)
WT1 I -KTS(h) --/ IGF-1 receptor(r) (transrepression)
WT1 I -KTS(h) + ER-alpha(m.s.) <==> WT1 I -KTS(h):ER-alpha(m.s.) (binding)
WT1 I -KTS(h) + Slim-3(h) <==> WT1 I -KTS(h):Slim-3(h) (binding)
Slim-3(m.s.) + WT1 I -KTS(h) <==> Slim-3(m.s.):WT1 I -KTS(h) (binding)
WT1 I -KTS(h) --> DAX1(m) (transactivation)
WT1(h) --> WT1 I -KTS(h) (expression).
WT1 -KTS(h) --> IGF-1 receptor(r) (DNA binding).
p73alpha(mo) + WT1 -KTS(h) <==> p73alpha(mo):WT1 -KTS(h) (binding)
WT1 -KTS(h) --/ IGF-1 receptor(r) (transrepression)
WT1(h) --> WT1 -KTS(h) (expression).
WT1 I(h) --> IGF-1 receptor(r) (DNA binding).
p73alpha(mo) + WT1 I(h) <==> p73alpha(mo):WT1 I(h) (binding)
WT1 I(h) --/ IGF-1 receptor(r) (transrepression)
WT1(h) --> WT1 I(h) (expression).
WT1(h) --> WT1-del2(h) (expression).
WT1(h) --> WT1 I-del2(h) (expression).
WT1(h) --> c-myb(h) (DNA binding).
WT1(h) --> TBXA2R(h) (DNA binding).
WT1(h) --> WT1(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)	PTM type	Literature	Database

Methylation Profile From DiseaseMeth database

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Chromosome	Location	Source
chr11	Promoter: 32413163 - 32415163	GoldenGate_Methylation_Cancer_Panel_I
chr11	Promoter: 32413163 - 32415163	GoldenGate_Methylation_Cancer_Panel_I
chr11	Promoter: 32413163 - 32415163	GoldenGate_Methylation_Cancer_Panel_I
chr11	Promoter: 32413163 - 32415163	GoldenGate_Methylation_Cancer_Panel_I
chr11	Promoter: 32413163 - 32415163	GSE27584
chr11	Promoter: 32413163 - 32415163	GSE27584
chr11	Promoter: 32413163 - 32415163	GSE27584
chr11	Promoter: 32413163 - 32415163	GSE27584
chr11	Promoter: 32413163 - 32415163	Agilent_014791_44K
chr11	Promoter: 32413163 - 32415163	E-GEOD-20553
chr11	Promoter: 32413163 - 32415163	E-GEOD-20553
chr11	Promoter: 32413163 - 32415163	E-GEOD-20553
chr11	Promoter: 32413163 - 32415163	E-GEOD-20553
chr11	Promoter: 32413163 - 32415163	PMID:16134181
chr11	Promoter: 32413163 - 32415163	PMID:16134181
chr11	Promoter: 32413163 - 32415163	PMID:16134181
chr11	Promoter: 32413163 - 32415163	PMID:16134181
chr11	Promoter: 32413163 - 32415163	PMID:17289889
chr11	Promoter: 32413163 - 32415163	PMID:17289889
chr11	Promoter: 32413163 - 32415163	PMID:17289889
chr11	Promoter: 32413163 - 32415163	PMID:17289889
chr11	Promoter: 32413163 - 32415163	PMID:15367334
chr11	Promoter: 32413163 - 32415163	PMID:15367334
chr11	Promoter: 32413163 - 32415163	PMID:15367334
chr11	Promoter: 32413163 - 32415163	PMID:15367334
chr11	Promoter: 32413163 - 32415163	PMID:16435073
chr11	Promoter: 32413163 - 32415163	PMID:16435073
chr11	Promoter: 32413163 - 32415163	PMID:16435073
chr11	Promoter: 32413163 - 32415163	PMID:16435073