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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 7490 |
Name | WT1 |
Synonymous | AWT1|EWS-WT1|GUD|NPHS4|WAGR|WIT-2|WT33;Wilms tumor 1;WT1;Wilms tumor 1 |
Definition | Wilms tumor protein|amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1 |
Position | 11p13 |
Gene Type | protein-coding |
Gene Mutation: | Substitution Insertion & Deletion Other Mutation |
Substitution | | Top | |
There is no record for WT1 |
Indel | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Deletion - Frameshift; c.345_363del19; 11:32412901-32412919 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.455_459delTCACC; 11:32406725-32406729 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.925_928delACTC; 11:32374496-32374499 |
kidney | unilateral; Wilms_tumour |
Deletion - Frameshift; c.920_932del13; 11:32374492-32374504 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.924_927delGACT; 11:32374497-32374500 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Deletion - Frameshift; c.80_83delCTGT; 11:32413181-32413184 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.933delA; 11:32374491-32374491 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.898_929del32; 11:32374495-32374526 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.993_993delT; 11:32374431-32374431 |
haematopoietic_and_lymphoid_ti | M1; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.900_937del38; 11:32374487-32374524 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia_therapy_related; haematopoietic_neoplasm |
Deletion - In frame; c.1136_1228del93; 11:32370094-32370186 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_leukaemia; lymphoid_neoplasm |
Deletion - Frameshift; c.933delA; 11:32374491-32374491 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.926_945del20; 11:32374479-32374498 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.231_264del34; 11:32413000-32413033 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.1298_1299delGC; 11:32367231-32367232 |
kidney | unilateral; Wilms_tumour |
Deletion - Frameshift; c.932_933delTA; 11:32374491-32374492 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.590delC; 11:32406156-32406156 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.593delC; 11:32406153-32406153 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.206_209delACTC; 11:32413055-32413058 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Deletion - Frameshift; c.940_946delGCATCTG; 11:32374478-32374484 |
haematopoietic_and_lymphoid_ti | M4; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.1298_1299delGC; 11:32367231-32367232 |
kidney | unilateral; Wilms_tumour |
Deletion - Frameshift; c.919_934del16; 11:32374490-32374505 |
kidney | unilateral; Wilms_tumour |
Deletion - Frameshift; c.440delA; 11:32412824-32412824 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.1093delT; 11:32370830-32370830 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.932_939delTACGGTCG; 11:32374485-32374492 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.925_928delACTC; 11:32374496-32374499 |
kidney | unilateral; Wilms_tumour |
Deletion - Frameshift; c.372_376delGGCCA; 11:32412888-32412892 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.168delG; 11:32413096-32413096 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.1190_1200del11; 11:32370122-32370132 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.932_939delTACGGTCG; 11:32374485-32374492 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.928_931delCTTG; 11:32374493-32374496 |
haematopoietic_and_lymphoid_ti | M4; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.928_931delCTTG; 11:32374493-32374496 |
haematopoietic_and_lymphoid_ti | M4; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - In frame; c.937_939delTCG; 11:32374485-32374487 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.933delA; 11:32374491-32374491 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.901delC; 11:32374523-32374523 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Deletion - Frameshift; c.711delC; 11:32395734-32395734 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.933delA; 11:32374491-32374491 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.904delC; 11:32374520-32374520 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Deletion - Frameshift; c.993_993delT; 11:32374431-32374431 |
haematopoietic_and_lymphoid_ti | M1; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.928_929delCT; 11:32374495-32374496 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.442_667del226; |
kidney | unilateral; Wilms_tumour |
Deletion - Frameshift; c.904delC; 11:32374520-32374520 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.1297_1298delCG; 11:32367232-32367233 |
kidney | Wilms_tumour |
Deletion - Frameshift; c.932_933delTA; 11:32374491-32374492 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Deletion - Frameshift; c.172delC; 11:32413092-32413092 |
kidney | bilateral; Wilms_tumour |
Deletion - Frameshift; c.172delC; 11:32413092-32413092 |
kidney | bilateral; Wilms_tumour |
Other Mutation | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Complex - frameshift; c.1153_1159TGTAAAA>CGAACTTGTAAACTGTAA; 11:32370163-32370169 |
kidney | unilateral; Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Complex - frameshift; c.902_903GA>CGG; 11:32374521-32374522 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.934_934C>GG; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Whole gene deletion; c.?_?del?; |
kidney | Wilms_tumour |
Complex - frameshift; c.905_905G>CC; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.905_906GT>CCGACCC; 11:32374518-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.926_936>AGT; 11:32374488-32374498 |
haematopoietic_and_lymphoid_ti | M4; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Whole gene deletion; c.?_?del?; |
haematopoietic_and_lymphoid_ti | M1; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Whole gene deletion; c.?_?del?; |
haematopoietic_and_lymphoid_ti | Ph_negative; chronic_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.934_934C>GG; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.927_956>CGTAC; 11:32374468-32374497 |
kidney | bilateral; Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Complex - frameshift; c.?; |
haematopoietic_and_lymphoid_ti | M8; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.903_925>GCCCCTCTCCCCCGT; 11:32374499-32374521 |
haematopoietic_and_lymphoid_ti | M5; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.923_925CGA>TGAG; 11:32374499-32374501 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.902_903GA>CGG; 11:32374521-32374522 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.905_905G>TGACGATAC; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.905_905G>TGACGATAC; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.901_901C>GG; 11:32374523-32374523 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Whole gene deletion; c.?_?del?; |
kidney | bilateral; Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Complex - frameshift; c.934_934C>GG; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | M1; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Whole gene deletion; c.?_?del?; |
kidney | Wilms_tumour |
Complex - frameshift; c.903_905ACG>GC; 11:32374519-32374521 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.898_900GTG>AACTTAC; 11:32374524-32374526 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.934_937CGGT>GGGGC; 11:32374487-32374490 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.905_908GTGT>TC; 11:32374516-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.901_934>GGGGGTAGGAAA; 11:32374490-32374523 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.901_901C>TCA; 11:32374523-32374523 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.928_937CTTGTACGGT>GAAACGTC; 11:32374487-32374496 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.924_926GAC>AGTTTTT; 11:32374498-32374500 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Whole gene deletion; c.?_?del?; |
kidney | Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Complex - frameshift; c.934_934C>GG; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.901_901C>GG; 11:32374523-32374523 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.905_905G>CCC; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.416_417AG>GGACTCGTC; 11:32412847-32412848 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Complex - frameshift; c.902_906GACGT>AAGA; 11:32374518-32374522 |
haematopoietic_and_lymphoid_ti | M2; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.901_901C>GCG; 11:32374523-32374523 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.926_935CTCTTGTACG>NNNNNNNNNNNN; 11:32374489-32374498 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.905_905G>CC; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.371_371A>TCTCGTTA; 11:32412893-32412893 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.905_908GTGT>CCATGTGG; 11:32374516-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.904_907CGTG>AGGGCCCTTCCC; 11:32374517-32374520 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.557_562GCTCGC>CCCCTACCCGA; 11:32406622-32406627 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.905_905G>CT; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.934_934C>GG; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.937_940TCGG>AGATGAAGCACCGATACTT; |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.905_905G>CCC; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.934_934C>TA; |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.934_934C>GGG; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Whole gene deletion; c.?_?del?; |
kidney | bilateral; Wilms_tumour |
Complex - frameshift; c.1291_1297TTAGTCC>CATGCCCG; 11:32367233-32367239 |
kidney | unilateral; Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | Wilms_tumour |
Complex - frameshift; c.204_206TCA>CC; 11:32413058-32413060 |
kidney | Wilms_tumour |
Complex - frameshift; c.934_934C>GG; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.901_901C>GG; 11:32374523-32374523 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.934_934C>GA; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.900_905GCGACG>CCCTTCCTATGATTTCTCCT; 11:32374519-32374524 |
haematopoietic_and_lymphoid_ti | M1; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.900_904GCGAC>ACCAGGGGG; 11:32374520-32374524 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.905_905G>CC; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.934_934C>AG; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.934_934C>AA; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.905_905G>CCCCC; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - deletion inframe; c.1172_1177delAGTTCT; |
y; haematopoietic_and_lymphoid_ti | M5; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Whole gene deletion; c.?_?del?; |
kidney | Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | Wilms_tumour |
Whole gene deletion; c.?_?del?; |
kidney | unilateral; Wilms_tumour |
Complex - frameshift; c.901_905CGACG>GCTCAGTGGGGGGAC; 11:32374519-32374523 |
haematopoietic_and_lymphoid_ti | M6; acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.905_905G>CC; 11:32374519-32374519 |
haematopoietic_and_lymphoid_ti | acute_myeloid_leukaemia; haematopoietic_neoplasm |
Complex - frameshift; c.923_952>TGAGAGGGCCG; 11:32374472-32374501 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.1085_1093GAAGGTTTT>AC; 11:32370830-32370838 |
kidney | unilateral; Wilms_tumour |
Complex - frameshift; c.904_906CGT>AGCTGGATTT; 11:32374518-32374520 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.937_943TCGGCAT>ATCGGGGGTCAC; 11:32374481-32374487 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.901_902CG>ACGG; 11:32374522-32374523 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.912_916TGGAG>CGG; 11:32374508-32374512 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Complex - frameshift; c.934_934C>AA; 11:32374490-32374490 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |