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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 8795 |
Name | TNFRSF10B |
Synonym | CD262|DR5|KILLER|KILLER/DR5|TRAIL-R2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9;tumor necrosis factor receptor superfamily, member 10b;TNFRSF10B;tumor necrosis factor receptor superfamily, member 10b |
Definition | Fas-like protein|TNF-related apoptosis-inducing ligand receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|death receptor 5|p53-regulated DNA da |
Position | 8p22-p21 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | Thus TRAIL-R may function as an inflammation and tumor suppressor in multiple tissues in vivo. |
potential | TRAIL-R1 and TRAIL-R2 act as dosage-dependent tumor suppressor genes whose monoallelic deletion can impair TRAIL-induced apoptosis in B-cell lymphoma. |
| More detail of all 2 literatures about TNFRSF10B | |
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Pathways and Diseases |
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Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | TRAIL signaling;PID Reactome;500257 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Disease | Adenocarcinoma;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Emphysema;FunDO |
Disease | Rhabdomyosarcoma;FunDO |
Disease | Liver tumor;FunDO |
Disease | Squamous cell carcinoma, head and neck;OMIM |
Disease | Leukemia;FunDO |
Disease | Brain tumor;FunDO |
Disease | Breast cancer;FunDO |
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External Links |
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Links to Entrez Gene | 8795 |
Links to all GeneRIF Items | 8795 |
Links to iHOP | 8795 |
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Sequence Information |
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Nucleotide Sequence |
>8795 : length: 1323 atggaacaacggggacagaacgccccggccgcttcgggggcccggaaaaggcacggccca ggacccagggaggcgcggggagccaggcctgggccccgggtccccaagacccttgtgctc gttgtcgccgcggtcctgctgttggtctcagctgagtctgctctgatcacccaacaagac ctagctccccagcagagagcggccccacaacaaaagaggtccagcccctcagagggattg tgtccacctggacaccatatctcagaagacggtagagattgcatctcctgcaaatatgga caggactatagcactcactggaatgacctccttttctgcttgcgctgcaccaggtgtgat tcaggtgaagtggagctaagtccctgcaccacgaccagaaacacagtgtgtcagtgcgaa gaaggcaccttccgggaagaagattctcctgagatgtgccggaagtgccgcacagggtgt cccagagggatggtcaaggtcggtgattgtacaccctggagtgacatcgaatgtgtccac aaagaatcaggtacaaagcacagtggggaagtcccagctgtggaggagacggtgacctcc agcccagggactcctgcctctccctgttctctctcaggcatcatcataggagtcacagtt gcagccgtagtcttgattgtggctgtgtttgtttgcaagtctttactgtggaagaaagtc cttccttacctgaaaggcatctgctcaggtggtggtggggaccctgagcgtgtggacaga agctcacaacgacctggggctgaggacaatgtcctcaatgagatcgtgagtatcttgcag cccacccaggtccctgagcaggaaatggaagtccaggagccagcagagccaacaggtgtc aacatgttgtcccccggggagtcagagcatctgctggaaccggcagaagctgaaaggtct cagaggaggaggctgctggttccagcaaatgaaggtgatcccactgagactctgagacag tgcttcgatgactttgcagacttggtgccctttgactcctgggagccgctcatgaggaag ttgggcctcatggacaatgagataaaggtggctaaagctgaggcagcgggccacagggac accttgtacacgatgctgataaagtgggtcaacaaaaccgggcgagatgcctctgtccac accctgctggatgccttggagacgctgggagagagacttgccaagcagaagattgaggac cacttgttgagctctggaaagttcatgtatctagaaggtaatgcagactctgccatgtcc taa |
Protein Sequence |
>8795 : length: 440 MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQD LAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVH KESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKV LPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGV NMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRK LGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIED HLLSSGKFMYLEGNADSAMS |