|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 999 |
Name | CDH1 |
Synonym | Arc-1|CD324|CDHE|ECAD|LCAM|UVO;cadherin 1, type 1, E-cadherin (epithelial);CDH1;cadherin 1, type 1, E-cadherin (epithelial) |
Definition | CAM 120/80|E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin-1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|epithelial cadherin|uvomorulin |
Position | 16q22.1 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 6 PubMed records as below. |
|
Evidence Status |
Description |
reviewed | "Cancerous tissues from 30 patients with HPSCC were examined for LOH in 4 tumor suppressor genes (TSGs) (p16, Rb, E-cadherin, and p53) at loci 9p21, 13q21, 6q22, and 17p13, respectively, using microsatellite markers amplified by polymerase chain reaction." |
reviewed | Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. |
reviewed | "in addition to the previously implicated tumor suppressor activity of E-cadherin, modified forms of this glycoprotein might also play a role in growth promotion". |
reviewed | The high frequency of methylation of the CDH1 gene promoter suggests that the inactivation of tumor suppressor genes and of the genes related to the control of cellular proliferation through this mechanism is involved in gallbladder carcinogenesis. |
reviewed | The tumor-suppressor function of E-cadherin. |
reviewed | "The transgenic adenocarcinoma of mouse prostate model encompasses androgen depletion independent sublines with increased tumorigenicity and invasiveness. All showed downregulation in tumor suppressor, E-cadherin, and metastatis suppressor, KAI-1." |
| More detail of all 6 literatures about CDH1 | |
|
Pathways and Diseases |
|
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Cell junction organization;Reactome;REACT:20676 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | tgf beta signaling pathway;PID BioCarta;100017 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;PID Reactome;500477 |
Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | a6b1 and a6b4 Integrin signaling;PID Curated;200162 |
Pathway | Nectin adhesion pathway;PID Curated;200053 |
Pathway | Thyroid cancer;KEGG PATHWAY;hsa05216 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Pathway | downregulated of mta-3 in er-negative breast tumors;PID BioCarta;100102 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | E-cadherin signaling events;PID Curated;200094 |
Pathway | E-cadherin signaling in the nascent adherens junction;PID Curated;200105 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Arf6 trafficking events;PID Curated;200046 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155 |
Pathway | sumoylation as a mechanism to modulate ctbp-dependent gene responses;PID BioCarta;100195 |
Pathway | Apoptotic cleavage of cell adhesion proteins;PID Reactome;500272 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Disease | Thyroid cancer;KEGG DISEASE;H00032 |
Disease | Gastric cancer;KEGG DISEASE;H00018 |
Disease | urothelial cancer;GAD |
Disease | urinary calculus;GAD |
Disease | bladder cancer;GAD |
Disease | Breast cancer, lobular;OMIM |
Disease | Endometrial carcinoma;OMIM |
Disease | Cleft lip with or without cleft palate, with gastric cancer, familial diffuse;OMIM |
Disease | IMMUNE;GAD |
Disease | transitional cell carcinoma of the bladder.;GAD |
Disease | Cancers of endocrine organs;KEGG DISEASE |
Disease | prostate cancer;GAD |
Disease | METABOLIC;GAD |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Ulcerative colitis;NHGRI |
Disease | gastric carcinoma risk;GAD |
Disease | colorectal cancer;GAD |
Disease | Breast cancer;KEGG DISEASE;H00031 |
Disease | Gastric cancer, familial diffuse;OMIM |
Disease | Hepatocellular carcinoma;KEGG DISEASE;H00048 |
Disease | Crohn Disease;GAD |
Disease | Penile cancer;KEGG DISEASE;H00025 |
Disease | CANCER;GAD |
Disease | Colorectal cancer;NHGRI |
Disease | Ovarian carcinoma;OMIM |
Disease | Cancers of the breast and female genital organs;KEGG DISEASE |
Disease | Listeria monocytogenes, susceptibility to;OMIM |
Disease | Cancers;KEGG DISEASE |
Disease | diffuse gastric cancer;GAD |
Disease | Cancers of the urinary system and male genital organs;KEGG DISEASE |
Disease | Nasopharyngeal cancer;KEGG DISEASE;H00054 |
Disease | Head and neck cancers;KEGG DISEASE |
Disease | ulcerative colitis;GAD |
Disease | stomach cancer;GAD |
|
External Links |
|
Links to Entrez Gene | 999 |
Links to all GeneRIF Items | 999 |
Links to iHOP | 999 |
|
Sequence Information |
|
Nucleotide Sequence |
>999 : length: 2649 atgggcccttggagccgcagcctctcggcgctgctgctgctgctgcaggtctcctcttgg ctctgccaggagccggagccctgccaccctggctttgacgccgagagctacacgttcacg gtgccccggcgccacctggagagaggccgcgtcctgggcagagtgaattttgaagattgc accggtcgacaaaggacagcctatttttccctcgacacccgattcaaagtgggcacagat ggtgtgattacagtcaaaaggcctctacggtttcataacccacagatccatttcttggtc tacgcctgggactccacctacagaaagttttccaccaaagtcacgctgaatacagtgggg caccaccaccgccccccgccccatcaggcctccgtttctggaatccaagcagaattgctc acatttcccaactcctctcctggcctcagaagacagaagagagactgggttattcctccc atcagctgcccagaaaatgaaaaaggcccatttcctaaaaacctggttcagatcaaatcc aacaaagacaaagaaggcaaggttttctacagcatcactggccaaggagctgacacaccc cctgttggtgtctttattattgaaagagaaacaggatggctgaaggtgacagagcctctg gatagagaacgcattgccacatacactctcttctctcacgctgtgtcatccaacgggaat gcagttgaggatccaatggagattttgatcacggtaaccgatcagaatgacaacaagccc gaattcacccaggaggtctttaaggggtctgtcatggaaggtgctcttccaggaacctct gtgatggaggtcacagccacagacgcggacgatgatgtgaacacctacaatgccgccatc gcttacaccatcctcagccaagatcctgagctccctgacaaaaatatgttcaccattaac aggaacacaggagtcatcagtgtggtcaccactgggctggaccgagagagtttccctacg tataccctggtggttcaagctgctgaccttcaaggtgaggggttaagcacaacagcaaca gctgtgatcacagtcactgacaccaacgataatcctccgatcttcaatcccaccacgtac aagggtcaggtgcctgagaacgaggctaacgtcgtaatcaccacactgaaagtgactgat gctgatgcccccaataccccagcgtgggaggctgtatacaccatattgaatgatgatggt ggacaatttgtcgtcaccacaaatccagtgaacaacgatggcattttgaaaacagcaaag ggcttggattttgaggccaagcagcagtacattctacacgtagcagtgacgaatgtggta ccttttgaggtctctctcaccacctccacagccaccgtcaccgtggatgtgctggatgtg aatgaagcccccatctttgtgcctcctgaaaagagagtggaagtgtccgaggactttggc gtgggccaggaaatcacatcctacactgcccaggagccagacacatttatggaacagaaa ataacatatcggatttggagagacactgccaactggctggagattaatccggacactggt gccatttccactcgggctgagctggacagggaggattttgagcacgtgaagaacagcacg tacacagccctaatcatagctacagacaatggttctccagttgctactggaacagggaca cttctgctgatcctgtctgatgtgaatgacaacgcccccataccagaacctcgaactata ttcttctgtgagaggaatccaaagcctcaggtcataaacatcattgatgcagaccttcct cccaatacatctcccttcacagcagaactaacacacggggcgagtgccaactggaccatt cagtacaacgacccaacccaagaatctatcattttgaagccaaagatggccttagaggtg ggtgactacaaaatcaatctcaagctcatggataaccagaataaagaccaagtgaccacc ttagaggtcagcgtgtgtgactgtgaaggggccgctggcgtctgtaggaaggcacagcct gtcgaagcaggattgcaaattcctgccattctggggattcttggaggaattcttgctttg ctaattctgattctgctgctcttgctgtttcttcggaggagagcggtggtcaaagagccc ttactgcccccagaggatgacacccgggacaacgtttattactatgatgaagaaggaggc ggagaagaggaccaggactttgacttgagccagctgcacaggggcctggacgctcggcct gaagtgactcgtaacgacgttgcaccaaccctcatgagtgtcccccggtatcttccccgc cctgccaatcccgatgaaattggaaattttattgatgaaaatctgaaagcggctgatact gaccccacagccccgccttatgattctctgctcgtgtttgactatgaaggaagcggttcc gaagctgctagtctgagctccctgaactcctcagagtcagacaaagaccaggactatgac tacttgaacgaatggggcaatcgcttcaagaagctggctgacatgtacggaggcggcgag gacgactag |
Protein Sequence |
>999 : length: 882 MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDC TGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVG HHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGN AVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAI AYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT AVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDG GQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDV NEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTG AISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTI FFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEV GDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILAL LILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARP EVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGS EAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD |