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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 999 |
Name | CDH1 |
Synonymous | Arc-1|CD324|CDHE|ECAD|LCAM|UVO;cadherin 1, type 1, E-cadherin (epithelial);CDH1;cadherin 1, type 1, E-cadherin (epithelial) |
Definition | CAM 120/80|E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin-1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|epithelial cadherin|uvomorulin |
Position | 16q22.1 |
Gene Type | protein-coding |
Gene Mutation: | Substitution Insertion & Deletion Other Mutation |
Substitution | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Substitution - coding silent; c.1008G>A; 16:67403263-67403263 |
stomach | signet_ring_adenocarcinoma; carcinoma |
Substitution - coding silent; c.2355C>T; 16:67421117-67421117 |
urinary_tract; bladder | transitional_cell_carcinoma; carcinoma |
Substitution - coding silent; c.2253C>T; 16:67419666-67419666 |
stomach | intestinal_adenocarcinoma; carcinoma |
Substitution - coding silent; c.864C>T; 16:67403119-67403119 |
stomach | intestinal_adenocarcinoma; carcinoma |
Substitution - coding silent; c.1008G>A; 16:67403263-67403263 |
stomach | adenocarcinoma; carcinoma |
Substitution - coding silent; c.1027C>T; 16:67403557-67403557 |
biliary_tract; bile_duct | adenocarcinoma; carcinoma |
Substitution - coding silent; c.1107C>T; 16:67403637-67403637 |
biliary_tract; bile_duct | adenocarcinoma; carcinoma |
Indel | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Deletion - Frameshift; c.1836delA; 16:67413529-67413529 |
breast | lobular_carcinoma; carcinoma |
Deletion - In frame; c.?; |
stomach | mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable; carcinoma |
Deletion - In frame; c.1321_1389del69; 16:67406919-67406987 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.164_387del224; |
breast | lobular_carcinoma; carcinoma |
Deletion - In frame; c.469_531del63; 16:67399909-67399971 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.49_163del115; 16:67329701-67329815 |
breast | luminal_NS_carcinoma; carcinoma |
Deletion - Frameshift; c.136_143delCTGGAGAG; 16:67329788-67329795 |
breast | ER-PR-positive_carcinoma; carcinoma |
Deletion - Frameshift; c.338_348delAAGTCACGCTG; |
y; breast | carcinoma |
Deletion - In frame; c.493_510del18; 16:67399933-67399950 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1519_1525delTCCTACA; 16:67407117-67407123 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.602delC; 16:67400167-67400167 |
large_intestine; colon; ascending | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1269delT; 16:67404848-67404848 |
breast | lobular_carcinoma; carcinoma |
Deletion - In frame; c.1009_1137del129; 16:67403539-67403667 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1196_1199delCTGA; 16:67404775-67404778 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1196_1199delCTGA; 16:67404775-67404778 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1196_1199delCTGA; 16:67404775-67404778 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.761_777del17; 16:67401674-67401690 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1948_1964del17; 16:67414814-67414830 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.2044_2062del19; 16:67414910-67414928 |
breast | lobular_carcinoma; carcinoma |
Deletion - In frame; c.1138_1320del183; 16:67404717-67404899 |
breast | ductal_carcinoma; carcinoma |
Deletion - In frame; c.1252_1269del18; 16:67404831-67404848 |
stomach | undifferentiated_adenocarcinoma; carcinoma |
Deletion - In frame; c.?; |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1881_1888delAGCAGAAC; 16:67413574-67413581 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.548_549delAC; 16:67400113-67400114 |
breast | ER-PR-positive_carcinoma; carcinoma |
Deletion - Frameshift; c.846delG; |
y; breast | carcinoma |
Deletion - Frameshift; c.60_79del20; 16:67329712-67329731 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.846_867del22; 16:67403101-67403122 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1027delC; 16:67403557-67403557 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.2410delC; 16:67421172-67421172 |
breast | atypical_lobular_hyperplasia; hyperplasia |
Deletion - Frameshift; c.2047_2048delGT; 16:67414913-67414914 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1027delC; 16:67403557-67403557 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - In frame; c.?; |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1269delT; 16:67404848-67404848 |
breast | luminal_NS_carcinoma; carcinoma |
Deletion - Frameshift; c.1966_1987del22; 16:67414832-67414853 |
breast | ER-PR-positive_carcinoma; carcinoma |
Deletion - In frame; c.821_832del12; 16:67401736-67401753 |
stomach | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1309_1310delAA; 16:67404888-67404889 |
breast | lobular_carcinoma_in_situ; carcinoma_in_situ |
Deletion - Frameshift; c.866_867delCG; 16:67403121-67403122 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1548_1560del13; 16:67407146-67407158 |
breast | lobular_carcinoma; carcinoma |
Deletion - In frame; c.1198_1200delGAT; 16:67404777-67404779 |
stomach | undifferentiated_adenocarcinoma; carcinoma |
Deletion - In frame; c.?; |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.2275delG; |
y; breast | carcinoma |
Deletion - Frameshift; c.22_43del22; 16:67328841-67328862 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1529_1533delCCCAG; 16:67407127-67407131 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.864_865delCG; 16:67403119-67403120 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.866_867delCG; 16:67403121-67403122 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1323_1333del11; 16:67406921-67406931 |
breast | lobular_carcinoma_in_situ; carcinoma_in_situ |
Deletion - Frameshift; c.1224delG; 16:67404803-67404803 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.459delG; 16:67399899-67399899 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1844delT; 16:67413537-67413537 |
breast | lobular_carcinoma; carcinoma |
Deletion - In frame; c.821_832del12; 16:67401736-67401753 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - In frame; c.1138_1320del183; 16:67404717-67404899 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - In frame; c.612_620del9; 16:67400177-67400185 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - In frame; c.821_832del12; 16:67401736-67401753 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.377delC; 16:67393287-67393287 |
stomach | intestinal_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1054_1058delGGTGA; 16:67403584-67403588 |
breast | basal_(triple-negative)_carcinoma; carcinoma |
Deletion - Frameshift; c.1215_1234del20; |
y; breast | carcinoma |
Deletion - Frameshift; c.372delC; 16:67393282-67393282 |
breast | ductal_carcinoma; carcinoma |
Deletion - Frameshift; c.522_531del10; 16:67399962-67399977 |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1861delC; 16:67413554-67413554 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.357delG; 16:67393267-67393267 |
oesophagus | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.49_163del115; 16:67329701-67329815 |
breast | carcinoma |
Deletion - Frameshift; c.2029delC; 16:67414895-67414895 |
breast | lobular_carcinoma; carcinoma |
Deletion - In frame; c.493_510del18; 16:67399933-67399950 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1627delT; 16:67410745-67410745 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.1971delC; 16:67414837-67414837 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.357delG; 16:67393267-67393267 |
oesophagus | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1008delG; 16:67403263-67403263 |
stomach | signet_ring_adenocarcinoma; carcinoma |
Deletion - In frame; c.?; |
stomach | diffuse_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.49_163del115; 16:67329701-67329815 |
breast | lobular_carcinoma; carcinoma |
Deletion - Frameshift; c.377delC; 16:67393287-67393287 |
stomach | diffuse_adenocarcinoma; carcinoma |
Other Mutation | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Complex - frameshift; c.862_867GACGCG>A; 16:67403117-67403122 |
breast | lobular_carcinoma; carcinoma |
Complex - frameshift; c.786_794CACCCAGGA>T; 16:67401699-67401707 |
breast | ductal_carcinoma_in_situ; carcinoma_in_situ |
Complex - frameshift; c.1795_1796AC>T; 16:67413488-67413489 |
breast | lobular_carcinoma; carcinoma |
Complex - deletion inframe; c.786_794del9; 16:67401699-67401707 |
breast | lobular_carcinoma_in_situ; carcinoma_in_situ |
Complex - frameshift; c.786_794CACCCAGGA>T; 16:67401699-67401707 |
breast | ductal_carcinoma_in_situ; carcinoma_in_situ |
Complex - frameshift; c.786_794CACCCAGGA>T; 16:67401699-67401707 |
breast | ductal_carcinoma_in_situ; carcinoma_in_situ |
Complex - frameshift; c.786_794CACCCAGGA>T; 16:67401699-67401707 |
breast | ductal_and_lobular_carcinoma_in_situ; carcinoma_in_situ |
Whole gene deletion; c.1_2649del2649; |
oesophagus | adenocarcinoma; carcinoma |
Complex - frameshift; c.786_794CACCCAGGA>T; 16:67401699-67401707 |
breast | ductal_and_lobular_carcinoma_in_situ; carcinoma_in_situ |
Complex - frameshift; c.786_794CACCCAGGA>T; 16:67401699-67401707 |
breast | ductal_carcinoma; carcinoma |