Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

1026

Name

CDKN1A

Synonymous

CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1;cyclin-dependent kinase inhibitor 1A (p21, Cip1);CDKN1A;cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Definition

CDK-interacting protein 1|CDK-interaction protein 1|DNA synthesis inhibitor|cyclin-dependent kinase inhibitor 1|melanoma differentiation associated protein 6|wild-type p53-activated fragment 1

Position

6p21.2

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction

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Interaction Type

Interactor

Data Source

interacts with

 MAP3K5BIOGRID; PUBMED:12820963;

interacts with

 MDM2BIOGRID; PUBMED:14761977;

interacts with

 MAPK8BIOGRID; PUBMED:20102411;

interacts with

 MDM4BIOGRID; PUBMED:18086887;

interacts with

 CDC27BIOGRID; PUBMED:17679094;

interacts with

 TEX11BIOGRID; PUBMED:16189514;

interacts with

 CDK1BIOGRID; PUBMED:17679094;

interacts with

 CDK6BIOGRID; PUBMED:20102411;

interacts with

 TK1BIOGRID; PUBMED:11389691;

interacts with

 CREBBPBIOGRID; PUBMED:15743834;

interacts with

 CDK2BIOGRID; PUBMED:10878006;

interacts with

 CDK2BIOGRID; PUBMED:12417722;

interacts with

 CDK2BIOGRID; PUBMED:12839982;

interacts with

 CDK2BIOGRID; PUBMED:15557281;

interacts with

 CDK2BIOGRID; PUBMED:15647383;

interacts with

 CDK2BIOGRID; PUBMED:20102411;

interacts with

 CDK2BIOGRID; PUBMED:20587660;

interacts with

 CDK2BIOGRID; PUBMED:8242751;

interacts with

 CDK2BIOGRID; PUBMED:9858587;

interacts with

 BCCIPBIOGRID; PUBMED:10878006;

interacts with

 ESR1BIOGRID; PUBMED:15743834;

interacts with

 HERC5BIOGRID; PUBMED:10581175;

interacts with

 HDAC2BIOGRID; PUBMED:16082198;

interacts with

 HDAC11BIOGRID; PUBMED:16169070;

interacts with

 HDAC1BIOGRID; PUBMED:16082198;

interacts with

 HDAC1BIOGRID; PUBMED:20154723;

interacts with

 HDAC6BIOGRID; PUBMED:16082198;

interacts with

 HDAC4BIOGRID; PUBMED:16082198;

interacts with

 GET4BIOGRID; PUBMED:16169070;

interacts with

 GAPDHBIOGRID; PUBMED:16474839;

interacts with

 GADD45GBIOGRID; PUBMED:10455148;

interacts with

 GADD45GBIOGRID; PUBMED:11022036;

interacts with

 GADD45ABIOGRID; PUBMED:10912791;

interacts with

 GADD45ABIOGRID; PUBMED:10973963;

interacts with

 DTLBIOGRID; PUBMED:18703516;

interacts with

 DTLBIOGRID; PUBMED:18794347;

interacts with

 EP300BIOGRID; PUBMED:18263614;

interacts with

 E2F1BIOGRID; PUBMED:15964998;

interacts with

 CCDC85BBIOGRID; PUBMED:16189514;

interacts with

 CCND3BIOGRID; PUBMED:16189514;

interacts with

 CDC20BIOGRID; PUBMED:17679094;

interacts with

 CCND2BIOGRID; PUBMED:16189514;

interacts with

 CUL4ABIOGRID; PUBMED:18794347;

interacts with

 DDB1BIOGRID; PUBMED:18703516;

interacts with

 DDB1BIOGRID; PUBMED:18794347;

interacts with

 CSNK2BBIOGRID; PUBMED:10679299;

interacts with

 CDK4BIOGRID; PUBMED:15695403;

interacts with

 CDK4BIOGRID; PUBMED:20102411;

interacts with

 JUNBIOGRID; PUBMED:20102411;

interacts with

 RNF144BBIOGRID; PUBMED:12853982;

interacts with

 RAB1ABIOGRID; PUBMED:16169070;

interacts with

 CCNA2BIOGRID; PUBMED:12947099;

interacts with

 CCNA2BIOGRID; PUBMED:17679094;

interacts with

 CCNB1BIOGRID; PUBMED:16082198;

interacts with

 CCNB1BIOGRID; PUBMED:17679094;

interacts with

 PIM1BIOGRID; PUBMED:12431783;

interacts with

 PSMC5BIOGRID; PUBMED:18086887;

interacts with

 PSME3BIOGRID; PUBMED:17588519;

interacts with

 PSMD2BIOGRID; PUBMED:18086887;

interacts with

 PSMA3BIOGRID; PUBMED:11350925;

interacts with

 CCNE1BIOGRID; PUBMED:12839982;

interacts with

 CCNE1BIOGRID; PUBMED:17293600;

interacts with

 SKP2BIOGRID; PUBMED:17477906;

interacts with

 SKP2BIOGRID; PUBMED:17679094;

interacts with

 STAT3BIOGRID; PUBMED:10764767;

interacts with

 TSG101BIOGRID; PUBMED:11943869;

interacts with

 CCND1BIOGRID; PUBMED:15695403;

interacts with

 CCND1BIOGRID; PUBMED:16082198;

interacts with

 CCND1BIOGRID; PUBMED:17081987;

interacts with

 CCND1BIOGRID; PUBMED:8657154;

interacts with

 SETBIOGRID; PUBMED:12407107;

interacts with

 SETBIOGRID; PUBMED:16474839;

interacts with

 TP53BIOGRID; PUBMED:11896572;

interacts with

 PARP1BIOGRID; PUBMED:12930846;

interacts with

 PARP1BIOGRID; PUBMED:20302655;

interacts with

 PARP1BIOGRID; PUBMED:20303835;

interacts with

 PCNABIOGRID; PUBMED:11313979;

interacts with

 PCNABIOGRID; PUBMED:11350925;

interacts with

 PCNABIOGRID; PUBMED:12930846;

interacts with

 PCNABIOGRID; PUBMED:16082198;

interacts with

 PCNABIOGRID; PUBMED:16189514;

interacts with

 PCNABIOGRID; PUBMED:16474839;

interacts with

 PCNABIOGRID; PUBMED:17115032;

interacts with

 PCNABIOGRID; PUBMED:17588519;

interacts with

 PCNABIOGRID; PUBMED:18086887;

interacts with

 PCNABIOGRID; PUBMED:19704162;

interacts with

 PCNABIOGRID; PUBMED:8861913;

interacts with

 PCNABIOGRID; PUBMED:8861969;

interacts with

 PCNABIOGRID; PUBMED:9465025;

interacts with

 PCNABIOGRID; PUBMED:9545252;

interacts with

 CIZ1BIOGRID; PUBMED:10529385;

interacts with

 CHEK1BIOGRID; PUBMED:11896572;

interacts with

 CDK2CELL_MAP; PUBMED:12144826;

interacts with

 MCM10HPRD; PUBMED:15232106;

interacts with

 MAP3K5HPRD; PUBMED:12820963;

interacts with

 MDM2HPRD; PUBMED:17139261;

interacts with

 MAPK8HPRD; PUBMED:12058028;

interacts with

 SLC25A11HPRD; PUBMED:16169070;

interacts with

 CDC27HPRD; PUBMED:17679094;

interacts with

 TEX11HPRD; PUBMED:16189514;

interacts with

 TOP1HPRD; PUBMED:11254741;

interacts with

 CDC45HPRD; PUBMED:15232106;

interacts with

 CCNE2HPRD; PUBMED:15232106;

interacts with

 ITGB1BP3HPRD; PUBMED:16169070;

interacts with

 CDK6HPRD; PUBMED:15232106;

interacts with

 TK1HPRD; PUBMED:11389691;

interacts with

 PRKCHHPRD; PUBMED:11175348;

interacts with

 CDK2HPRD; PUBMED:10878006;

interacts with

 CDK2HPRD; PUBMED:11175348;

interacts with

 CDK2HPRD; PUBMED:12839982;

interacts with

 CDK2HPRD; PUBMED:16765349;

interacts with

 CDK2HPRD; PUBMED:17911387;

interacts with

 CDK2HPRD; PUBMED:8101826;

interacts with

 C1orf123HPRD; PUBMED:16169070;

interacts with

 BCCIPHPRD; PUBMED:10878006;

interacts with

 ESR1HPRD; PUBMED:17911387;

interacts with

 HDAC11HPRD; PUBMED:16169070;

interacts with

 CDK3HPRD; PUBMED:9811456;

interacts with

 GADD45BHPRD; PUBMED:8700517;

interacts with

 GET4HPRD; PUBMED:16169070;

interacts with

 GMNNHPRD; PUBMED:15232106;

interacts with

 GADD45GHPRD; PUBMED:10455148;

interacts with

 CEBPAHPRD; PUBMED:9372966;

interacts with

 CDC7HPRD; PUBMED:15232106;

interacts with

 CASP3HPRD; PUBMED:9660939;

interacts with

 CCDC85BHPRD; PUBMED:16189514;

interacts with

 CDK14HPRD; PUBMED:17517622;

interacts with

 CCND3HPRD; PUBMED:15232106;

interacts with

 CDC5LHPRD; PUBMED:15232106;

interacts with

 CDC20HPRD; PUBMED:17679094;

interacts with

 CDC6HPRD; PUBMED:15232106;

interacts with

 CCND2HPRD; PUBMED:16189514;

interacts with

 CSNK2A1HPRD; PUBMED:11255227;

interacts with

 DHX9HPRD; PUBMED:11254741;

interacts with

 DAPK3HPRD; PUBMED:15001356;

interacts with

 CSNK2BHPRD; PUBMED:10679299;

interacts with

 CDK4HPRD; PUBMED:11254741;

interacts with

 CDK4HPRD; PUBMED:15232106;

interacts with

 RNF144BHPRD; PUBMED:12853982;

interacts with

 RAB1AHPRD; PUBMED:16169070;

interacts with

 RPA1HPRD; PUBMED:11254741;

interacts with

 RB1HPRD; PUBMED:10486249;

interacts with

 CCNA2HPRD; PUBMED:8662825;

interacts with

 AKT1HPRD; PUBMED:11756412;

interacts with

 CCNB1HPRD; PUBMED:11559705;

interacts with

 CCNB1HPRD; PUBMED:8662825;

interacts with

 PIM1HPRD; PUBMED:12431783;

interacts with

 PSMA3HPRD; PUBMED:11350925;

interacts with

 CCNE1HPRD; PUBMED:11175348;

interacts with

 CCNE1HPRD; PUBMED:16765349;

interacts with

 CCNE1HPRD; PUBMED:17911387;

interacts with

 CCNE1HPRD; PUBMED:8756624;

interacts with

 SKP2HPRD; PUBMED:17679094;

interacts with

 STAT3HPRD; PUBMED:10764767;

interacts with

 XRCC6HPRD; PUBMED:9798959;

interacts with

 TTLL5HPRD; PUBMED:16169070;

interacts with

 TSG101HPRD; PUBMED:11943869;

interacts with

 CCND1HPRD; PUBMED:8101826;

interacts with

 CCND1HPRD; PUBMED:8657154;

interacts with

 CCNB2HPRD; PUBMED:15232106;

interacts with

 SETHPRD; PUBMED:12407107;

interacts with

 PARP1HPRD; PUBMED:12930846;

interacts with

 PCNAHPRD; PUBMED:11254741;

interacts with

 PCNAHPRD; PUBMED:11559705;

interacts with

 PCNAHPRD; PUBMED:12964161;

interacts with

 PCNAHPRD; PUBMED:8101826;

interacts with

 CIZ1HPRD; PUBMED:10529385;

interacts with

 OBFC2BINTACT; PUBMED:21242961;

interacts with

 MKRN1MINT; DOI:10.1038/emboj.2009.164;

interacts with

 MCM7MINT; PUBMED:16289477;

interacts with

 CDC45MINT; PUBMED:15232106;

interacts with

 CDK6MINT; PUBMED:15232106;

interacts with

 CDK2MINT; PUBMED:15232106;

interacts with

 CDK2MINT; PUBMED:16765349;

interacts with

 CDK2MINT; PUBMED:16962592;

interacts with

 CDK2MINT; PUBMED:9284049;

interacts with

 HAUS1MINT; PUBMED:15232106;

interacts with

 GMNNMINT; PUBMED:15232106;

interacts with

 CCNA1MINT; PUBMED:15232106;

interacts with

 CDC7MINT; PUBMED:15232106;

interacts with

 CCND3MINT; PUBMED:15232106;

interacts with

 CDC6MINT; PUBMED:15232106;

interacts with

 CCND2MINT; PUBMED:16765349;

interacts with

 CDK4MINT; PUBMED:15232106;

interacts with

 CDK4MINT; PUBMED:16962592;

interacts with

 CCNB1MINT; PUBMED:15251430;

interacts with

 CCNE1MINT; PUBMED:16765349;

interacts with

 SKP2MINT; PUBMED:16376880;

interacts with

 SKP1MINT; PUBMED:16376880;

interacts with

 CCND1MINT; PUBMED:15232106;

interacts with

 Tsg101MINT; PUBMED:11943869;

interacts with

 CCNB2MINT; PUBMED:15232106;

interacts with

 TP53MINT; PUBMED:16616141;

Metabolic Interaction

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Interaction Type

Interactor

Data Source

metabolic catalysis

 MAXNCI_NATURE; PUBMED:12545156;PUBMED:10920185;PUBMED:15616584;PUBMED:20190815;PUBMED:12384701;

metabolic catalysis

 MITFNCI_NATURE; PUBMED:15716956;

metabolic catalysis

 TAF9NCI_NATURE; PUBMED:17719541;PUBMED:7796420;PUBMED:17110336;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 TAF9NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:17707234;PUBMED:17938176;PUBMED:17409421;PUBMED:18250150;PUBMED:19011621;

metabolic catalysis

 TAF9NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:18485870;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 TADA2BNCI_NATURE; PUBMED:17719541;PUBMED:7796420;PUBMED:17110336;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 TADA2BNCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:17707234;PUBMED:17938176;PUBMED:17409421;PUBMED:18250150;PUBMED:19011621;

metabolic catalysis

 TADA2BNCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:18485870;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 TEKNCI_NATURE; PUBMED:14726409;PUBMED:9926914;

metabolic catalysis

 NOTCH1NCI_NATURE; PUBMED:11432830;

metabolic catalysis

 NOC2LNCI_NATURE; PUBMED:21335238;PUBMED:15965232;PUBMED:19898465;PUBMED:20123734;

metabolic catalysis

 MYCNCI_NATURE; PUBMED:11844794;PUBMED:11804596;PUBMED:10435630;PUBMED:12213815;

metabolic catalysis

 MYCNCI_NATURE; PUBMED:12545156;PUBMED:10920185;PUBMED:15616584;PUBMED:20190815;PUBMED:12384701;

metabolic catalysis

 HBP1NCI_NATURE; PUBMED:9191053;PUBMED:10030670;

metabolic catalysis

 HDAC2NCI_NATURE; PUBMED:17719541;PUBMED:7796420;PUBMED:17110336;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 HDAC2NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:17707234;PUBMED:17938176;PUBMED:17409421;PUBMED:18250150;PUBMED:19011621;

metabolic catalysis

 HDAC2NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:18485870;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 GFI1NCI_NATURE; PUBMED:12545156;PUBMED:10920185;PUBMED:15616584;PUBMED:20190815;PUBMED:12384701;

metabolic catalysis

 FOXG1NCI_NATURE; PUBMED:15084259;

metabolic catalysis

 EP300NCI_NATURE; PUBMED:21335238;PUBMED:15965232;PUBMED:19898465;PUBMED:16462763;

metabolic catalysis

 EP300NCI_NATURE; PUBMED:21335238;PUBMED:15965232;PUBMED:19898465;PUBMED:20123734;

metabolic catalysis

 E2F1NCI_NATURE; PUBMED:9191053;PUBMED:10030670;

metabolic catalysis

 DNMT3ANCI_NATURE; PUBMED:12545156;PUBMED:10920185;PUBMED:15616584;PUBMED:20190815;PUBMED:12384701;

metabolic catalysis

 RB1NCI_NATURE; PUBMED:15716956;

metabolic catalysis

 ANGPT2NCI_NATURE; PUBMED:14726409;PUBMED:9926914;

metabolic catalysis

 POU4F1NCI_NATURE; PUBMED:17719541;PUBMED:7796420;PUBMED:17110336;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 POU4F1NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:17707234;PUBMED:17938176;PUBMED:17409421;PUBMED:18250150;PUBMED:19011621;

metabolic catalysis

 POU4F1NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:18485870;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 SSRP1NCI_NATURE; PUBMED:21335238;PUBMED:12374749;PUBMED:19898465;

metabolic catalysis

 STAT5ANCI_NATURE; PUBMED:14726409;PUBMED:9926914;

metabolic catalysis

 RBPJNCI_NATURE; PUBMED:11432830;

metabolic catalysis

 SMAD4NCI_NATURE; PUBMED:15084259;

metabolic catalysis

 SMAD4NCI_NATURE; PUBMED:9618481;PUBMED:10878024;

metabolic catalysis

 SMARCB1NCI_NATURE; PUBMED:14729964;PUBMED:14673169;

metabolic catalysis

 SMARCA4NCI_NATURE; PUBMED:14729964;PUBMED:14673169;

metabolic catalysis

 SMARCA4NCI_NATURE; PUBMED:17719541;PUBMED:7796420;PUBMED:17110336;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 SMARCA4NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:17707234;PUBMED:17938176;PUBMED:17409421;PUBMED:18250150;PUBMED:19011621;

metabolic catalysis

 SMARCA4NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:18485870;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 SP1NCI_NATURE; PUBMED:9191053;PUBMED:10030670;

metabolic catalysis

 SP1NCI_NATURE; PUBMED:9618481;PUBMED:10878024;

metabolic catalysis

 ZBTB17NCI_NATURE; PUBMED:12545156;PUBMED:10920185;PUBMED:15616584;PUBMED:20190815;PUBMED:12384701;

metabolic catalysis

 ZNF385ANCI_NATURE; PUBMED:17719541;PUBMED:7796420;PUBMED:17110336;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 ZNF385ANCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:17707234;PUBMED:17938176;PUBMED:17409421;PUBMED:18250150;PUBMED:19011621;

metabolic catalysis

 ZNF385ANCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:18485870;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 TP53NCI_NATURE; PUBMED:11080152;

metabolic catalysis

 TP53NCI_NATURE; PUBMED:17719541;PUBMED:7796420;PUBMED:17110336;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 TP53NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:17707234;PUBMED:17938176;PUBMED:17409421;PUBMED:18250150;PUBMED:19011621;

metabolic catalysis

 TP53NCI_NATURE; PUBMED:7796420;PUBMED:17719541;PUBMED:18485870;PUBMED:17409421;PUBMED:17938176;PUBMED:17707234;PUBMED:18250150;

metabolic catalysis

 TP53REACTOME; PUBMED:8242752;

Signaling Interaction

   | Top |

Interaction Type

Interactor

Data Source

reacts with

 CDK2NCI_NATURE; PUBMED:7629134;PUBMED:14673169;

reacts with

 CDKN1ANCI_NATURE; PUBMED:11231573;PUBMED:16982699;

reacts with

 CDKN1ANCI_NATURE; PUBMED:7629134;PUBMED:14673169;

reacts with

 AKT2NCI_NATURE; PUBMED:11231573;PUBMED:16982699;

state change

 AKT1NCI_NATURE; PUBMED:11231573;PUBMED:16982699;

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