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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 1026 |
Name | CDKN1A |
Synonymous | CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1;cyclin-dependent kinase inhibitor 1A (p21, Cip1);CDKN1A;cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
Definition | CDK-interacting protein 1|CDK-interaction protein 1|DNA synthesis inhibitor|cyclin-dependent kinase inhibitor 1|melanoma differentiation associated protein 6|wild-type p53-activated fragment 1 |
Position | 6p21.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
p21Cip1(h) --/ PS1(h) (inhibition) | Cdk4(h) + p21Cip1(h) <==> Cdk4(h):p21Cip1(h) (binding) | cyclinA(h) + p21Cip1(h) <==> cyclinA(h):p21Cip1(h) (binding) | Cdk2(h) + p21Cip1(h) <==> Cdk2(h):p21Cip1(h) (binding) | PCNA(h) + p21Cip1(h) <==> PCNA(h):p21Cip1(h) (binding) | SET(h) + p21Cip1(h) <==> SET(h):p21Cip1(h) (binding) | cyclinE(h) + p21Cip1(h) <==> cyclinE(h):p21Cip1(h) (binding) | calmodulin(h):Ca + p21Cip1(h) <==> calmodulin(h):Ca:p21Cip1(h) (binding) | pRb(h) + p21Cip1(h) <==> pRb(h):p21Cip1(h) (binding) | cyclinA(h):Cdk2(h) + p21Cip1(h) <==> cyclinA(h):Cdk2(h):p21Cip1(h) (binding) | cyclinD1(h) + p21Cip1(h) <==> cyclinD1(h):p21Cip1(h) (binding) | cyclinE(h):Cdk2(h) + p21Cip1(h) <==> cyclinE(h):Cdk2(h):p21Cip1(h) (binding) | CKII-beta(x) + p21Cip1(h) <==> CKII-beta(x):p21Cip1(h) (binding) | CKII(x) + p21Cip1(h) + ATP --> CKII(x):p21Cip1(h) + ADP (binding; phosphorylation) | p21Cip1(h) + ATP --AKT(b)--> p21Cip1(h){pT145} + ADP (phosphorylation) | PCNA(mo) + p21Cip1(h) <==> PCNA(mo):p21Cip1(h) (binding) | Cdk2(h){pT160} + p21Cip1(h) + TOK-1alpha(h) <==> Cdk2(h){pT160}:p21Cip1(h):TOK-1alpha(h) (binding) | p21Cip1(h) + TOK-1alpha(h) <==> p21Cip1(h):TOK-1alpha(h) (binding) | cyclinD1(h) + Cdk4(h) + p21Cip1(h) <==> cyclinD1(h):Cdk4(h):p21Cip1(h) (binding) | E2F-4(h):DP-1(h):p107(h):cyclinA(h):Cdk2(h) + p21Cip1(h) <==> E2F-4(h):DP-1(h):p107(h) + cyclinA(h):Cdk2(h):p21Cip1(h) (binding; dissociation) | p21Cip1(h) + STAT3(h) <==> p21Cip1(h):STAT3(h) (binding) | p21Cip1(h) + E7(HPV16) <==> p21Cip1(h):E7(HPV16) (binding) | p21Cip1(h) + PARP(h) <==> p21Cip1(h):PARP(h) (binding) | Pold2(h) + p21Cip1(h) <==> Pold2(h):p21Cip1(h) (binding) | p21Cip1(h) + MGMT(h) <==> p21Cip1(h):MGMT(h) (binding) | p21Cip1(h) + TK1(h) <==> p21Cip1(h):TK1(h) (binding) | GADD45-alpha(h) + p21Cip1(h) <==> GADD45-alpha(h):p21Cip1(h) (binding) | p21Cip1(h) --> p21Cip1(h) (translocation) | p21Cip1(h) + ATP --PKCdelta(h)--> p21Cip1(h){pS146} + ADP (phosphorylation) | p21Cip1(h) + ATP --PKCdelta(m.s.)--> p21Cip1(h){pS146} + ADP (phosphorylation) | p21Cip1(h) --> p21Cip1-p15(h) + protein remnants (cleavage) | p21Cip1(h) + HCV-Core-1B-Japanese(HCV1BJapan) <==> p21Cip1(h):HCV-Core-1B-Japanese(HCV1BJapan) (binding) | p21Cip1(h) + Cdk1(h) <==> p21Cip1(h):Cdk1(h) (binding) | p21Cip1(h) + cyclinD2(h) <==> p21Cip1(h):cyclinD2(h) (binding) | cyclinD3(h) + p21Cip1(h) <==> cyclinD3(h):p21Cip1(h) (binding) | p21Cip1(h) + DIPA(h) <==> p21Cip1(h):DIPA(h) (binding) | p21Cip1(h) + TGC1(h) <==> p21Cip1(h):TGC1(h) (binding) | CDKN1A(h) --> p21Cip1(h) (expression). | SMAR1-isoform1(m) --> p21Cip1(h) (increase of abundance) | p53(h) --> p21Cip1(h) (increase of abundance) | catalase(m.s.) --> p21Cip1(h) (regulation of abundance) | HAUSP(h) --/ p21Cip1(h) (decrease of abundance) | H-Ras(h) --> p21Cip1(h) (increase of abundance) | mdm2-isoform1(h) --/ p21Cip1(h) (decrease of abundance) | GSK3beta(m.s.) --/ p21Cip1(h) (decrease of abundance) | PTIP(h) --> p21Cip1(h) (increase of abundance) | TGFbeta1(h) --> p21Cip1(h) (increase of abundance) | TGFbeta1(m.s.) --> p21Cip1(h) (increase of abundance) | TGFbeta(m.s.) --> p21Cip1(h) (increase of abundance) | AKT-1(h) --/ p21Cip1(h) (decrease of abundance) | p53-isoform1(h) --> p21Cip1(h) (increase of abundance) | p16-INK4a-p14(m.s.) --> p21Cip1(h) (increase of abundance) | nucleophosmin(m.s.) --/ p21Cip1(h) (decrease of abundance) | p21Cip1(h) --> p21Cip1(h) (translocation) | p16INK4a(m.s.) --> p21Cip1(h) (increase of abundance) | p53-isoform1(h){pS315} --> p21Cip1(h) (increase of abundance) | RNF96(h) --/ p21Cip1(h) (decrease of abundance) | MULE(h) --/ p21Cip1(h) (decrease of abundance) | mdm2(h) --/ p21Cip1(h) (decrease of abundance) | COP1(h) --/ p21Cip1(h) (decrease of abundance) | PIRH2(h) --/ p21Cip1(h) (decrease of abundance) | p16INK4a-xbb1(h) --> p21Cip1(h) (increase of abundance) | NIAM(h) --> p21Cip1(h) (increase of abundance) | APC7(h) --> p21Cip1(h) (increase of abundance) | APC5(h) --> p21Cip1(h) (increase of abundance) | HCV-NS5A-1B-Japanese(HCV1BJapan) --/ p21Cip1(h) (decrease of abundance) | HCV-NS5A-1A-H(HCV1AH) --> p21Cip1(h) (increase of abundance) | 14-3-3gamma(h) --> p21Cip1(h) (increase of abundance) | Mdm4(h) --/ p21Cip1(h) (decrease of abundance) | HCV-NS5A-1A-H(HCV1AH) --/ p21Cip1(h) (decrease of abundance) | PIAS1(m.s.) --/ p21Cip1(h) (decrease of abundance) | p73alpha(h) --> p21Cip1(h) (increase of abundance) | p53(m.s.) --> p21Cip1(h) (increase of abundance) | Cdc6-p49(h) --> p21Cip1(h) (increase of abundance) | Cdc6-p32(h) --> p21Cip1(h) (increase of abundance) | p63gamma(m.s.) --> p21Cip1(h) (increase of abundance) | p73alpha(m.s.) --> p21Cip1(h) (increase of abundance) | p73beta(m.s.) --> p21Cip1(h) (increase of abundance) | Cdx-2(h) --> p21Cip1(h) (increase of abundance) | p16INK4a-p14(h) --> p21Cip1(h) (increase of abundance) | NRG1(m.s.) --> p21Cip1(h) (increase of abundance) | EGF(h) --> p21Cip1(h) (increase of abundance) | NRG-Beta1(m.s.) --> p21Cip1(h) (increase of abundance) | EGF(m.s.) --> p21Cip1(h) (increase of abundance) | NDKA(h) --> p21Cip1(h) (increase of abundance) | STRAP(h) --> p21Cip1(h) (increase of abundance) | GIF(m.s.) --/ p21Cip1(h) (decrease of abundance) | GIF(h) --/ p21Cip1(h) (decrease of abundance) | s100a11(h) --/ p21Cip1(h) (decrease of abundance) | Skp2(m.s.) --/ p21Cip1(h) (decrease of abundance) | PTEN(h) --> p21Cip1(h) (increase of abundance) | RASSF1-A(m.s.) --> p21Cip1(h) (activation; increase of abundance) | Apak(h) --/ p21Cip1(h) (decrease of abundance) | rps6(h) --/ p21Cip1(h) (decrease of abundance) | rps23(h) --/ p21Cip1(h) (decrease of abundance) | rpl7a(h) --/ p21Cip1(h) (decrease of abundance) | chd8-isoform2(m) --/ p21Cip1(h) (decrease of abundance) | Chfr(h) --> p21Cip1(h) (increase of abundance) | MATH1(m.s.) --> p21Cip1(h) (increase of abundance) | UBP41(h) --/ p21Cip1(h) (inhibition; decrease of abundance) | EIF5A1-isoform1(h) --> p21Cip1(h) (increase of abundance) | Pold2(h) + p21Cip1(h) <==> Pold2(h):p21Cip1(h) (binding) | PCNA(h) + p21Cip1(h) <==> PCNA(h):p21Cip1(h) (binding) | c-Myc(h) + p21Cip1(h) <==> c-Myc(h):p21Cip1(h) (binding) | PCNA(m.s.) + p21Cip1(h) <==> PCNA(m.s.):p21Cip1(h) (binding) | p21Cip1(h) + TK1(h) <==> p21Cip1(h):TK1(h) (binding) | Cdk2(m) + p21Cip1(h) <==> Cdk2(m):p21Cip1(h) (binding) | p21Cip1(h) + SET-isoform2(h) <==> p21Cip1(h):SET-isoform2(h) (binding) | p21Cip1(h) + calmodulin(h) <==> p21Cip1(h):calmodulin(h) (binding) | p21Cip1(h) + ATP --Rac(m.s.)--> p21Cip1(h){p} + ADP (phosphorylation) | p21Cip1(h) + ATP --PKC(r)--> p21Cip1(h){p} + ADP (phosphorylation) | p21Cip1(h) + PCNA(m.s.) <==> p21Cip1(h):PCNA(m.s.) (binding) | p21Cip1(h) + ASK1(h) <==> p21Cip1(h):ASK1(h) (binding) | p21Cip1(h) + ATP --PKCdelta(h)--> p21Cip1(h){pS146} + ADP (phosphorylation) | Cdk2(m.s.) + p21Cip1(h) <==> Cdk2(m.s.):p21Cip1(h) (binding) | Cdk2(h) + p21Cip1(h) <==> Cdk2(h):p21Cip1(h) (binding) | p21Cip1(h) + HCV-Core-1B-Japanese(HCV1BJapan) <==> p21Cip1(h):HCV-Core-1B-Japanese(HCV1BJapan) (binding) | p21Cip1(h) + Cdk4(h) <==> p21Cip1(h):Cdk4(h) (binding) | p21Cip1(h) + cyclinE(h) + Cdk2(h) <==> p21Cip1(h):cyclinE(h):Cdk2(h) (binding) | CDKN1A(h) --> p21Cip1(h) (expression). | p15INK4b(h) --/ p21Cip1(h) (decrease of abundance) | Smad4(m.s.) --> p21Cip1(h) (increase of abundance) | CDKN1A(h) --> CDKN1A(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
2 | N-acetylserine. | Swiss-Prot 53.0 | 130 | Phosphoserine. | Swiss-Prot 53.0 | 145 | Phosphothreonine (by PKA and PKB/AKT1). | Swiss-Prot 53.0 | 146 | Phosphoserine (by PKC). | Swiss-Prot 53.0 | 160 | Phosphoserine; by PKC; in vitro. | Swiss-Prot 53.0 | 145 | Phosphoserine (PKC alpha;PK) | 11756412;10753973 | Phospho.ELM 6.0 | 56 | Phosphothreonine (GSK-3beta;MA) | 12058028;11779850 | Phospho.ELM 6.0 | 152 | Phosphoserine (DYRK1B) | 15851482 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr6 |
Promoter: 36752965 - 36754965 | Agilent_014791 |
chr6 |
Promoter: 36752965 - 36754965 | GoldenGate_Methylation_Cancer_Panel_I |
chr6 |
Promoter: 36752965 - 36754965 | GoldenGate_Methylation_Cancer_Panel_I |
chr6 |
Promoter: 36752965 - 36754965 | GSE27584 |
chr6 |
Promoter: 36752965 - 36754965 | GSE27584 |
chr6 |
Promoter: 36752965 - 36754965 | Agilent_014791 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:12149142 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:12149142 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:11943705 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:11943705 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:16276353 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:16276353 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:11895758 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:11895758 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:10866323 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:10866323 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:17216555 |
chr6 |
Promoter: 36752965 - 36754965 | PMID:17216555 |